Abstract:
:In part I of this report, the CSF circulatory dynamics of autologous leucocytes labelled with indium-111 and injected in the subarachnoid space, in patients operated on for glioblastoma, were studied. In the Part II, a series of 11 patients with recurrent glioblastoma was studied for evaluating the efficacy of intrathecal injection of autologous leucocytes. Six patients previously had radiotherapy. The results in Part I show that after intrathecal injection of autologous leucocytes, these cells follow throughout the subarachnoid space and pass to the systemic blood circulation, showing no evidence of colonization of the tumour or deposit in the tumoural region. The mean survival of the patients studied in Part II was 8 months. Those six patients who received radiotherapy had a mean survival of 11.4 months, and those five who received only intrathecal injection of autologous leucocytes after surgery, had a mean survival of 4 months. This results seem to demonstrate that immunotherapy, as used in this study, is ineffective in patients with glioblastoma.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Vaquero J,Martínez R,Barbolla L,de Haro J,de Oya S,Coca S,Ramiro Jdoi
10.1007/BF01406665subject
Has Abstractpub_date
1987-01-01 00:00:00pages
37-42issue
1-2eissn
0001-6268issn
0942-0940journal_volume
89pub_type
杂志文章abstract:BACKGROUND:Treatment of complex intracranial aneurysms requires strategic pre-interventional or preoperative planning. In addition to modern three-dimensional (3D) rotational angiography, computed tomography angiography (CTA) or magnetic resonance angiogram (MRA), a solid, tangible 3D model may improve anatomical compr...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-016-2892-3
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:van Gijn and co-workers identified "Perimesencephalic haemorrhage" (PM) as distinct, benign, non-aneurysmal subarachnoid haemorrhage. However, there is only one retrospective series of this entity outside the Netherlands. PURPOSE:to confirm (or not) the benign nature of perimesencephalic subarachnoid haemor...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01404842
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVES:A number of different image-guided surgical techniques have been developed during the past decade. None of these methods can provide the surgeon with information about the dynamic changes that occur intra-operatively. MATERIAL AND METHOD:The first vertical open 0.5T MRI-scanner for intra-operative MRI-guide...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010050325
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Wound healing impairment is a serious problem in surgical disciplines which may be associated with chronic morbidity, increased cost and patient discomfort. Here we aimed to investigate the relevance of bacterial colonisation on suture material using polymerase chain reaction (PCR) to detect and taxonomicall...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-017-3404-9
更新日期:2018-03-01 00:00:00
abstract::Event related potential recording and psychometric evaluation of cognitive impairment were carried out on 21 patients with brain tumours, 21 patients with severe head injuries and 24 controls. The tumour and trauma patients who met the psychometric inclusion criteria for dementia, but not the non-demented patients, ha...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01812285
更新日期:1986-01-01 00:00:00
abstract::In addition to the high rate of shunt complications due to obstruction and infection there is a considerable number of undesirable side effects caused by excessive drainage of CSF. Four hundred shunt treated patients are analyzed for overdrainage signs: acute decompression symptoms produced by upward shifting of the b...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01774384
更新日期:1978-01-01 00:00:00
abstract::Behçet's disease is an unusual medical condition in central Europe and North America, however more common in Turkey and Japan. It was originally described in Turkey, characterized by recurrent oral ulcers, genital ulcers and also uveitis. A variety of vascular lesions such as venous occlusions, arterial aneurysms and ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-005-0516-4
更新日期:2005-05-01 00:00:00
abstract::In the last 3.5 years (up to August 1988) out of 450 patients with surgically treated intracranial aneurysms in 100 cases (22%) acute surgery was performed (up to 72 h after SAH). Patients in grade I-III (WFNS scale) were operated upon. In all the cases there were supratentorial aneurysms. CSF drainage during the oper...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01420184
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Advantages of telemetric devices for long-term intracranial pressure (ICP) measurement have been mentioned several times in the literature. However, descriptions of associated complications are lacking. Therefore, the presented observational study focused on clinical and radiological findings after insertion...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-013-1991-7
更新日期:2014-05-01 00:00:00
abstract:OBJECT:Hydrocephalus is characterised by elevated intracranial pressure (ICP) and gives rise to brain damage. The aim of this study was to investigate the significance of brain specific proteins as markers in the evaluation of brain damage in hydrocephalus. Therefore we determined the levels of four brain specific prot...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-002-1019-1
更新日期:2003-01-01 00:00:00
abstract::Our understanding of the complexity of genetic abnormalities involved in the tumourigenesis of malignant gliomas is as yet rudimentary. However, we can discern distinctive patterns of loss of genetic material and amplification of chromosomal regions that characterize both the different types of gliomas as well as the ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/BF01411992
更新日期:1997-01-01 00:00:00
abstract::Glossopharyngeal neuralgia (GPN), or better named vago-glossopharyngeal neuralgia (VGPN), is a rare disorder amounting to 1 % of the incidence of trigeminal neuralgia (TN). Pain is paroxysmal, of the electrical shooting type, and mainly provoked by stimulation of the pharynx or deep throat, especially during swallowin...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-014-2302-7
更新日期:2015-02-01 00:00:00
abstract::After ventricular catheterization magnetic resonance (MR) imaging very often demonstrates a focal area of high signal along the drain track which corresponds to parenchymal oedema. This high signal seemed to be more pronounced when the frontal area was catheterized than when the junctional parieto-temporo-occipital pa...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01406499
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Post-operative CSF leak is the major source of morbidity following endoscopic transsphenoidal surgery. The purpose of this study was to identify factors associated with post-operative CSF leak in patients undergoing this surgery and facilitate the prospective identification of patients at higher risk of this...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-020-04334-5
更新日期:2020-06-01 00:00:00
abstract::Two cases of rupture of intracranial aneurysms and opacification of the lateral ventricles occurring during carotid angiography are reported and X-rays of the haemorrhage from the aneurysms are presented. Though the possibility of this complications remains a real one, the early use of this valuable procedure should n...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01406041
更新日期:1984-01-01 00:00:00
abstract::Technological developments in neuroendoscopy are leading to an expansion of applications into the realm of microneurosurgical procedures. The new dimension that using an endoscope provides requires insight into different neuroanatomical aspects and a new kind of strategy in planning a microneurosurgical procedure. To ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01417688
更新日期:1995-01-01 00:00:00
abstract::Twiddler syndrome occurs when a patient intentionally or unintentionally manipulates an implantable generator (usually a pacemaker) and dislodges the pacing leads, causing malfunction of the device. Though the syndrome has been described in patients with pacemakers, to our knowledge only one spontaneous case has been ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0366-6
更新日期:2010-03-01 00:00:00
abstract::The paper deals with the possibility of applying linear control theory and the theory of statistical dynamics to the complex and quantitative analysis of electroencephalographic records. The aim is to specify signals in the brain environment, in particular sources, speed and direction of signals, and the determination...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::A case of dumbbell-shaped hypoglossal neurinoma with intra- and extracranial extension is reported. The tumour was surgically completely removed in a one-stage operation via a dorsolateral sub-occipital transcondylar approach. Clinical presentation and the role of high-resolution CT-scan, MRI and angio-MRI in diagnosi...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s007010050185
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Increasingly, biomarkers have been identified that correlate with improved overall and progression-free survival (OS and PFS) in glioblastoma, including MGMT methylation status and mutations in the IDH1 gene. In this study, we investigated the clinical and biological factors associated with long-term surviva...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-016-2928-8
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:The microsurgical unilateral laminotomy (MUL) technique for bilateral decompression of lumbar spinal stenosis (LSS) is a less destabilizing alternative to laminectomy and leads to good short-term outcomes. However, little is known about the long-term results including predictive factors. METHODS:Medical rec...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-016-2804-6
更新日期:2016-06-01 00:00:00
abstract:OBJECT:Parafalcine subdural empyema and those along the superior and inferior surface of the tentorium are rare entities. We present a series of 10 patients where we have attempted to describe the pathophysiology, clinical features, and management of subdural empyema. METHODS:The study group included 10 cases of falco...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-010-0695-5
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Eloquent area surgery has become safer with the development of intraoperative neurophysiological monitoring and brain mapping techniques. However, the usefulness of intraoperative electric brain stimulation techniques applied to the management and surgical treatment of cavernous malformations in supratentori...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-018-3644-3
更新日期:2018-10-01 00:00:00
abstract::From a clinical standpoint recovery of spinal nerve roots is less likely than that of peripheral nerves, despite their identical structures. This may be due to several factors including the length of gap to be bridged, changes in the proximal stump or neuroma, and chromatolysis. In this paper we discuss the roles of s...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405874
更新日期:1976-01-01 00:00:00
abstract::The superficial middle cerebral veins (SMCVs) are large veins to drain the brain and therefore anatomical knowledge of them is important for neurosurgeons and neuroradiologists. In a patient with a ruptured blister aneurysm, we incidentally found during angiography an aberrant drainage of the SMCVs, which penetrated t...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-019-03838-z
更新日期:2019-04-01 00:00:00
abstract::Somatosensory evoked potentials (SEP) and intracranial pressure (ICP) were studied in cats, suffering from a chronic space-occupying lesion produced by enlargement of an epidural balloon over the left sensomotory cortex. Our study shows that latency alterations of SEP are not dependent on the degree of ICP. Additional...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01446995
更新日期:1993-01-01 00:00:00
abstract::The main aim in the surgery of the canalicular and extracanalicular lumbar disc herniation is to remove safely the hidden fragment without complete destruction of the normal facet joint, without damage to the nerve root and with minimal compromise of the stability of the spinal column. This report describes a lateral ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01456353
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Successful deep brain stimulation is mostly dependent on accurate positioning of the leads at the optimal target points. We investigated whether the identification of the subthalamic nucleus in T2-weighted 3-T MRI, fluid-attenuated inversion recovery 3-T MRI and susceptibility-weighted 3-T MRI is confirmed b...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-014-2328-x
更新日期:2015-03-01 00:00:00
abstract::A modification of the previous methods of producing cerebral ischaemia in rats (Koizumi et al., Longa et al.), using an intraluminal thread technique, is described. The middle cerebral artery is occluded by introducing a simple 3-0 nylon thread (0.20-0.249 mm in diameter) through the internal carotid artery in the nec...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01403007
更新日期:1991-01-01 00:00:00
abstract::The authors present a case of cauda equina paraparesis due to compression by tabetic osteo-arthropathy. Diagnosis was confirmed by the typical clinical picture of tabes and by the history of a chancre 53 years earlier. Radiography of the spine showed vertibral osteo-arthropathy. Opaque contrast myelography showed comp...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01774757
更新日期:1978-01-01 00:00:00