Meningiomas from a developmental perspective: exploring the crossroads between meningeal embryology and tumorigenesis.

Abstract:

:Meningiomas are tumors arising from the meninges and represent the most frequent central nervous system tumors in adults. Recent large-scale genetic studies and preclinical meningioma mouse modelling led to a better comprehension of meningioma development and suggested evidences of close relationships between meningeal embryology and tumorigenesis. In this non-systematic review, we summarize the current knowledge on meningeal embryology and developmental biology, and illustrate how meningioma tumorigenesis is deeply related to meningeal embryology, concerning the potential cell of origin, the role of reactivation of embryonic stem cells, the influence of the embryonic tissue of origin, and the parallelism between topography-dependant molecular pathways involved in normal meninges and in meningioma development. Our study emphasizes why future studies on meningeal embryology are mandatory to affine our comprehension of mechanisms underlying meningioma initiation and development.

journal_name

Acta Neurochir (Wien)

journal_title

Acta neurochirurgica

authors

Boetto J,Peyre M,Kalamarides M

doi

10.1007/s00701-020-04650-w

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

57-66

issue

1

eissn

0001-6268

issn

0942-0940

pii

10.1007/s00701-020-04650-w

journal_volume

163

pub_type

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