Static and dynamic responses of periodontal ligament mechanoreceptors and intradental mechanoreceptors.

Abstract:

:1. The response properties of 39 periodontal ligament mechanoreceptors (PDLMs) and 12 intradental mechanoreceptors (IMs) related to the intact mandibular canine tooth were isolated by extracellular recording methods from the ipsilateral trigeminal semilunar ganglion. 2. The stimulus threshold and response magnitude of individual PDLMs depended on the direction of steady force applied to the intact canine tooth. Canine PDLMs as a population, however, did not have a preferred stimulus direction. IMs were activated only by a rapid mechanical transient applied to the intact tooth in any direction. The stimulus threshold and response magnitude of each IM were approximately equipotent in all stimulus directions. 3. Application of quantifiable ramp-and-hold stimulation showed that PDLMs can encode the intensity of steady forces as well as the rate of force ramps. Increasing the ramp rates decreased the total ramp discharge but increased the peak discharge frequency. IMs encoded only the rate of force ramps that were applied by percussion. Higher ramp rates increased both the total discharges and peak discharge frequency of IMs. 4. The dynamic response properties of PDLMs and IMs were clearly differentiated by sinusoidal vibratory stimulation. The maximum frequencies for entrainment of IM discharge at the stimulus cycle length (251 +/- 103 Hz, mean +/- SD) and at any periodicity including multiples of the stimulus cycle length (295 +/- 100 Hz) were significantly higher than the maximum frequencies for PDLM discharge entrainment at the stimulus cycle length (103 +/- 53 Hz) and at any periodicity (133 +/- 62 Hz). 5. The functional similarities of PDLMs and IMs, respectively, to slowly adapting type II mechanoreceptors and Pacinian corpuscle receptors in the skin are discussed. Our present findings, which complement earlier anatomic and behavioral evidence, strongly suggest that IMs subserve nonnociceptive and nonpain functions. Both PDLMs and IMs may provide a continuum of dynamic afferent inputs necessary for tactile sensibility of teeth.

journal_name

J Neurophysiol

authors

Dong WK,Shiwaku T,Kawakami Y,Chudler EH

doi

10.1152/jn.1993.69.5.1567

subject

Has Abstract

pub_date

1993-05-01 00:00:00

pages

1567-82

issue

5

eissn

0022-3077

issn

1522-1598

journal_volume

69

pub_type

杂志文章
  • Excitation of lumbar motoneurons by the medial longitudinal fasciculus in the in vitro brain stem spinal cord preparation of the neonatal rat.

    abstract::1. The excitation of lumbar motoneurons by reticulospinal axons traveling in the medial longitudinal fasciculus (MLF) was investigated in the newborn rat using intracellular recordings from lumbar motoneurons in an in vitro preparation of the brain stem and spinal cord. The tracer DiI (1,1'-dioctadecyl-3,3,3',3'-tetra...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.70.6.2241

    authors: Floeter MK,Lev-Tov A

    更新日期:1993-12-01 00:00:00

  • Synchronization of golgi and granule cell firing in a detailed network model of the cerebellar granule cell layer.

    abstract::The granular layer of the cerebellum has a disproportionately large number of excitatory (granule cells) versus inhibitory neurons (Golgi cells). Its synaptic organization is also unique with a dense reciprocal innervation between granule and Golgi cells but without synaptic contacts among the neurons of either popula...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.5.2521

    authors: Maex R,De Schutter E

    更新日期:1998-11-01 00:00:00

  • A long closed state of the synaptosomal bursting potassium channel confers a statistical memory.

    abstract::1. The statistical properties of the bursting potassium channel from fused Torpedo synaptosomes were studied by using patch-clamp recording and time series analysis. 2. Voltage steps produce channel openings; the number of channels opening fluctuates from trial to trial. The maximal current observed in each trial is s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1992.68.6.2260

    authors: Rahamimoff R,Edry-Schiller J,Ginsburg S

    更新日期:1992-12-01 00:00:00

  • Reach target selection in humans using ambiguous decision cues containing variable amounts of conflicting sensory evidence supporting each target choice.

    abstract::Human subjects chose between two color-coded reach targets using multicolored checkerboard-like decision cues (DCs) that presented variable amounts of conflicting sensory evidence supporting both target choices. Different DCs contained different numbers of small squares of the two target colors. The most ambiguous DCs...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00145.2014

    authors: Coallier É,Kalaska JF

    更新日期:2014-12-01 00:00:00

  • Multisensory integration in mesencephalic trigeminal neurons in Xenopus tadpoles.

    abstract::Mesencephalic trigeminal (M-V) neurons are primary somatosensory neurons with somata located within the CNS, instead of in peripheral sensory ganglia. In amphibians, these unipolar cells are found within the optic tectum and have a single axon that runs along the mandibular branch of the trigeminal nerve. The axon has...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.91317.2008

    authors: Pratt KG,Aizenman CD

    更新日期:2009-07-01 00:00:00

  • Modulation of pursuit eye movements by stimulation of cortical areas MT and MST.

    abstract::1. Many cells in the superior temporal sulcus (STS) of the monkey that represent the foveal region of the visual field discharge during pursuit eye movements. Damage to these areas produces a deficit in the maintenance of pursuit eye movements when the target towards the side of the brain with the lesion. In the prese...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1989.62.1.31

    authors: Komatsu H,Wurtz RH

    更新日期:1989-07-01 00:00:00

  • Reconstruction of hippocampal CA1 pyramidal cell electrophysiology by computer simulation.

    abstract::1. We have developed a 16-compartment model that reproduces most of the features of the CA1 pyramidal cell electrophysiology observed experimentally. The model was constructed using seven active ionic conductances: gNa, gCa, gDR, gCT, gA, gM, and gAHP whose kinetics have been, inferred, in most cases, from the availab...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.71.6.2033

    authors: Warman EN,Durand DM,Yuen GL

    更新日期:1994-06-01 00:00:00

  • Is the olfactory bulb computationally similar to the retina?

    abstract::The computational role of the olfactory bulb remains a mystery after 60 yr of physiological research. Recently, Fantana and colleagues proposed a new model of bulb function based on sparse inhibitory connections between glomeruli, the functional units of the bulb, rather than the existing lateral inhibition model. I p...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.91146.2008

    authors: Ghatpande AS

    更新日期:2009-01-01 00:00:00

  • The magnitude of the somatosensory cortical activity is related to the mobility and strength impairments seen in children with cerebral palsy.

    abstract::The noted disruption of thalamocortical connections and abnormalities in tactile sensory function has resulted in a new definition of cerebral palsy (CP) that recognizes the sensorimotor integration process as central to the motor impairments seen in these children. Despite this updated definition, the connection betw...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00602.2014

    authors: Kurz MJ,Heinrichs-Graham E,Becker KM,Wilson TW

    更新日期:2015-05-01 00:00:00

  • The effects of microstimulation of the dorsomedial frontal cortex on saccade latency.

    abstract::Neural regions in the dorsomedial frontal cortex (DMFC), including the supplementary eye field (SEF) and the presupplementary motor area (pre-SMA), are likely candidates for generating top-down control of saccade target selection. To investigate this, we applied electrical microstimulation to these structures while sa...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00119.2007

    authors: Yang SN,Heinen SJ,Missal M

    更新日期:2008-04-01 00:00:00

  • Primate rubromotoneuronal cells: parametric relations and contribution to wrist movement.

    abstract::1. Fifty-nine rubromotoneuronal (RM) cells were identified in two rhesus monkeys on the basis of their postspike facilitation (PSpF) of rectified electromyographic (EMG) activity. These cells were studied in relation to a step tracking task requiring wrist movements between fixed target zones in flexion and extension....

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.1.14

    authors: Mewes K,Cheney PD

    更新日期:1994-07-01 00:00:00

  • Spatiotemporal response properties of direction-selective neurons in the nucleus of the optic tract and dorsal terminal nucleus of the wallaby, Macropus eugenii.

    abstract::1. The spatial and temporal response characteristics of direction-selective neurons in the nucleus of the optic tract and dorsal terminal nucleus of the accessory optic system (NOT-DTN) of the wallaby were established using moving sinusoidal gratings. This is the first comprehensive investigation of the spatiotemporal...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.6.2927

    authors: Ibbotson MR,Mark RF,Maddess TL

    更新日期:1994-12-01 00:00:00

  • Mixed slip-trip perturbation training for improving reactive responses in people with chronic stroke.

    abstract::This study determined the effect of mixed (slip- and trip-like stance perturbation) training on reactive responses in people with chronic stroke (PwCS) and examined modulation of their reactive responses on higher intensity perturbations posttraining (scaling). Twelve PwCS were exposed to consecutive blocks of treadmi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00671.2019

    authors: Dusane S,Bhatt T

    更新日期:2020-07-01 00:00:00

  • Does an extraocular proprioceptive signal reach the superior colliculus?

    abstract::1. The primary functions of the superior colliculus (SC) are thought to include both the spatial localization of sensory stimuli and the initiation of an orienting response. It has been hypothesized that, in cat, both of these SC functions may be influenced by feedback from the extraocular muscles. The present investi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1989.62.6.1360

    authors: Nelson JS,Meredith MA,Stein BE

    更新日期:1989-12-01 00:00:00

  • Gaze-stabilizing deficits and latent nystagmus in monkeys with brief, early-onset visual deprivation: eye movement recordings.

    abstract::The normal development and the capacity to calibrate gaze-stabilizing systems may depend on normal vision during infancy. At the end of 1 yr of dark rearing, cats have gaze-stabilizing deficits similar to that of the newborn human infant including decreased monocular optokinetic nystagmus (OKN) in the nasal to tempora...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.86.2.651

    authors: Tusa RJ,Mustari MJ,Burrows AF,Fuchs AF

    更新日期:2001-08-01 00:00:00

  • Cellular mechanisms underlying intrathalamic augmenting responses of reticular and relay neurons.

    abstract::Augmenting (or incremental) responses are progressively growing potentials elicited by 5- to 15-Hz stimulation within the thalamus, cerebral cortex, or by setting into action reciprocal thalamocortical neuronal loops. These responses are associated with short-term plasticity processes in thalamic and cortical neurons....

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.5.2716

    authors: Timofeev I,Steriade M

    更新日期:1998-05-01 00:00:00

  • KCC2 antagonism increases neuronal network excitability but disrupts ictogenesis in vitro.

    abstract::The potassium-chloride cotransporter 2 (KCC2) plays a role in epileptiform synchronization, but it remains unclear how it influences such a process. Here, we used tetrode recordings in the in vitro rat entorhinal cortex (EC) to analyze the effects of the KCC2 antagonist VU0463271 on 4-aminopyridine (4AP)-induced ictal...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00266.2019

    authors: Chen LY,Lévesque M,Avoli M

    更新日期:2019-09-01 00:00:00

  • Optogenetic fMRI sheds light on the neural basis of the BOLD signal.

    abstract::Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) is widely used as a measure of neuronal activity, despite an incomplete understanding of the hemodynamic and neural bases for BOLD signals. Recent work by Lee and colleagues investigated whether activating genetically specified neuro...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00535.2010

    authors: Palmer HS

    更新日期:2010-10-01 00:00:00

  • Two-tone suppression in the basilar membrane of the cochlea: mechanical basis of auditory-nerve rate suppression.

    abstract::1. The vibratory response to two-tone stimuli was measured in the basilar membrane of the chinchilla cochlea by means of the Mössbauer technique or laser velocimetry. Measurements were made at sites with characteristic frequency (CF, the frequency at which an auditory structure is most sensitive) of 7-10 kHz, located ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1992.68.4.1087

    authors: Ruggero MA,Robles L,Rich NC

    更新日期:1992-10-01 00:00:00

  • Using spatiotemporal correlations to learn topographic maps for invariant object recognition.

    abstract::The retinal image of visual objects can vary drastically with changes of viewing angle. Nevertheless, our visual system is capable of recognizing objects fairly invariant of viewing angle. Under natural viewing conditions, different views of the same object tend to occur in temporal proximity, thereby generating tempo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.90651.2008

    authors: Michler F,Eckhorn R,Wachtler T

    更新日期:2009-08-01 00:00:00

  • Ocular gaze is anchored to the target of an ongoing pointing movement.

    abstract::It is well known that, typically, saccadic eye movements precede goal-directed hand movements to a visual target stimulus. Also pointing in general is more accurate when the pointing target is gazed at. In this study, it is hypothesized that saccades are not only preceding pointing but that gaze also is stabilized dur...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.2.639

    authors: Neggers SF,Bekkering H

    更新日期:2000-02-01 00:00:00

  • Response features across the auditory midbrain reveal an organization consistent with a dual lemniscal pathway.

    abstract::The central auditory system has traditionally been divided into lemniscal and nonlemniscal pathways leading from the midbrain through the thalamus to the cortex. This view has served as an organizing principle for studying, modeling, and understanding the encoding of sound within the brain. However, there is evidence ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00008.2014

    authors: Straka MM,Schmitz S,Lim HH

    更新日期:2014-08-15 00:00:00

  • Characterization of cutaneous primary afferent fibers excited by acetic acid in a model of nociception in frogs.

    abstract::Acetic acid applied to the hind limb of a frog evokes nocifensive behaviors, including a vigorous wiping of the exposed skin, referred to as the wiping response. The aim of this study was to examine the responses of cutaneous primary afferent fibers in frogs to acetic acid (pH 2.84-1.42) applied topically to the skin....

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00324.2003

    authors: Hamamoto DT,Simone DA

    更新日期:2003-08-01 00:00:00

  • Atypical phenotypes from flatworm Kv3 channels.

    abstract::Divergence of the Shaker superfamily of voltage-gated (Kv) ion channels early in metazoan evolution created numerous electrical phenotypes that were presumably selected to produce a wide range of excitability characteristics in neurons, myocytes, and other cells. A comparative approach that emphasizes this early radia...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00858.2005

    authors: Klassen TL,Buckingham SD,Atherton DM,Dacks JB,Gallin WJ,Spencer AN

    更新日期:2006-05-01 00:00:00

  • Role of primate magnocellular red nucleus neurons in controlling hand preshaping during reaching to grasp.

    abstract::Reaching to grasp is of fundamental importance to primate motor behavior and requires coordinating hand preshaping with limb transport and grasping. We aimed to clarify the role of cerebellar output via the magnocellular red nucleus (RNm) to the control of reaching to grasp. Rubrospinal fibers originating from RNm con...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.85.4.1461

    authors: van Kan PL,McCurdy ML

    更新日期:2001-04-01 00:00:00

  • Organization of action sequences and the role of the pre-SMA.

    abstract::To understand the contribution of the human presupplementary motor area (pre-SMA) in sequential motor behavior, we performed a series of finger key-press experiments. Experiment 1 revealed that each subject had a spontaneous tendency to organize or "chunk" a long sequence into shorter components. We hypothesized that ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00651.2003

    authors: Kennerley SW,Sakai K,Rushworth MF

    更新日期:2004-02-01 00:00:00

  • Stomatin and sensory neuron mechanotransduction.

    abstract::Somatic sensory neurons of the dorsal root ganglia are necessary for a large part of our mechanosensory experience. However, we only have a good knowledge of the molecules required for mechanotransduction in simple invertebrates such as the nematode Caenorhabiditis elegans. In C. elegans, a number of so-called mec gen...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00860.2007

    authors: Martinez-Salgado C,Benckendorff AG,Chiang LY,Wang R,Milenkovic N,Wetzel C,Hu J,Stucky CL,Parra MG,Mohandas N,Lewin GR

    更新日期:2007-12-01 00:00:00

  • Homomeric and heteromeric ion channels formed from the kainate-type subunits GluR6 and KA2 have very small, but different, unitary conductances.

    abstract::1. Patch-clamp methods were used to study recombinant glutamate receptor (GluR) ion channels expressed in human embryonic kidney cells (HEK 293) after transfection of the cells with cDNAs encoding kainate (KA)-type GluR subunits. Cells were transiently or stably transfected with the fully edited (R) version of GluR6 o...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.76.1.510

    authors: Howe JR

    更新日期:1996-07-01 00:00:00

  • A pallidus-habenula-dopamine pathway signals inferred stimulus values.

    abstract::The reward value of a stimulus can be learned through two distinct mechanisms: reinforcement learning through repeated stimulus-reward pairings and abstract inference based on knowledge of the task at hand. The reinforcement mechanism is often identified with midbrain dopamine neurons. Here we show that a neural pathw...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00158.2010

    authors: Bromberg-Martin ES,Matsumoto M,Hong S,Hikosaka O

    更新日期:2010-08-01 00:00:00

  • Astrocytic inwardly rectifying potassium currents are dependent on external sodium ions.

    abstract::1. Two subtypes of astrocytes that expressed distinctly different ion channel complements were identified in primary cultures from rat spinal cord and hippocampus using whole cell patch-clamp techniques. One population of cells expressed voltage-activated Na+ currents and displayed outwardly rectifying I-V relationshi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.76.1.626

    authors: Ransom CB,Sontheimer H,Janigro D

    更新日期:1996-07-01 00:00:00