Radio- and chemotherapy of malignant gliomas. Pathological changes in the normal nervous tissue.

Abstract:

:The pathological effects of radio- and chemotherapy on the normal nervous tissue have been studied in 42 brains with malignant gliomas. The brains have been examined by means of the complete study technique. In seven cases the picture of delayed radionecrosis has been found. Apart from this, many histological features have been related to post-operative survival, radiation dose, interval between radiation and death, chemotherapy, steroids, size and activity of the tumour. Some alterations, such as peritumoural necroses, macrophage areas, vessel wall degenerations etc. result from radiotherapy. The relations and pathogenesis are discussed.

journal_name

Acta Neurochir (Wien)

journal_title

Acta neurochirurgica

authors

Schiffer D,Giordana MT,Soffietti R,Tarenzi L,Milani R,Vasario E,Paoletti P

doi

10.1007/BF01401682

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

37-58

issue

1-2

eissn

0001-6268

issn

0942-0940

journal_volume

58

pub_type

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