Abstract:
:One hundred patients with a verified subarachnoid haemorrhage were studied in a double blind, placebo-controlled trial at a single centre to determine the value and relative risks of tranexamic acid (TXA) in the management of ruptured intracranial aneurysms. The incidence of recurrent haemorrhage between active and placebo groups was identical (12%) and the mortality from recurrent haemorrhage was 7% and 5%, respectively. The overall incidence of cerebral infarction before surgery, at discharge and at 6 months follow-up was greater in the TXA group (27%) than in the control group (11%). Post-operative cerebral ischaemia was significantly more frequent in the active, 18 of 29 as compared to 6 of 32 patients, in the placebo group. In a fifth of the patients in whom cerebral blood flow was estimated there was a significant reduction of cerebral blood flow (CBF) on the side of the ruptured aneurysm in the TXA treated group. It is suggested that this may be the cause of the increased incidence of cerebral ischaemia in this group. There was no significant difference in the incidence of cerebral vasospasm, hydrocephalus, visual disturbances and gastrointestinal disturbances. More fatalities were encountered from ischaemia and recurrent haemorrhage in the TXA group but these differences did not reach statistical significance at the 5% level. Given that disability was due to either vasospasm or recurrent haemorrhage than a patient under TXA treatment was significantly more likely to have disability due to vasospasm (p less than 0.04); the reverse was true for the placebo patient (p less than 0.05).
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Tsementzis SA,Hitchcock ER,Meyer CHdoi
10.1007/BF01402177subject
Has Abstractpub_date
1990-01-01 00:00:00pages
1-10issue
1-2eissn
0001-6268issn
0942-0940journal_volume
102pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:Early detection of residual disease may benefit management strategies in patients undergoing transsphenoidal surgery for acromegaly. This requires establishing objective thresholds for early postoperative growth hormone (GH) assays, and incorporating these parameters into a scale for outcome prediction. MET...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-014-2098-5
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:This study is aimed to describe the observable anatomical variants of the innervation of extensor hallucis longus muscle (EHLM) in order to have the surgical coordinates to perform neurotomy on the targeted branches of its innervation and to give a valuable alternative to the commonly used technique of fascic...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0504-1
更新日期:2009-10-01 00:00:00
abstract::The effects of thromboxane A2 synthetase inhibitor and hyperdynamic therapy on delayed cerebral ischaemia following aneurysmal subarachnoid haemorrhage were evaluated in a series of twenty eight patients, who underwent aneurysmal clipping with 72 hours after subarachnoid haemorrhage. Postoperatively, 13 patients were ...
journal_title:Acta neurochirurgica
pub_type: 临床试验,杂志文章
doi:10.1007/BF01401822
更新日期:1993-01-01 00:00:00
abstract::The purpose of this paper is to present an in vitro method for examining cerebral vasospasm after subarachnoid haemorrhage (SAH) which correlates to the patients' condition. The O2 consumption of the porcine carotid artery was monitored, using an oxygen electrode, after exposure to cerebrospinal fluid (CSF) from patie...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010170140
更新日期:2001-01-01 00:00:00
abstract::Patients with multiple intracranial aneurysms present a great challenge to neurosurgical practice. The presence of one or more additional aneurysms, whether recognized or unrecognized, along with the source of the haemorrhage profoundly changes the outcome. It also alters the timing and strategy of surgery. In this st...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01456314
更新日期:1986-01-01 00:00:00
abstract:INTRODUCTION:Intraoperative detection of residual tumor remains an important challenge in surgery to treat gliomas. New developments in optical techniques offer non-invasive high-resolution imaging that may integrate well into the workflow of neurosurgical operations. Using an intracranial glioma model, we have recentl...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0248-y
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Neurogenic pulmonary edema (NPE) is a clinical syndrome characterized by the acute onset of pulmonary edema after a significant central nervous system (CNS) insult. NPE occurs as a result of release of catecholamines into the blood immediately after aneurysm rupture. The aim of this study is to investigate t...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-017-3091-6
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:The practice of endoscopic endonasal surgery is still limited in children because of the relative rarity of sellar lesions in the paediatric population. However, such an approach is increasingly reported in the literature as an alternative option to standard sublabial microsurgery, and its surgical results a...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-010-0929-6
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:The management of pineal cysts is still debatable, especially for asymptomatic incidental ones. For symptomatic cysts associated with hydrocephalus, the surgical management is mandatory and may include either classical microsurgical approaches to the pineal region or endoscopic trans-ventricular approaches i...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-013-1849-z
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Spinal dural arterio-venous fistulae (SDAVF) are slow-flow extramedullary vascular lesions which account for 75-80% of all spinal vascular malformations. At present there is no agreed view with regard to the best therapeutic option being surgical or endovascular, and several reports favour one or other form ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-008-1560-7
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:The evolution of pituitary surgery has made it a safe and effective form of treatment; however, risks of inadequate tumor resection, cerebrospinal fluid (CSF) leak, pituitary dysfunction, and vascular injury still exist. The use of intraoperative ultrasonography (IOUS) in pituitary surgery has been well desc...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-020-04674-2
更新日期:2021-01-05 00:00:00
abstract::We report on a young woman operated for a ganglioglioma involving the right auditory cortex (AC), presenting with auditory seizures. Despite a normal pre-operative examination, a specific post-operative disorder affecting the perception of a human voice occurred. The patient was unable to recognise the tone of familia...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-008-1495-4
更新日期:2008-06-01 00:00:00
abstract::The characteristic findings of metrizamide CT cisternography in two cases of epidermoid are reported. The main finding was a "cauliflower-like" appearance and was thought to be caused by the irregular interstices of epidermoids. Metrizamide CT cisternography may be helpful in making a diagnosis of an epidermoid. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01400854
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:The use of endoscopes in transnasal surgery offers increased visualization. To minimize rhinological morbidity without restriction in manipulation, we introduced the mononostril transethmoidal-paraseptal approach. METHODS:The aim of the transethmoidal-paraseptal approach is to create sufficient space within...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-017-3075-6
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:The de novo development of an aneurysm in an previously normal artery is an uncommon event. We describe a patient who developed a de novo bleeding aneurysm of the basilar artery in the three weeks following the surgical removal of a large cerebellar AVM. METHOD-FINDINGS: A 48-year-old man suddenly developed ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-003-0125-z
更新日期:2003-12-01 00:00:00
abstract::In theory, lymphokine-activated killer (LAK) cells offer a potential method to treat cerebral gliomas, especially low-grade gliomas. LAK cells would be administered by repeated injections straight into the cavity of a subtotally removed tumour. However, brain-tumour cyst fluid has been shown to be immunosuppressive in...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01400532
更新日期:1988-01-01 00:00:00
abstract::Rats were inoculated with staphylococcus aureus to produce cerebral abscesses and treated with either antibiotic or dexamethasone and with antibiotic plus dexamethasone at sequential stages of abscess formation. Antibiotic alone shortened the cerebritis stage, accelerated the encapsulation and affected the bacterial c...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01456174
更新日期:1989-01-01 00:00:00
abstract::Unstable fracture dislocations due to torn ligaments, fractures of both articular processes, or detachments of entire vertebral arches from vertebral bodies still pose the problem of fixation after anterior fusion. The application of internal metal plate fixation--using the small AO (ASFI) fragment equipment--is descr...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405907
更新日期:1975-01-01 00:00:00
abstract::Direct and indirect arteriovenous fistulas were applied to the cervical vessels of 19 rats in order to study the haemodynamic parameters of angioma-like, rapid blood flow in small vessels. Flow was measured electromagnetically and intraoperatively using the Doppler sonography, and both methods were compared. Resultant...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01403495
更新日期:1989-01-01 00:00:00
abstract::MRI is routinely used in the evaluation and management of patients with failed back surgery syndrome (FBSS). However, its value is unclear in the early detection of signs that can negatively affect that later course of surgical cases. The purpose of the present study is to describe the MR images of early postoperative...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01844746
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Under the definition "glomus tumors" are often erroneously enclosed neoplasms that are absolutely unlike for origin, location, and behavior. Glomus tumors (GTs) are small but extremely painful skin tumors of mesenchymal origin. GTs derive from the neuromyoarterial glomus in adults of middle-age and are gener...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-016-2723-6
更新日期:2016-04-01 00:00:00
abstract::Event related potential recording and psychometric evaluation of cognitive impairment were carried out on 21 patients with brain tumours, 21 patients with severe head injuries and 24 controls. The tumour and trauma patients who met the psychometric inclusion criteria for dementia, but not the non-demented patients, ha...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01812285
更新日期:1986-01-01 00:00:00
abstract:INTRODUCTION:To report the incidence, treatment and outcome of occipital condyle fractures (OCFs) based on the experience of a single neurosurgical department over a period of two years. MATERIAL AND METHODS:From April 1999 to April 2001, ten cases of OCFs were identified in 110 cervical traumas observed over a period...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-004-0289-1
更新日期:2004-08-01 00:00:00
abstract::The authors present the case of a 66-year-old female who developed progressive pulsating exophthalmos, a bruit, and conjunctival chemosis 7 months after a head injury. These symptoms, though highly suspicious of carotid cavernous fistula, were caused by an arteriovenous fistula (AVF) between the inferolateral trunk (I...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-011-1226-8
更新日期:2012-03-01 00:00:00
abstract::4 patients with aneurysms of different size and location were examined by cerebral angiography, computed tomography, angio-computed tomography, magnetic resonance imaging and angiography, in order to demonstrate haemodynamic and morphological aspects of cerebral aneurysms. Turbulent flow within aneurysms could be show...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF02001461
更新日期:1993-01-01 00:00:00
abstract::Regional cerebral blood flow (rCBF) was measured in three patients after relief of elevated intracranial pressure and restoration of normal cerebral perfusion pressure. Two patients, studied within 4 hours after closed head injury were found to have marked impairment of cortical blood flow and elevation of cerebrovasc...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01406289
更新日期:1975-01-01 00:00:00
abstract::A 34-year-old female patient suffering from right-sided facial palsy presented to our hospital. Her hearing range was within normal limits. She had undergone GKS after receiving a diagnosis of facial nerve schwannoma (FNS). On the fourth day after GKS, the patient experienced sudden onset hearing loss on the right sid...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-013-1983-7
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:The aim of this work was to retrospectively study the long-term reliability of the common consensus endocrinological criteria for the assessment of postoperative remission of acromegaly. PATIENTS AND METHODS:In 96 consecutive patients, surgical remission of acromegaly following transsphenoidal surgery was co...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-010-0790-7
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The effectiveness of repeated gamma knife radiosurgery (GKS) for the treatment of multiple metastatic brain tumours was evaluated. METHODS:This study included 16 patients with 242 tumours, 10 men and 6 women with a mean age of 60.3 years at initial GKS, who underwent GKS four times or more for newly develop...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-004-0306-4
更新日期:2004-09-01 00:00:00
abstract::Cavernous malformations (CM) occur very rarely in the ventricular system. We report a patient with a rare location in the third ventricle who had intermittent headaches as the initial symptom. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-004-0393-2
更新日期:2005-01-01 00:00:00