Gentamicin blocks both fast and slow effects of olivocochlear activation in anesthetized guinea pigs.

Abstract:

:The medial olivocochlear (MOC) efferent system, which innervates cochlear outer hair cells, suppresses cochlear responses. MOC-mediated suppression includes both slow and fast components, with time courses differing by three orders of magnitude. Pharmacological studies in anesthetized guinea pigs suggest that both slow and fast effects on cochlear responses require an initial acetylcholine activation of alpha-9 nicotinic receptors on outer hair cells and that slow effects require additional intracellular events downstream from those mediating fast effects. Gentamicin, an aminoglycoside antibiotic, has been reported to block fast effects of sound-evoked OC activation following intramuscular injection in unanesthetized guinea pigs, without changing slow effects. In the present study, we show that electrically evoked fast and slow effects in the anesthetized guinea pig are both blocked by either intramuscular or intracochlear gentamicin, with similar time courses and/or dose-response curves. We suggest that sound-evoked slow effects in unanesthetized animals are fundamentally different from electrically evoked slow effects in anesthetized animals, and that the former may arise from effects of the lateral OC system.

journal_name

J Neurophysiol

authors

Yoshida N,Liberman MC,Brown MC,Sewell WF

doi

10.1152/jn.1999.82.6.3168

subject

Has Abstract

pub_date

1999-12-01 00:00:00

pages

3168-74

issue

6

eissn

0022-3077

issn

1522-1598

journal_volume

82

pub_type

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