Abstract:
OBJECT:Hydrocephalus is characterised by elevated intracranial pressure (ICP) and gives rise to brain damage. The aim of this study was to investigate the significance of brain specific proteins as markers in the evaluation of brain damage in hydrocephalus. Therefore we determined the levels of four brain specific proteins in cerebrospinal fluid (CSF) and serum of symptomatic hydrocephalic patients. METHODS:During 41 CSF shunt-operations (both primarily placed shunts and shunt-revisions) CSF and blood samples were obtained and analysed for neuron-specific enolase (NSE), S-100b, glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP). The results were compared with an age-matched control group. Patients with varying clinical symptoms, denoting different levels of increased intracranial pressure prior to surgery, were included in this study. RESULTS:We observed significantly increased CSF-levels of S-100b and GFAP in the hydrocephalic patients, whereas NSE and MBP were markedly increased only in patients with very severe symptoms. Serum levels of all proteins were only minimally increased and did not correlate with CSF-levels. The slightly elevated levels of CSF-NSE in most of the patients suggest only subtle neuronal damage, which is not related to permanent neurological symptoms. The elevated levels of S-100b and GFAP are indicative of a reactive astrogliosis, which has also been demonstrated in histopathological studies. No demyelination seems to occur, according to the normal levels of MBP observed in this study. CONCLUSIONS:Although CSF levels of brain specific proteins are elevated in hydrocephalic patients, indicating brain damage due to hydrocephalus, neither CSF- nor serum-concentrations of brain specific proteins seem to be valuable tools in the clinical evaluation of the severity of hydrocephalus.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Beems T,Simons KS,Van Geel WJ,De Reus HP,Vos PE,Verbeek MMdoi
10.1007/s00701-002-1019-1subject
Has Abstractpub_date
2003-01-01 00:00:00pages
37-43issue
1eissn
0001-6268issn
0942-0940journal_volume
145pub_type
杂志文章abstract::Monostotic manifestation of fibrous dysplasia in the spine is exceedingly rare. We report the case of a 30 year-old woman suffering from slowly increasing low back pain. Radiologically a polycyclic, slightly gadolinium-enhancing, solitary lesion within the first lumbar vertebral body was detected. The lesion was remov...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-003-0133-z
更新日期:2003-11-01 00:00:00
abstract::The role of superficial temporal artery--middle cerebral artery (STA-MCA) anastomosis was investigated with an ultrasonic Doppler flowmeter in 3 patients with sphenoid ridge meningiomas and one with a parasellar malignant teratoma, all of which involved the intracranial internal carotid artery. The intraoperative Dopp...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01406817
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:This study aimed to clarify the characteristics of the basilar arteries of rabbits two and seven days after subarachnoid haemorrhage (SAH) and to investigate the influence of hypoxia on vascular responses to acetylcholine and endothelin-1. METHODS:Thirty four New Zealand white rabbits were divided into 3 gr...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-003-0024-3
更新日期:2003-07-01 00:00:00
abstract::The facial electromyographic response was monitored intraoperatively in 40 patients with hemifacial spasm who were operated on by microvascular decompression of the facial nerve. All 40 patients showed an abnormal facial electromyographic response (lateral spread response) with a latency of about 10 msec after stimula...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01411718
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Neurogenic pulmonary edema (NPE) is a clinical syndrome characterized by the acute onset of pulmonary edema after a significant central nervous system (CNS) insult. NPE occurs as a result of release of catecholamines into the blood immediately after aneurysm rupture. The aim of this study is to investigate t...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-017-3091-6
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:The natural history of vertebrobasilar artery dissection (VAD) is not fully known. The purpose of this study was to review the clinical outcome of the patients with VAD, then to propose an appropriate management strategy for VAD. METHOD:From 1992 to 2004, 35 VAD patients admitted to our institutes were retr...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-006-0742-4
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:Several studies have investigated the relation between intraoperative abnormal muscle response (AMR) findings and postoperative results in patients undergoing microvascular decompression (MVD) for hemifacial spasm (HFS). However, there is some debate over the reliability of AMR as an indicator of postoperati...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-005-0571-x
更新日期:2005-09-01 00:00:00
abstract::Though the brain bulk has been considered to be constant in several pressure homeostasis studies, the central nervous tissue may be responsible for the accommodation of extracerebral masses exceeding the volume regulation capacity of the cerebral blood and cerebrospinal fluid. Volume buffering of the nervous tissue ma...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/BF01405174
更新日期:1993-01-01 00:00:00
abstract::It is not clear whether the pre-operative treatment of GH-secreting pituitary adenomas with Octreotide improves the surgical remission rates of acromegaly. In a prospective controlled study the results of transsphenoidal surgery in newly diagnosed GH-secreting macro-adenomas were compared in patients with (n = 11, gro...
journal_title:Acta neurochirurgica
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-01-01 00:00:00
abstract:PURPOSE:Patients with oligodendrogliomas with allelic loss of chromosomal arm 1p and 19q have been shown, especially with anaplastic oligodendrogliomas, to have both a better initial and long-term response to chemotherapy as well as an improved overall survival. Effective treatment of patients with brain tumors require...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
abstract:PURPOSE:To illustrate the use of indocyanine green (ICG) video-angiography to confirm abolition of spinal dural arteriovenous fistula (SDAVF) and preserve the normal vascular anatomy intraoperatively. METHODS:A 73-year-old woman presenting with progressive myelopathy was diagnosed with an SDAVF, where the origin of th...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0445-8
更新日期:2010-03-01 00:00:00
abstract::In the last 3.5 years (up to August 1988) out of 450 patients with surgically treated intracranial aneurysms in 100 cases (22%) acute surgery was performed (up to 72 h after SAH). Patients in grade I-III (WFNS scale) were operated upon. In all the cases there were supratentorial aneurysms. CSF drainage during the oper...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01420184
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Cerebral ischemia is considered a key factor in the development of secondary damage after Traumatic Brain Injury (TBI). Studies on Cerebral Blood Flow (CBF) have documented decreased flow in over 50% of patients with TBI, studied in the acute phase. Transcranial Doppler (TCD) sonography is a non-invasive tec...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-002-1012-8
更新日期:2002-11-01 00:00:00
abstract::The use of cold as a therapeutic agent has a long and colorful history. The Edwin Smith Papyrus, the most ancient medical text known, dated 3500 B.C., made numerous references to the use of cold as therapy. Baron de Larrey, a French army surgeon during Napoleon's Russian campaign, packed the limbs in ice prior to ampu...
journal_title:Acta neurochirurgica
pub_type: 历史文章,杂志文章
doi:10.1007/s00701-006-0747-z
更新日期:2006-05-01 00:00:00
abstract::Although intracranial cavernomas are known to cause haemorrhage, data concerning the frequency, severity and delay of recurrent bleedings are controversial. We report a series of 6 patients with histologically proven cavernoma, presenting with early clinical signs and radiological proof of rebleeding, that is occurrin...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/BF01411299
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:The aims were to investigate the early effects of graded, closed, mild head injury on neurofilament protein (NF160) and microtubule-associated protein-2 (MAP2) and to examine the levels of lipid peroxidation and the impact of mexilitine, inhibitor of lipid peroxidation, pretreatment on tissue damage. MATERIA...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-003-0209-9
更新日期:2004-06-01 00:00:00
abstract:PURPOSE:To assess reliability of wall shear stress (WSS)calculations using computational fluid dynamics (CFD) dependent on inflow in internal carotid artery aneurysms (ICA). MATERIALS AND METHODS:Six unruptured ICA aneurysms were studied. 3D computational meshes were created from 3D digital subtraction angiographic im...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-010-0647-0
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Lumbar microendoscopic discectomy (MED) is a minimally invasive transmuscular approach that combines standard lumbar microsurgical techniques with endoscopy. MED advantages include reduced tissue trauma, direct visualization of the nerve root and disc disease, and allowing bony decompression in cases with sp...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-016-2743-2
更新日期:2016-04-01 00:00:00
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journal_title:Acta neurochirurgica
pub_type: 临床试验,杂志文章
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journal_title:Acta neurochirurgica
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更新日期:2004-09-01 00:00:00
abstract::27 cases of cranioplasty with autogenous bone grafts stored in a deep-freezer and autoclaved before use are reported. The results of follow-up for an average period of one year were satisfactory from the standpoint of brain protection and cosmetic reconstruction. A small area of absorption of grafted bone was observed...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01402184
更新日期:1990-01-01 00:00:00
abstract::The levels of circulating immune complexes (CIC) were assayed in the sera of 109 patients with intracranial space occupying lesions. The CIC levels were significantly increased in all the brain tumours. After treatment, the CIC levels were still significantly increased when compared to the controls but showed no chang...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01420068
更新日期:1995-01-01 00:00:00
abstract::First described on pre-B leukemia cells, the common acute lymphoblastic leukemia antigen (cALLa) is also expressed on glioma cells in vitro. Its identity to neutral endopeptidase (NEP) (E.C.3.24.11) was corroborated by our finding that cALLa positive glioma cells had NEP activity. To study cALLa/NEP distribution on gl...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01401105
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:This study was aimed at the evaluation of the relationship between genetic polymorphisms of catechol-O-methyltransferase (COMT) (rs4680:A > G-Val158Met, rs6269:A > G, rs4633:C > T, rs4818:C > G) and pain sensitivity after lumbar discectomy. METHODS:All patients had one-level symptomatic disc herniation from...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-013-1895-6
更新日期:2014-02-01 00:00:00
abstract::Quantitative isotope ventriculography (QIV) has been suggested as a method for diagnosing hydrocephalus and predicting the results of CSF shunt insertion. However, the physiological significance of this and other tracer clearance studies is questionable. Using a simplified mathematical model for tracer clearance follo...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01808440
更新日期:1981-01-01 00:00:00
abstract::The main aim in the surgery of the canalicular and extracanalicular lumbar disc herniation is to remove safely the hidden fragment without complete destruction of the normal facet joint, without damage to the nerve root and with minimal compromise of the stability of the spinal column. This report describes a lateral ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01456353
更新日期:1987-01-01 00:00:00
abstract::The authors report a series of 37 cases of unruptured aneurysms, admitted and operated upon over a 5 year period (1985-1990), which represents an incidence of 18% of the total number of aneurysm patients operated upon during this period. These unruptured aneurysms were discovered in 4 types of circumstances: 1) Associ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01541779
更新日期:1992-01-01 00:00:00
abstract::The effects of the new spasmolytic agent HA1077, which belongs to the calciumantagonists but acts by mechanisms different from those of conventional calcium channel blockers, on the cerebral microcirculation were studied in rats using isolated and cannulated intracerebral (parenchymal) arterioles of 50 microns average...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01420194
更新日期:1990-01-01 00:00:00
abstract::An intensive experimental spinal cord impact trauma in rabbits led, after 90 minutes, to a significant increase of serotonin content in the segments of spinal cord at the injury epicentres. Adjacent segments showed normal values. It is suggested that the existing contradictory published data concerning the serotonin c...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
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更新日期:1977-01-01 00:00:00