Absence of autoregulation of cerebral blood flow during halothane and enflurane anesthesia.

Abstract:

:The effects of halothane and enflurane anesthesia under conditions of normo-, hyper-, and hypocarbia on the autoregulation of cerebral blood flow (CBF) in the goat were evaluated. The goat was selected because of its unique arterial blood supply to the head and the development of a method by which CBF may be continuously measured. The study revealed that 1 MAC of halothane or enflurane anesthesia at normocarbia abolished cerebral autoregulation, CBF increasing or decreasing with increasing or decreasing peripheral blood pressure. Reduction of anesthesia to 0.5 MAC partially restored cerebral autoregulatory capability. The effect of 1 MAC and 0.5 MAC anesthesia on cerebral autoregulation of blood flow was potentiated by hypercarbia and antagonized by hypocarbia, indicating that the vascular response to blood CO2 fluctuations remained intact.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Miletich DJ,Ivankovich AD,Albrecht RF,Reimann CR,Rosenberg R,McKissic ED

doi

10.1213/00000539-197601000-00024

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

100-9

issue

1

eissn

0003-2999

issn

1526-7598

journal_volume

55

pub_type

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