Abstract：
:The neural activity pattern of the subthalmic nucleus (STN) was investigated in five patients with Parkinson's disease who were scheduled for electrode implantation for chronic stimulation of the STN. The initial target was placed 8 mm or 10 mm lateral to the midline, 3 mm to 4 mm posterior to the midcommissural point, and 5 mm to 6 mm below the intercommissural (AC-PC) line. The STN was identified by semi-microelectrode recordings with a trajectory moving laterally in 2-mm steps. The amplitudes of multi-unit activities were relatively low at depths from 8 mm to 5 mm above and from 1 mm to 4 mm below the target, while those 4 mm to 0 mm above the target were significantly higher than at the other sites (ANOVA, Fisher's test, p < 0.05), with the highest amplitude at 2 mm above the target (91.0 +/- 23.3 mu v, n = 15). In the mediolateral direction, amplitudes were relatively higher in the lateral portion, and amplitudes at 14 mm lateral to the midline were significantly higher than at the other sites (ANOVA, Fisher's test, p < 0.05). The target for chronic electrical stimulation was determined to be at the midpoint of the hyperactive STN, i.e., 12 mm lateral to the midline in three patients and 13 mm lateral in two patients. Movement-related neural activity was observed at 5 sites, i.e., 3 sites responded to passive movement of the contralateral wrist and 2 sites to passive knee and/or ankle movement. In conclusion, our data show that the lateral part of the STN is hyperactive in PD, and recordings of neural activities contributed greatly to identifying the STN and determining the target for chronic stimulation within it.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Yokoyama T,Sugiyama K,Nishizawa S,Tanaka T,Yokota N,Ohta S,Uemura Kdoi
10.1007/s007010050251subject
Has Abstractpub_date
1998-01-01 00:00:00pages
1287-90; discussion 1291issue
12eissn
0001-6268issn
0942-0940journal_volume
140pub_type
杂志文章abstract：OBJECTIVE:Rathke's cleft cysts are often difficult to differentiate from other sellar cystic lesions using conventional MR imaging. The purpose of this study was to investigate the usefulness of single-shot fast spin-echo (SSFSE) diffusion-weighted MR imaging (DWI) in the diagnosis of a Rathke's cleft cyst. PATIENTS A...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-007-1234-x
更新日期：2007-08-01 00:00:00
abstract：:Aneurysms of the vertebro-basilar junction area have been considered the most difficult to be surgically treated because of their deep location, the proximity of the brain stem and the cranial nerves. However, at present, new endovascular techniques and new transbasal surgical approaches offer valuable management stra...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF02747192
更新日期：1997-01-01 00:00:00
abstract：:Traditional clinical outcome measures for the treatment of Parkinson's disease (PD) have focused on motor function and activities of daily living. However, in the past decade there has been a new emphasis on the use of health related quality of life (HRQOL) measures for translating how a patient's response to treatmen...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010070090
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Surgical treatment of petroclival meningiomas remains challenging. In order to refine indications for the use of stereotactic radiosurgery in the treatment of these tumours, we retrospectively evaluated our experience in this field. METHODS:Thirty-two patients harboring a petroclival meningioma were treated...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-003-0123-1
更新日期：2003-10-01 00:00:00
abstract：:To clarify the value of clinical long-term follow-up with radiological examination, ranging from 12 to 63 months (average: 35 months), 18 consecutive patients suffering from spontaneous carotid cavernous fistula (CCF), were studied prospectively. Five aged patients without aggressive symptoms were treated conservative...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010050059
更新日期：1998-01-01 00:00:00
abstract：:SPECT scanning with Tl-201 and Tc-99m offers a unique, inexpensive functional imaging modality to combine with CT stereotactic craniotomy for guiding resection of necrosis and/or tumour in patients treated with escalated doses of radiation (> 6000 cGy) by either brachytherapy or radiosurgery. Thirty-two cases were ana...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01405531
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND:Aneurysmal subarachnoid haemorrhage (aSAH) is an acute cerebrovascular event with high socioeconomic impact as it tends to affect younger patients. The recent NCEPOD study looking into management of aSAH has recommended that neurovascular units in the United Kingdom should aim to secure cerebral aneurysms wi...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-016-2746-z
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:Many high-grade glioma (HGG) patients have cognitive impairments, which impact daily functioning. Cognitive impairments can be caused by tumour-, treatment-, and patient-related factors. The effect of the tumour and of surgical resection on cognition is, however, not well known. We investigated tumour and su...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-014-2115-8
更新日期：2014-08-01 00:00:00
abstract：:Four patients harbouring a colloid cyst of the 3rd ventricle were operated on endoscopically. With the "classical" monoportal technique, through a precoronal burr hole only partial removal could be achieved in the first case. As the crucial point of the procedure is the safe dissection of the cyst from the thela chori...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010050466
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Early recognition of emerging delayed neurological deficits (DND) in patients after subarachnoid haemorrhage (SAH) is not always possible by transcranial Doppler sonography. Aim of this study was to investigate a) whether determination of blood flow velocities in deep cerebral basal veins can predict DND in ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010170033
更新日期：2001-08-01 00:00:00
abstract：OBJECTIVE:Distal middle cerebral artery (dMCA) aneurysms are very rare with a reported frequency of 2-6%. Typically, patients with ruptured distal MCA aneurysms have poor clinical outcomes because often there is both a subarachnoid haemorrhage (SAH) and an intracerebral haematoma (ICH). The goals of this study were to ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-007-1061-5
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:Advanced states of vertebral osteomyelitis accompanied by spinal instability, epidural abscess formation, and neurological deficits require surgical decompression, stabilization, and often reconstruction of the anterior and posterior columns. The efficacy of a posterolateral approach with resection of inflam...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-015-2507-4
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Drain insertion following chronic subdural haematoma (CSDH) evacuation reduces recurrence and improves outcomes. The mechanism of this improvement is uncertain. We assessed whether drains result in improved postoperative imaging, and which radiological factors are associated with recurrence and functional ou...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,多中心研究
doi：10.1007/s00701-020-04356-z
更新日期：2020-06-01 00:00:00
abstract：:Stereotactic targeting of the postero-ventral pallidum (PVP) presents special challenges to the surgeon 1) The target is in intimate relation to the optic tract and the internal capsule. 2) Proper angulation of the trajectory is crucial to achieve optimal effects given the long craniocaudal extension of the PVP. 3) Th...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01411480
更新日期：1996-01-01 00:00:00
abstract：:The authors report a series of 36 vein of Galen aneurysmal malformations (VGM) diagnosed in the paediatric (78%) and adult (22%) populations that were referred to them for therapeutic management between 1982 and 1988. The clinical signs leading to the diagnosis were variable: 36% of systemic manifestations, 22% of neu...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01407773
更新日期：1989-01-01 00:00:00
abstract：:In spite of the recent advances in neuroradiology including the CT scan and the spin-echo-magnetic resonance (MR), accurate diagnosis of arteriovenous malformations (AVMs) involving the spinal cord is still based on selective angiography. This last procedure is invasive and needs to be repeated during the follow up. P...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01476287
更新日期：1993-01-01 00:00:00
abstract：:Basal forebrain cells of foetal rats were transplanted into the subarachnoid space of adult rats harbouring a kainic acid-induced unilateral lesion in the nucleus basalis magnocellularis. Passive avoidance response tests were performed eight weeks after the transplantation, and the results were compared with those of ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01404951
更新日期：1995-01-01 00:00:00
abstract：:Ninety-six patients with aneurysmal subarachnoid haemorrhage underwent serial measurement of regional cerebral blood flow throughout the period of their treatment over the period of 5 years (1983 to 1988). A portable bedside xenon cerebral blood flow machine was used in this study and the initial slope index (ISI) val...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01407659
更新日期：1991-01-01 00:00:00
abstract：:The hypothesis is developed that plateau waves (PW) are caused by an abrupt elevation of postcapillary flow resistance induced by compression of the outlets of the leptomeningeal veins. It is shown by means of a physical model that the main prerequisite for venous outlet compression consists in an elevation of the out...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01407125
更新日期：1981-01-01 00:00:00
abstract：PURPOSE:Complete yet safe resection close to motor areas in medically intractable epilepsy requires functional information. New deficit may occur despite preservation of motor cortex, e.g., through vascular compromise. Here, we explore for the first time the feasibility, safety, and the clinical value of continuous mot...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-010-0675-9
更新日期：2010-08-01 00:00:00
abstract：:Between 1976 and 1983, 251 patients underwent surgery for the treatment of cervical degenerative disc disease. Anterior microsurgical discectomy at one or more cervical segments without interbody fusion was performed in each case. 109 patients with radiculopathy and 55 patients with myelopathy were followed up clinica...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01560567
更新日期：1988-01-01 00:00:00
abstract：:For measurement of the cerebral blood flow (CBF) the thermal diffusion method is quite convenient and allows the chronological measurement of CBF and CO2 reactivity of cerebral vessels. We investigated the CO2 reactivity of fifteen head injury patients. The results showed that in head injury cases, the disturbance of ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01842829
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:The suprameatal tubercle (SMT) may obscure the neurovascular compression (NVC) in microvascular decompression (MVD) for trigeminal neuralgia (TGN). The aim of this study is to address the necessity of resecting SMT in MVD for TGN. METHODS:We retrospectively analyzed radiological findings of 461 MVDs in pati...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-020-04242-8
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:The purpose was to review our experience with the surgical management of brainstem cavernomas (BSCs) and especially the impact of the surgical timing on the clinical outcome. METHOD:We retrospectively reviewed 22 patients harboring a BSC, who underwent 23 procedures. FINDINGS:Surgery was carried out during...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-005-0671-7
更新日期：2006-04-01 00:00:00
abstract：:Meningiomas are tumors arising from the meninges and represent the most frequent central nervous system tumors in adults. Recent large-scale genetic studies and preclinical meningioma mouse modelling led to a better comprehension of meningioma development and suggested evidences of close relationships between meningea...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,评审
doi：10.1007/s00701-020-04650-w
更新日期：2021-01-01 00:00:00
abstract：:Cerebral primitive neuro-ectodermal tumour (PNET) occurring as a second primary malignancy in childhood is exceedingly rare. We present a 7-year-old boy who developed a proven supratentorial PNET five years after enucleation and radio-/chemotherapy for a sporadic, unilateral retinoblastoma with optic nerve invasion. T...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01420048
更新日期：1997-01-01 00:00:00
abstract：:This paper is based on a study of sixty cases of cranio-cerebral erosion treated in the Department of Neurosurgery. All India Institute of Medical Sciences, New Delhi during the last 20 years. This constitutes the largest series, so far reported from anywhere. It has provided a unique opportunity to get a comprehensiv...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,评审
doi：10.1007/BF01400508
更新日期：1987-01-01 00:00:00
abstract：BACKGROUND:Oculomotor cistern extension (OMCE) of pituitary adenoma through the oculomotor triangle may be one of the major characteristics of multi-lobulated adenoma. The OMCE may be hard to remove only through the endonasal approach. METHOD:We applied the simultaneous combined supra-infrasellar approach to remove pi...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-019-03869-6
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:We present a unique example of an intra-sellar schwannoma co-existing with a growth hormone (GH)-secreting pituitary adenoma. METHOD AND FINDINGS:The patient presented with acromegaly and magnetic resonance imaging (MRI) revealed an intra-sellar mass. The tumour was totally resected via a sub-labial trans-s...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-009-0304-7
更新日期：2009-12-01 00:00:00
abstract：:The management of vestibular schwannomata is controversial. Surveillance remains an acceptable option for elderly patients or those with small lesions. Stereoradiosurgery is also an option, while surgery is often preferred in younger patients with larger lesions. In elderly patients with lesions causing brainstem comp...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-009-0493-0
更新日期：2010-01-01 00:00:00
