Abstract:
OBJECTIVE:The aims were to investigate the early effects of graded, closed, mild head injury on neurofilament protein (NF160) and microtubule-associated protein-2 (MAP2) and to examine the levels of lipid peroxidation and the impact of mexilitine, inhibitor of lipid peroxidation, pretreatment on tissue damage. MATERIAL AND METHOD:One hundred and twenty-six rats were divided into groups as follows: Group 1 (n = 14) were controls; group 2 (n = 56) sustained trauma alone; and group 3 (n = 56) were pretreated with mexilitine (50 mg/kg). Groups 2 and 3 were subdivided into subgroups (n = 14 each), which were subjected to 100 g/cm2, 125 g/cm2, 150 g/cm2, and 175 g/cm2 trauma forces, respectively. Two hours after trauma, the frontal lobes from all groups were removed and processed for lipid peroxidation H&E staining, immunofluorescent labelling of neurofilaments and microtubules with anti-NF160 and anti-MAP2 antibodies. RESULTS:Compared to control findings, all the trauma-only animals showed increased lipid peroxidation levels and the elevations paralleled the amount of force applied. Administration of mexilitine significantly reduced the level of lipid peroxidation. In NF160 stainings, in group 2, the degree of impairment in axonal organization paralleled the different levels of force that were applied. Groups 3C and 3D (mexilitine pretreated) showed well-preserved axons and intact perikarya. In MAP2 stainings group 2 animals showed remarkably less MAP2 staining throughout the sections. There were no significant differences in MAP2 staining intensity or pattern among the group 2 subgroups. In contrast, in the sections from the group 3 animals, the level of MAP2 positivity was markedly preserved. CONCLUSION:In conclusion, our results show that the cytoskeletal proteins we investigated have different capacities for resisting injury, and that MAP2 is more vulnerable to injury than NF160. One of the reason for this cytoskeletal disruption may be increased lipid peroxidation. Inhibition of lipid peroxidation by pre-treatment with 50-mg/kg mexilitine significantly reduces the level of lipid peroxidation and may protect MAP2 and NF160 integrity in closed mild head injury. This protection is inversely proportional to the magnitude of the applied force.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Caner H,Can A,Atalay B,Erdogan B,Albayrak AH,Kilinc K,Bavbek M,Altinors Ndoi
10.1007/s00701-003-0209-9subject
Has Abstractpub_date
2004-06-01 00:00:00pages
611-21; discussion 621issue
6eissn
0001-6268issn
0942-0940journal_volume
146pub_type
杂志文章abstract:OBJECTIVE:Adjuvant systemic chemotherapy increases survival of primary malignant glioma patients beyond 12-18 months. The only interstitial chemotherapy treatment approved for malignant glioma is Gliadel wafer containing carmustine (BCNU) placed in the resection cavity at surgery. Analysis of a large trial by Westphal ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00701-005-0707-z
更新日期:2006-03-01 00:00:00
abstract::Primary spinal cord oligodendrogliomas are rare tumours. Only 3 holocord cases have been reported in the literature. We present a primary intramedullary "holocord" oligodendroglioma in a 13 year-old male. Scoliosis was the initial symptom. Neurological deterioration prompted MRI, which demonstrated the lesion. Total r...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
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abstract::An intensive experimental spinal cord impact trauma in rabbits led, after 90 minutes, to a significant increase of serotonin content in the segments of spinal cord at the injury epicentres. Adjacent segments showed normal values. It is suggested that the existing contradictory published data concerning the serotonin c...
journal_title:Acta neurochirurgica
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abstract::Postoperative recovery of patients with chronic subdural haematoma (CSH) was investigated by comparing pre- and postoperative coagulant and fibrinolytic activity in the haematoma contents of 15 patients with SCH. Patients in this study were treated draining the haematoma cavity without irrigation, a procedure dubbed t...
journal_title:Acta neurochirurgica
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doi:10.1007/s007010050283
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abstract:OBJECTIVE:Distal middle cerebral artery (dMCA) aneurysms are very rare with a reported frequency of 2-6%. Typically, patients with ruptured distal MCA aneurysms have poor clinical outcomes because often there is both a subarachnoid haemorrhage (SAH) and an intracerebral haematoma (ICH). The goals of this study were to ...
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abstract::The pathological effects of radio- and chemotherapy on the normal nervous tissue have been studied in 42 brains with malignant gliomas. The brains have been examined by means of the complete study technique. In seven cases the picture of delayed radionecrosis has been found. Apart from this, many histological features...
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abstract::The various hypotheses regarding the pathophysiologies of trigeminal neuralgia and hemifacial spasm are reviewed, and the results of recent physiological studies on the pathogenesis of hemifacial spasm are discussed. Evidence is presented that strongly supports the hypothesis that the symptoms and signs of hemifacial ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
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abstract::We investigated the characteristic features of intramedullary spinal cord tumour associated with neurofibromatosis type 1 (NF-1). We have experienced 44 cases of pathologically confirmed intramedullary spinal cord tumour. Diagnosis of NF-1 was done according to the criteria set by the National Institute of Health Cons...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
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journal_title:Acta neurochirurgica
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abstract::The origin of cranial epidermoid cysts (EC) remains controversial, and although generally considered to be congenital, acquired origin has been reported. EC represent 0.2 to 1.8% of all brain tumours, and only one fourth are intradiploic in location. We report of a 44-year-old woman with a giant intradiploic EC of the...
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abstract:BACKGROUND:There is no universal management protocol concerning invasive malignant tumors of the scalp with bone and dura mater invasion. The aims of this study were to report and discuss our experience in the management of these forms of tumors. METHODS:We retrospectively reviewed all consecutive patients of microsur...
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abstract::We present a case of recurrent metastatic brain tumour spread across a cranial fixation device. ...
journal_title:Acta neurochirurgica
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更新日期:2007-12-01 00:00:00
abstract::The effect of acetazolamide on the cerebral blood flow was studied in gerbils with unilateral carotid ligation. According to the effect of ligation the animals were divided into three groups: first group-the reduction more than 70%, second-CBF reduction 30-70% and the third group-CBF reduction less than 30%. The effec...
journal_title:Acta neurochirurgica
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pub_type: 临床试验,杂志文章
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journal_title:Acta neurochirurgica
pub_type: 杂志文章
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journal_title:Acta neurochirurgica
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pub_type: 临床试验,杂志文章
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更新日期:2012-05-01 00:00:00
abstract::Radiosurgery is either a primary or an adjunctive management approach used to treat patients with vestibular schwannomas. We sought to determine outcomes measuring the potential benefits against the neurological risks in patients who underwent radiosurgery after previous microsurgical subtotal resection or recurrence ...
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doi:10.1007/s00701-002-0950-5
更新日期:2002-07-01 00:00:00
abstract::A new case of hypothalamic hamartoma associated with precocious puberty is presented. After reviewing the literature, 23 other cases appeared. The ultrastructural study of the present case revealed common features with other hamartomatous lesions of the central nervous system and with the gangliogliomas. The data sugg...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01418802
更新日期:1985-01-01 00:00:00
abstract::In Europe only few neurosurgeons are trained in both open surgical clipping as well as in endovascular techniques for treatment of intracranial aneurysms. To investigate the safety and efficacy of performing both techniques we, two dual trained neurosurgeons, analyzed our results in repairing ruptured intracranial ane...
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pub_type: 杂志文章
doi:10.1007/s00701-014-2101-1
更新日期:2014-07-01 00:00:00
abstract:PURPOSE:We aim to analyse the relationship between the quality of information during the decision-making process regarding surgery to treat high-grade gliomas and the level of anxiety of the patients. METHODS:This is a transversal, descriptive and correlational study on 26 patients with a clinical and radiological dia...
journal_title:Acta neurochirurgica
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更新日期:2009-04-01 00:00:00
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更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:For gliomas, the goal of surgery is to maximise the extent of resection (EOR) while minimising the postoperative morbidity. The purpose of this study was to evaluate the benefits of a protocol developed for the surgical management of gliomas located in language areas, where tractography-integrated navigation...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1580-1
更新日期:2013-03-01 00:00:00