Intrathecal injection of autologous leucocytes in glioblastoma: circulatory dynamics within the subarachnoid space and clinical results.

Abstract:

:In part I of this report, the CSF circulatory dynamics of autologous leucocytes labelled with indium-111 and injected in the subarachnoid space, in patients operated on for glioblastoma, were studied. In the Part II, a series of 11 patients with recurrent glioblastoma was studied for evaluating the efficacy of intrathecal injection of autologous leucocytes. Six patients previously had radiotherapy. The results in Part I show that after intrathecal injection of autologous leucocytes, these cells follow throughout the subarachnoid space and pass to the systemic blood circulation, showing no evidence of colonization of the tumour or deposit in the tumoural region. The mean survival of the patients studied in Part II was 8 months. Those six patients who received radiotherapy had a mean survival of 11.4 months, and those five who received only intrathecal injection of autologous leucocytes after surgery, had a mean survival of 4 months. This results seem to demonstrate that immunotherapy, as used in this study, is ineffective in patients with glioblastoma.

journal_name

Acta Neurochir (Wien)

journal_title

Acta neurochirurgica

authors

Vaquero J,Martínez R,Barbolla L,de Haro J,de Oya S,Coca S,Ramiro J

doi

10.1007/BF01406665

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

37-42

issue

1-2

eissn

0001-6268

issn

0942-0940

journal_volume

89

pub_type

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