Abstract:
BACKGROUND:Wnt proteins are bifunctional axon guidance molecules, several of which appear to mediate guidance of corticospinal tract axons along the spinal cord. Here, we studied increasing effect on regeneration by Wnt-containing alginate scaffolds on spinal cord injury (SCI). METHODS:A total of 32 rats were injured at the T7-8 level with an NYU impactor. According to transplantation materials, rats were classified into four groups: a Wnt3a-secreting fibroblast transplantation group (Wnt group, n = 8), a Wnt3a-secreting fibroblast with alginate transplantation group (Wnt + alginate group, n = 8), an alginate transplantation group (alginate group, n = 8), and a contusion-only group (sham group, n = 8). Behavioral tests were performed on the first, second, and third days after injury, and then weekly for 8 weeks. Five of the eight rats from each group were selected for manganese-enhanced magnetic resonance imaging (ME-MRI). Two rats from each group were examined for GAP43 and MAP2 expression using monoclonal and polyclonal primary antibodies, respectively. RESULTS:Seven weeks after transplantation (8 weeks after SCI), Wnt + alginate group rats achieved an average Basso-Beattie-Bresnahan locomotor score of 19.0, which was significantly higher than that of other groups. ME-MRI at 8 weeks after SCI revealed significantly higher relative signal intensities in the Wnt + alginate group. Gap43 and Map2 immunostaining, showed strong positive in the Wnt + alginate group. CONCLUSION:The Wnt + alginate complex exerted significantly enhanced recovery in a rat SCI model compared to alginate or Wnt3a alone. These results suggest that alginate scaffolds facilitate the regeneration of axon working with Wnt3a protein that promotes regeneration of the injured spinal cord.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Park JH,Min J,Baek SR,Kim SW,Kwon IK,Jeon SRdoi
10.1007/s00701-013-1663-7subject
Has Abstractpub_date
2013-05-01 00:00:00pages
809-16issue
5eissn
0001-6268issn
0942-0940journal_volume
155pub_type
杂志文章abstract::In Europe only few neurosurgeons are trained in both open surgical clipping as well as in endovascular techniques for treatment of intracranial aneurysms. To investigate the safety and efficacy of performing both techniques we, two dual trained neurosurgeons, analyzed our results in repairing ruptured intracranial ane...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-014-2101-1
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:The purpose was to review our experience with the surgical management of brainstem cavernomas (BSCs) and especially the impact of the surgical timing on the clinical outcome. METHOD:We retrospectively reviewed 22 patients harboring a BSC, who underwent 23 procedures. FINDINGS:Surgery was carried out during...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-005-0671-7
更新日期:2006-04-01 00:00:00
abstract:INTRODUCTION:Stereotactic radiosurgery (SRS) is increasingly used as a minimally invasive alternative in many neurosurgical conditions, including benign and malignant tumors, vascular malformations, and functional procedures. As for any surgical procedure, strict safety guidelines and checklists are necessary to avoid ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-019-03843-2
更新日期:2019-04-01 00:00:00
abstract::Analysis of verbal responses to electrical stimulation of the trigeminal ganglion and rootlets has been the only method available so far to localize the electrode tip in the most appropriate trigeminal division or division segment, prior to thermocoagulation during percutaneous treatment for trigeminal neuralgia. A di...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01418517
更新日期:1991-01-01 00:00:00
abstract::The Glasgow Coma Scale, based upon eye opening, verbal and motor responses has proved a practical and consistent means of monitoring the state of head injured patients. Observations made in the early stages after injury define the depth and duration of coma and, when combined with clinical features such as a patient's...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405862
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abstract::Unstable fracture dislocations due to torn ligaments, fractures of both articular processes, or detachments of entire vertebral arches from vertebral bodies still pose the problem of fixation after anterior fusion. The application of internal metal plate fixation--using the small AO (ASFI) fragment equipment--is descr...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405907
更新日期:1975-01-01 00:00:00
abstract:INTRODUCTION:A 55-year-old man underwent a microvascular decompression procedure for a pharmacoresistant trigeminal neuralgia. Preoperative MRI showed a neurovascular conflict between the Vth nerve root and the superior cerebellar artery. METHODS:Dissection of the intracisternal trigeminal root was undertaken, and a p...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0488-x
更新日期:2010-04-01 00:00:00
abstract::Recent animal research has provided evidence that brain ischaemia is associated with a shift of energy related metabolites (lactate, adenosine, inosine, and hypoxanthine) and several transmitters from the intracellular to the extracellular fluid (ECF). These chemical changes of the ECF reflect the energy crisis of the...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405420
更新日期:1990-01-01 00:00:00
abstract::The accuracy of CAT in the diagnosis of infratentorial expanding lesions is analysed on the basis of 224 personal cases. The posterior fossa lesions are classified in four groups according to the reliability of CAT as the only pre-operative examination. The present indications for conventional neuroadiological procedu...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01811344
更新日期:1978-01-01 00:00:00
abstract:INTRODUCTION:To report the incidence, treatment and outcome of occipital condyle fractures (OCFs) based on the experience of a single neurosurgical department over a period of two years. MATERIAL AND METHODS:From April 1999 to April 2001, ten cases of OCFs were identified in 110 cervical traumas observed over a period...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-004-0289-1
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Peripheral nerve lesions usually are associated with neuropathic pain. In the present paper, we describe a simple scale to quantify pain after brachial plexus injuries and apply this scale to a series of patients to determine initial outcomes after reconstructive surgery. METHODS:Fifty-one patients with tra...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-010-0709-3
更新日期:2011-01-01 00:00:00
abstract::We present a retrospective study of 41 patients treated by simple decompression for ulnar neuropathy. Pre- and postoperatively, patients were evaluated clinically and electrophysiologically. The median follow-up was 2 years (minimum: 0.5 years, maximum: 5.1 years). The leading pre-operative sign was motor loss in the ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01411742
更新日期:1996-01-01 00:00:00
abstract::A case of a ruptured aneurysm is presented in which the angiograms did not disclose the sac. Rupture of an aneurysm of the anterior communicating artery was suspected from the distribution of subarachnoid blood on computerized tomography (CT), and the presence of a sac was highly suggestive on magnetic resonance imagi...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405281
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Drain insertion following chronic subdural haematoma (CSDH) evacuation reduces recurrence and improves outcomes. The mechanism of this improvement is uncertain. We assessed whether drains result in improved postoperative imaging, and which radiological factors are associated with recurrence and functional ou...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,多中心研究
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更新日期:2020-06-01 00:00:00
abstract::4 patients with aneurysms of different size and location were examined by cerebral angiography, computed tomography, angio-computed tomography, magnetic resonance imaging and angiography, in order to demonstrate haemodynamic and morphological aspects of cerebral aneurysms. Turbulent flow within aneurysms could be show...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF02001461
更新日期:1993-01-01 00:00:00
abstract::The facial electromyographic response was monitored intraoperatively in 40 patients with hemifacial spasm who were operated on by microvascular decompression of the facial nerve. All 40 patients showed an abnormal facial electromyographic response (lateral spread response) with a latency of about 10 msec after stimula...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01411718
更新日期:1996-01-01 00:00:00
abstract::The effect of acetazolamide on the cerebral blood flow was studied in gerbils with unilateral carotid ligation. According to the effect of ligation the animals were divided into three groups: first group-the reduction more than 70%, second-CBF reduction 30-70% and the third group-CBF reduction less than 30%. The effec...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01411729
更新日期:1996-01-01 00:00:00
abstract::An infrared based frameless stereotactic navigation device (Easy Guide Neuro) was investigated for its clinical applicability, registration/application accuracy and limitations in a standard operating room set-up. In a five-month period 40 frameless stereotactic procedures (23 female, 17 male, mean age 46.4, yrs range...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF02750999
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Several studies have included different co-morbid conditions in prediction models for stroke patients. For subarachnoid haemorrhage (SAH), it is not known whether the Charlson Co-morbidity Index (CCI) is associated with outcome. We evaluated if this index was associated with outcome in patients with ruptured...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
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journal_title:Acta neurochirurgica
pub_type: 杂志文章
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更新日期:2012-05-01 00:00:00
abstract::Described are: 1. A very thin intracisternal part of the vertebral artery (0.9 mm). 2. A very rare course of the vertebral artery (dorsal to the hypoglossal nerve). 3. Rare anastomoses between the vertebral artery and the PICA. 4. A rare upwards coiling of the PICA and 5. The origin and prevertebral course of the vert...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01809336
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abstract::Basal forebrain cells of foetal rats were transplanted into the subarachnoid space of adult rats harbouring a kainic acid-induced unilateral lesion in the nucleus basalis magnocellularis. Passive avoidance response tests were performed eight weeks after the transplantation, and the results were compared with those of ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01404951
更新日期:1995-01-01 00:00:00
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journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-008-0002-x
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:In this article, we present our experience with such operations performed under local anaesthesia. METHODS:From January 1997 to November 2007, there were 387 patients operated on for asymptomatic carotid stenosis. Patient data were retrospectively evaluated. Thirty-day neurological morbidity and mortality f...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-010-0806-3
更新日期:2011-02-01 00:00:00
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journal_title:Acta neurochirurgica
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doi:10.1007/s00701-017-3416-5
更新日期:2018-02-01 00:00:00
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journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-007-1133-1
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Patients with glioblastoma treated with BCNU wafer implantation for recurrence frequently receive frontline chemoradiotherapy with temozolomide as part of the Stupp protocol. A retrospective investigation was conducted of surgical complications in a cohort of these patients treated at a single institution. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-013-1931-6
更新日期:2014-02-01 00:00:00
abstract::The present study is aimed at examining the therapeutic effect of Nicorandil on chronic vasospasm using beagle dogs subjected to a "two-haemorrhage" insult, as well as its dilatory effect on the PDA [phorbol-12,13 diacetate]-induced contraction of the canine basilar artery. 1. A total of 12 animals of either sex, weig...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01476428
更新日期:1994-01-01 00:00:00
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journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1473-3
更新日期:2012-10-01 00:00:00
abstract::Anterior spinal decompression and fusion was used as the primary treatment for thoracolumbar fractures in eleven patients with neurological deficits. Each patient achieved stability by interbody fusion. Significant progressive kyphosis did not occur. No patients with a complete neurological deficit was improved by ope...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
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更新日期:1981-01-01 00:00:00