Abstract:
BACKGROUND:Studies of deep brain stimulation (DBS) in mice are rare due to their small size, agility, aversion to handling, and high anxiety compared to larger species. Studying DBS modulation of neural circuitry in murine models of human behavior may ensure safety, guide stimulatory parameters for clinical trials in humans, and inform a long-eluded mechanism. METHODS:Stereotactic deep brain electrode implantation in a mouse is performed. Mechanical etching of the skull with a high-speed drill is used with placement of cyanoacrylate glue and molding of dental acrylate to affix the electrode in place. Stimulation experiments are conducted in the home cage after a habituation period. After testing is complete, electrode placement is verified in fixed tissue. RESULTS:Electrodes can be safely and accurately implanted in mice for DBS experimentation. Previous findings demonstrated accuracy in placement within the nucleus accumbens shell of 93 % [14]. In this study, there were no hardware malfunctions that required interrupting experimentation. CONCLUSIONS:Stereotactic DBS studies may be safely and effectively performed in mice to investigate neuropsychiatric disorders. In addition, examining the biochemical and molecular mechanisms underlying these disorders may be facilitated by widely available transgenic mouse lines and the Cre-Lox recombination system.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Halpern CH,Attiah MA,Tekriwal A,Baltuch GHdoi
10.1007/s00701-014-2062-4subject
Has Abstractpub_date
2014-08-01 00:00:00pages
1515-21issue
8eissn
0001-6268issn
0942-0940journal_volume
156pub_type
杂志文章abstract:OBJECTIVE:To introduce reliable and minimally invasive virtual surgical planning for superficial temporal artery to middle cerebral artery (STA-MCA) bypass surgery using three-dimensional (3-D) rotational reconstruction digital subtraction angiography (DSA). METHODS:Twenty-eight consecutive patients (11 women and 17 m...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-010-0681-y
更新日期:2010-09-01 00:00:00
abstract::In this paper, a brief information on factors taking role in intracranial air formation and tension pneumocephalus because of two cases epidural air formation and tension pneumocephalus following transsphenoidal operation is presented. Two cases were treated conservatively. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF02188782
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:The excitotoxic amino acid glutamate is known to aggravate pre-existing neuropathology. Since volatile anesthetics increase plasma amino acid levels, we investigated if the anesthetics isoflurane and propofol increase plasma and cerebrospinal fluid (CSF) glutamate in neurosurgical patients. METHODS:In disce...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-005-0562-y
更新日期:2005-08-01 00:00:00
abstract::The authors report two unusual cases in which a malignant astrocytoma developed at the site of the excision of an earlier medulloblastoma. While the precise etiology of these astrocytic tumours was unproven, theories of the origins of the second tumours, particularly in relation to the basic nature of medulloblastomas...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010170048
更新日期:2001-01-01 00:00:00
abstract:INTRODUCTION:Intraneural ganglion cysts in the tarsal tunnel are rare but are being increasingly reported. The cysts involve the tibial or plantar nerves and are most commonly derived from a neighboring (degenerative) joint, (i.e., the tibiotalar or subtalar) via an articular branch arising from the medial aspect of th...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-019-04027-8
更新日期:2019-10-01 00:00:00
abstract::Aneurysms of the vertebro-basilar junction area have been considered the most difficult to be surgically treated because of their deep location, the proximity of the brain stem and the cranial nerves. However, at present, new endovascular techniques and new transbasal surgical approaches offer valuable management stra...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF02747192
更新日期:1997-01-01 00:00:00
abstract::The effectiveness of percutaneous epidural stimulation has been evaluated in 11 patients with multiple sclerosis. Trial stimulation was performed at the thoracic level and lasted for 4 to 10 days. Evaluation was accomplished before the start and at regular intervals during and after the treatment. The scoring systems ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01809178
更新日期:1979-01-01 00:00:00
abstract::Colloid cysts of the third ventricle have been investigated by chemical characterization of the cyst contents using ELISA with monoclonal antibodies for certain carbohydrate epitopes as well as a polyclonal antiserum against peptide domains, and immunohistochemistry on the cyst wall using the same antibodies. Furtherm...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010050102
更新日期:1998-01-01 00:00:00
abstract::Eosinophilic granuloma (EG) is a rare disease but is more common in adults than children. It's often self-limiting. Spinal involvement is rare. It is the localized and most benign form of Langerhans' cell histiocytosis (previously known as histiocytosis X), characterised by lytic lesions in one or more bones. Spontane...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-003-0182-3
更新日期:2004-02-01 00:00:00
abstract::Supervolt radiation therapy produced no improved survival rates in the treatment of glioblastoma multiforme as compared to orthovolt therapy. Survival times of more than one year or two years must still be considered a rarity. The application of computer techniques to the calculation of dose distributions greatly enha...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01406633
更新日期:1978-01-01 00:00:00
abstract:PURPOSE:Oculomotor nerve palsy (ONP) occasionally occurs in cases of pituitary apoplexy (PA) associated with pituitary adenoma, but its mechanism remains unclear. Intracranial nerves are clearly visualized by fast-imaging employing with steady-state acquisition (FIESTA). Here, we assessed the oculomotor nerve compressi...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-020-04632-y
更新日期:2021-02-01 00:00:00
abstract::MRI is routinely used in the evaluation and management of patients with failed back surgery syndrome (FBSS). However, its value is unclear in the early detection of signs that can negatively affect that later course of surgical cases. The purpose of the present study is to describe the MR images of early postoperative...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01844746
更新日期:1997-01-01 00:00:00
abstract::Between 1976 and 1983, 251 patients underwent surgery for the treatment of cervical degenerative disc disease. Anterior microsurgical discectomy at one or more cervical segments without interbody fusion was performed in each case. 109 patients with radiculopathy and 55 patients with myelopathy were followed up clinica...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01560567
更新日期:1988-01-01 00:00:00
abstract::Magnetic Resonance Imaging (MRI) scanning would prove useful for lesions that are not visualized on computed tomography (CT) scan or are better defined on MRI scan. The problem of reference marker visualization can be overcome by coating them with mineral oil or by placing paramagnetic fluid filled rods on them. The u...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01456375
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Successful deep brain stimulation is mostly dependent on accurate positioning of the leads at the optimal target points. We investigated whether the identification of the subthalamic nucleus in T2-weighted 3-T MRI, fluid-attenuated inversion recovery 3-T MRI and susceptibility-weighted 3-T MRI is confirmed b...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-014-2328-x
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:As there are many collateral pathways between venous systems, intraoperative venous injury rarely induces venous infarction. In some patients, however, venous injury during microsurgical manipulation may cause acute and/or delayed serious complications. Although intraoperative evaluation using indocyanine gr...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-020-04617-x
更新日期:2020-10-21 00:00:00
abstract::The authors review the literature and present 8 cases of extradural haematoma of the posterior fossa operated from 1979 to 1985 at the Neurosurgical Clinic of the University of Pavia. Emphasis is placed on the importance of an early diagnosis of the symptoms which are often ignored due to the absence of specific clini...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01809553
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Surgeons often rely on intraoperative electrophysiological monitoring to determine whether decompression is sufficient during microvascular decompression surgery for hemifacial spasms. A new monitoring method is needed when an abnormal muscle response is occasionally not available or is unreliable. This stud...
journal_title:Acta neurochirurgica
pub_type: 临床试验,杂志文章
doi:10.1007/s00701-012-1304-6
更新日期:2012-05-01 00:00:00
abstract::Clinical presentation, diagnosis, surgical technique and results of 25 cases of intramedullary tumours in patients under 16 years of age are analyzed. Pre-operative spinal deformity was present in 9 patients. Surgery was performed in all. After multilaminectomy with preservation of the intervertebral joints, total rem...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF02001471
更新日期:1993-01-01 00:00:00
abstract::Changes in vestibulospinal evoked potentials (VsEP) and motor evoked potentials (MEP) were examined in 10 cats before and after two different weight-dropping spinal cord injuries. In six animals somatosensory evoked potentials (SEP) were also monitored. The recordings were done from epidural spinal cord electrodes. Be...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01410530
更新日期:1989-01-01 00:00:00
abstract::Basal forebrain cells of foetal rats were transplanted into the subarachnoid space of adult rats harbouring a kainic acid-induced unilateral lesion in the nucleus basalis magnocellularis. Passive avoidance response tests were performed eight weeks after the transplantation, and the results were compared with those of ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01404951
更新日期:1995-01-01 00:00:00
abstract::We present our clinical experience and the results of surgical management with 25 cavernomas of the CNS, treated in our hospital in the last 10 years. The location of the lesion assessed by clinical and CT scan examinations, proved to be the most significative factor determining the prognosis of cavernomas of the CNS,...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01402366
更新日期:1987-01-01 00:00:00
abstract::This article will look at how one female neurosurgeon in Turkey made her mark in the field. In 1954, Dr. Aysima Altinok began her residency training in neurosurgery at Haydarpaşa Numune Hospital where the first official department of neurosurgery in Turkey had been founded five years earlier. On November 22, 1959, she...
journal_title:Acta neurochirurgica
pub_type: 传,历史文章,杂志文章
doi:10.1007/s00701-007-1252-8
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:We verified the effectiveness of training in endoscopic endonasal transsphenoidal surgery (eETSS) techniques using chicken eggs and a skull model. METHODS:We verified the area of eggshell removed by drilling when five residents and four experts used the chicken eggs and a skull model. RESULTS:When resident...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-014-2035-7
更新日期:2014-07-01 00:00:00
abstract::Primary spinal cord oligodendrogliomas are rare tumours. Only 3 holocord cases have been reported in the literature. We present a primary intramedullary "holocord" oligodendroglioma in a 13 year-old male. Scoliosis was the initial symptom. Neurological deterioration prompted MRI, which demonstrated the lesion. Total r...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01402122
更新日期:1991-01-01 00:00:00
abstract::Patients with multiple intracranial aneurysms present a great challenge to neurosurgical practice. The presence of one or more additional aneurysms, whether recognized or unrecognized, along with the source of the haemorrhage profoundly changes the outcome. It also alters the timing and strategy of surgery. In this st...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01456314
更新日期:1986-01-01 00:00:00
abstract::Fifteen cases of large thalamic gliomas were treated by laser surgery and CUSA under X8 magnification and subsequently they were subjected to radiotherapy. More than 50% of the tumours were located in the dominant hemisphere and therefore an interhemispheric approach was carried out to avoid disturbances of speech and...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01418796
更新日期:1985-01-01 00:00:00
abstract::Forty-three patients were operated on for ruptured intracranial aneurysms during a 12-month-period. Intraoperative evaluation of cortical blood flow by means of a thermal diffusion probe was performed in 23 out of the 41 patients who were operated on for aneurysms of the anterior circulation. The autoregulation index ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01401447
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Hypertrophic olivary degeneration (HOD) is a pathological phenomenon that occurs after injury to the dentato-olivary pathway. Its hallmarks include hypertrophy of the olive with increased T2 signal intensity on magnetic resonance imaging, and it often manifests with palatal tremor and oscillopsia clinically....
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-007-1470-0
更新日期:2008-02-01 00:00:00
abstract::The paper deals with the possibility of applying linear control theory and the theory of statistical dynamics to the complex and quantitative analysis of electroencephalographic records. The aim is to specify signals in the brain environment, in particular sources, speed and direction of signals, and the determination...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00