Abstract:
:Recent animal research has provided evidence that brain ischaemia is associated with a shift of energy related metabolites (lactate, adenosine, inosine, and hypoxanthine) and several transmitters from the intracellular to the extracellular fluid (ECF). These chemical changes of the ECF reflect the energy crisis of the ischaemic tissue. We have proposed that measurement of these metabolites in the ECF using microdialysis may be a useful technique for detection of secondary ischaemia in neurosurgical intensive care patients. As a first step in the evaluation of such a possible clinical application of microdialysis the aim of this study was to measure energy related metabolites and amino acid transmitters during cerebral ischaemia in man. Microdialysis probes were inserted in tumour-free cortical tissue in the frontal lobe in patients undergoing frontal lobe resection as a treatment for brain tumours. Dialysis samples were collected in 10 minutes fractions before and during frontal lobe resection, thus serving as a simulated ischaemia model. The resection procedure was associated with markedly elevated levels of the energy related metabolites as well as transmitter amino acids. The tissue surrounding the probes was examined histologically, and the degree of oedema was estimated from CT scans. In two of the patients the tissue hosting the probes was oedematous. These patients had markedly higher basal levels of lactate. The main conclusions were (1) that the results support the clinical potential of microdialysis, (2) that lactate may be a sensitive indicator of the metabolic disturbances associated with brain oedema, and (3) that frontal lobe resection may be a useful human brain ischaemia model.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Hillered L,Persson L,Pontén U,Ungerstedt Udoi
10.1007/BF01405420subject
Has Abstractpub_date
1990-01-01 00:00:00pages
91-7issue
3-4eissn
0001-6268issn
0942-0940journal_volume
102pub_type
杂志文章abstract::A simple, reliable and cheap device for intra-operative monitoring of the facial nerve during surgery for cerebellopontine angle tumours is presented. It consists of a single use tracheostomy tube with a low pressure air inflatable cuff placed in the mouth of the patient on the side of the tumour, connected by a press...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01400638
更新日期:1992-01-01 00:00:00
abstract::The present study compares the clinical outcome, as expressed by the Glasgow outcome scale, of two groups of severely head injured patients treated before (49 patients) and after (72 patients) the establishment of a neurosurgical intensive care (NIC) unit at the department of neurosurgery. Uppsala University Hospital....
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01402049
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Spinal dural arterio-venous fistulae (SDAVF) are slow-flow extramedullary vascular lesions which account for 75-80% of all spinal vascular malformations. At present there is no agreed view with regard to the best therapeutic option being surgical or endovascular, and several reports favour one or other form ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-008-1560-7
更新日期:2008-06-01 00:00:00
abstract::An infrared based frameless stereotactic navigation device (Easy Guide Neuro) was investigated for its clinical applicability, registration/application accuracy and limitations in a standard operating room set-up. In a five-month period 40 frameless stereotactic procedures (23 female, 17 male, mean age 46.4, yrs range...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF02750999
更新日期:1997-01-01 00:00:00
abstract::The treatment of hydrocephalus, over the centuries, underwent three stages of evolution. During antiquity, middle ages and Renaissance, hydrocephalus was not understood. Medical treatment was useless; surgery was hopeless. The second stage extends from the XIXth century to the end of the first half of the XXth century...
journal_title:Acta neurochirurgica
pub_type: 历史文章,杂志文章,评审
doi:10.1007/BF01540869
更新日期:1992-01-01 00:00:00
abstract::The authors present a case of cauda equina paraparesis due to compression by tabetic osteo-arthropathy. Diagnosis was confirmed by the typical clinical picture of tabes and by the history of a chancre 53 years earlier. Radiography of the spine showed vertibral osteo-arthropathy. Opaque contrast myelography showed comp...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01774757
更新日期:1978-01-01 00:00:00
abstract::The origin of cranial epidermoid cysts (EC) remains controversial, and although generally considered to be congenital, acquired origin has been reported. EC represent 0.2 to 1.8% of all brain tumours, and only one fourth are intradiploic in location. We report of a 44-year-old woman with a giant intradiploic EC of the...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-008-1490-9
更新日期:2008-04-01 00:00:00
abstract::In 15 patients without acute brain injury the concentrations of Neuron-specific Enolase (NSE), S-100 Protein (S-100), Creatine Kinase (CK), and Creatine Kinase BB isoenzyme (CK-BB) in ventricular cerebrospinal fluid (CSF) were measured immediately after lateral ventricle cannulation for diagnostic or treatment purpose...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01400675
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate gross and microscopic anatomical features of the vestibulocochlear nerve or eighth cranial nerve (CNVIII) from fresh cadavers, especially the nerve's central myelin portion (CMP) and transitional zone (TZ), and to consider any pathological implications. METHODS:Six fres...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1479-x
更新日期:2012-12-01 00:00:00
abstract::Ki-67 antigen is used as a marker of proliferative activity that is linked to growth rate, invasiveness and prognosis of pituitary adenomas. So far the distribution of Ki-67 index within an individual adenoma has not been investigated. If Ki-67 antigen expression differs significantly within an individual pituitary ad...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-004-0390-5
更新日期:2004-12-01 00:00:00
abstract::In 41 out of 130 encapsulated chronic subdural haematomas erythroblasts were found. As there were no skull fractures and no erythroblasts were found in peripheral blood smears, it is concluded, that these colonies of erythroblasts originate from the granulation tissue during the formation of membranes. The actual outp...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01402896
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Intraoperative vessel visualization is highly desirable, especially when the target is related to or close to main vessels, such as in the skull base and vascular surgery. Contrast-enhanced ultrasound (CEUS) is an imaging technique that allows visualization of tissue perfusion and vascularization through the...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-015-2412-x
更新日期:2015-06-01 00:00:00
abstract::There is a potential risk of sacrificing the cortical vein during neurosurgical operations, particularly in the interhemispheric or subtemporal approach. An impaired cortical vein might cause cerebral venous circulatory disturbances (CVCDs) resulting in venous infarction. In this article, we have reviewed the manageme...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-005-0501-y
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:The natural history of vertebrobasilar artery dissection (VAD) is not fully known. The purpose of this study was to review the clinical outcome of the patients with VAD, then to propose an appropriate management strategy for VAD. METHOD:From 1992 to 2004, 35 VAD patients admitted to our institutes were retr...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-006-0742-4
更新日期:2006-04-01 00:00:00
abstract::While bone invasion and hyperostosis are frequent phenomena in meningiomas, primary intra-osseous meningiomas are rare. With only 15 reported cases, the osteolytic form of primary intra-osseous meningiomas is most uncommon. Its occurrence in the skull base is an extra-ordinary exception. We have reviewed and categoriz...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-004-0380-7
更新日期:2004-11-01 00:00:00
abstract:INTRODUCTION:In low-grade glioma (LGG) surgery, intraoperative differentiation between tumor and most likely tumor-free brain tissue can be challenging. Intraoperative ultrasound can facilitate tumor resection. The aim of this study is to evaluate the accuracy of linear array ultrasound in comparison to conventional in...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-014-2314-3
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Thoracic disc herniation (TDH) is a rare condition with severe neurological sequelae. Surgical management is still a matter of debate and challenging. METHOD:We present a modification of the transdural approach for TDH. The approach has been described in a stepwise fashion, analysing pre-, peri-, and postop...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-020-04387-6
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:As an effective treatment for post-craniotomy epidural haematomas (EDHs), a novel method of urokinase instillation using a closed suction drain is presented and the procedure feasibility and outcomes assessed. METHOD:A closed system, comprising a closed suction drain with a three-spring 200 mL evacuator, fl...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-007-1487-4
更新日期:2008-04-01 00:00:00
abstract::50 patients with acromegaly and carpal tunnel syndrome have been examined electrophysiologically before and after transnasal operation of the pituitary adenoma. 32 of the 50 patients (64%) had symptoms of carpal tunnel syndrome. 13 of them had neurological deficits. 28 of the examined patients had pathological neurogr...
journal_title:Acta neurochirurgica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01420508
更新日期:1986-01-01 00:00:00
abstract:PURPOSE:Complete yet safe resection close to motor areas in medically intractable epilepsy requires functional information. New deficit may occur despite preservation of motor cortex, e.g., through vascular compromise. Here, we explore for the first time the feasibility, safety, and the clinical value of continuous mot...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-010-0675-9
更新日期:2010-08-01 00:00:00
abstract::Fourteen cases of midline vertebro-basilar trunk aneurysms were operated on by four routes of surgical approach: middle fossa anterior transpetrosal approach (ATP), presigmoid transpetrosal approach (PTP), conventional lateral suboccipital approach (LSO) or suboccipital transcondylar approach (STC). There was no morta...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01420302
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Microendoscopic discectomy (MED) is emerging as a minimally invasive alternative to conventional microsurgical discectomy (MSD). EASYGO! is a new system for spinal endoscopy that claims smooth transition from MSD to MED, with a reduced learning curve period. The aims of this study were to describe the compli...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1321-5
更新日期:2012-06-01 00:00:00
abstract::Venous malformations in the posterior fossa are relatively rare. Although the introduction of CT and MRI has made them easier to detect, their treatment is still controversial. Based on our experience with six patients and a review of the literature, we have tried to establish guidelines for their treatment. Since the...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01476418
更新日期:1994-01-01 00:00:00
abstract:INTRODUCTION:Radiosurgery (RS) and fractionated radiotherapy (FRT) are part of the therapeutic armamentarium for the management of cavernous sinus meningiomas. We propose a systematic review of the local tumor control and clinical outcomes after monofractionated radiosurgical treatment, including gamma knife radiosurge...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,meta分析
doi:10.1007/s00701-018-3711-9
更新日期:2018-12-01 00:00:00
abstract::A case of repeated subarachnoid haemorrhage (SAH) caused by rupture of a dissecting intracranial vertebral aneurysm is reported. The clinical manifestations, angiographic findings, pre-operative assessment with neurophysiological monitoring, and surgery are presented. A review of the literature suggests that this type...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01842895
更新日期:1990-01-01 00:00:00
abstract::This study investigated the association of intracranial aneurysms and abdominal aortic aneurysms to elucidate the incidence and independent risk factors for this association. Ultrasonography of the abdominal aorta was performed in 181 patients with 224 intracranial aneurysms. Six patients had suffered subarachnoid hae...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-006-1077-x
更新日期:2007-03-01 00:00:00
abstract::A case of bilateral internal carotid artery thrombosis after blunt injury to the head in a 54 years old male is described. The literature is reviewed and comment is made on the causes. Unilateral thrombosis of the internal carotid artery after closed or blunt injury to the head and neck is well known but not common. T...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01401637
更新日期:1978-01-01 00:00:00
abstract::Our understanding of the complexity of genetic abnormalities involved in the tumourigenesis of malignant gliomas is as yet rudimentary. However, we can discern distinctive patterns of loss of genetic material and amplification of chromosomal regions that characterize both the different types of gliomas as well as the ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/BF01411992
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:The placement of intervertebral cages in anterior cervical discectomy (ACDF) supposedly maintains foraminal height. The most commonly reported cage-related complication is subsidence, although it is unknown whether a correlation between subsidence and clinical outcome exists. AIM:To assess the incidence and...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-018-3490-3
更新日期:2018-04-01 00:00:00
abstract::The superficial middle cerebral veins (SMCVs) are large veins to drain the brain and therefore anatomical knowledge of them is important for neurosurgeons and neuroradiologists. In a patient with a ruptured blister aneurysm, we incidentally found during angiography an aberrant drainage of the SMCVs, which penetrated t...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-019-03838-z
更新日期:2019-04-01 00:00:00