Abstract:
BACKGROUND:Side-to-side neurorrhaphy may protect the denervated end organ and preserve the initial connection with proximal stump. We examined the effect of protective side-to-side anastomosis on nerve and end organ regeneration in proximal nerve injury model. METHODS:The left common peroneal nerve of 24 Sprague Dawley rats was proximally transected. In groups B and C, side-to-side neurorrhaphy was performed distally between the peroneal and tibial nerves without (group B) and with (group C) partial donor nerve axotomy inside the epineural window. Group A served as an unprotected control. After 26 weeks, the proximal transection was repaired with end-to-end neurorrhaphy on all animals. Regeneration was followed during 12 weeks with the walk track analysis. Morphometric studies and wet muscle mass calculations were conducted at the end of the follow-up period. RESULTS:The results of the walk track analysis were significantly better in groups B and C compared to group A. Groups B and C showed significantly higher wet mass ratios of the tibialis anterior and extensor digitorum longus muscle compared to group A. Group C showed significantly higher morphometric values compared to group A. Group B reached higher values of the fibre count, fibre density, and percentage of the fibre area compared to group A. CONCLUSIONS:Protective distal side-to-side neurorrhaphy reduced muscle atrophy and had an improving effect on the morphometric studies and walk track analysis. Distal side-to-side neurorrhaphy does not prevent the regenerating axons to grow from the proximal stump to achieve distal nerve stump.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Rönkkö H,Göransson H,Taskinen HS,Paavilainen P,Vahlberg T,Röyttä Mdoi
10.1007/s00701-019-03835-2subject
Has Abstractpub_date
2019-04-01 00:00:00pages
645-656issue
4eissn
0001-6268issn
0942-0940pii
10.1007/s00701-019-03835-2journal_volume
161pub_type
杂志文章abstract::We estimated the volume doubling time (Vd) of the ethyl-nitrosourea-induced rat glioma by serial magnetic resonance imaging, and the results were compared with potential doubling time (Tp) determined immunohistochemically. Vd ranged from 3.3 to 29.2 days (11.3 +/- 7.74) and Tp ranged from 2.3 to 13.3 days (6.81 +/- 3....
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010050148
更新日期:1998-01-01 00:00:00
abstract::Primary spinal cord oligodendrogliomas are rare tumours. Only 3 holocord cases have been reported in the literature. We present a primary intramedullary "holocord" oligodendroglioma in a 13 year-old male. Scoliosis was the initial symptom. Neurological deterioration prompted MRI, which demonstrated the lesion. Total r...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01402122
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Peripheral nerve lesions usually are associated with neuropathic pain. In the present paper, we describe a simple scale to quantify pain after brachial plexus injuries and apply this scale to a series of patients to determine initial outcomes after reconstructive surgery. METHODS:Fifty-one patients with tra...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-010-0709-3
更新日期:2011-01-01 00:00:00
abstract::Intervertebral disc herniation is an important health problem from both the social and economic aspect. It is often accompanied by a decrease in the content of water and proteoglycan (PG). The present study was undertaken to elucidate the effect of neodymium-yttrium-aluminum-garnet (Nd:YAG) laser on degenerated disc t...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01411066
更新日期:1996-01-01 00:00:00
abstract::Venous malformations in the posterior fossa are relatively rare. Although the introduction of CT and MRI has made them easier to detect, their treatment is still controversial. Based on our experience with six patients and a review of the literature, we have tried to establish guidelines for their treatment. Since the...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01476418
更新日期:1994-01-01 00:00:00
abstract::Among 64 patients with hemifacial spasm (HFS) and 60 with trigeminal neuralgia (TN) treated by microvascular decompression (MVD), repeated MVD performed on 3 cases with HFS resulted in the absence of spasm in all cases. In 7 cases with TN, this technique resulted in complete remission in 2, recurrence in 3, and no pai...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01400583
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Recent advances in endoscopic techniques have allowed minimally invasive approaches to the cranio-vertebral junction (CVJ) through the oropharynx (ETA) in addition to the transnasal approach (EEA). These minimally invasive endoscopic techniques allow for increased surgical exposure using no visible incisions...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-017-3103-6
更新日期:2017-04-01 00:00:00
abstract:INTRODUCTION:The quality of surgical treatment of intracranial aneurysms is determined by complete aneurysm occlusion and restoration of flow in the parent, branching and perforating vessels. In postoperative digital subtraction angiography (DSA), unexpected aneurysm residuals and vessel occlusions are frequently detec...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-010-0723-5
更新日期:2010-09-01 00:00:00
abstract::The findings of computerized tomography and clinical features were studied in 19 patients with traumatic intraventricular haemorrhage. Blood was found in various portion of the ventricles. Main sites of the blood was as follows: around the foramen of Monro, 6 patients; in the body and occipital horn of the lateral ven...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01404144
更新日期:1987-01-01 00:00:00
abstract::In the last 3.5 years (up to August 1988) out of 450 patients with surgically treated intracranial aneurysms in 100 cases (22%) acute surgery was performed (up to 72 h after SAH). Patients in grade I-III (WFNS scale) were operated upon. In all the cases there were supratentorial aneurysms. CSF drainage during the oper...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01420184
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Little is known about the nature of spine surgery training received by European neurosurgical trainees during their residency and the level of competence they acquire in dealing with spinal disorders. METHODS:A three-part questionnaire entailing 32 questions was devised and distributed to the neurosurgical ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0259-8
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:The middle meningeal artery (MMA) is well known to function as an important collateral channel to the territory of the anterior cerebral artery in moyamoya disease. This study was aimed to evaluate whether indocyanine green (ICG) videoangiography could visualize the anterior branch of the MMA before cranioto...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-016-3060-5
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:We introduce a user-friendly, standardized protocol for tractography of the major language fiber bundles. METHOD:The introduced method uses dMRI images for tractography whereas the ROI definition is based on structural T1 MPRAGE MRI templates, without normalization to MNI space. ROIs for five language-relev...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-019-03899-0
更新日期:2019-06-01 00:00:00
abstract::Event related potential recording and psychometric evaluation of cognitive impairment were carried out on 21 patients with brain tumours, 21 patients with severe head injuries and 24 controls. The tumour and trauma patients who met the psychometric inclusion criteria for dementia, but not the non-demented patients, ha...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01812285
更新日期:1986-01-01 00:00:00
abstract::When operating on a child with a large myelomeningocele and kyphosis, coverage with skin of high quality and a supporting layer of subcutaneous tissue can be difficult. The dermal circulation in the newborn is finite and an extensive mobilisation of the skin is a risky venture. Between 1988 and 2003 five children with...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-005-0704-2
更新日期:2006-03-01 00:00:00
abstract::Homovanillic acid (HVA) and 5-hydroxyindolacetic acid (5-HIAA) in ventricular CSF were determined in 19 patients (12 female 7 male) with brain tumours. No relationship was found between ventricular fluid pressure (VFP) and levels of HVA and 5-HIAA. A relationship was observed between ventricular CSF, HVA concentration...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405944
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:Treatment of small ruptured aneurysms (SRAs) remains controversial, with literature reporting difficulty with endovascular versus microsurgical approaches. This paper analyzes outcomes after endovascular coiling and microsurgical clipping among patients with SRAs prospectively enrolled in the Barrow Ruptured...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-020-04602-4
更新日期:2021-01-01 00:00:00
abstract::The review of the literature on Cheyne-Stokes respiratory periods reveals enormous variation of the opinions expressed. The original description concerned periodicity characterized by rhythmic changes of respiratory phases and respiratory pauses in a relation of 60 : 15 seconds. In the respiratory phase there were 30 ...
journal_title:Acta neurochirurgica
pub_type: 历史文章,杂志文章,评审
doi:10.1007/BF01809226
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:Transposition of the vertebral artery (VA) for microvascular decompression for hemifacial spasm (HFS) is often challenging. Various procedures have been proposed to transpose the immobile tortuous VA that cannot be decompressed satisfactorily in the usual manner. METHODS:A Teflon piece that is cut into a we...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-018-03793-1
更新日期:2019-07-01 00:00:00
abstract::For measurement of the cerebral blood flow (CBF) the thermal diffusion method is quite convenient and allows the chronological measurement of CBF and CO2 reactivity of cerebral vessels. We investigated the CO2 reactivity of fifteen head injury patients. The results showed that in head injury cases, the disturbance of ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01842829
更新日期:1990-01-01 00:00:00
abstract::The authors report their experience with CT scanning ina series of 4 cases of subdural empyema, over a period of 10 months; all the patients were male, aged 16 to 25 years. A review of the literature shows that this disease, in spite of the large variety and efficacy of the available antibiotics, is marked by a signif...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01740084
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Meticulous haemostasis is one of the most important factors during microneurosurgical resection of brain arteriovenous malformation (AVM). Controlling major arterial feeders and draining veins with clips and bipolar coagulation are well-established techniques, while managing with bleeding from deep tiny vess...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-017-3138-8
更新日期:2017-05-01 00:00:00
abstract::Regression of meningioma after haemorrhage and the cessation of hormone treatment is well reported. However, spontaneous regression is very rarely observed. Here, we report the spontaneous regression of a parafalcine meningioma in a 56-year-old woman with multiple sclerosis, who was referred to our department after an...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-016-3019-6
更新日期:2017-03-01 00:00:00
abstract::The authors review the literature and present 8 cases of extradural haematoma of the posterior fossa operated from 1979 to 1985 at the Neurosurgical Clinic of the University of Pavia. Emphasis is placed on the importance of an early diagnosis of the symptoms which are often ignored due to the absence of specific clini...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01809553
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:This study was aimed at the evaluation of the relationship between genetic polymorphisms of catechol-O-methyltransferase (COMT) (rs4680:A > G-Val158Met, rs6269:A > G, rs4633:C > T, rs4818:C > G) and pain sensitivity after lumbar discectomy. METHODS:All patients had one-level symptomatic disc herniation from...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-013-1895-6
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:The visualization of any morphological volume (i.e. CT, MRI) together with an additional second morphological volume (i.e. CT, MRI) or functional data set, which may come from SPECT or PET, is a new method for treatment planning, verification and follow-up of interstitial irradiation. METHOD:The authors pre...
journal_title:Acta neurochirurgica
pub_type: 临床试验,杂志文章
doi:10.1007/s007010070022
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:Malignant gliomas are highly infiltrative tumours with a fatal prognosis. F18-fluoroethyl-tyrosine (FET)-positron emission tomography (PET) often reveals a broader extension of these tumours compared with contrast-enhanced magnetic resonance imaging (MRI). Complete resection of the contrast-enhancing lesion is ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0462-7
更新日期:2009-11-01 00:00:00
abstract::The purpose of this in vitro study is to compare the stabilities provided by anterior cervical H-plating with screws purchased either subcortically or bicortically on porcine cervical spines. Nine porcine cervical spines (C3-C4) were challenged by 12 Nm in extension followed by 6 Nm in flexion in 6 consecutive steps, ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01411356
更新日期:1996-01-01 00:00:00
abstract::The authors report on four unusual cases of chronic adult hydrocephalus extracted from a large personal series of patients with hydrocephalic dementia. A syndrome resembling that of normal pressure hydrocephalus was due to the following aetiologies in these patients: Paget's disease of the skull, unruptured cerebral a...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01808923
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:The axolemmal distribution and density of voltage-gated sodium channels largely determines the electrical excitability of sprouting neurites. Recent evidence suggests that accumulation of sodium channels at injured axonal tips may be responsible for ectopic axonal hyperexcitability and the resulting abnormal...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-002-0970-1
更新日期:2002-08-01 00:00:00