Treatment of high numbers of brain metastases with Gamma Knife radiosurgery: a review.


:Effectiveness of stereotactic radiosurgery (SRS) has been shown in patients with one to four brain metastases. Work has been done to evaluate the role of SRS alone treatment without whole-brain radiation therapy in patients with more than four metastases. A recent multiinstitutional JLGK 0901 prospective study revealed the class-2 evidence that SRS without whole-brain radiation therapy is an effective treatment for patients up to 10 metastatic lesions. Several retrospective studies exist to show the efficacy and safety of SRS for patients with even more than 10 lesions. However, patient selection is very critical for SRS alone treatment. The PubMed database was searched using combinations of search terms and synonyms for multiple brain metastases, Gamma Knife and SRS published between January 1, 2005 and January 1, 2015 in order to address the effectiveness of Gamma Knife for patients with multiple brain metastases. Good performance status, controlled primary disease, total treated tumor volume of 15 cm(3) or less have been found to be significant predictors for survival among patients with two or more brain lesions. The data suggest that SRS can be used and whole brain radiation therapy can be withheld in selected patients with multiple lesions to avoid acute or chronic adverse effects, especially neurocognitive decline, without causing survival disadvantage. In this review, we assessed the evidence for SRS treatment of patients with multiple brain metastases.


Acta Neurochir (Wien)


Acta neurochirurgica


Hatiboglu MA,Tuzgen S,Akdur K,Chang EL




Has Abstract


2016-04-01 00:00:00














  • Single center experiences with telemetric intracranial pressure measurements in patients with CSF circulation disturbances.

    abstract:BACKGROUND:Hydrocephalus may present with heterogeneous signs and symptoms. The indication for its treatment and the optimal drainage in complex cases may be challenging. Telemetric intracranial pressure measurements (TICPM) may open new perspectives for those circumstances. We report our experiences using the Neuroven...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Pennacchietti V,Prinz V,Schaumann A,Finger T,Schulz M,Thomale UW

    更新日期:2020-10-01 00:00:00

  • Staging, scoring and grading of medulloblastoma. A postoperative prognosis predicting system based on the cases of a single institute.

    abstract::Although recently survival of some medulloblastoma patients increased remarkably, it remains a serious diagnosis in others. In order to predict the postoperative prognosis in patients treated for medulloblastoma, a new staging, scoring and grading system was developed. Sixty-six patients operated on microsurgically be...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Sure U,Berghorn WJ,Bertalanffy H,Wakabayashi T,Yoshida J,Sugita K,Seeger W

    更新日期:1995-01-01 00:00:00

  • Evaluation of results of temporal bone resection.

    abstract::The results of 16 cases of temporal bone resection were evaluated. The resections, 12 of which were total and 4 partial, had mostly been performed for squamous cell carcinoma invading the temporal bone. Five patients in whom the intervention was considered radical and not followed by irradiation, were alive and well 9...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Go KG,Annyas AA,Vermey A,Robinson PH,Belopavlovic M,Mehta DM

    更新日期:1991-01-01 00:00:00

  • CT-target determination in postero-ventral pallidotomy: a universal method. Technical note.

    abstract::Stereotactic targeting of the postero-ventral pallidum (PVP) presents special challenges to the surgeon 1) The target is in intimate relation to the optic tract and the internal capsule. 2) Proper angulation of the trajectory is crucial to achieve optimal effects given the long craniocaudal extension of the PVP. 3) Th...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Spiegelmann R,Gofman J

    更新日期:1996-01-01 00:00:00

  • The results of radiosurgical management of 72 middle fossa meningiomas.

    abstract::Of 812 patients with intracranial tumours treated by radiosurgery during the period 1984-1990, 129 had meningiomas. Of these latter, 72 had middle fossa meningiomas. Patients with meningiomas treated by us since March 1990 are not included in this report since we established the investigative principle of a minimum of...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Valentino V,Schinaia G,Raimondi AJ

    更新日期:1993-01-01 00:00:00

  • Haem derivatives in subdural haematomas.

    abstract::The oxyhaemoglobin, methaemoglobin and bilirubin concentrations were determined in subdural haematomas and cerebrospinal fluid from 18 patients. The total haem derivative concentration ranged from 55 mumol/l to 13.9 mmol/l in the haematomas and from 0.1 mumol/l to 8.2 mumol/l in the cerebrospinal fluid. Bilirubin was ...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Wahlgren NG,Lindquist C

    更新日期:1988-01-01 00:00:00

  • Usefulness of bone window CT images parallel to the transnasal surgical route for pituitary disorders.

    abstract:OBJECTIVE:Before operating on 130 patients with pituitary disorders, we evaluated their bone window CT images sliced parallel to the transnasal surgical route to assess the surgical anatomy of the nasal cavity for transnasal surgery. METHODS:High resolution bone window CT was performed in 3- to 5-mm slices parallel to...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Abe T,Asahina N,Kunii N,Ikeda H,Izumiyama H

    更新日期:2003-02-01 00:00:00

  • Acute posttraumatic paraplegia associated with asymptomatic thoracic meningioma.

    abstract::A case of a patient with acute paraparesis after compression fracture of the twelfth vertebra with progressive neurological deterioration is reported. The occurrence of clinical asymptomatic thoracic meningioma and coincidence with posttraumatic compression fracture of the vertebra at the same level resulting in acute...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Rasche D,Bonsanto MM,Hamer J,Unterberg A,Tronnier V

    更新日期:2005-06-01 00:00:00

  • The chicken egg and skull model of endoscopic endonasal transsphenoidal surgery improves trainee drilling skills.

    abstract:BACKGROUND:We verified the effectiveness of training in endoscopic endonasal transsphenoidal surgery (eETSS) techniques using chicken eggs and a skull model. METHODS:We verified the area of eggshell removed by drilling when five residents and four experts used the chicken eggs and a skull model. RESULTS:When resident...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Okuda T,Yamashita J,Fujita M,Yoshioka H,Tasaki T,Kato A

    更新日期:2014-07-01 00:00:00

  • Small intracranial aneurysms in the Barrow Ruptured Aneurysm Trial (BRAT).

    abstract:BACKGROUND:Treatment of small ruptured aneurysms (SRAs) remains controversial, with literature reporting difficulty with endovascular versus microsurgical approaches. This paper analyzes outcomes after endovascular coiling and microsurgical clipping among patients with SRAs prospectively enrolled in the Barrow Ruptured...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Catapano JS,Nguyen CL,Frisoli FA,Sagar S,Baranoski JF,Cole TS,Labib MA,Whiting AC,Ducruet AF,Albuquerque FC,Lawton MT

    更新日期:2021-01-01 00:00:00

  • Anterior cervical discectomy and fusion: is surgical education safe?

    abstract:BACKGROUND:Operative skills are key to neurosurgical resident training. They should be acquired in a structured manner and preferably starting early in residency. The aim of this study was to test the hypothesis that the outcome and complication rate of anterior cervical discectomy and fusion with or without instrument...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Stienen MN,Joswig H,Jucker D,Hildebrandt G,Schaller K,Gautschi OP

    更新日期:2015-09-01 00:00:00

  • Cerebral blood flow and oxidative brain metabolism during and after moderate and profound arterial hypoxaemia.

    abstract::In anaesthetized artificially ventilated dogs, the effect of graded arterial hypoxaemia on cerebral blood flow (CBF) and on the oxidative carbohydrate metabolism of the brain was tested. It is shown that the hypoxic vasodilatory influence on cerebral vessels is present even at moderate systemic hypoxaemia, provide tha...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Hamer J,Hoyer S,Alberti E,Weinhardt F

    更新日期:1976-01-01 00:00:00

  • Delayed occurrence of intracranial supratentorial chondroma following compound depressed skull fracture.

    abstract::We describe an exceptional case of a frontal convexity chondroma arising at the site of a compound depressed skull fracture operated on 12 years earlier. We conclude that intracranial chondroma should be included in the differential diagnosis of a calcified mass for the patients who had had a compound, depressed skull...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Hong JT,Lee SW,Son BC,Sung JH,Choi HC,Kim MC

    更新日期:2005-03-01 00:00:00

  • False aneurysms of the intracavernous carotid artery--report of 7 cases.

    abstract::We present 7 cases of false intracavernous carotid artery aneurysms. Four occurred after trauma and three were caused iatrogenically. Two of the latter occurred in patients with pituitary adenomas, one after transsphenoidal microsurgery and the other after yttrium [YI90] seed implantation into the sella. The third iat...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Bavinzski G,Killer M,Knosp E,Ferraz-Leite H,Gruber A,Richling B

    更新日期:1997-01-01 00:00:00

  • Infection of the intervertebral space following conventional and microsurgical operation on the herniated lumbar intervertebral disc. A controlled clinical trial.

    abstract::Review of the literature reveals that considerable knowledge has accumulated on intervertebral space infection following lumbar disc surgery. This is based on more than 400 observations. There are, however, no unifying concepts regarding the pathogenesis of the condition. While the reported incidence has seemed to inc...

    journal_title:Acta neurochirurgica

    pub_type: 临床试验,杂志文章


    authors: Dauch WA

    更新日期:1986-01-01 00:00:00

  • Atorvastatin preconditioning attenuates the production of endothelin-1 and prevents experimental vasospasm in rats.

    abstract:OBJECTIVE:Induced endothelin-1 (ET-1) production and decreased nitric oxide synthase (NOS) bioavailability have been found in aneurysmal subarachnoid hemorrhage (SAH). Atorvastatin is recognized to have pleiotropic effects including increasing NOS bioavailability as well as reducing inflammation and oxidative damage ot...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Chang CZ,Wu SC,Lin CL,Hwang SL,Howng SL,Kwan AL

    更新日期:2010-08-01 00:00:00

  • Meningioma manifesting intracerebral haemorrhage: a possible mechanism of haemorrhage.

    abstract::We present a possible mechanism of intracerebral peritumoural haemorrhage in meningioma based on the clinical data of three of our cases. A meningioma manifesting intracerebral haemorrhage is uncommon and some sporadic case reports have been presented, but without any proven mechanisms. We are presenting three cases o...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Kim DG,Park CK,Paek SH,Choe GY,Gwak HS,Yoo H,Jung HW

    更新日期:2000-01-01 00:00:00

  • Acute serious rebleeding after angiographically successful coil embolization of ruptured cerebral aneurysms.

    abstract:PURPOSE:The present study investigated the incidence of acute rebleeding after successful coil embolization of a ruptured cerebral aneurysm, including clinical outcomes, and possible mechanisms of the events other than coil compaction and/or incomplete embolization. MATERIALS AND METHODS:This study included 591 consec...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Kang DH,Kim YS,Baik SK,Park SH,Park J,Hamm IS

    更新日期:2010-05-01 00:00:00

  • Reconstructive stent-buttressed coil embolization of a traumatic pseudoaneurysm of the supraclinoid internal carotid artery.

    abstract::It is critical that traumatic intracranial pseudoaneurysms should be removed completely from the parent artery because there is a possibility of significant morbidity and mortality from the high risk of rebleeding from any remnants of the pseudoaneurysm. However, the deconstruction of the parent artery has the risk of...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Lim YC,Kang JK,Chung J

    更新日期:2012-03-01 00:00:00

  • Epidural monitoring of the intracranial pressure in severe head injury characterized by non-localizing motor response.

    abstract::Recent studies on prognostic variables and the intensive care of head injuries enabled us to select 64 patients and administer a standard treatment protocol to prevent secondary brain injury. All the patients were in coma with a flexor motor pattern as the best response between 6 and 24 hours after the accident and/or...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Nordby HK,Gunnerød N

    更新日期:1985-01-01 00:00:00

  • Impact of antibiotic-impregnated catheters on the timing of cerebrospinal fluid infections in non-traumatic subarachnoid hemorrhage.

    abstract:BACKGROUND:Subarachnoid hemorrhage (SAH) has been recognized as a risk factor for ventriculostomy-related infections (VRI). In addition to the hemorrhagic cerebrospinal fluid (CSF), the potential need for prolonged catheterization may contribute to the increased CSF infection rate in this population. The use of antibio...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: McLaughlin N,St-Antoine P,Bojanowski MW

    更新日期:2012-04-01 00:00:00

  • Minimally invasive procedure for removal of infected ventriculoatrial shunts.

    abstract:BACKGROUND:Ventriculoatrial shunts were one of the most common treatments of hydrocephalus in pediatric and adult patients up to about 40 years ago. Thereafter, due to the widespread recognition of the severe cardiac and renal complications associated with ventriculoatrial shunts, they are almost exclusively implanted ...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Magrassi L,Mezzini G,Moramarco LP,Cionfoli N,Shepetowsky D,Seminari E,Di Matteo A,Quaretti P

    更新日期:2021-02-01 00:00:00

  • Successful removal of pontine haematoma due to rupture of cryptic arteriovenous malformation. Case report.

    abstract::One case of a pontine haematoma with clinical symptoms of cerebellopontine angle tumour is described. The haematoma was successfully evacuated, and preoperative neurological deficits disappeared except for minimal right fifth nerve palsy. The pathological specimen was diagnosed as arteriovenous malformation. Lateropon...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Inoue Y,Sato O

    更新日期:1983-01-01 00:00:00

  • Anterior decompression and fusion for thoracolumbar fractures with neurological deficits.

    abstract::Anterior spinal decompression and fusion was used as the primary treatment for thoracolumbar fractures in eleven patients with neurological deficits. Each patient achieved stability by interbody fusion. Significant progressive kyphosis did not occur. No patients with a complete neurological deficit was improved by ope...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Young B,Brooks WH,Tibbs PA

    更新日期:1981-01-01 00:00:00

  • Stump pressure as a guide to the safety of permanent occlusion of the internal carotid artery.

    abstract::Does the absolute value of the stump pressure (post-occlusion back pressure) become a useful index of a good collateral circulation? The authors continuously monitored the mean arterial pressure before, during and after 20-minute balloon test occlusion in 24 patients. The stump pressure was then compared with the resu...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Kurata A,Miyasaka Y,Tanaka C,Ohmomo T,Yada K,Kan S

    更新日期:1996-01-01 00:00:00

  • The medial safe zone for treating intraneural ganglion cysts in the tarsal tunnel: a technical note.

    abstract:INTRODUCTION:Intraneural ganglion cysts in the tarsal tunnel are rare but are being increasingly reported. The cysts involve the tibial or plantar nerves and are most commonly derived from a neighboring (degenerative) joint, (i.e., the tibiotalar or subtalar) via an articular branch arising from the medial aspect of th...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Puffer RC,Spinner RJ

    更新日期:2019-10-01 00:00:00

  • Purely endoscopic resection of pineal region tumors using infratentorial supracerebellar approach: How I do it.

    abstract:BACKGROUND:Infratentorial supracerebellar approach via microscope still has some limitations in resection of pineal region tumors. METHODS:The authors describe a purely endoscopic infratentorial supracerebellar approach for resection of pineal region tumors with matched air-driven arm and navigation. The lateral obliq...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Gu Y,Hu F,Zhang X

    更新日期:2016-11-01 00:00:00

  • Anatomical study of the central myelin portion and transitional zone of the vestibulocochlear nerve.

    abstract:BACKGROUND:The aim of this study was to evaluate gross and microscopic anatomical features of the vestibulocochlear nerve or eighth cranial nerve (CNVIII) from fresh cadavers, especially the nerve's central myelin portion (CMP) and transitional zone (TZ), and to consider any pathological implications. METHODS:Six fres...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Guclu B,Sindou M,Meyronet D,Streichenberger N,Simon E,Mertens P

    更新日期:2012-12-01 00:00:00

  • Application of a three-dimensional graft of autologous osteodifferentiated adipose stem cells in patients undergoing minimally invasive transforaminal lumbar interbody fusion: clinical proof of concept.

    abstract:BACKGROUND:The authors applied a scaffold-free osteogenic three-dimensional (3D) graft made of adipose-derived mesenchymal stem cells (AMSCs) in patients undergoing minimally invasive transforaminal lumbar interbody fusion (MI-TLIF). METHODS:Three patients (two patients and one patient with 1 and 2 levels, respectivel...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Fomekong E,Dufrane D,Berg BV,André W,Aouassar N,Veriter S,Raftopoulos C

    更新日期:2017-03-01 00:00:00

  • Discovery of a new waveform for intraoperative monitoring of hemifacial spasms.

    abstract:BACKGROUND:Surgeons often rely on intraoperative electrophysiological monitoring to determine whether decompression is sufficient during microvascular decompression surgery for hemifacial spasms. A new monitoring method is needed when an abnormal muscle response is occasionally not available or is unreliable. This stud...

    journal_title:Acta neurochirurgica

    pub_type: 临床试验,杂志文章


    authors: Zheng X,Hong W,Tang Y,Ying T,Wu Z,Shang M,Feng B,Zhang W,Hua X,Zhong J,Li S

    更新日期:2012-05-01 00:00:00