Abstract:
BACKGROUND:This study aimed to clarify the characteristics of the basilar arteries of rabbits two and seven days after subarachnoid haemorrhage (SAH) and to investigate the influence of hypoxia on vascular responses to acetylcholine and endothelin-1. METHODS:Thirty four New Zealand white rabbits were divided into 3 groups: 1) control (n=6), 2) 2 days post SAH (n=15), and 3) 7 days post SAH (n=13). Rabbits in the groups 2 and 3 underwent vertebral angiography before sacrifice. Harvested vascular rings were suspended in a small vessel myograph system for isometric tension recording in response to vasodilatory and vasoconstrictory stimulation in oxygenated (95% O2/5% CO2) and hypoxic (95% N2/5% CO2) conditions. To investigate the response to a vasodilator, acetylcholine (ACh) (10(-7) to 3 x 10(-4) M) was applied to a basilar artery pre-contracted with histamine (10(-6) approximately 10(-5) M). To investigate the response to a vasoconstrictor, the effect of endothelin-1 (ET-1) (10(-11) to 3 x 10(-8) M) was observed in quiescent rings. FINDINGS:Seven of 15 rabbits that underwent angiography two days after operation showed vasospasm to 64.3+/-11.2% of the original diameter; likewise seven of the 13 rabbits studied seven days after operation showed vasospasm to 64.9+/-10.9% of the original diameter. Hypoxic conditions significantly reduced the relaxation response to ACh but did not influence basilar artery contraction to ET-1. Responses to ACh and ET-1 did not differ significantly in vessels from animals with or without vasospasm at 2 days. In contrast, at 7 days vascular responses to ACh and ET-1 were significantly less in vessels from animals with vasospasm than those without (p=0.029, 0.032), and also less than in vessels from animals with vasospasm at day 2 (p=0.002, 0.004). There was not a significant difference in the vascular responses of basilar arteries from animals without vasospasm. INTERPRETATION:The markedly lower vascular responses of basilar arteries of rabbits to ACh and ET-1 found seven days after SAH may relate to delayed vasospasm in patients with SAH.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Kim CY,Paek SH,Seo BG,Kim JH,Han DHdoi
10.1007/s00701-003-0024-3subject
Has Abstractpub_date
2003-07-01 00:00:00pages
571-7issue
7eissn
0001-6268issn
0942-0940journal_volume
145pub_type
杂志文章abstract:BACKGROUND:The wide variety of intraspinal cystic lesions necessitates different elaborate diagnostic procedures to choose the right therapeutic management in symptomatic patients. Based on the case reports of seven patients with symptomatic spinal arachnoid cysts we discuss the aetiology, diagnostic procedures and the...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010170102
更新日期:2001-01-01 00:00:00
abstract::The case is described of a 52 year old patient admitted for acauda equina compression syndrome (flaccid paraplegia of the lower limbs, bilateral lumbar and sciatic pains, urinary incontinence) of rapid onset and due to narrowing of the lumbar canal from tabetic arthropathy. These vertebral manifestations occur in a lo...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405747
更新日期:1976-01-01 00:00:00
abstract::Ependymomas and tuberculomas are common paediatric posterior fossa lesions in developing countries and may be confused with each other due to some overlapping features. The distinction is important as the treatment for each is entirely different. We have described three young children in whom clinical-radiological fea...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-013-1811-0
更新日期:2013-10-01 00:00:00
abstract::The results of electro-oculographic recordings made after caloric vestibular stimulation (C.O.G.) in severe head injured patients are discussed. It was found that: 1. The C.O.G. correlates with the state of consciousness of the patients. 2. The rate of improvement of the C.O.G. correlates with the rate of the clinical...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405860
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:Aneurysms associated with brain arteriovenous malformations (bAVMs) influence the natural history of these lesions and pose important therapeutic challenges. However, the epidemiology, natural history, and appropriate management of the aneurysms associated with bAVMs are not completely understood due to the ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,meta分析
doi:10.1007/s00701-016-2957-3
更新日期:2016-11-01 00:00:00
abstract::Regional cerebral blood flow (rCBF) was measured in three patients after relief of elevated intracranial pressure and restoration of normal cerebral perfusion pressure. Two patients, studied within 4 hours after closed head injury were found to have marked impairment of cortical blood flow and elevation of cerebrovasc...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01406289
更新日期:1975-01-01 00:00:00
abstract::Changes of plasma thromboxane level in subarachnoid haemorrhage (SAH) were studied clinically and experimentally using 11-dehydro-thromboxane B2 (11 DTX) as a measuring index. 11 DTX is a major long-lived metabolite formed from thromboxane (TX) B2, and is said to be a more reliable parameter for detecting TXA2 product...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01403202
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Anterior cervical decompression and fusion (ACDF) may necessitate acute and late re-operations. Published long-term follow studies after ACDF are scarce. OBJECTIVE:Our goal was to give a detailed description of early and late re-operations after ACDF in an 11-year follow-up. METHODS:We retrospectively anal...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1563-2
更新日期:2013-02-01 00:00:00
abstract::Extravasation of Onyx is a rare complication during embolization of arteriovenous malformations (AVM). We present a case of embolization that was complicated by leakage of Onyx into the cerebellum which was later encountered during surgical excision of the AVM. Our goal is to report this rare event and to outline succ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-019-04199-3
更新日期:2020-04-01 00:00:00
abstract::The findings of computerized tomography and clinical features were studied in 19 patients with traumatic intraventricular haemorrhage. Blood was found in various portion of the ventricles. Main sites of the blood was as follows: around the foramen of Monro, 6 patients; in the body and occipital horn of the lateral ven...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01404144
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Long-term survival of patients with recurrent gliomas depends on the extent of resection. Thus, the desirability of an intra-operative imaging modality that can augment the resection extension without affecting vital surrounding structures is more than obvious. It was the aim of the present study to evaluate...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-006-0858-6
更新日期:2006-10-01 00:00:00
abstract:AIM:Numerous materials have been used to replace defects in the dura mater as result of neurosurgical and spinal procedures. Tissudura is a biomatrix made of cross-linked equine collagen fibrils, mainly of the interstitial type I. The specially engineered dura-like layered structure provides a non porous primary water ...
journal_title:Acta neurochirurgica
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s00701-009-0290-9
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:By now it has been well established that vertebral artery injury (VAI) is associated with unstable cervical spine injuries resulting from blunt trauma. A more complete understanding of predisposing factors and the mechanism of injury in VAI should result in improved outcomes and reduced risk for patients wit...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1499-6
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Patients with glioblastoma treated with BCNU wafer implantation for recurrence frequently receive frontline chemoradiotherapy with temozolomide as part of the Stupp protocol. A retrospective investigation was conducted of surgical complications in a cohort of these patients treated at a single institution. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-013-1931-6
更新日期:2014-02-01 00:00:00
abstract::Magnetic Resonance Imaging (MRI) scanning would prove useful for lesions that are not visualized on computed tomography (CT) scan or are better defined on MRI scan. The problem of reference marker visualization can be overcome by coating them with mineral oil or by placing paramagnetic fluid filled rods on them. The u...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01456375
更新日期:1986-01-01 00:00:00
abstract::To evaluate the operative mortality and morbidity of definitive intracranial microsurgical aneurysm obliteration as a function of timing of early operative intervention and as a function of clinical condition at the acute state, we retrospectively review 164 consecutive patients who underwent surgery within 72 hours f...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01728872
更新日期:1982-01-01 00:00:00
abstract::MRI is routinely used in the evaluation and management of patients with failed back surgery syndrome (FBSS). However, its value is unclear in the early detection of signs that can negatively affect that later course of surgical cases. The purpose of the present study is to describe the MR images of early postoperative...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01844746
更新日期:1997-01-01 00:00:00
abstract::Cerebrovascular anomalies remain an issue of controversy regarding diagnosis, classification, and treatment. We report the first case of total and asymptomatic regression and disappearance of a vein of Galen malformation associated with a posterior fossa venous pouch. Different aspects of the vein of Galen are discuss...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-002-1007-5
更新日期:2002-11-01 00:00:00
abstract::The accuracy of CAT in the diagnosis of infratentorial expanding lesions is analysed on the basis of 224 personal cases. The posterior fossa lesions are classified in four groups according to the reliability of CAT as the only pre-operative examination. The present indications for conventional neuroadiological procedu...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01811344
更新日期:1978-01-01 00:00:00
abstract::The authors have reviewed the literature concerning measures for cerebral protection during carotid endarterectomy, with particular reference to the controversy regarding the use of an intraluminar shunt. The authors use preoperative EEG analysis during the carotid compression test as well as intraoperative EEG monito...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01401154
更新日期:1984-01-01 00:00:00
abstract::In part I of this report, the CSF circulatory dynamics of autologous leucocytes labelled with indium-111 and injected in the subarachnoid space, in patients operated on for glioblastoma, were studied. In the Part II, a series of 11 patients with recurrent glioblastoma was studied for evaluating the efficacy of intrath...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01406665
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:The benefits of surgery for symptomatic spinal metastases have been demonstrated, largely based on series of patients undergoing debulking and instrumentation operations. However, as cancer treatments improve and overall survival lengths increase, the incidence of recurrent spinal cord compression after debu...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,多中心研究
doi:10.1007/s00701-019-04197-5
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:The endoscopic transorbital approach has been recently proposed for the surgical management of spheno-orbital lesions as an alternative to craniotomy surgeries. METHOD:We analyze the technical nuances and what we have changed as our experience increased after the first operations performed for 12 different ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-018-3529-5
更新日期:2018-06-01 00:00:00
abstract::Bilateral chylothorax following anterior cervical spine surgery is very rare. This report documents the first case of chylothorax after anterior cervical spine surgery through a right-side surgical approach. Unidentified chyle leakage can easily remain unrecognized and, thus, is difficult to treat. For early diagnosis...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-017-3294-x
更新日期:2017-10-01 00:00:00
abstract::The ventriculographic findings of a severe ascending transtentorial herniation that occurred after shunting in an infant with a posterior fossa tumour are described. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405337
更新日期:1978-01-01 00:00:00
abstract::Two cases of primary extraosseous intradural spinal Ewing's sarcoma are reported with a review of the current literature. This rare neoplasm shares features with cerebral primitive neuroectodermal tumors, complicating a correct diagnosis. Gross total resection seems to be the main treatment, although adjuvant therapie...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-013-1739-4
更新日期:2013-07-01 00:00:00
abstract::Retroclival arachnoid cysts are rarely reported. A 40-year-old woman had a sudden onset of occipitocervical pain. Magnetic resonance imaging (MRI) revealed a cystic mass lesion located in the retroclival region and complicated with intracystic haemorrhage. At operation, by a right lateral suboccipital approach, an old...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0381-7
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Intravenous recombinant tissue-type plasminogen activator (rt-PA) with/without endovascular treatment is not as effective in atherosclerotic steno-occlusive acute ischemic stroke. Urgent superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis is effective to some extent in progressing stroke...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-018-3576-y
更新日期:2018-09-01 00:00:00
abstract::Intraspinal nerve-sheath tumours are generally slow growing and are diagnosed after causing symptoms such as back pain and progressive neurological symptoms. We present a rare example of multiple schwannomas located in the thoracolumbar spine in a previously asymptomatic patient who developed severe neurological defic...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0239-z
更新日期:2009-06-01 00:00:00
abstract::A case of cauda equina paraganglioma is described; subsequent intracranial and intraspinal metastases occurred after partial resection and adjunctive radiotherapy. Cerebrospinal fluid dissemination is a rare complication of spinal paragangliomas. Factors predictive of this unusual biological behaviour are discussed. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01420312
更新日期:1996-01-01 00:00:00