Abstract:
:Odors activate lobster olfactory receptor neurons (ORNs) through phosphoinositide signaling that appears to target a Na(+)-gated nonselective cation channel. The Na(+)-gated channel is a potential member of the growing family of transient receptor potential (TRP) channels. Here, we test the effect of potential antagonists on the channel in cell-free patches from cultured lobster ORNs. We show that the channel is antagonized by H+ and the TRP channel blockers 2-aminoethoxydiphenyl borate, SKF96365, ruthenium red, Al3+, Gd3+, and La3+. We then use this enhanced antagonist profile together with the agonists Na+ and Ca2+ to implicate the channel in signal amplification in the cells.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Bobkov YV,Ache BWdoi
10.1152/jn.00990.2004subject
Has Abstractpub_date
2005-03-01 00:00:00pages
1372-80issue
3eissn
0022-3077issn
1522-1598pii
00990.2004journal_volume
93pub_type
杂志文章abstract::Histamine is a known secretagogue in adrenal chromaffin cells. Activation of G-protein linked H(1) receptors stimulates phospholipase C, which generates inositol trisphosphate leading to release of intracellular calcium stores and stimulation of calcium influx through store operated and other channels. This calcium le...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2000.83.3.1435
更新日期:2000-03-01 00:00:00
abstract::Fast inhibitory synaptic transmission in the brain relies on ionotropic GABA(A) receptors (GABA(A)R). Eighteen genes code for GABA(A)R subunits, but little is known about the epsilon subunit. Our aim was to identify the synaptic transmission properties displayed by native receptors incorporating epsilon. Immunogold lo...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00227.2009
更新日期:2009-10-01 00:00:00
abstract::When a monkey attends to, remembers, and looks toward targets, the activity of some neurons in the lateral intraparietal area (LIP) changes. We recorded from isolated neurons during both a spatial and a shape match-to-sample task to examine and characterize voluntary active processes in LIP. Many LIP neurons show spat...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00431.2005
更新日期:2006-02-01 00:00:00
abstract::We examined how subjects plan speeded reaching movements when the precise target of the movement is not known at movement onset. Before each reach, subjects were given only a probability distribution on possible target positions. Only after completing part of the movement did the actual target appear. In separate expe...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00858.2007
更新日期:2007-11-01 00:00:00
abstract::When an object is lifted vertically, the normal force increases and decreases in tandem with tangential (load) force to safely avoid slips. For horizontal object transport, horizontal forces at the contact surfaces can be decomposed into manipulation forces (producing acceleration/deceleration) and grasping forces. Al...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00267.2007
更新日期:2007-08-01 00:00:00
abstract::Recent studies have reported that human subjects show varying degrees of ability to use contextual cues to recall the motor skills required to compensate for different dynamic external force fields during arm movements. In particular, the subjects showed little or no ability to use color cues to adjust motor outputs i...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00779.2002
更新日期:2003-02-01 00:00:00
abstract::The spider VS-3 slit-sense organ contains two types of primary mechanoreceptor neurons that are morphologically similar but have different electrical behavior. Type A neurons fire only one or two action potentials in response to a mechanical or electrical step of any amplitude above the threshold, whereas type B neuro...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00440.2001
更新日期:2002-03-01 00:00:00
abstract::The functional significance of vestibular information for the generation of gaze shifts is controversial and less well established than the vestibular contribution to gaze stability. In this study, we asked seven bilaterally avestibular patients to execute voluntary, whole body pivot turns to visual targets up to 180°...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00343.2019
更新日期:2019-11-01 00:00:00
abstract::Amino acid and bile salt odorants are detected by zebrafish with relatively independent odorant receptors, but the transduction cascade(s) subsequently activated by these odorants remains unknown. Electro-olfactogram recording methods were used to determine the effects of two drugs, reported to affect phospholipase C ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.3.1183
更新日期:1998-03-01 00:00:00
abstract::Behavioral and physiological characteristics of standing were studied in nontrained spinal cats and in spinal cats that received daily stand training of the hindlimbs for 12 wk. Training consisted of assisting the cats to stand with full weight support either on both hindlimbs or on one hindlimb (30 min/day, 5 days/wk...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.80.1.83
更新日期:1998-07-01 00:00:00
abstract::1. It was the aim of this study to show that nucleus Z of the cat medulla acts as a relay between the spinal cord and the ventral lateral (VL) nucleus of the motor thalamus. For this purpose, extracellular recordings were made from neurons that were antidromically identified by stimulation in the rostral thalamus, par...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1993.69.5.1607
更新日期:1993-05-01 00:00:00
abstract::During auditory stimulation with several frequency components, distortion products (DPs) are generated as byproduct of nonlinear cochlear amplification. After generated, DP energy is reemitted into the ear channel where it can be measured as DP otoacoustic emission (DPOAE), and it also induces an excitatory response a...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90805.2008
更新日期:2009-03-01 00:00:00
abstract::Weight predictions used to scale lifting forces adapt quickly when repeatedly lifting unusually weighted objects and are readily updated by explicit information provided about weight. In contrast, weight predictions used when making perceptual judgments about weight are more resistant to change and are largely unaffec...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01051.2015
更新日期:2016-09-01 00:00:00
abstract::Current and voltage-clamp recordings were made at room temperature from cultured mouse spinal neurons using conventional two-electrode voltage-clamp techniques and electrodes filled with either 3 M KCl, 3 M CsCl, or 3 M Cs2SO4. In the presence of tetraethylammonium and tetrodotoxin, "fast" (rapidly rising and falling)...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1986.55.6.1115
更新日期:1986-06-01 00:00:00
abstract::Microelectrode arrays (MEAs) are appealing tools to probe large neural ensembles and build neural prostheses. Microelectronics microfabrication technologies now allow building high-density MEAs containing several hundreds of microelectrodes. However, several major problems become limiting factors when the size of the ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00711.2011
更新日期:2012-09-01 00:00:00
abstract::The blood oxygen level-dependent (BOLD) functional magnetic resonance imaging signal arises as a consequence of changes in blood flow and oxygen usage that in turn are modulated by changes in neural activity. Much attention has been given to both theoretical and experimental aspects of the energetics but not to the ne...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00352.2017
更新日期:2018-03-01 00:00:00
abstract::Children do not typically appear to move with the same skill and dexterity as adults, although they can still improve their motor performance in specific tasks with practice. One possible explanation is that their motor performance is limited by an inherently higher level of movement variability, but that their motor ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01173.2002
更新日期:2003-08-01 00:00:00
abstract::Movement duration is an integral component of motor control, but nearly all extant optimization models of motor planning prefix duration instead of explaining it. Here we propose a new optimization principle that predicts movement duration. The model assumes that the brain attempts to minimize movement duration under ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00751.2005
更新日期:2006-06-01 00:00:00
abstract::We examined the characteristics of heterosynaptic long-term depression (LTD) and depotentiation of previously established long-term potentiation (LTP) in the medial and lateral entorhinal afferents to the dentate gyrus in the awake rat. Rats were prepared for chronic recording of dentate gyrus evoked potentials to act...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.77.2.571
更新日期:1997-02-01 00:00:00
abstract::1. In taste neurophysiology, from Pfaffmann's (49, 50) pioneering work until the present, the possibility of types of neurons corresponding in some sense with the "primary" taste qualities of Henning (33) has been entertained: recently types of gustatory neurons in peripheral nerves have been established according to ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1979.42.5.1390
更新日期:1979-09-01 00:00:00
abstract::Neurons in the visual cortex respond selectively to stimulus orientation and spatial frequency. Changes in response amplitudes of these neurons could be the neurophysiological basis of orientation and spatial frequency discrimination. We have estimated the minimum differences in stimulus orientation and spatial freque...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1987.57.3.755
更新日期:1987-03-01 00:00:00
abstract::The ability to adjust the amplitude of gaze shifts in response to persistent visual errors ("gaze adaptation") has been investigated primarily by introducing visual errors at the end of saccades produced by head-restrained primates. Very little is known about the behavior and neural mechanisms underlying gaze adaptati...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90735.2008
更新日期:2009-01-01 00:00:00
abstract::Combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) enables noninvasive neurophysiological investigation of the human cortex. A TMS paradigm of short-latency afferent inhibition (SAI) is characterized by attenuation of the motor-evoked potential (MEP) and modulation of N100 of the TMS-evoke...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00260.2016
更新日期:2016-09-01 00:00:00
abstract::Previous studies have shown that regional slow-wave activity (SWA) during non-rapid eye movement (NREM) sleep is modulated by prior experience and learning. Although this effect has been convincingly demonstrated for the sensorimotor domain, attempts to extend these findings to the visual system have provided mixed re...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00085.2019
更新日期:2019-06-01 00:00:00
abstract::The ionic mechanisms underlying the termination of action-potential (AP) bursts and postburst afterhyperpolarization (AHP) in intrinsically bursting (IB) neocortical neurons were investigated by performing intracellular recordings in thin slices of rat sensorimotor cortex. The blockade of Ca(2+)-activated K(+) current...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00695.2002
更新日期:2003-04-01 00:00:00
abstract::We measured the timing of spontaneous membrane potential fluctuations and action potentials of medial and lateral agranular corticostriatal and striatal neurons with the use of in vivo intracellular recordings in urethan-anesthetized rats. All neurons showed spontaneous subthreshold membrane potential shifts from 7 to...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.77.4.1697
更新日期:1997-04-01 00:00:00
abstract::The vestibular system plays a critical role in detection of head movements and is essential for normal postural control. Because of their anatomical proximity to the cochlea, the otolith organs are selectively exposed to sound pressure and are at risk for noise overstimulation. Clinical reports suggest a link between ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00668.2017
更新日期:2018-02-01 00:00:00
abstract::Recording simultaneous activity of a large number of neurons in distributed neuronal networks is crucial to understand higher order brain functions. We demonstrate the in vivo performance of a recently developed electrophysiological recording system comprising a two-dimensional, multi-shank, high-density silicon probe...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00318.2016
更新日期:2016-11-01 00:00:00
abstract::The suppressive action of a moving textured background on responses to moving bars was investigated in 118 striate neurons, 19 dorsal lateral geniculate neurons, and 5 perigeniculate neurons in paralyzed and anesthetized cats. In standard conditions the background was a two-dimensional (2D) noise pattern, the bar move...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1987.57.6.1767
更新日期:1987-06-01 00:00:00
abstract::Frequency facilitation is a process whereby neurosecretion increases as a function of stimulation frequency during repetitive synaptic activity. To examine the physiological basis underlying facilitation, we have estimated the frequency dependence of the synaptic parameters n (number of units capable of responding to ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.78.1.417
更新日期:1997-07-01 00:00:00