Combined multiple surgical intervention and chemotherapy for multicentric WHO grade II glioma : a long-term follow-up study.

Abstract:

BACKGROUND:Multicentric WHO grade II gliomas constitute a rare entity. Their pathogenesis and treatment are still a matter of debate. OBJECTIVE:We present a 23 year-old female with two synchronous but separate WHO grade II oligodendrogliomas in the temporal and frontal lobes. CLINICAL FEATURES:The two lesions showed independent evolution, requiring surgical treatment at different stages. For a recurrence of the disease at the frontal site, a temozolomide chemotherapy regimen was commenced with a favourable response. After 7 years follow-up, the patient is free of neurological symptoms and enjoys a normal life. CONCLUSION:The problems concerning the pathophysiology, diagnosis and treatment of this condition are discussed. On the basis of our results, we suggest that an active therapeutic strategy, by combining multiple surgical procedures and complementary treatment, should be systematically considered in multicentric WHO grade II gliomas, as in similar unifocal neoplasms.

journal_name

Acta Neurochir (Wien)

journal_title

Acta neurochirurgica

authors

Vergani F,Sanson M,Duffau H

doi

10.1007/s00701-009-0306-5

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

1699-704

issue

12

eissn

0001-6268

issn

0942-0940

journal_volume

151

pub_type

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