Pharmacological properties and functional role of a TRP-related ion channel in lobster olfactory receptor neurons.

Abstract:

:Odors activate lobster olfactory receptor neurons (ORNs) through phosphoinositide signaling that appears to target a Na(+)-gated nonselective cation channel. The Na(+)-gated channel is a potential member of the growing family of transient receptor potential (TRP) channels. Here, we test the effect of potential antagonists on the channel in cell-free patches from cultured lobster ORNs. We show that the channel is antagonized by H+ and the TRP channel blockers 2-aminoethoxydiphenyl borate, SKF96365, ruthenium red, Al3+, Gd3+, and La3+. We then use this enhanced antagonist profile together with the agonists Na+ and Ca2+ to implicate the channel in signal amplification in the cells.

journal_name

J Neurophysiol

authors

Bobkov YV,Ache BW

doi

10.1152/jn.00990.2004

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

1372-80

issue

3

eissn

0022-3077

issn

1522-1598

pii

00990.2004

journal_volume

93

pub_type

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