Abstract:
:Therapy for vasogenic brain oedema (VBE) is still an unsolved problem. Experimental work with the aim of establishing an oncotherapeutic option is presented. VBE is performed by focal freeze injury in rats. Using a stereotactic head holder hypo- or hyperosmolar human serum albumin is administered via the intraventricular route. The goal is to enhance the migration of oedema fluid with the aid of oncotic pressures. Early and late results are obtained for each group respectively four and twenty-four hours after the infliction of cold injury. The efficacy of therapy is evaluated by cerebrospinal fluid (CSF) osmolality, cerebral water content, tissue specific gravity, and blood-brain barrier (BBB) permeability. Posttherapeutic values for CSF osmolality are obtained by cisterna magna puncture. Hyperosmolar CSF after performance of cold injury (p < 0.05) is thought to be a result of fluid accumulation in the traumatized region partially from the intraventricular space. Posttherapeutic values after hyperosmolar albumin administration have revealed iso-osmolar CSF, increase in specific gravity (p < 0.001), and decrease in BBB permeability (p < 0.05). These results are in accordance with withdrawal of oedema fluid into the ventricles which can be interpreted as a positive therapeutic effect. Late results in hyperosmolar group have disclosed a hypo-iso-osmolar CSF, persistent increase in specific gravity, and no regression. These values have shown that hyperosmolar albumin administration does not interfere with CSF circulation. Early results of hypoosmolar albumin application are discouraging. This preliminary work of a therapeutic trial on VBE may be a basis for future investigations with different dosages and time modalities.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Onal C,Unal F,Turantan MI,Uzüm G,Hasanoğlu A,Kaynar MYdoi
10.1007/BF01412002subject
Has Abstractpub_date
1997-01-01 00:00:00pages
661-8; discussion 668-9issue
7eissn
0001-6268issn
0942-0940journal_volume
139pub_type
杂志文章abstract::The feasibility of diagnosing the malignancy and viability of intraparenchymal brain tumours using Gd-DTPA, enhanced and unenhanced T1-weighted MRIs was investigated. The relationship between the Gd-DTPA enhancement pattern, the growth fraction (GF) determined by using the anti-bromide-oxyuridine (BrdU) monoclonal ant...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01400619
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:The retrolabyrinthine and transcrusal approaches (RLA and TCA, respectively) are the two most often used posterior transpetrosal approaches that are used to treat lesions in the retrochiasmatic region. Endoscopes are increasingly used in neurosurgical practice. To determine whether a difference exists betwee...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-016-2733-4
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:The type of paraclinoid aneurysm has been used to decide management methods. Our aim was to assess the relation of the types of paraclinoid aneurysms and outcomes after endovascular treatment and the efficiency of present endovascular techniques. METHODS:A retrospective analysis was performed on patients wi...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-013-1830-x
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Nitric oxide is a key mediator of post-traumatic inflammation in the brain. We examined the expressions of iNOS, nNOS, and eNOS in inbred DA and PVGa rat strains where DA is susceptible to autoimmune neuroinflammation and PVGa-resistant. METHODS:Parietal contusions using a weight drop model were produced in...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1297-1
更新日期:2012-04-01 00:00:00
abstract::During intracranial tumor resection, the delayed kinking of a major encased vessel has never been described in literature. We present a case which required urgent endovascular treatment performed through a stent positioning. A patient was hospitalized with symptomatic sphenoid meningioma in the left middle cranial fos...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-019-03822-7
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:An external ventricular drain (EVD) is used to measure intracranial pressure (ICP) and to drain cerebrospinal fluid (CSF). The procedure is generally safe, but parenchymal sequelae are reported as a possible side effect, with variable incidence. We investigated the mechanical sequelae of EVD insertion and th...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-017-3291-0
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:We used an assembly of electrodes C3 and C4-Cz in order to activate the motor cortical area of the corticobulbar tract to elucidate the motor-evoked potential of the contralateral mentalis muscle. METHOD:We compared this setup to that of an assembly with electrodes C5 or C6-Cz using a train of electrical pul...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1505-z
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:The supracerebellar infratentorial approach is a commonly used route in neurosurgery. It provides a narrow and deep corridor to the dorsal midbrain and pineal region. The authors describe a surgical technique to expand the operative corridor and the surgeon's working angles during this approach. METHODS:Thi...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-013-1844-4
更新日期:2013-10-01 00:00:00
abstract::The characteristic findings of metrizamide CT cisternography in two cases of epidermoid are reported. The main finding was a "cauliflower-like" appearance and was thought to be caused by the irregular interstices of epidermoids. Metrizamide CT cisternography may be helpful in making a diagnosis of an epidermoid. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01400854
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Pituitary transposition preserving gland function is possible when approaching superior clival region tumors. Clinical experience along with detailed anatomical knowledge makes this technique safe and effective. METHOD:We present a step by step description of our technique based on the most recent anatomica...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-019-04012-1
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:We present a unique example of an intra-sellar schwannoma co-existing with a growth hormone (GH)-secreting pituitary adenoma. METHOD AND FINDINGS:The patient presented with acromegaly and magnetic resonance imaging (MRI) revealed an intra-sellar mass. The tumour was totally resected via a sub-labial trans-s...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0304-7
更新日期:2009-12-01 00:00:00
abstract::Ki-67 antigen is used as a marker of proliferative activity that is linked to growth rate, invasiveness and prognosis of pituitary adenomas. So far the distribution of Ki-67 index within an individual adenoma has not been investigated. If Ki-67 antigen expression differs significantly within an individual pituitary ad...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-004-0390-5
更新日期:2004-12-01 00:00:00
abstract:PURPOSE:Malignant gliomas are highly infiltrative tumours with a fatal prognosis. F18-fluoroethyl-tyrosine (FET)-positron emission tomography (PET) often reveals a broader extension of these tumours compared with contrast-enhanced magnetic resonance imaging (MRI). Complete resection of the contrast-enhancing lesion is ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0462-7
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Intraventricular chemotherapy via Ommaya reservoir is an important part of the treatment in patients with malignant central nervous system tumors. In these patients, catheter placement can be challenging due to the normal-sized ventricles. METHOD:Intraoperative ultrasound guidance was used for Ommaya reserv...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-021-04719-0
更新日期:2021-01-20 00:00:00
abstract::The authors describe a case of accidental electrocution from a high voltage current in a young worker, who was struck by the electric shock in the mid-occipital region. The case is especially interesting due to the improbability of anyone surviving after receiving a shock of more than 1000 V., and to the development o...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01402395
更新日期:1986-01-01 00:00:00
abstract::Changes of plasma thromboxane level in subarachnoid haemorrhage (SAH) were studied clinically and experimentally using 11-dehydro-thromboxane B2 (11 DTX) as a measuring index. 11 DTX is a major long-lived metabolite formed from thromboxane (TX) B2, and is said to be a more reliable parameter for detecting TXA2 product...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01403202
更新日期:1991-01-01 00:00:00
abstract::The influence of moderately reduced arterial oxygen tension (aPO2 of about 45 Torr) on the metabolism and the blood flow of the brain was tested in 20 anaesthetized, artificially ventilated normotensive, normocapnic beagle dogs. It is demonstrated that the decrease in systemic oxygen delivery to the brain is countered...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01402057
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:The endoscopic endonasal approach for optic nerve decompression is suited for the management of non-traumatic optic neuropathy but remains underreported, presumably due to transcranial approaches still being favoured at individual centres. METHOD:The optic canal is approached endoscopically and transsphenoi...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-020-04476-6
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Many high-grade glioma (HGG) patients have cognitive impairments, which impact daily functioning. Cognitive impairments can be caused by tumour-, treatment-, and patient-related factors. The effect of the tumour and of surgical resection on cognition is, however, not well known. We investigated tumour and su...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-014-2115-8
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Glioblastoma (GBM) is the most common and malignant brain tumor in adults. Despite therapeutic advances, almost all patients eventually experience tumor recurrence. Leptomeningeal spread (LMS) is not a rare condition of recurrence. However, the standard management protocol of LMS has not been established. Th...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-015-2344-5
更新日期:2015-04-01 00:00:00
abstract::Although disorders of cerebral autoregulation are commonly seen in neurosurgical disease, there is currently no test of autoregulation in widespread use that may be performed safely at the bedside. The presence of autoregulation, however, can be seen in the brief hyperemic response in the middle cerebral artery distri...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01407660
更新日期:1991-01-01 00:00:00
abstract::We estimated the volume doubling time (Vd) of the ethyl-nitrosourea-induced rat glioma by serial magnetic resonance imaging, and the results were compared with potential doubling time (Tp) determined immunohistochemically. Vd ranged from 3.3 to 29.2 days (11.3 +/- 7.74) and Tp ranged from 2.3 to 13.3 days (6.81 +/- 3....
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010050148
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:We present the results of the visualisation of radial oxygen gradients in rats' cortices and their potential use in neurocritical management. METHODS:PO₂ maps of the cortex of ten sedated, intubated and controlled ventilated Wistar rats were obtained with a camera (SensiMOD, PCO, Kelheim, Germany). Those pictu...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-010-0777-4
更新日期:2010-12-01 00:00:00
abstract::The blocking effect of ketanserin, a 5-hydroxytryptamine (5-HT)2 receptor antagonist, was examined on responses to intra-luminal 5-HT or potassium chloride (KCl) in isolated and perfused canine basilar arteries before and after extraluminal whole blood by means of the stainless-steel cannula inserting method. Four hou...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01412316
更新日期:1996-01-01 00:00:00
abstract::An extensive and segmental spasm of the ophthalmic artery has been demonstrated angiographically a few hours after a car accident in a case with posttraumatic amaurosis. The possibility of a correlation between ophthalmic artery spasm and posttraumatic amaurosis has been discussed. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01886679
更新日期:1976-01-01 00:00:00
abstract::The indications and results of transsphenoidal surgery for pituitary adenomas are analysed. The advantages and disadvantages of Bromocriptine and radiotherapy are considered. Transsphenoidal surgery does not damage pre-existing pituitary function. It produces excellent results in micro and mesoadenomas, curing about 7...
journal_title:Acta neurochirurgica
pub_type: 传,历史文章,杂志文章
doi:10.1007/BF01435863
更新日期:1988-01-01 00:00:00
abstract::Colloid cysts of the third ventricle have been investigated by chemical characterization of the cyst contents using ELISA with monoclonal antibodies for certain carbohydrate epitopes as well as a polyclonal antiserum against peptide domains, and immunohistochemistry on the cyst wall using the same antibodies. Furtherm...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010050102
更新日期:1998-01-01 00:00:00
abstract::The intracranial fracture of aneurysm clips due to stress corrosion failure is an increasingly common long term postoperative complication. To study the susceptibility of different clips to this process, we evaluated seven aneurysm clips (Mayfield, Yasargil, Vari-Angle McFadden, Scoville, Heifetz, and Pivot) in vitro....
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01406875
更新日期:1984-01-01 00:00:00
abstract::The cerebral pareses occurring in early childhood or produced subsequently by trauma or spontaneous cerebral haemorrhages, present a heterogenous symptomatic picture. In the forefront we find the spastic pareses associated with extra-pyramidal motor hyperkinesia (athetosis, dystonia, ballism). 36 C.P.-patients were su...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/978-3-7091-8482-0_2
更新日期:1977-01-01 00:00:00
abstract:STUDY DESIGN:Retrospective analysis of 357 cases of degenerative disc disease treated by interbody fusion with threaded titanium cages. OBJECTIVE:To determine the safety and efficiency of cervical and lumbar interbody fusions using threaded titanium cages and autogenous bone. SUMMARY OF BACKGROUND DATA:Stabilizing th...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010050453
更新日期:2000-01-01 00:00:00