Abstract:
BACKGROUND:The exact aetiology, growth and rupture of intracranial aneurysms is unclear. In this study we investigated a possible association between intracranial aneurysm rupture and polymorphism of the endothelial nitric oxide synthase gene G894T. METHODS:Endothelial nitric oxide synthase gene polymorphism of 53 patients with ruptured intracranial aneurysms and 60 control subjects were analysed by the polymerase chain reaction-restriction fragment length polymorphism technique. The genotype distribution and allele frequencies of endothelial nitric oxide synthase gene polymorphism in patients with ruptured intracranial aneurysm and healthy subjects were compared. FINDINGS:The homozygous (TT) genotype frequency was significantly higher in patients with ruptured intracranial aneurysms. It was also found that the presence of eNOS 894TT genotype was significantly associated with the risk of intracranial aneurysm rupture (p < 0.05). CONCLUSION:Polymorphism in exon 7 of the endothelial nitric oxide synthase gene G894T seems to be a possible risk factor for intracranial aneurysm rupture.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Ozüm U,Bolat N,Gül E,Ozdemir Odoi
10.1007/s00701-007-1467-8subject
Has Abstractpub_date
2008-01-01 00:00:00pages
57-61; discussion 62issue
1eissn
0001-6268issn
0942-0940journal_volume
150pub_type
杂志文章abstract:BACKGROUND:In terms of response to fractionated radiotherapy, metastatic brain tumors of certain origins are considered radioresistant. OBJECTIVE:To determine the influence of "radioresistant" histology on outcomes of brain metastases treated with radiosurgery. METHODS:Between 2001 and 2017, 121 patients with brain m...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-018-3726-2
更新日期:2018-12-01 00:00:00
abstract::A modification of the previous methods of producing cerebral ischaemia in rats (Koizumi et al., Longa et al.), using an intraluminal thread technique, is described. The middle cerebral artery is occluded by introducing a simple 3-0 nylon thread (0.20-0.249 mm in diameter) through the internal carotid artery in the nec...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01403007
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abstract:BACKGROUND:The diagnosis of Chiari 1 malformation is based on the extent of tonsillar ectopia. OBJECTIVE:To examine the relationship between the extent of tonsillar ectopia and the intra-operative findings and clinical outcome following Chiari decompression surgery. METHODS:Patients were divided into four groups depe...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-019-04172-0
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abstract::Double fenestration of the anterior communicating artery (ACoA) complex associated with an aneurysm is a very rare finding and is usually caused by ACoA duplication and the presence of a median artery of the corpus callosum (MACC). We present a patient in whom double fenestration was not associated with ACoA duplicati...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-007-1401-0
更新日期:2008-03-01 00:00:00
abstract::From a clinical standpoint recovery of spinal nerve roots is less likely than that of peripheral nerves, despite their identical structures. This may be due to several factors including the length of gap to be bridged, changes in the proximal stump or neuroma, and chromatolysis. In this paper we discuss the roles of s...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405874
更新日期:1976-01-01 00:00:00
abstract::In 131 cases of craniocerebral trauma it was shown in what respect definite changes in the lungs, demonstrated by clinical course, radiographs and blood gas analyses, occurred in proportion to the severity of the trauma. The causes of these changes were considered and the possibility of complicating the course of the ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405745
更新日期:1976-01-01 00:00:00
abstract::The patient is a 44-year-old man who underwent resection of a posterior nasopharynx tumor 12 years earlier via left lateral rhinotomy approach. The final pathological analysis indicated the tumor was a craniopharyngioma, and the patient subsequently underwent focal radiation. The patient returned to medical attention ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
abstract::We investigated the characteristic features of intramedullary spinal cord tumour associated with neurofibromatosis type 1 (NF-1). We have experienced 44 cases of pathologically confirmed intramedullary spinal cord tumour. Diagnosis of NF-1 was done according to the criteria set by the National Institute of Health Cons...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/BF01411560
更新日期:1997-01-01 00:00:00
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journal_title:Acta neurochirurgica
pub_type: 临床试验,杂志文章
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abstract::In anaesthetized artificially ventilated dogs, the effect of graded arterial hypoxaemia on cerebral blood flow (CBF) and on the oxidative carbohydrate metabolism of the brain was tested. It is shown that the hypoxic vasodilatory influence on cerebral vessels is present even at moderate systemic hypoxaemia, provide tha...
journal_title:Acta neurochirurgica
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journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
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更新日期:2009-04-01 00:00:00
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journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-013-1663-7
更新日期:2013-05-01 00:00:00
abstract::A simple, reliable and cheap device for intra-operative monitoring of the facial nerve during surgery for cerebellopontine angle tumours is presented. It consists of a single use tracheostomy tube with a low pressure air inflatable cuff placed in the mouth of the patient on the side of the tumour, connected by a press...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01400638
更新日期:1992-01-01 00:00:00
abstract::Therapy for vasogenic brain oedema (VBE) is still an unsolved problem. Experimental work with the aim of establishing an oncotherapeutic option is presented. VBE is performed by focal freeze injury in rats. Using a stereotactic head holder hypo- or hyperosmolar human serum albumin is administered via the intraventricu...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01412002
更新日期:1997-01-01 00:00:00
abstract::During a period of 10 years (1977-1986) 40 cases of tumour of the pineal region have been treated at the Istituto Neurologico "C. Besta"-of Milan. Out of these 40 cases, 27 (67.5%) were in the paediatric (10-15 years) or juvenile (15-20 years) age at the time of operation. Since 1983 a specific diagnostic and therapeu...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01403491
更新日期:1989-01-01 00:00:00
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journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-020-04673-3
更新日期:2021-01-06 00:00:00
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journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0411-5
更新日期:2009-11-01 00:00:00
abstract::Somatosensory evoked potentials (SEP) and intracranial pressure (ICP) were studied in cats, suffering from a chronic space-occupying lesion produced by enlargement of an epidural balloon over the left sensomotory cortex. Our study shows that latency alterations of SEP are not dependent on the degree of ICP. Additional...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01446995
更新日期:1993-01-01 00:00:00
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journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010170048
更新日期:2001-01-01 00:00:00
abstract::Octreotide is a potent agonist of somatostatin that lowers the serum level of growth hormone (GH), and reduces the size of somatotropinomas. However, the detailed mechanism of shrinkage of this tumour is not known. We, therefore, evaluated 11 patients with somatotropinomas who were treated with octreotide 300 microgra...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01411403
更新日期:1997-01-01 00:00:00
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journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1473-3
更新日期:2012-10-01 00:00:00
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journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-017-3199-8
更新日期:2017-07-01 00:00:00
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journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-005-0626-z
更新日期:2006-01-01 00:00:00
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journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0504-1
更新日期:2009-10-01 00:00:00
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journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-017-3117-0
更新日期:2017-04-01 00:00:00
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journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-005-0689-x
更新日期:2006-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-04-01 00:00:00
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journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01809178
更新日期:1979-01-01 00:00:00
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journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01406346
更新日期:1981-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00