Manual for clinical language tractography.

Abstract:

BACKGROUND:We introduce a user-friendly, standardized protocol for tractography of the major language fiber bundles. METHOD:The introduced method uses dMRI images for tractography whereas the ROI definition is based on structural T1 MPRAGE MRI templates, without normalization to MNI space. ROIs for five language-relevant fiber bundles were visualized on an axial, coronal, or sagittal view of T1 MPRAGE images. The ROIs were defined based upon the tracts' obligatory pathways, derived from literature and own experiences in peritumoral tractography. RESULTS:The resulting guideline was evaluated for each fiber bundle in ten healthy subjects and ten patients by one expert and three raters. Overall, 300 ROIs were evaluated and compared. The targeted language fiber bundles could be tracked in 88% of the ROI pairs, based on the raters' result blinded ROI placements. The evaluation indicated that the precision of the ROIs did not relate to the varying experience of the raters. CONCLUSIONS:Our guideline introduces a standardized language tractography method for routine preoperative workup and for research contexts. The ROI placement guideline based on easy-to-identify anatomical landmarks proved to be user-friendly and accurate, also in inexperienced test persons.

journal_name

Acta Neurochir (Wien)

journal_title

Acta neurochirurgica

authors

Fekonja L,Wang Z,Bährend I,Rosenstock T,Rösler J,Wallmeroth L,Vajkoczy P,Picht T

doi

10.1007/s00701-019-03899-0

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

1125-1137

issue

6

eissn

0001-6268

issn

0942-0940

pii

10.1007/s00701-019-03899-0

journal_volume

161

pub_type

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