Abstract：
INTRODUCTION:The Amyotrophic Lateral Sclerosis (ALS) is a disease characterized by the selective degeneracy of the superior motoneurons of the cortex motor and of the inferior motoneurons at level of the encephalic trunk and spinal marrow. Exist sporadic and familiar forms, being estimated an incidence of 1-2 cases by 100,000 inhabitants. The cause of the neuronal degeneracy is yet unknown, being implied, between other mechanisms, the glutamic exotoxicity is the responsible for the death neuronal. The riluzol is a benzothiazole derivative whose neuroprotector mechanism still it has not been totally clarified, though seems that reduces the neuroexcitatory action of the glutamic acid blocking his transmission. DEVELOPMENT:Two clinical trials have been accomplished with similar characteristics: multicentre, randomized, double blind, and placebo-controlled. Between both studies have been included more than 1,100 patient, obtained significant statistic results in the prolongation of the survival time, however this effect was not going accompanied of an improvement in the muscular force neither of the pulmonary capacity, what is translated in which the riluzol does not modify the quality of life of the patient. The drug presents good tolerance and mild adverse effects and as consequence of this in 1996, the FDA approved his marketing and utilization in the treatment of the ALS. The approval of the riluzol as first agent for the treatment of the ALS has raised an important number of problems about the efficiency and cost of the treatment. CONCLUSION:Though its benefits are modest, it is considered a starting point in the pharmacotherapy of the ALS.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Borrás-Blasco J,Plaza-Macías I,Navarro-Ruiz A,Perís-Martí J,Antón-Cano Asubject
Has Abstractpub_date
1998-12-01 00:00:00pages
1021-7issue
160eissn
0210-0010issn
1576-6578journal_volume
27pub_type
杂志文章,评审abstract：AIM:Different patients exhibit wide variability in the way they respond to medications. Individual differences in drug response can result from environmental factors, as well as genetic determinants. In particular, inherited differences in the metabolism and disposition of drugs can have a great influence on the effica...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2004-12-01 00:00:00
abstract：TITLE:Síndrome de depleción de ADN mitocondrial tipo 13: un caso con un inicio poco común. : ...
journal_title：Revista de neurologia
pub_type： 信件
doi：10.33588/rn.6910.2019221
更新日期：2019-11-16 00:00:00
abstract：AIM:The aim is to review the molecular and genetic aspects of the dystrophic and no dystrophic myotonias. BACKGROUND:Myotonic diseases are hereditary conditions of the skeletal muscle, classified in two groups depending on the symptoms. In the first group are the myotonic dystrophies, with the myotonic dystrophies typ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2004-04-01 00:00:00
abstract：INTRODUCTION:Transient cognitive disorders (CD) in benign rolandic epilepsy (BRE), the most common of idiopathic partial epilepsy (IPE), may be secondary to interictal epileptiform discharges (IED). OBJECTIVES:To determine incidence and risk factors for persistent TC in students with IE before, during and after antiep...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-02-01 00:00:00
abstract：:Magnetic resonance is the most sensitive para-clinical method available for the diagnosis of multiple sclerosis since it shows changes in 95% of the patients with clinically definite multiple sclerosis. However, little correlation has been found, in different studies, between the parameters of magnetic resonance and t...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-16 00:00:00
abstract：AIM:To analyze the safety profile and clinical outcome of patients with acute cerebral ischemia who received open treatment with tissue plasminogen activator (rt-PA) in a hospital without previous experience. PATIENTS AND METHODS:This prospective and observational study were realized from January 2004 to January 2007....
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVES:1. To critically analyze the concept of 'vegetative' state and a number of reasons that seem to justify the abandonment of this term. 2. To propose a new conceptual approach to the syndrome and, based on this approach, a new terminology. DEVELOPMENT:The concept of 'vegetative' state became popular in the me...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-12-16 00:00:00
abstract：:We present the association of a distrophinopathy with a case of facioscupulohumeral dystrophy in two individuals belonging to the same family. The discrepancy in the seric creatinphosphokinase (CPK) of the two patients together with certain clinical data suggests the possibility that it is a question of two different ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
abstract：INTRODUCTION:'Sword stroke' linear scleroderma, which is better known as linear scleroderma en coup de sabre (LSCS), is a rare disease with an uncertain causation that is characterised by progressive craniofacial focal atrophy and is, at least in part, different from Parry-Romberg syndrome (PRS). CASE REPORTS:Here, we...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-11-01 00:00:00
abstract：INTRODUCTION:Despite their importance, little attention has been given to the recognition of early markers of hyperactivity in the scientific literature and in everyday practice it can be difficult to separate some of the physiological behaviours displayed by older babies or preschool infants from pathological processe...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-02-13 00:00:00
abstract：:The most relevant data presented at the 29th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), held in October 2013 in Denmark, were summarised at the sixth edition of the Post-ECTRIMS Expert Meeting held in Madrid in October 2013, resulting in this review, which is being p...
journal_title：Revista de neurologia
pub_type：
doi：
更新日期：2014-10-16 00:00:00
abstract：:INTRODUCTION. Since James Parkinson published what can be considered the first treaty on the disease that bears his name in 1817, the scientific literature on this pathology has not ceased to grow. But the illness has also been represented in literature, the cinema and on television, where the symptoms, treatment and ...
journal_title：Revista de neurologia
pub_type： 历史文章,杂志文章
doi：
更新日期：2014-02-01 00:00:00
abstract：INTRODUCTION:Vestibular evoked myogenic potential (VEMP) elicited by acoustic stimulation, has been proposed in the assessment of vestibulospinal pathways. AIM:To research the clinical utility of VEMP on multiple sclerosis (MS). SUBJECTS AND METHODS:Forty-four individuals were evaluated (30 normal state and 14 had MS...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2009-03-16 00:00:00
abstract：AIM AND DEVELOPMENT:To debate about the application of on-going 'revolutions' in medical knowledge to Spanish neurological journals in the 21st century. This article reviews the current status of five revolutions in the field of health sciences, in general, and in neurological sciences, in particular: 1) the knowledge ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-16 00:00:00
abstract：INTRODUCTION:Performing amniocentesis between the fourth and sixth months of gestation is a widespread practice. However, it can entail serious consequences, apart from the loss of the foetus, such as injuries to the developing central nervous system. CASE REPORTS:Over the past few years we have dealt with four patien...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：INTRODUCTION:Throughout the history of thought, science and philosophy have addressed the problem of mind-brain from different epistemic perspectives. The first covers specific areas of reality and constructs hypotheses with limited scope and multiple inter-scientific connectivity with the aim of validating theoretical...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2016-08-01 00:00:00
abstract：:The association of unilateral ptosis and contralateral palpebral retraction named as "palpebral plus-minus syndrome" by Gaynard et al is an infrequent finding. Most cases described are of peripheral origin and secondary to muscle pathology or neuromuscular union. Cases secondary to central lesions are exceptional. We ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：INTRODUCTION:The retina is a neuronal membrane that covers the posterior part of the eye chamber and is formed by several layers. The retinal function can be synthesize as the light translation into nervous impulses in the optic nerve. MATERIAL AND METHODS:The ERG is the expression of the changes of the electrical pot...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-03-01 00:00:00
abstract：INTRODUCTION:Studies about childhood epilepsy with centrotemporal spikes (CECTS), most of them retrospective, include patients with highly heterogeneous features. AIM:To investigate the prognostic value of objective diagnostic criteria for CECTS applied at six month of evolution of epilepsy. PATIENTS AND METHODS:All ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：10.33588/rn.7006.2019357
更新日期：2020-03-16 00:00:00
abstract：INTRODUCTION:The motor control deficits after stroke affect the gait pattern. There is a significant variability between subjects. AIMS:To analyse, by using a capture motion system, the gait pattern in stroke patients with different levels of motor function, and to establish, despite the participants heterogeneity, wh...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2016-11-16 00:00:00
abstract：INTRODUCTION:The rapid-onset dystonia-parkinsonism is a movement disorder which associates dystonic symptoms, especially those affecting orofacial muscles, and parkinsonian symptoms. All these symptoms start suddenly and then they stabilize along the process. This disorder usually occurs to young adults and is an autos...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2008-12-16 00:00:00
abstract：INTRODUCTION:The Real Ordinance 2070/1999 meant an important modification in the legislation, when including transcranial Doppler (TCD) in explorations to confirm the clinical diagnosis of brain death (BD). Habitually for their employment in the diagnosis of BD, we look for blood flow signal from the middle cerebral ar...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2001-11-16 00:00:00
abstract：INTRODUCTION:In this research we study primary headaches, which are currently considered to be a public health problem. We also examine the fact that an ever increasing number of people are affected and that in some cases such headaches can eventually be disabling because they bring about different degrees of functiona...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-05-16 00:00:00
abstract：INTRODUCTION:Colloid cysts are intracranial lesions with an estimated incidence of three individuals per million people per year. They are benign tumours in the anterosuperior portion of the third ventricle. The normal flow of cerebrospinal fluid may be interrupted by a large cyst that obstructs the foramen of Monro. T...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2003-05-01 00:00:00
abstract：INTRODUCTION:At present, cholinesterase inhibitors constitute the basis for therapy of Alzheimer's disease (AD); these drugs were rationally introduced given the loss of central cholinergic neurotransmission, even though there are many other systems affected in AD, including glutamatergic pathway. DEVELOPMENT:In addit...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-04-16 00:00:00
abstract：INTRODUCTION:Epilepsy is one of the most common neurological disorders, affecting about one percent of the world population. Pharmacological treatment fails in one-third of these patients. Surgical intervention has become an accepted treatment option for those patients with seizure disorders that are refractory to conv...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-10-01 00:00:00
abstract：INTRODUCTION:The value of the P300 cognitive event-related potential in the diagnosis of Alzheimer subtype neurocognitive disorders is still incipient. Recent studies suggest that combining it with neuropsychological tests by cognitive domains would allow an objective and early characterisation of the cognitive impairm...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：10.33588/rn.7101.2019341
更新日期：2020-07-01 00:00:00
abstract：INTRODUCTION:Over the last twenty years much work has been done to study the P300 in alcoholism. A systematically reduced amplitude, both in patients and in populations at risk (children of alcoholics) was found. Besides, studies on twins indicate that the waves of the evoked potentials are under genetic control. Furth...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2000-04-16 00:00:00
abstract：INTRODUCTION:The treatment of cervical spondylosis may be medical, surgical or both. Surgical treatment is indicated mainly in patients with untreatable pain, progressive neurological deficit and proven compression of the nerve roots and spinal cord. Corporectomy with a graft and fusion is one of the most widely used t...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-02-01 00:00:00
abstract：AIM:To assess the budget impact of the treatment for relapsing remitting multiple sclerosis (RRMS), interferons, and glatiramer acetate, from the National Health System perspective in Spain. PATIENTS AND METHODS:A budget impact model was designed to compare the cost of RRMS treatment in different settings, using a fiv...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2011-08-01 00:00:00
