Evidence for the participation of vascular endothelium originated humoral factors to cerebral vasospasm.

Abstract:

:Vascular endothelium synthesizes mediators which either cause vasorelaxation or vasoconstriction. The purpose of this study is to investigate the role of these mediators in the pathogenesis of cerebral vasospasm. An inhibitor of endothelium-derived relaxing factor is haemoglobin; endothelium removal by triton X-100 and endothelin-1 caused narrowing in the diameter of basilar artery of the rabbit. The pathological, ultrastructural investigations and computerized tomography images are in accordance with this finding. These results indicate that not only an increase in vasoconstrictor mediator level but also the lack of endothelium-derived relaxing mediators are responsible of the spasm of the basilar artery.

journal_name

Acta Neurochir (Wien)

journal_title

Acta neurochirurgica

authors

Baykaner MK

doi

10.1007/BF01401136

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

135-8

issue

2-4

eissn

0001-6268

issn

0942-0940

journal_volume

124

pub_type

杂志文章
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  • Surgical treatment of spinal dural arterio-venous fistulae: long-term results and analysis of prognostic factors.

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    doi:

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