Abstract:
BACKGROUND:The axolemmal distribution and density of voltage-gated sodium channels largely determines the electrical excitability of sprouting neurites. Recent evidence suggests that accumulation of sodium channels at injured axonal tips may be responsible for ectopic axonal hyperexcitability and the resulting abnormal sensory phenomena of pain and paresthesias. For future improvement in pain management it is necessary to identify structurally significant generators of autorhythmicity. A first step in this regard will be to determine the predominant types of sodium channels in injured axons. The opportunity to test human specimens from painful and non-painful neuroma is of great value. METHODS:We employed immunocytochemical methods to investigate if two types of highly specific voltage-gated sodium channel subtypes could be detected in sections of human neuroma. FINDINGS:Both subtypes of sodium channels PN1 and PN3 accumulated abnormally in human neuromas. The immunoreactive pattern was more pronounced in painful neuromas. This is in contrast to previous reports that focused either on PN1 or PN3 as main generators of hyperexcitability induced pain. INTERPRETATION:Both, PN1 and PN3 seem to be involved in hyperexcitability induced pain. It can be expected that a variety of other highly specific voltage gated sodium channel subtypes will be detected in regenerating peripheral nerve in the near future, which contribute to the development of neuropathic pain states. Thus, in order to therapeutically control hyperexcitability induced neuropathic pain, it might be worthwhile to develop pharmaceuticals that can selectively block different sodium channel subtypes and subunits.A review of the role of sodium channels in neuropathic pain is implemented in the discussion.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Kretschmer T,Happel LT,England JD,Nguyen DH,Tiel RL,Beuerman RW,Kline DGdoi
10.1007/s00701-002-0970-1subject
Has Abstractpub_date
2002-08-01 00:00:00pages
803-10; discussion 810issue
8eissn
0001-6268issn
0942-0940journal_volume
144pub_type
杂志文章abstract::Behçet's disease is an unusual medical condition in central Europe and North America, however more common in Turkey and Japan. It was originally described in Turkey, characterized by recurrent oral ulcers, genital ulcers and also uveitis. A variety of vascular lesions such as venous occlusions, arterial aneurysms and ...
journal_title:Acta neurochirurgica
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abstract:BACKGROUND:The wide variety of intraspinal cystic lesions necessitates different elaborate diagnostic procedures to choose the right therapeutic management in symptomatic patients. Based on the case reports of seven patients with symptomatic spinal arachnoid cysts we discuss the aetiology, diagnostic procedures and the...
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pub_type: 杂志文章,多中心研究
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更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Trigeminal neuralgia (TN) is primarily diagnosed by symptoms and patient history. Magnetic resonance (MR) imaging can be helpful in visualizing the neurovascular compression of the trigeminal nerve in TN patients, but the current parameters used as diagnostic markers for TN are less than optimal. The aim of ...
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doi:10.1007/s00701-012-1327-z
更新日期:2012-09-01 00:00:00
abstract::One hundred patients with a verified subarachnoid haemorrhage were studied in a double blind, placebo-controlled trial at a single centre to determine the value and relative risks of tranexamic acid (TXA) in the management of ruptured intracranial aneurysms. The incidence of recurrent haemorrhage between active and pl...
journal_title:Acta neurochirurgica
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:The placement of intervertebral cages in anterior cervical discectomy (ACDF) supposedly maintains foraminal height. The most commonly reported cage-related complication is subsidence, although it is unknown whether a correlation between subsidence and clinical outcome exists. AIM:To assess the incidence and...
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更新日期:2018-04-01 00:00:00
abstract::In 40 postmortem specimens the cervical posterior roots were examined under the surgical microscope, and intradural communicating fibres between neighbouring segments were demonstrated. The implications of these frequent variants for the diagnosis of prolapsed cervical discs are discussed. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01400951
更新日期:1980-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-10-01 00:00:00
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更新日期:2010-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00701-009-0195-7
更新日期:2009-04-01 00:00:00
abstract::The authors outline the possible approaches to vertebromedullary tumours of the thoraco-lumbar spine using unilateral or bilateral transverso-arthro-pediculectomy and corporectomy. In a personal series of 20 cases. The technique and indications are described and the results. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01456263
更新日期:1986-01-01 00:00:00
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journal_title:Acta neurochirurgica
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
abstract::This study investigated the association of intracranial aneurysms and abdominal aortic aneurysms to elucidate the incidence and independent risk factors for this association. Ultrasonography of the abdominal aorta was performed in 181 patients with 224 intracranial aneurysms. Six patients had suffered subarachnoid hae...
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更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:We describe the management of osteomyelitis of the cervical spine, utilizing internal fixation with subsequent removal and culture of the implants. Four out of five patients had evidence of bacterial colonisation in close proximity to the internal fixation device. METHODS:Five consecutive patients (all fema...
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pub_type: 杂志文章
doi:10.1007/s00701-003-0129-8
更新日期:2003-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00701-009-0306-5
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Anterior cranial fossa dural arterio-venous fistulas (DAVFs) represent 6% of all intracranial DAVFs; characteristically they show an aggressive behaviour with high risk of intracranial haemorrhage. Peculiar anatomical features, such as feeding by the ethmoidal arteries and the pattern of venous drainage (fre...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,多中心研究
doi:10.1007/s00701-017-3107-2
更新日期:2017-05-01 00:00:00
abstract::BAK-C is a new autostabilizing interbody cage which is implanted during an anterior cervical procedure to provide stability to the motion segment and allow fusion to occur. Special instrumentation is provided with a bone collecting reamer. The system utilizes surgical site bone graft as the osteo-inductive material wi...
journal_title:Acta neurochirurgica
pub_type: 临床试验,杂志文章
doi:10.1007/s007010050049
更新日期:1998-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/BF01402293
更新日期:1987-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF01407682
更新日期:1979-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:1989-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-12-01 00:00:00