Abstract:
:Cell-mediated cytotoxicity (CTX) of meningioma patients towards meningioma cells and fibroblasts was studied in vitro before and after surgery, using the 3H-proline microcytotoxicity test. When incubated with allogeneic target cells before surgery, lymphocytes from three out of seven donors showed a specific destruction of meningioma tissue, and two were cytotoxic on both types of targets. Five patients were tested against their own tumour and against skin fibroblasts; this was feasible by keeping their lymphocytes frozen in liquid nitrogen until their target cells grew as suitable monolayers in vitro. Three patients showed a specific cytotoxic response. After excision of the tumour a gradual loss of this reactivity was observed in both allogeneic and autologous systems. Sera of three patients, whose lymphocytes were not reactive against their own tumour, induced antibody-dependent cellular cytotoxicity (ADCC) towards autologous tumours if normal effector cells were used. This type of response was detectable mainly in postoperative sera, and could not be elicited in autologous lymphocytes. On the contrary, autologous sera inhibited CTX of meningioma effector cells. The data suggest that meningiomas can induce a complex immunological response in the host, which is dependent on the presence or absence of a large tumour burden.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Pees HWdoi
10.1007/BF01808518subject
Has Abstractpub_date
1979-01-01 00:00:00pages
217-27issue
3-4eissn
0001-6268issn
0942-0940journal_volume
50pub_type
杂志文章abstract::An adjustable telescopic suction tube has been developed for microsurgery. Owing to this innovation, the surgeon can easily set the suction tube to a suitable length by gently pulling the end of the telescopic tube out or in. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01401302
更新日期:1992-01-01 00:00:00
abstract::The use of cold as a therapeutic agent has a long and colorful history. The Edwin Smith Papyrus, the most ancient medical text known, dated 3500 B.C., made numerous references to the use of cold as therapy. Baron de Larrey, a French army surgeon during Napoleon's Russian campaign, packed the limbs in ice prior to ampu...
journal_title:Acta neurochirurgica
pub_type: 历史文章,杂志文章
doi:10.1007/s00701-006-0747-z
更新日期:2006-05-01 00:00:00
abstract::The cerebral pareses occurring in early childhood or produced subsequently by trauma or spontaneous cerebral haemorrhages, present a heterogenous symptomatic picture. In the forefront we find the spastic pareses associated with extra-pyramidal motor hyperkinesia (athetosis, dystonia, ballism). 36 C.P.-patients were su...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/978-3-7091-8482-0_2
更新日期:1977-01-01 00:00:00
abstract:CLINICAL DETAILS:A 52-year-old man presented with neck pain, nausea and vomiting (Hunt-Hess grade 1). CT scan showed subarachnoid hemorrhage. Cerebral angiography showed multiple arterial aneurysms (right communicating posterior, right anterior choroid, left pericallosal, intraorbital ophthalmic bilaterally). All aneur...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0352-z
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:The aim of this study is to describe microsurgical anatomy and to quantitatively analyze exposure using the posterior subtemporal keyhole (PSK) approach combined with the transchoroidal keyhole (TCK) approach to the ambient cistern. METHODS:We determined the proper location of craniotomy of such combined keyho...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-010-0800-9
更新日期:2010-11-01 00:00:00
abstract::Our understanding of the complexity of genetic abnormalities involved in the tumourigenesis of malignant gliomas is as yet rudimentary. However, we can discern distinctive patterns of loss of genetic material and amplification of chromosomal regions that characterize both the different types of gliomas as well as the ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/BF01411992
更新日期:1997-01-01 00:00:00
abstract:INTRODUCTION:In low-grade glioma (LGG) surgery, intraoperative differentiation between tumor and most likely tumor-free brain tissue can be challenging. Intraoperative ultrasound can facilitate tumor resection. The aim of this study is to evaluate the accuracy of linear array ultrasound in comparison to conventional in...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-014-2314-3
更新日期:2015-02-01 00:00:00
abstract::Recent studies on prognostic variables and the intensive care of head injuries enabled us to select 64 patients and administer a standard treatment protocol to prevent secondary brain injury. All the patients were in coma with a flexor motor pattern as the best response between 6 and 24 hours after the accident and/or...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01413271
更新日期:1985-01-01 00:00:00
abstract:PURPOSE:To analyse the intraoperative complications of a single neurosurgeon, with emphasis on devastating intraoperative incidents, and how they possibly could have been avoided. METHODS:All the patients operated upon by the author between 1986 and 2002, i.e. 252 patients with 270 craniotomies for 294 aneurysms, were...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0452-9
更新日期:2009-09-01 00:00:00
abstract:STUDY DESIGN:This report characterises a 25 year old male patient with a complete burst fracture of the fifth lumbar vertebra with dislocation. He was treated by posterior surgery with transpedicular instrumentation and an expandable cage from the posterior approach. OBJECTIVES:Burst fractures of the fifth lumbar vert...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-008-0149-5
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:We report 24 patients with a traumatic acute subdural haematoma of the posterior fossa managed between 1997 and 1999 at 8 Italian neurosurgical centres. METHOD:Each centre provided data about patients' clinico-radiological findings, management, and outcomes, which were retrospectively reviewed. FINDINGS:A ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,多中心研究
doi:10.1007/s00701-003-0150-y
更新日期:2003-12-01 00:00:00
abstract::Forty-two patients with 44 cephaloceles treated between 1966 and 1993 are presented. Eighteen lesions were occipital, 2 parietal, 1 at the anterior fontanelle, 11 sincipital, and 12 basal. In recent years computerized tomography (CT) and magnetic resonance imaging (MRI) provided better information on the site and natu...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01417678
更新日期:1995-01-01 00:00:00
abstract::Colloid cysts of the third ventricle have been investigated by chemical characterization of the cyst contents using ELISA with monoclonal antibodies for certain carbohydrate epitopes as well as a polyclonal antiserum against peptide domains, and immunohistochemistry on the cyst wall using the same antibodies. Furtherm...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010050102
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Public engagement has become one of the most effective tools in gaining feedback and perspectives from members of the public, involving patients with decisions, and inspiring young people to carry the medical profession forwards. Brainbook is a multi-platform, social media-based resource that was created spe...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-018-3757-8
更新日期:2019-01-01 00:00:00
abstract::The ES is a non-physiological stimulus of the brain. However it represents an important and indispensable part of stero-EEG investigation since it is an easily adjustable method, capable of inducing typical electro-clinical seizures. From the clinical and electrical responses elicited by ES and from the data of the st...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/978-3-7091-8444-8_4
更新日期:1976-01-01 00:00:00
abstract::We evaluated and analysed our own 31 cases of the haemorrhagic type of moyamoya disease to clarify the clinical features of this disease. The cases were divided into three groups. Group A consisted of 12 cases with aneurysms. Aneurysms on the circle of Willis were treated as ordinary saccular aneurysms. Group B consis...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01809751
更新日期:1996-01-01 00:00:00
abstract::In spite of the recent advances in neuroradiology including the CT scan and the spin-echo-magnetic resonance (MR), accurate diagnosis of arteriovenous malformations (AVMs) involving the spinal cord is still based on selective angiography. This last procedure is invasive and needs to be repeated during the follow up. P...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01476287
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Aneurysms of the proximal segment of anterior cerebral artery (A1) are uncommon, but present a unique challenge to surgeons because of the risk of injury to the nearby perforating arteries. Surgical issues and treatment options, however, have not been detailed in the previous literature. METHOD:We report a ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-002-1014-6
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:Fenestrations of intracranial arteries are variants resulting from incomplete fusion of vessels during development with unknown clinical significance. They are best visualised with 3D rotational angiography (3DRA). OBJECTIVE:In a prospective consecutive series of patients with suspected aneurysms, 3DRA was ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1587-7
更新日期:2013-02-01 00:00:00
abstract::Glossopharyngeal neuralgia (GPN), or better named vago-glossopharyngeal neuralgia (VGPN), is a rare disorder amounting to 1 % of the incidence of trigeminal neuralgia (TN). Pain is paroxysmal, of the electrical shooting type, and mainly provoked by stimulation of the pharynx or deep throat, especially during swallowin...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-014-2302-7
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:We compared the electrode positions of subthalamic nucleus (STN) deep brain stimulation (DBS) estimated at the immediate postoperative period with those estimated 6 months after surgery. METHODS:Brain CT scans were taken immediately and 6 months after bilateral STN DBS in 53 patients with Parkinson's disease...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-010-0771-x
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:The rostral expanded endoscopic approach (EEA) to anterior cranial fossa (ACF) has several advantages over transcranial/craniofacial surgery, providing early access to the vascular supply of tumors and reducing morbidities of craniotomy especially that of brain retraction. This article presents endoscopic la...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-020-04277-x
更新日期:2020-06-01 00:00:00
abstract:INTRODUCTION:Glomus jugulare tumours represent a great therapeutic challenge. Previous papers have documented good results from Gamma Knife surgery (GKS) with these tumours. However, the relationship between clinical improvement and tumour shrinkage has never been assessed. MATERIALS AND METHODS:There were 14 patients...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0268-7
更新日期:2009-05-01 00:00:00
abstract::Between 1984 and 1991 86 patients with single cerebral metastases underwent linear accelerator radiosurgery using the atraumatic and reproducible Greitz-Bergström head-fixation device. Routine one-month follow-up documented disappearance of the tumour in 16 patients, with resolution of the oedema and ventricular shift...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01809265
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:The necessity of red blood cell (RBC) transfusions in neurosurgical procedures is under debate. Although detailed recommendations exist for many other surgical disciplines, there are very limited data on the probability of transfusions during neurosurgical procedures. METHODS:Three-thousand and twenty-six c...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1373-6
更新日期:2012-07-01 00:00:00
abstract::Unstable fracture dislocations due to torn ligaments, fractures of both articular processes, or detachments of entire vertebral arches from vertebral bodies still pose the problem of fixation after anterior fusion. The application of internal metal plate fixation--using the small AO (ASFI) fragment equipment--is descr...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405907
更新日期:1975-01-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to evaluate the effect of endovascular treatment of ruptured dissecting aneurysms of the vertebral artery, the benefits of early embolization, and the predictors of outcomes. CLINICAL MATERIAL AND METHODS:Between September, 2001 and May, 2009, 25 patients with ruptured verteb...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-010-0683-9
更新日期:2010-09-01 00:00:00
abstract::The authors report the results of a study designed to compare the effectiveness of two different types of radiation in patients with acromegaly where surgical therapy had failed to normalize growth hormone (GH). Longterm follow-up after conventional high voltage radiation in 17 patients and proton therapy in 13 patien...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01403492
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Studies of deep brain stimulation (DBS) in mice are rare due to their small size, agility, aversion to handling, and high anxiety compared to larger species. Studying DBS modulation of neural circuitry in murine models of human behavior may ensure safety, guide stimulatory parameters for clinical trials in h...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-014-2062-4
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:To explore whether segmentation and 3D modeling are more accurate in the preoperative detection of the neurovascular relationship (NVR) in patients with trigeminal neuralgia (TN) compared to MRI fast imaging employing steady-state acquisition (FIESTA). METHOD:Segmentation and 3D modeling using 3D Slicer were...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-016-2936-8
更新日期:2016-11-01 00:00:00