Intraventricular urokinase to treat a blocked ventriculoperitoneal shunt in a glioblastoma patient with leptomeningeal spread.

Abstract:

:Leptomeningeal spread and hydrocephalus are increasingly recognized as late disease complications of glioblastoma with almost a quarter of patients requiring early cerebrospinal fluid shunting. The neurosurgeon is challenged with maintaining shunt patency when tumor disease progression is rapid and adjuvant oncologic therapy has yet to be initiated. We describe our experience in treating a young female with diffuse glioblastoma leptomeningeal spread and communicating hydrocephalus who had several episodes of shunt obstruction due to intraluminal tumor cell-fibrin deposits. Regular intraventricular instillations of urokinase fibrinolytic therapy not only re-established shunt patency but also contributed to the resolution of her hydrocephalus.

journal_name

Acta Neurochir (Wien)

journal_title

Acta neurochirurgica

authors

Woo PYM,Zhuang JTF,Ho JMK,Seto A,Wong HT,Chan KY

doi

10.1007/s00701-018-3509-9

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

1073-1077

issue

5

eissn

0001-6268

issn

0942-0940

pii

10.1007/s00701-018-3509-9

journal_volume

160

pub_type

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