Effect of niravoline (RU51599), a kappa-opioid receptor agonist, on tumour-origin brain oedema.

Abstract:

:Niravoline is a selective kappa-opioid receptor agonist. Its effect on tumour-origin brain oedema was investigated in a brain tumour model created by implantation of C6 glioma cells into the brain of Wistar rats. Five weeks after the tumour cell implantation, niravoline was administered i.v. at 1 mg/kg, a total of four times at one-hour intervals. In the control group (i.e., saline or vehicle-treated rats), this brain tumour model was found to result in a statistically significant increase in the water content in selected brain regions except for the frontal region, the tumour-containing region and the region surrounding the tumour-containing region. Administration of niravoline inhibited the increase in the water content in the brain regions remote from the tumour.

journal_name

Acta Neurochir (Wien)

journal_title

Acta neurochirurgica

authors

Takahashi H,Hamada H,Teramoto A

doi

10.1007/s007010050374

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

771-8

issue

7

eissn

0001-6268

issn

0942-0940

journal_volume

141

pub_type

杂志文章
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    doi:10.1007/BF01406753

    authors: George B,Laurian C

    更新日期:1980-01-01 00:00:00

  • Red blood cell transfusion in neurosurgery.

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    doi:10.1007/BF01402450

    authors: Ryba M,Pastuszko M,Iwanska K,Bidzinski J,Dziewiecki C

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    doi:10.1007/s00701-009-0259-8

    authors: Boszczyk BM,Mooij JJ,Schmitt N,Di Rocco C,Fakouri BB,Lindsay KW

    更新日期:2009-06-01 00:00:00

  • Tension pneumocephalus after transsphenoidal surgery: two case reports.

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    pub_type: 杂志文章

    doi:10.1007/BF02188782

    authors: Yüceer N,Cakíroğlu K,Erdoğan A,Gökalp HZ,Bağdatoğlu C

    更新日期:1995-01-01 00:00:00

  • Tumour and surgery effects on cognitive functioning in high-grade glioma patients.

    abstract:BACKGROUND:Many high-grade glioma (HGG) patients have cognitive impairments, which impact daily functioning. Cognitive impairments can be caused by tumour-, treatment-, and patient-related factors. The effect of the tumour and of surgical resection on cognition is, however, not well known. We investigated tumour and su...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章

    doi:10.1007/s00701-014-2115-8

    authors: Habets EJ,Kloet A,Walchenbach R,Vecht CJ,Klein M,Taphoorn MJ

    更新日期:2014-08-01 00:00:00

  • Surgery for syringomyelia: an analysis based on 163 surgical cases.

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    pub_type: 杂志文章

    doi:10.1007/s007010050038

    authors: Goel A,Desai K

    更新日期:2000-01-01 00:00:00

  • Traumatic intraventricular haemorrhage.

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    journal_title:Acta neurochirurgica

    pub_type: 杂志文章

    doi:10.1007/BF01404144

    authors: Sato M,Tanaka S,Kohama A,Fujii C

    更新日期:1987-01-01 00:00:00

  • Clinical analysis of vertebrobasilar dissection.

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    journal_title:Acta neurochirurgica

    pub_type: 杂志文章

    doi:10.1007/s00701-006-0742-4

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    更新日期:2006-04-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2008-09-01 00:00:00

  • Anatomical study of the central myelin portion and transitional zone of the vestibulocochlear nerve.

    abstract:BACKGROUND:The aim of this study was to evaluate gross and microscopic anatomical features of the vestibulocochlear nerve or eighth cranial nerve (CNVIII) from fresh cadavers, especially the nerve's central myelin portion (CMP) and transitional zone (TZ), and to consider any pathological implications. METHODS:Six fres...

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    pub_type: 杂志文章

    doi:10.1007/s00701-012-1479-x

    authors: Guclu B,Sindou M,Meyronet D,Streichenberger N,Simon E,Mertens P

    更新日期:2012-12-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1007/s00701-006-0858-6

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  • Bilateral internal carotid artery thrombosis after closed head injury.

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  • Ventral compression in adult patients with Chiari 1 malformation sans basilar invagination: cause and management.

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    pub_type: 杂志文章

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  • Pain and brachial plexus lesions: evaluation of initial outcomes after reconstructive microsurgery and validation of a new pain severity scale.

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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  • Intraoperative facial nerve monitoring (IFNM) predicts facial nerve outcome after resection of vestibular schwannoma.

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    更新日期:1998-01-01 00:00:00

  • What is a reasonable surgical procedure for spinal extradural arachnoid cysts: is cyst removal mandatory? Eight consecutive cases and a review of the literature.

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  • Giant supratentorial meningeal haemangiopericytoma in a newborn.

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