Endothelial nitric oxide synthase gene [G894T] polymorphism as a possible risk factor in aneurysmal subarachnoid haemorrhage.

Abstract:

BACKGROUND:The exact aetiology, growth and rupture of intracranial aneurysms is unclear. In this study we investigated a possible association between intracranial aneurysm rupture and polymorphism of the endothelial nitric oxide synthase gene G894T. METHODS:Endothelial nitric oxide synthase gene polymorphism of 53 patients with ruptured intracranial aneurysms and 60 control subjects were analysed by the polymerase chain reaction-restriction fragment length polymorphism technique. The genotype distribution and allele frequencies of endothelial nitric oxide synthase gene polymorphism in patients with ruptured intracranial aneurysm and healthy subjects were compared. FINDINGS:The homozygous (TT) genotype frequency was significantly higher in patients with ruptured intracranial aneurysms. It was also found that the presence of eNOS 894TT genotype was significantly associated with the risk of intracranial aneurysm rupture (p < 0.05). CONCLUSION:Polymorphism in exon 7 of the endothelial nitric oxide synthase gene G894T seems to be a possible risk factor for intracranial aneurysm rupture.

journal_name

Acta Neurochir (Wien)

journal_title

Acta neurochirurgica

authors

Ozüm U,Bolat N,Gül E,Ozdemir O

doi

10.1007/s00701-007-1467-8

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

57-61; discussion 62

issue

1

eissn

0001-6268

issn

0942-0940

journal_volume

150

pub_type

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