Retrospective analysis of 620 cases of brain abscess in Chinese patients in a single center over a 62-year period.


BACKGROUND:Despite advances in laboratory diagnostics, antibiotic regimens, and neurosurgical techniques, brain abscess (BA) remains a potentially fatal infectious disease. This study analyzed clinical and epidemiological aspects of BA in Chinese patients treated at a single center during a 62-year period. METHOD:We retrospectively analyzed 620 BA patients treated at Tianjin Medical University General Hospital, Tianjin, PR China from 1952 to 2014. Because of the initiation of imaging technology use in 1992, and other specific changes, we analyzed data over three study periods: 1952-1972, 1980-1991, and 2002-2014. Information including incidence, sex, age, community distribution, BA size and location, therapeutic method, prognosis and outcome of BA patients was collected and evaluated. RESULTS:Our study included 620 BA patients. The percentage mortality significantly decreased from 22.8 % in 1952 to 6.3 % in 2014 (p < 0.001). Although the incidence of BA was higher in males than females, there was no significant change in the male/female incidence ratio over time: 2.5 in 1952-1972, 2.6 in 1980-1991, and 2.2 in 2002-2014. The cryptogenic infection incidence significantly increased over time (p < 0.001). The number of positive bacterial cultures significantly decreased over the three study periods (p < 0.01). CONCLUSIONS:The prognosis of patients with BA has gradually improved over the past 62 years in Tianjin, China. This may be because improvements in neurosurgical techniques, cranial imaging, and antimicrobial regimens have facilitated less invasive and more precise neurosurgical procedures.


Acta Neurochir (Wien)


Acta neurochirurgica


Zhang Z,Cai X,Li J,Kang X,Wang H,Zhang L,Yan R,Gao N,Liu S,Yue S,Zhang J,Yang S,Yang X




Has Abstract


2016-04-01 00:00:00














  • Non-functionalized soft alginate hydrogel promotes locomotor recovery after spinal cord injury in a rat hemimyelonectomy model.

    abstract:BACKGROUND:Spinal cord injury (SCI) and the consecutive devastating neurological sequelae have an enormous individual and economic impact. Implantation of functionalized hydrogels is a promising approach, because they can serve as a matrix for the regenerating tissue, carry and release bioactive molecules and various c...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Sitoci-Ficici KH,Matyash M,Uckermann O,Galli R,Leipnitz E,Later R,Ikonomidou C,Gelinsky M,Schackert G,Kirsch M

    更新日期:2018-03-01 00:00:00

  • Surgical approach to large thalamic gliomas.

    abstract::Fifteen cases of large thalamic gliomas were treated by laser surgery and CUSA under X8 magnification and subsequently they were subjected to radiotherapy. More than 50% of the tumours were located in the dominant hemisphere and therefore an interhemispheric approach was carried out to avoid disturbances of speech and...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Prakash B

    更新日期:1985-01-01 00:00:00

  • Dexamethasone inhibits ICAM-1 and MMP-9 expression and reduces brain edema in intracerebral hemorrhagic rats.

    abstract:BACKGROUND:The molecular mechanism of hemorrhagic stroke is unclear, and the identification of therapeutic agents for attenuating post-stroke brain damage remains an unresolved challenge. Dexamethasone (DEX) is used clinically to treat spinal cord injury and brain tumor patients by reducing edema formation, but has pro...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Yang JT,Lee TH,Lee IN,Chung CY,Kuo CH,Weng HH

    更新日期:2011-11-01 00:00:00

  • Microvascular auscultation. A new technique, using a diplo-microphone, for analysis of blood flow at suture lines in small arteries.

    abstract::A new atraumatic method for patency and blood flow control of microvascular anastomoses has been developed. Sounds proximal and distal to a suture line are separately detected by means of two specially modified miniature microphones built together as an auscultation unit and named a diplo-microphone. Transmission of t...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Wintermantel E

    更新日期:1980-01-01 00:00:00

  • Novel entry point for intraoperative ventricular puncture during the transsylvian approach.

    abstract:OBJECTIVE:In dealing with cases of oedematous brain, relaxation during the transsylvian approach to supratentorial aneurysms has been accomplished by ventricular drainage by using the anatomic point defined by Dr. Paine. However, we have experienced patient complications when using this point. We propose a novel anatom...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Hyun SJ,Suk JS,Kwon JT,Kim YB

    更新日期:2007-10-01 00:00:00

  • Is the complete excision of circumferential intradural spinal meningiomas achievable?

    abstract:BACKGROUND:Circumferential intradural spinal meningiomas are exceptionally rare. They pose several surgical challenges and a complete excision is not easy. The aim of this study is to provide surgical strategies to facilitate a full excision of such tumors. METHODS:A fully circumferential intradural meningioma at T9/1...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Vergara P

    更新日期:2017-12-01 00:00:00

  • Long-term intracranial pressure monitoring in comatose patients suffering from head injuries. A critical survey.

    abstract::On the basis of a series of 75 patients, the practical use of Icp continuous long-term recording in severe head injuries without mass lesions or remaining deeply comatose after surgical procedures is critically analyzed. ICP monitoring alone seems to be not essential for prognosis. Conversely it is of much greater use...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Papo I,Caruselli G

    更新日期:1977-01-01 00:00:00

  • Prolapsed lumbar intervertebral disc with partial or total occlusion of the spinal canal. A study of 30 patients with and 28 patients without cauda equina symptoms.

    abstract::The clinical findings and operation results in two series of patients with medial prolapse of an intervertebral disc with total or partial occlusion of the spinal canal are reported. In one of the series (30 patients) symptoms of cauda equina compression, with bladder and rectal disturbances, were present, and in the ...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Spännare BJ

    更新日期:1978-01-01 00:00:00

  • Treatment of patients with ruptured aneurysm by neurosurgeons that perform both open surgical and endovascular techniques is safe and effective: results of a single centre in Europe.

    abstract::In Europe only few neurosurgeons are trained in both open surgical clipping as well as in endovascular techniques for treatment of intracranial aneurysms. To investigate the safety and efficacy of performing both techniques we, two dual trained neurosurgeons, analyzed our results in repairing ruptured intracranial ane...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: de Vries J,Boogaarts HD

    更新日期:2014-07-01 00:00:00

  • Approach through the temporal horn of the lateral ventricle for clipping of large dorsal type basilar bifurcation aneurysms.

    abstract::The authors describe an approach through the temporal horn of the lateral ventricle which proved to be useful for clipping of a large dorsal type basilar bifurcation aneurysms. It facilitates the preservation of the perforating arteries behind the aneurysm, because it gives sufficient working space to move the aneurys...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Sakaki T,Matsuyama T,Yabuno T,Hashimoto H,Kurokawa S,Kawaguchi S,Morimoto T

    更新日期:1995-01-01 00:00:00

  • Atypical forms of spinal tuberculosis.

    abstract::Twenty-three patients with atypical forms of spinal tuberculosis treated between 1975 and 1985, are described. All presented with signs and symptoms of compression of the spinal cord or cauda equina, ranging from paraesthesiae and increasing weakness of extremities to paraplegia and loss of sphincter control. None of ...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Naim-Ur-Rahman,Al-Arabi KM,Khan FA

    更新日期:1987-01-01 00:00:00

  • Near-infrared indocyanine green videoangiography versus microvascular Doppler sonography in aneurysm surgery.

    abstract:INTRODUCTION:The quality of surgical treatment of intracranial aneurysms is determined by complete aneurysm occlusion and restoration of flow in the parent, branching and perforating vessels. In postoperative digital subtraction angiography (DSA), unexpected aneurysm residuals and vessel occlusions are frequently detec...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Fischer G,Stadie A,Oertel JM

    更新日期:2010-09-01 00:00:00

  • Intraoperative monitoring of sensory part of the trigeminal nerve using blink reflex during microvascular decompression for trigeminal neuralgia.

    abstract::Intraoperative monitoring during cerebellopontine angle surgery is widely accepted. While techniques which monitor cranial motor nerves are commonly used, monitoring the sensory afferents has been challenging. Considering the reflex arc, blink reflex (BR) might be useful in monitoring the sensory part of the trigemina...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Simioni V,Capone JG,Sette E,Granieri E,Farneti M,Cavallo MA,Tugnoli V

    更新日期:2018-01-01 00:00:00

  • Internal fixation for osteomyelitis of cervical spine: the issue of persistence of culture positive infection around the implants.

    abstract:BACKGROUND:We describe the management of osteomyelitis of the cervical spine, utilizing internal fixation with subsequent removal and culture of the implants. Four out of five patients had evidence of bacterial colonisation in close proximity to the internal fixation device. METHODS:Five consecutive patients (all fema...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Shad A,Shariff S,Fairbank J,Byren I,Teddy PJ,Cadoux-Hudson TA

    更新日期:2003-11-01 00:00:00

  • Multiplex PCR as a novel method in the diagnosis of spinal tuberculosis-a pilot study.

    abstract:BACKGROUND:Establishment of a reliable and rapid diagnosis is of paramount importance in spinal tuberculosis. The available gadgetry of investigations, such as AFB smear, culture of Mycobacterium tuberculosis, and Uniplex PCR, suffers from a lack of adequate sensitivity and/or a lack of rapidity. Therefore, many times ...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Sharma K,Meena RK,Aggarwal A,Chhabra R

    更新日期:2017-03-01 00:00:00

  • Ectopic choroid plexus associated with trigeminal neuralgia: case report.

    abstract:INTRODUCTION:A 55-year-old man underwent a microvascular decompression procedure for a pharmacoresistant trigeminal neuralgia. Preoperative MRI showed a neurovascular conflict between the Vth nerve root and the superior cerebellar artery. METHODS:Dissection of the intracisternal trigeminal root was undertaken, and a p...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Abeloos L,Massager N

    更新日期:2010-04-01 00:00:00

  • Genetic aberrations in sporadic and neurofibromatosis 2 (NF2)-associated schwannomas studied by comparative genomic hybridization (CGH).

    abstract:BACKGROUND:Schwannomas occur sporadically or in association with neurofibromatosis 2 (NF2), an autosomal dominant disorder, which predisposes to multiple schwannomas, meningiomas and spinal ependymomas, with bilateral vestibular schwannomas as the classic hallmark. As NF2 and sporadic schwannomas differ in some respect...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Antinheimo J,Sallinen SL,Sallinen P,Haapasalo H,Helin H,Horelli-Kuitunen N,Wessman M,Sainio M,Jääskeläinen J,Carpén O

    更新日期:2000-01-01 00:00:00

  • Surgical management of haemangioblastoma of the posterior fossa.

    abstract::Fifty-one cases of posterior fossa haemangioblastoma have been seen in our department over a period of 23 years. Seven cases were associated with spinal cord lesions and one with a supratentorial lesion. There were 22 cases of Lindau's disease (43%). The onset was earlier and recurrences commoner than in isolated case...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Symon L,Murota T,Pell M,Bordi L

    更新日期:1993-01-01 00:00:00

  • Lumbar disc herniation associated with separation of the posterior ring apophysis: analysis of five surgical cases and review of the literature.

    abstract:BACKGROUND:Separation of the posterior ring apophysis of an adjacent vertebral body can sometimes accompany lumbar intervertebral disc herniation. The condition can be both difficult to detect in conventional radiographs and is somewhat controversial to treat. Although there is general agreement on the frequent need fo...

    journal_title:Acta neurochirurgica

    pub_type: 临床试验,杂志文章


    authors: Asazuma T,Nobuta M,Sato M,Yamagishi M,Fujikawa K

    更新日期:2003-06-01 00:00:00

  • Image fusion of MR images and real-time ultrasonography: evaluation of fusion accuracy combining two commercial instruments, a neuronavigation system and a ultrasound system.

    abstract:OBJECTIVE:The aim of our study was to evaluate MRI/Ultrasonography fusion accuracy depending on three ultrasonographic parameters. METHOD:An ultrasonography and MRI compatible model was created, consisting of a plastic box, which contained 3 objects. MRI scans were performed with 128 sagittal slices. The objects were ...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Schlaier JR,Warnat J,Dorenbeck U,Proescholdt M,Schebesch KM,Brawanski A

    更新日期:2004-03-01 00:00:00

  • Cyclosporine A prevents neurological deterioration of patients with SAH--a preliminary report.

    abstract::In the present study we found that the neurological outcome in patients anaesthetized for early clipping (up to 72 h after SAH) of a ruptured aneurysm and treated with cyclosporine A was significantly better than the neurological state of control patients without immuno-suppressive treatment. The results justify the p...

    journal_title:Acta neurochirurgica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ryba M,Pastuszko M,Iwanska K,Bidzinski J,Dziewiecki C

    更新日期:1991-01-01 00:00:00

  • Discovery of a new waveform for intraoperative monitoring of hemifacial spasms.

    abstract:BACKGROUND:Surgeons often rely on intraoperative electrophysiological monitoring to determine whether decompression is sufficient during microvascular decompression surgery for hemifacial spasms. A new monitoring method is needed when an abnormal muscle response is occasionally not available or is unreliable. This stud...

    journal_title:Acta neurochirurgica

    pub_type: 临床试验,杂志文章


    authors: Zheng X,Hong W,Tang Y,Ying T,Wu Z,Shang M,Feng B,Zhang W,Hua X,Zhong J,Li S

    更新日期:2012-05-01 00:00:00

  • Neurometabolic monitoring of the ischaemic human brain using microdialysis.

    abstract::Recent animal research has provided evidence that brain ischaemia is associated with a shift of energy related metabolites (lactate, adenosine, inosine, and hypoxanthine) and several transmitters from the intracellular to the extracellular fluid (ECF). These chemical changes of the ECF reflect the energy crisis of the...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Hillered L,Persson L,Pontén U,Ungerstedt U

    更新日期:1990-01-01 00:00:00

  • Optimal treatment of leptomeningeal spread in glioblastoma: analysis of risk factors and outcome.

    abstract:BACKGROUND:Glioblastoma (GBM) is the most common and malignant brain tumor in adults. Despite therapeutic advances, almost all patients eventually experience tumor recurrence. Leptomeningeal spread (LMS) is not a rare condition of recurrence. However, the standard management protocol of LMS has not been established. Th...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Noh JH,Lee MH,Kim WS,Lim DH,Kim ST,Kong DS,Nam DH,Lee JI,Seol HJ

    更新日期:2015-04-01 00:00:00

  • Comparative study of single and dual nerve transfers for repairing shoulder abduction.

    abstract:OBJECTIVE:The purpose of this study was to compare the effects of single and dual nerve transfer for the repair of shoulder abduction in patients with upper or upper and middle trunk root avulsion. METHODS:We carried out a retrospective analysis of 20 patients with C5-C6 or C5-C7 root avulsion treated by nerve transfe...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Xiao F,Zhao X,Lao J

    更新日期:2019-04-01 00:00:00

  • Cauda equina paraganglioma with subsequent intracranial and intraspinal metastases.

    abstract::A case of cauda equina paraganglioma is described; subsequent intracranial and intraspinal metastases occurred after partial resection and adjunctive radiotherapy. Cerebrospinal fluid dissemination is a rare complication of spinal paragangliomas. Factors predictive of this unusual biological behaviour are discussed. ...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Roche PH,Figarella-Branger D,Regis J,Peragut JC

    更新日期:1996-01-01 00:00:00

  • Microsurgical anatomy of the anterior choroidal artery.

    abstract::The anterior choroidal artery ( was studied in 140 hemispheres of the human brain. In 50 specimens the artery was cannulated and perfused with acrylic resin, in 20 specimens the, was selectively cannulated and perfused with dye. The artery then was microsurgically dissected and photographically documen...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Hussein S,Renella RR,Dietz H

    更新日期:1988-01-01 00:00:00

  • Surgical resection of tumors located in subcortex of language area.

    abstract:OBJECT:Although functional mapping facilitates the planning of surgery in and around eloquent areas, the resection of tumors adjacent to language areas remains challenging. In this report, we took notice that the language areas (Broca's and Wernicke's) present at the perisylvian fissure. We posit that if there is non-e...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Sakurada K,Sato S,Sonoda Y,Kokubo Y,Saito S,Kayama T

    更新日期:2007-02-01 00:00:00

  • Range of voluntary neck motility predicts outcome of pallidal DBS for cervical dystonia.

    abstract:BACKGROUND:The effectiveness of pallidal deep brain stimulation (GPi DBS) for cervical dystonia has been extensively described, but controversies exist about which prognostic factor is clinically useful. We previously reported that classification of tonic- or phasic-type cervical dystonia is useful for predicting clini...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Huh R,Chung M

    更新日期:2019-12-01 00:00:00

  • Epidural spinal cord stimulation for neuropathic pain: a neurosurgical multicentric Italian data collection and analysis.

    abstract:BACKGROUND:Spinal cord stimulation (SCS) is a technique used worldwide to treat several types of chronic neuropathic pain refractory to any conservative treatment. The aim of this data collection is to enforce evidence of SCS effectiveness on neuropathic chronic pain reported in the literature and to speculate on the u...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章,多中心研究


    authors: Colombo EV,Mandelli C,Mortini P,Messina G,De Marco N,Donati R,Irace C,Landi A,Lavano A,Mearini M,Podetta S,Servello D,Zekaj E,Valtulina C,Dones I

    更新日期:2015-04-01 00:00:00