Abstract：
OBJECTIVE:Adjuvant systemic chemotherapy increases survival of primary malignant glioma patients beyond 12-18 months. The only interstitial chemotherapy treatment approved for malignant glioma is Gliadel wafer containing carmustine (BCNU) placed in the resection cavity at surgery. Analysis of a large trial by Westphal and colleagues (n = 240) showed a 29% risk reduction (P = 0.03) in the BCNU wafer-treated group over the course of the 30-month trial. Long-term follow-up of these patients was undertaken to determine the survival benefit at 2 and 3 years. METHODS:Survival proportions for the placebo and treatment groups over the 56-month study were estimated by the Kaplan-Meier method. Multiple-regression analyses using the Cox proportional hazards model included prognostic factors of age, KPS, and tumor type. A secondary analysis was conducted for 207 GBM patients. RESULTS:Of the 59 patients available for long-term follow-up, 11 were alive at 56 months: 9 had received BCNU wafers and 2 had received placebo wafers. Median survival of patients treated with BCNU wafers was 13.8 months vs 11.6 months in placebo-treated patients (P = 0.017) with a hazard ratio of 0.73 (P = 0.018), representing a 27% significant risk reduction. This survival advantage was maintained at 1, 2, and 3 years and was statistically significant (P = 0.01) at 3 years. Two of 207 GBM patients remained alive at the end of the follow-up period, both in the BCNU wafer-treated group. CONCLUSION:Malignant glioma patients treated with BCNU wafers at the time of initial surgery in combination with radiation therapy demonstrated a survival advantage at 2 and 3 years follow-up compared with placebo.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Westphal M,Ram Z,Riddle V,Hilt D,Bortey E,Executive Committee of the Gliadel Study Group.doi
10.1007/s00701-005-0707-zsubject
Has Abstractpub_date
2006-03-01 00:00:00pages
269-75; discussion 275issue
3eissn
0001-6268issn
0942-0940journal_volume
148pub_type
杂志文章,多中心研究,随机对照试验abstract：:Cerebral primitive neuro-ectodermal tumour (PNET) occurring as a second primary malignancy in childhood is exceedingly rare. We present a 7-year-old boy who developed a proven supratentorial PNET five years after enucleation and radio-/chemotherapy for a sporadic, unilateral retinoblastoma with optic nerve invasion. T...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01420048
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Percutaneous trigeminal nerve rhizotomy is usually performed by free-handed puncture of the foramen ovale under radiographic control with the patient kept semiconscious. The procedure has thus been reported to be highly uncomfortable for both the patient and surgeon. To our knowledge, this is the first descr...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-019-03859-8
更新日期：2019-05-01 00:00:00
abstract：:The radiological aspect, pathology, treatment and results of 132 subdural haematomas observed in 100 patients, are discussed. The majority of these cases were characterized by a nonhomogenous CT scan picture, resulting from repeated bleeding in a previous subdural haematoma evolving to chronicity, or in a pre-existent...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF02188772
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND:Fenestrations of intracranial arteries are variants resulting from incomplete fusion of vessels during development with unknown clinical significance. They are best visualised with 3D rotational angiography (3DRA). OBJECTIVE:In a prospective consecutive series of patients with suspected aneurysms, 3DRA was ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-012-1587-7
更新日期：2013-02-01 00:00:00
abstract：:An intensive experimental spinal cord impact trauma in rabbits led, after 90 minutes, to a significant increase of serotonin content in the segments of spinal cord at the injury epicentres. Adjacent segments showed normal values. It is suggested that the existing contradictory published data concerning the serotonin c...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01405241
更新日期：1977-01-01 00:00:00
abstract：BACKGROUND:According to recent findings, diffusion tensor tractography (DTT) only allows prediction of facial nerve location in relation to vestibular schwannoma (VS) with high probability. However, previous studies have not mentioned why only the facial nerve was selectively visualized. Our previous report investigate...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-015-2411-y
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:We report 24 patients with a traumatic acute subdural haematoma of the posterior fossa managed between 1997 and 1999 at 8 Italian neurosurgical centres. METHOD:Each centre provided data about patients' clinico-radiological findings, management, and outcomes, which were retrospectively reviewed. FINDINGS:A ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,多中心研究
doi：10.1007/s00701-003-0150-y
更新日期：2003-12-01 00:00:00
abstract：:The usefulness of microrecording guidance to adequately place pallidotomy lesions is not thoroughly accepted. We have analysed in 23 consecutive Parkinsonian patients the deviation of the first recording track (FRT), which was directed to the theoretical stereotactic target, from the sensorimotor area of the internal ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010050418
更新日期：1999-01-01 00:00:00
abstract：:A diagnostic protocol for patients with suspected instability and irritative state of a "lumbar motion segment" following lumbar disc surgery is presented and the results of internal fixation are analyzed. In this group of patients the clinical picture and physical signs may be quite distinct and suggestive of instabi...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01407776
更新日期：1989-01-01 00:00:00
abstract：:A treatment protocol for a controlled open study in patients with subarachnoid haemorrhage (SAH) from cerebral aneurysms is presented, applying acute surgery and pharmacological prevention of symptomatic vasospasm: In patients clinically graded I-III (Hunt and Hess), operation is performed within 48 to 72 hours. After...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01401814
更新日期：1983-01-01 00:00:00
abstract：BACKGROUND:The management of pineal cysts is still debatable, especially for asymptomatic incidental ones. For symptomatic cysts associated with hydrocephalus, the surgical management is mandatory and may include either classical microsurgical approaches to the pineal region or endoscopic trans-ventricular approaches i...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-013-1849-z
更新日期：2013-10-01 00:00:00
abstract：:Intracranial meningiomas are characteristically benign tumours with a tendency to recur following surgical resection. Our group is investigating the pathogenesis of meningioma recurrence. In our initial studies we identified two cases of dural "tails" associated with intracranial meningiomas. Gadolinium-enhanced magne...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01401115
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:Ganglioglioma is a common seizure-associated tumor, and some factors that may influence the postoperative seizure outcome have not been discussed or are controversial. The goal of this study was to observe the postoperative seizure outcome and the prognostic factors in patients with epileptogenic ganglioglio...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-011-1259-z
更新日期：2012-05-01 00:00:00
abstract：INTRODUCTION:Titanium fixation plates are routinely used for rigid fixation of bone flaps after craniotomy. In craniofacial surgery or after craniotomy involving orbitozygomatic osteotomies, these plates are occasionally removed because of infection, pain, protrusion, soft tissue erosion, and plate malfunction. However...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-016-2929-7
更新日期：2016-10-01 00:00:00
abstract：:Changes of plasma thromboxane level in subarachnoid haemorrhage (SAH) were studied clinically and experimentally using 11-dehydro-thromboxane B2 (11 DTX) as a measuring index. 11 DTX is a major long-lived metabolite formed from thromboxane (TX) B2, and is said to be a more reliable parameter for detecting TXA2 product...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01403202
更新日期：1991-01-01 00:00:00
abstract：:The authors report the case of a 67-year-old woman with primary micro-invasive squamous cell carcinoma located in the lateral ventricle and originating from an epidermoid cyst. Radiological and histological features of the neoplasm are described and the relevant literature is studied briefly. Two consecutive surgical ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01411292
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:The wide variety of intraspinal cystic lesions necessitates different elaborate diagnostic procedures to choose the right therapeutic management in symptomatic patients. Based on the case reports of seven patients with symptomatic spinal arachnoid cysts we discuss the aetiology, diagnostic procedures and the...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010170102
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVE:Rathke's cleft cysts are often difficult to differentiate from other sellar cystic lesions using conventional MR imaging. The purpose of this study was to investigate the usefulness of single-shot fast spin-echo (SSFSE) diffusion-weighted MR imaging (DWI) in the diagnosis of a Rathke's cleft cyst. PATIENTS A...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-007-1234-x
更新日期：2007-08-01 00:00:00
abstract：OBJECTIVES:Ballistic injuries to peripheral nerves pose special challenges in terms of indications, timing and type of surgical intervention. The aim of the present work was to analyze our experience in the surgical treatment of peripheral nerve ballistic injuries with respect to the mechanism of injury (gunshot versus...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-014-2139-0
更新日期：2014-08-01 00:00:00
abstract：:1. The use of rapid sequential gamma camera scintigraphy in conjunction with computer aided storage and evaluation of data has been shown to be a promising method for the analysis of CSF dynamics in man. 2. Using this method rapid flow of CSF in the basal cisterns can be studied. The further course of tracer activity ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01405983
更新日期：1977-01-01 00:00:00
abstract：BACKGROUND:As the volume of scientific publications increases, the rate of retraction of published papers is also likely to increase. In the present study, we report the characteristics of retracted papers from clinical neurosurgery and allied clinical and basic science specialties. METHODS:Retracted papers were ident...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-020-04615-z
更新日期：2021-01-01 00:00:00
abstract：:Intervertebral disc herniation is an important health problem from both the social and economic aspect. It is often accompanied by a decrease in the content of water and proteoglycan (PG). The present study was undertaken to elucidate the effect of neodymium-yttrium-aluminum-garnet (Nd:YAG) laser on degenerated disc t...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01411066
更新日期：1996-01-01 00:00:00
abstract：:Acute cerebrovascular congestion after a closed head injury is significantly related to intracranial hypertension. As an indirect method of cerebral blood flow measurement; transcranial doppler sonography (TCD) provides a rapid and noninvasive assessment of cerebral haemodynamics, including hyperaemic conditions. TCD ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01476289
更新日期：1993-01-01 00:00:00
abstract：:The system consists of an inverted U-shaped frame with right angled corners, so mounted that it can be adjusted vertically, antero-posteriorly and made to rotate on an axis ("the axis of the frame") formed by its free ends. The frame carries an arc probe carrier whose probe holder slides on an arc which is centered on...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01406198
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVE:To establish the risk of recurrence in patients with chronic subdural hematoma (cSDH) on antithrombotic treatment (AT, i.e., antiplatelets and anticoagulants). Secondary end points were perioperative morbidity and mortality between groups (AT vs. no-AT group) and exploration if timing of resumption of AT trea...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-017-3330-x
更新日期：2017-11-01 00:00:00
abstract：INTRODUCTION:Desmoid-type fibromatosis (DTF) frequently arises in patients with neuromuscular choristoma (NMC). We hypothesize that NMC-associated DTF occurs in soft tissues innervated by the NMC-affected nerve, and arises from CTNNB1-mutated (myo) fibroblasts within or directly adjacent to the NMC. MATERIALS AND METH...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-019-04178-8
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:Intraoperative navigated ultrasonography has reached clinical acceptance, while published data for the accuracy of some systems are missing. We technically quantified and optimised the accuracy of the integration of an external ultrasonography system into a BrainLab navigation system. METHODS:A high-end ult...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-017-3416-5
更新日期：2018-02-01 00:00:00
abstract：:A 35-year-old female presented with partial complex seizures. Computed tomography (CT) showed a slightly high density mass over the right frontal convexity, with heterogeneous contrast enhancement. T1-weighted magnetic resonance (MR) imaging showed the tumour as a hypo-intense lesion, with faint reticular enhancement ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010050493
更新日期：1999-01-01 00:00:00
abstract：:We present a rare fatal complication of an occipital condylar fracture. The patient was initially neurologically intact, but showed secondary clinical deterioration. Imaging revealed extensive extra-axial hemorrhage at the craniocervical junction and an acute obstructive hydrocephalus. MR imaging demonstrated a T2 hyp...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-017-3165-5
更新日期：2017-06-01 00:00:00
abstract：:Diffuse brain injury in rabbits was caused by injecting olive oil and saline into one internal carotid artery. In this report, the fourth of a series, the effects of this experimental brain injury on respiration and acid-base balance of blood are analyzed. The animals that withstood the injury best were those that had...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01405898
更新日期：1975-01-01 00:00:00
