Abstract:
:Our understanding of the complexity of genetic abnormalities involved in the tumourigenesis of malignant gliomas is as yet rudimentary. However, we can discern distinctive patterns of loss of genetic material and amplification of chromosomal regions that characterize both the different types of gliomas as well as the different malignancy grades. In this review, we discuss through specific examples of recent work on astrocytomas and glioblastoma multiforme, the importance of several tumour suppressor genes and oncogenes in the development of these glial tumours. In conclusion it would seem that distinct genetic changes in different genes, the protein products of which interact in particular growth control mechanism may lead to the same cellular abnormality. It seems likely that many further genetic abnormalities affecting genes coding for proteins, either involved in the cellular mechanisms yet identified or in new growth control mechanisms. Will be found in the near future.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Van de Kelft Edoi
10.1007/BF01411992subject
Has Abstractpub_date
1997-01-01 00:00:00pages
589-99issue
7eissn
0001-6268issn
0942-0940journal_volume
139pub_type
杂志文章,评审abstract::Twenty-three patients with atypical forms of spinal tuberculosis treated between 1975 and 1985, are described. All presented with signs and symptoms of compression of the spinal cord or cauda equina, ranging from paraesthesiae and increasing weakness of extremities to paraplegia and loss of sphincter control. None of ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01400511
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:Before operating on 130 patients with pituitary disorders, we evaluated their bone window CT images sliced parallel to the transnasal surgical route to assess the surgical anatomy of the nasal cavity for transnasal surgery. METHODS:High resolution bone window CT was performed in 3- to 5-mm slices parallel to...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-002-1043-1
更新日期:2003-02-01 00:00:00
abstract:INTRODUCTION:To report the incidence, treatment and outcome of occipital condyle fractures (OCFs) based on the experience of a single neurosurgical department over a period of two years. MATERIAL AND METHODS:From April 1999 to April 2001, ten cases of OCFs were identified in 110 cervical traumas observed over a period...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-004-0289-1
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Until recently, neurosurgeons eagerly removed cerebellar lesions without consideration of future cognitive impairment that might be caused by the resection. In children, transient cerebellar mutism after resection has lead to a diminished use of midline approaches and vermis transection, as well as reduced r...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-008-1562-5
更新日期:2008-06-01 00:00:00
abstract::Although primary treatment of medulloblastoma is now successful in a high percentage of patients, its secondary manifestations still bear a poor prognosis. Thorough studies of secondary manifestations are therefore pivotal to plan therapeutic approaches for the long-term management of medulloblastoma. Here we describe...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01410612
更新日期:1995-01-01 00:00:00
abstract::The pathological effects of radio- and chemotherapy on the normal nervous tissue have been studied in 42 brains with malignant gliomas. The brains have been examined by means of the complete study technique. In seven cases the picture of delayed radionecrosis has been found. Apart from this, many histological features...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01401682
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVE:The aims were to investigate the early effects of graded, closed, mild head injury on neurofilament protein (NF160) and microtubule-associated protein-2 (MAP2) and to examine the levels of lipid peroxidation and the impact of mexilitine, inhibitor of lipid peroxidation, pretreatment on tissue damage. MATERIA...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-003-0209-9
更新日期:2004-06-01 00:00:00
abstract::A review is made of the current management strategies of abscesses in basal ganglia and thalamus, based on a review of the literature and three of our own cases. Clinical picture, aetiology, diagnostic, surgical treatment and outcome are discussed. Stereotactic abscess puncture in combination with temporary drainage a...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/BF01808554
更新日期:1994-01-01 00:00:00
abstract::The long-term outcome in 26 patients following operation of intracranial saccular aneurysms before the age of twenty is presented. The duration of follow-up ranged from 4 to 33 years (mean 14 years). The oldest patient is now 51 years old. 19 patients (73%) made a complete or good recovery with resumption of normal li...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01476214
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVE:To establish the risk of recurrence in patients with chronic subdural hematoma (cSDH) on antithrombotic treatment (AT, i.e., antiplatelets and anticoagulants). Secondary end points were perioperative morbidity and mortality between groups (AT vs. no-AT group) and exploration if timing of resumption of AT trea...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-017-3330-x
更新日期:2017-11-01 00:00:00
abstract::In the management of shunt infection, the use of ventricular catheters made of silicone rubber for the temporary external drainage of cerebrospinal fluid (CSF) is general practice. However, the eradication of the primary source of infection may be hindered by the affinity of bacteria to silicone-based material. Compar...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01411122
更新日期:1996-01-01 00:00:00
abstract:INTRODUCTION:An open collaborative international network has been established which aims to improve inter-centre standards for collection of high-resolution, neurointensive care data on patients with traumatic brain injury. The group is also working towards the creation of an open access, detailed and validated databas...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,多中心研究
doi:10.1007/s00701-003-0066-6
更新日期:2003-08-01 00:00:00
abstract::Anterior spinal decompression and fusion was used as the primary treatment for thoracolumbar fractures in eleven patients with neurological deficits. Each patient achieved stability by interbody fusion. Significant progressive kyphosis did not occur. No patients with a complete neurological deficit was improved by ope...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01664845
更新日期:1981-01-01 00:00:00
abstract::Double fenestration of the anterior communicating artery (ACoA) complex associated with an aneurysm is a very rare finding and is usually caused by ACoA duplication and the presence of a median artery of the corpus callosum (MACC). We present a patient in whom double fenestration was not associated with ACoA duplicati...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-007-1401-0
更新日期:2008-03-01 00:00:00
abstract::In our department extensive decompression craniectomies became the treatment of choice for patients with massive cerebral oedema following either trauma or acute cerebral infarction. The remarkable survival rates of this neurosurgical technique created the problem of adequate vault defect reconstruction. To evaluate t...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010050335
更新日期:1999-01-01 00:00:00
abstract::Between 1976 and 1983, 251 patients underwent surgery for the treatment of cervical degenerative disc disease. Anterior microsurgical discectomy at one or more cervical segments without interbody fusion was performed in each case. 109 patients with radiculopathy and 55 patients with myelopathy were followed up clinica...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01560567
更新日期:1988-01-01 00:00:00
abstract::Therapy for vasogenic brain oedema (VBE) is still an unsolved problem. Experimental work with the aim of establishing an oncotherapeutic option is presented. VBE is performed by focal freeze injury in rats. Using a stereotactic head holder hypo- or hyperosmolar human serum albumin is administered via the intraventricu...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01412002
更新日期:1997-01-01 00:00:00
abstract::We investigated the characteristic features of intramedullary spinal cord tumour associated with neurofibromatosis type 1 (NF-1). We have experienced 44 cases of pathologically confirmed intramedullary spinal cord tumour. Diagnosis of NF-1 was done according to the criteria set by the National Institute of Health Cons...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/BF01411560
更新日期:1997-01-01 00:00:00
abstract::Vascular endothelium synthesizes mediators which either cause vasorelaxation or vasoconstriction. The purpose of this study is to investigate the role of these mediators in the pathogenesis of cerebral vasospasm. An inhibitor of endothelium-derived relaxing factor is haemoglobin; endothelium removal by triton X-100 an...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01401136
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Schwannomas occur sporadically or in association with neurofibromatosis 2 (NF2), an autosomal dominant disorder, which predisposes to multiple schwannomas, meningiomas and spinal ependymomas, with bilateral vestibular schwannomas as the classic hallmark. As NF2 and sporadic schwannomas differ in some respect...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010070036
更新日期:2000-01-01 00:00:00
abstract::The authors report a family in which two members had multiple intracranial aneurysms. This is the third reported family with more than one member affected by multiple cerebral aneurysms. The congenital nature and the patterns of inheritance of the disease are discussed. The indications for elective investigation of th...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01407233
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Despite advances in laboratory diagnostics, antibiotic regimens, and neurosurgical techniques, brain abscess (BA) remains a potentially fatal infectious disease. This study analyzed clinical and epidemiological aspects of BA in Chinese patients treated at a single center during a 62-year period. METHOD:We r...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-016-2741-4
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:In surgical treatment of acute subdural hematoma (ASDH), neurosurgeons frequently encounter bleeding from cortical arteries, which is usually controlled with bipolar coagulation. However, bipolar coagulation is associated with a risk of sacrificing the cortical artery, which may affect the prognosis of neuro...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-018-3634-5
更新日期:2018-10-01 00:00:00
abstract::Myelocystoceles are rare lesions. Rarer still are thoracic myelocystoceles. Two patients with thoracic myelocystoceles are being reported. The first patient presented with swelling in the thoracic region with paraplegia and incontinence. MR with MR myelography revealed the malformation to be a thoracic myelocystocele....
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-006-0734-4
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Side-to-side neurorrhaphy may protect the denervated end organ and preserve the initial connection with proximal stump. We examined the effect of protective side-to-side anastomosis on nerve and end organ regeneration in proximal nerve injury model. METHODS:The left common peroneal nerve of 24 Sprague Dawle...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-019-03835-2
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:There are divergent opinions about the prognostic value of the extent of surgery and of different histological subtypes in supratentorial astrocytomas WHO grade II. METHODS:We reviewed 75 consecutive patients (36 females, 39 males) with supratentorial astrocytomas WHO grade II (59 primary and 16 recurrent tu...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010050241
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Drain insertion following chronic subdural haematoma (CSDH) evacuation reduces recurrence and improves outcomes. The mechanism of this improvement is uncertain. We assessed whether drains result in improved postoperative imaging, and which radiological factors are associated with recurrence and functional ou...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,多中心研究
doi:10.1007/s00701-020-04356-z
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Although endoscopic septostomy is widely adopted in the treatment of unilateral or specific types of hydrocephalus, there is no consensus on surgical indications, technical aspects and postoperative outcome. In particular, the choice of the ventricular access has been recently debated. We investigated the re...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1381-6
更新日期:2012-08-01 00:00:00
abstract::A case of bilateral internal carotid artery thrombosis after blunt injury to the head in a 54 years old male is described. The literature is reviewed and comment is made on the causes. Unilateral thrombosis of the internal carotid artery after closed or blunt injury to the head and neck is well known but not common. T...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01401637
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:Nitric oxide is a key mediator of post-traumatic inflammation in the brain. We examined the expressions of iNOS, nNOS, and eNOS in inbred DA and PVGa rat strains where DA is susceptible to autoimmune neuroinflammation and PVGa-resistant. METHODS:Parietal contusions using a weight drop model were produced in...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1297-1
更新日期:2012-04-01 00:00:00