Abstract:
:We estimated the volume doubling time (Vd) of the ethyl-nitrosourea-induced rat glioma by serial magnetic resonance imaging, and the results were compared with potential doubling time (Tp) determined immunohistochemically. Vd ranged from 3.3 to 29.2 days (11.3 +/- 7.74) and Tp ranged from 2.3 to 13.3 days (6.81 +/- 3.33). Each tumour showed a wide range of bromodeoxyuridine (BUdR) labelling indices (LI), however, Vd and Tp correlated well with BUdR-LI. Vd was estimated as 17.6 x BUdR-LI-0.63 (R = -0.76, P < 0.001, n = 13) and Tp was estimated as 22.6 x BUdR-LI-1.02 (R = -0.92, P < 0.0001, n = 12). In addition, we compared the apoptotic indices (AI), determined by terminal deoxynucleotidyltransferase (Tdt)-mediated biotinylated dUTP-biotin nick-end labelling (TUNEL) techniques, with BUdR-LI and mitoses indices (MI). The results were: AI = 0.23 + 0.25Ln(BUdR-LI) (R = 0.971, n = 8, P < 0.0001) and AI = 1.05 + 0.29Ln(MI) (R = 0.937, n = 8, P < 0.001). Cell loss factors (CLF) also correlated well with BUdR-LI and MI. However, CLF calculated from Tp and Vd were lower than the values previously presumed, probably because of shorter Vd than true doubling time for tumour cell population. These results suggest that even malignant tumours retain a mechanism of adjusting their growth at least partly.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Nakajima M,Nakasu S,Morikawa S,Inubushi Tdoi
10.1007/s007010050148subject
Has Abstractpub_date
1998-01-01 00:00:00pages
607-12; discussion 612-3issue
6eissn
0001-6268issn
0942-0940journal_volume
140pub_type
杂志文章abstract::The mechanisms by which mexiletine exerts its effects in increasing myocardial circulation, and smooth muscle perfusion and alleviating diabetic neuropathic pain have been widely discussed. The purpose of this study was to examine the protective effect of this compound in ischemia/reperfusion-induced cerebral injury f...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010200023
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:While large-to-giant pituitary adenomas (PAs) may be safely removed by experienced surgeons through a single route, the procedure is technically challenging. We present the outcome of a simultaneous combined transcranial and transsphenoidal approach and discuss its applications. METHODS:A retrospective revi...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-011-1029-y
更新日期:2011-07-01 00:00:00
abstract::Migration of the catheter tip of a ventriculoperitoneal shunt (VPS) through a patent processus vaginalis (PV) has seldom being reported. In this series, we analyzed all cases of inguinoscrotal migration of an VPS catheter at our center. Between 1975 and 2015, 295 VPS insertions were performed. In seven infants (2.3%),...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-017-3243-8
更新日期:2017-08-01 00:00:00
abstract::Thirteen of 145 patients with post-traumatic subdural hygroma (SDHy) developed chronic subdural haematoma (CSDH) at the involved site over a period of 6 years. CSDHs were found at the site of SDHys with no history of further head injury at a mean interval of 56 days. It appeared that these 13 patients did not have any...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01808545
更新日期:1994-01-01 00:00:00
abstract::After ventricular catheterization magnetic resonance (MR) imaging very often demonstrates a focal area of high signal along the drain track which corresponds to parenchymal oedema. This high signal seemed to be more pronounced when the frontal area was catheterized than when the junctional parieto-temporo-occipital pa...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01406499
更新日期:1994-01-01 00:00:00
abstract::We present an extremely rare complication after ventriculoperitoneal shunting. The peritoneal tube migrated into the stomach 8 months after the operation and patient presented with gastric bleeding. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-007-1413-9
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become an established therapeutic approach for the management of patients with late-stage idiopathic Parkinson's disease (PD). The aim of the present study was to assess regional cerebral blood flow (rCBF) changes related to mot...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1610-z
更新日期:2013-03-01 00:00:00
abstract:AIM:Numerous materials have been used to replace defects in the dura mater as result of neurosurgical and spinal procedures. Tissudura is a biomatrix made of cross-linked equine collagen fibrils, mainly of the interstitial type I. The specially engineered dura-like layered structure provides a non porous primary water ...
journal_title:Acta neurochirurgica
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s00701-009-0290-9
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:The effect of anterior cervical discectomy without fusion (ACD), ACD with fusion by stand-alone cage (ACDF) or with arthroplasty (ACDA) on cervical sagittal alignment is not known and is the subject of this study. METHODS:A total of 142 adult patients with single-level cervical disease were at random alloca...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00701-017-3312-z
更新日期:2017-12-01 00:00:00
abstract::Serpentine aneurysms of the posterior cerebral artery (PCA) treated by the internal maxillary artery (IMA) bypass are rare. Here, the authors report the case of a 34-year-old male patient who presented with a half-year history of gradual severe headache and right-sided limb monoparesis and paresthesia lasting for 1 we...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-019-03902-8
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Lateral orbitotomy can be minimalized using contemporary endoscopy. METHODS:Anatomy of the temporal fossa/orbital wall junction is described. The attachment of the temporal fascia is cut off from the orbital rim through a 1.5 cm skin incision in the lateral orbital wrinkle. The temporal muscle is detached f...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-014-2205-7
更新日期:2014-10-01 00:00:00
abstract:INTRODUCTION:Titanium fixation plates are routinely used for rigid fixation of bone flaps after craniotomy. In craniofacial surgery or after craniotomy involving orbitozygomatic osteotomies, these plates are occasionally removed because of infection, pain, protrusion, soft tissue erosion, and plate malfunction. However...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-016-2929-7
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:Before operating on 130 patients with pituitary disorders, we evaluated their bone window CT images sliced parallel to the transnasal surgical route to assess the surgical anatomy of the nasal cavity for transnasal surgery. METHODS:High resolution bone window CT was performed in 3- to 5-mm slices parallel to...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-002-1043-1
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:The retrolabyrinthine and transcrusal approaches (RLA and TCA, respectively) are the two most often used posterior transpetrosal approaches that are used to treat lesions in the retrochiasmatic region. Endoscopes are increasingly used in neurosurgical practice. To determine whether a difference exists betwee...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-016-2733-4
更新日期:2016-04-01 00:00:00
abstract::To study the in-vivo effects of direct Low-Energy Laser Irradiation (LELI) on the Peripheral Nervous System, the sciatic nerve in rats was surgically exposed, crushed and then subjected to the direct irradiation of either of two continuous-wave HeNe lasers--0.3 mW or 17 mW. We found that the 0.3 mW laser significantly...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01406620
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Lesions lateral to the lower brainstem in an area extending from the foraminae of Luschka to the foramen magnum are rare and include different pathologies. There is no consensus on an ideal surgical approach. METHOD:To gain access to this area, we use the midline suboccipital subtonsillar approach (STA). Th...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-017-3270-5
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:The wide variety of intraspinal cystic lesions necessitates different elaborate diagnostic procedures to choose the right therapeutic management in symptomatic patients. Based on the case reports of seven patients with symptomatic spinal arachnoid cysts we discuss the aetiology, diagnostic procedures and the...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010170102
更新日期:2001-01-01 00:00:00
abstract::We analyze a series of 44 medulloblastomas in patients aged 20 and older, listed in the Connecticut Tumor Registry. Average age was 34.1 years. Incidence was 0.058 per 100,000 per year. Headache and ataxia were the most frequent presenting complaints. Findings at diagnosis most often were papilloedema, cranial nerve p...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01419496
更新日期:1987-01-01 00:00:00
abstract::In this paper, we discuss the results of a study by light microscope of the effect of permanent clipping or ligation on the intracranial arteries of 38 operation dogs and 7 control dogs. The findings obtained are: 1. In the cerebral arterial circle, necrosis could easily result from ordinary clipping or ligation becau...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405851
更新日期:1982-01-01 00:00:00
abstract::Extravasation of Onyx is a rare complication during embolization of arteriovenous malformations (AVM). We present a case of embolization that was complicated by leakage of Onyx into the cerebellum which was later encountered during surgical excision of the AVM. Our goal is to report this rare event and to outline succ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-019-04199-3
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:We used [F-18] FDG microPET imaging as part of a longitudinal study to investigate changes in the brain. METHODS:Glucose metabolism during the development of neuropathic pain after tibial and sural nerve transection (TST) model rats. MicroPET images were obtained 1 week before operation and then weekly for ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-015-2415-7
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Multicentric WHO grade II gliomas constitute a rare entity. Their pathogenesis and treatment are still a matter of debate. OBJECTIVE:We present a 23 year-old female with two synchronous but separate WHO grade II oligodendrogliomas in the temporal and frontal lobes. CLINICAL FEATURES:The two lesions showed ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0306-5
更新日期:2009-12-01 00:00:00
abstract:INTRODUCTION:Desmoid-type fibromatosis (DTF) frequently arises in patients with neuromuscular choristoma (NMC). We hypothesize that NMC-associated DTF occurs in soft tissues innervated by the NMC-affected nerve, and arises from CTNNB1-mutated (myo) fibroblasts within or directly adjacent to the NMC. MATERIALS AND METH...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-019-04178-8
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:The phrenic nerve can be transferred to the musculocutaneous nerve in patients with traumatic brachial plexus palsy in order to recover biceps strength, but the results are controversial. There is also a concern about pulmonary function after phrenic nerve transection. In this paper, we performed a qualitati...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-016-2855-8
更新日期:2016-09-01 00:00:00
abstract::We studied the influence of the type of surgery (microsurgery or macrosurgery) and extent (complete resection with lobectomy, complete resection alone, partial resection with lobectomy or partial resection alone) on early postoperative results and survival time in 118 consecutive patients who underwent surgery for gli...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01402111
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Long-term survival of patients with recurrent gliomas depends on the extent of resection. Thus, the desirability of an intra-operative imaging modality that can augment the resection extension without affecting vital surrounding structures is more than obvious. It was the aim of the present study to evaluate...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-006-0858-6
更新日期:2006-10-01 00:00:00
abstract::Homovanillic acid (HVA) and 5-hydroxyindolacetic acid (5-HIAA) in ventricular CSF were determined in 19 patients (12 female 7 male) with brain tumours. No relationship was found between ventricular fluid pressure (VFP) and levels of HVA and 5-HIAA. A relationship was observed between ventricular CSF, HVA concentration...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405944
更新日期:1976-01-01 00:00:00
abstract::The effects of intravenous nitroglycerin (NTG) combined with dopamine on intracranial pressure (ICP) and cerebral arteriovenous oxygen difference (AVDO2) were studied in 11 patients with acute subarachnoid haemorrhage (SAH). The study was performed on Days 1 to 3 of SAH after aneurysmal clipping. Treatment consisted o...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01410622
更新日期:1995-01-01 00:00:00
abstract::Cell-mediated cytotoxicity (CTX) of meningioma patients towards meningioma cells and fibroblasts was studied in vitro before and after surgery, using the 3H-proline microcytotoxicity test. When incubated with allogeneic target cells before surgery, lymphocytes from three out of seven donors showed a specific destructi...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01808518
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:The ventro-lateral thalamus is the stereotactic target of choice for severe intention tremor. Nevertheless, the optimal target area has remained controversial, and targeting of the subthalamic area has been suggested to be superior. PATIENTS AND METHODS:Eleven patients with disabling intention tremor of dif...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-007-1230-1
更新日期:2007-08-01 00:00:00