Abstract：
BACKGROUND:The effectiveness of repeated gamma knife radiosurgery (GKS) for the treatment of multiple metastatic brain tumours was evaluated. METHODS:This study included 16 patients with 242 tumours, 10 men and 6 women with a mean age of 60.3 years at initial GKS, who underwent GKS four times or more for newly developed metastatic tumours. FINDINGS:Sixteen patients underwent a total of 83 GKS procedures (range 4 to 8, mean 5.2). The mean number of metastases at each GKS procedure was 2.9 and the number of tumours tended to increase at the 5th GKS procedure compared with the 1st, but not significantly. The mean interval between each procedure was 4.8 months and was not significantly different. Median survival was 22.4 months (range 9.4-78.9 months) and the primary site was not correlated with survival time. The total number of treated tumours tended to correlate to survival time, but not significantly. Use of adjuvant whole brain radiation also had no significant effect on survival time. The Karnofsky performance status was maintained at more than 70 in most patients, but decreased significantly between initial and final GKS. Death due to progression of brain lesions occurred in only about 30% of patients regardless of the multiple newly developed brain metastases. CONCLUSIONS:Repeated radiosurgery for brain metastases is effective and relatively long survival can be expected in some patients associated with a low risk of radiation-induced injury.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Shuto T,Fujino H,Inomori S,Nagano Hdoi
10.1007/s00701-004-0306-4subject
Has Abstractpub_date
2004-09-01 00:00:00pages
989-93; discussion 993issue
9eissn
0001-6268issn
0942-0940journal_volume
146pub_type
杂志文章abstract：:The clinical, radiological and surgical findings of 56 patients with congenital malformations of the craniovertebral junction who underwent surgical intervention in the Department of Neurosurgery, Hacettepe University Medical School were reviewed. The anomalies were classified according to their embryonic origin. Fort...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01808763
更新日期：1994-01-01 00:00:00
abstract：:Out of 502 patients with surgically treated drug-resistant chronic epilepsy (tumour cases excluded) in 12 (2%) a clear occipital focus was found. The pattern of seizures was in most cases nonspecific and polymorphic. EEG examination and neuroradiological findings led to proper localization of the epileptogenic focus. ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01400600
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:Accumulating results have disclosed that early brain injury (EBI) may play a major role in the determination of the outcome of aneurysmal subarachnoid hemorrhage (SAH) patients. This study is of interest to examine the efficacy of pitavastatin, a 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase) ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-015-2399-3
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:Most surgical teams currently consider that endoscopy has become the "gold standard" technique for the transsphenoidal approach to pituitary surgery. Pituitary adenomas are commonly benign tumours and should benefit from the least invasive approach. METHOD:In Foch Hospital, from 2006 to 2020, 2835 patients ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-020-04542-z
更新日期：2020-08-29 00:00:00
abstract：:One hundred patients with a verified subarachnoid haemorrhage were studied in a double blind, placebo-controlled trial at a single centre to determine the value and relative risks of tranexamic acid (TXA) in the management of ruptured intracranial aneurysms. The incidence of recurrent haemorrhage between active and pl...
journal_title：Acta neurochirurgica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01402177
更新日期：1990-01-01 00:00:00
abstract：:The treatment of hydrocephalus, over the centuries, underwent three stages of evolution. During antiquity, middle ages and Renaissance, hydrocephalus was not understood. Medical treatment was useless; surgery was hopeless. The second stage extends from the XIXth century to the end of the first half of the XXth century...
journal_title：Acta neurochirurgica
pub_type： 历史文章,杂志文章,评审
doi：10.1007/BF01540869
更新日期：1992-01-01 00:00:00
abstract：:Renal cell carcinoma has a complex and variable natural history. We report a case underlining this who presented concomitant renal cell carcinoma metastasis with pituitary and adrenocortical adenomas. A 62-year-old woman presented with visual loss. Imaging revealed a large sellar mass with suprasellar extension. Four ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-002-1060-0
更新日期：2003-03-01 00:00:00
abstract：:Intracranial meningiomas are characteristically benign tumours with a tendency to recur following surgical resection. Our group is investigating the pathogenesis of meningioma recurrence. In our initial studies we identified two cases of dural "tails" associated with intracranial meningiomas. Gadolinium-enhanced magne...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01401115
更新日期：1992-01-01 00:00:00
abstract：:The authors report the results of a study designed to compare the effectiveness of two different types of radiation in patients with acromegaly where surgical therapy had failed to normalize growth hormone (GH). Longterm follow-up after conventional high voltage radiation in 17 patients and proton therapy in 13 patien...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01403492
更新日期：1989-01-01 00:00:00
abstract：:The EC-IC Bypass Study Group could not detect any benefit from surgery compared to medical management in the prevention of stroke in 1985 [15]. During the past years surgical revascularization was re-evaluated and considered as an appropriate treatment for a small subgroup of patients with recurrent focal cerebral isc...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01411282
更新日期：1996-01-01 00:00:00
abstract：:The authors report on two types of carotid-A(1) junctional aneurysms projecting backwards. In the two A(1)-type examples, the aneurysm originated at the posterior wall of the proximal A(1) joining the carotid termination and could be clipped using an ipsilateral pterional approach. However, in the carotid-type example...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-007-1223-0
更新日期：2007-08-01 00:00:00
abstract：OBJECTIVE:Endoscopic 3rd ventriculostomy has become the method of choice in the management of occlusive hydrocephalus. The treatment is accompanied by significantly less peri-operative complications than the cerebrospinal fluid shunting procedures previously employed. Close surveillance of patients, however, is necessa...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010050294
更新日期：1999-01-01 00:00:00
abstract：:The indications and results of transsphenoidal surgery for pituitary adenomas are analysed. The advantages and disadvantages of Bromocriptine and radiotherapy are considered. Transsphenoidal surgery does not damage pre-existing pituitary function. It produces excellent results in micro and mesoadenomas, curing about 7...
journal_title：Acta neurochirurgica
pub_type： 传,历史文章,杂志文章
doi：10.1007/BF01435863
更新日期：1988-01-01 00:00:00
abstract：:A recent modification of the occipital transtentorial approach to the pineal region and medial-posterior hemisphere is described. The patient is operated upon in a lateral reclining (park bench) position with the side to undergo occipitoparietal craniotomy, slightly dependant. Following dural opening to the margins of...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01405427
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:Mortality and morbidity of aneurysmal subarachnoid haemorrhage (aSAH) remain high, and prognosis is influenced by multiple non-modifiable factors such as aSAH severity. By analysing the chronology of aSAH management, we aim at identifying modifiable factors with emphasis on the occurrence of rebleeds in a se...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-020-04673-3
更新日期：2021-01-06 00:00:00
abstract：BACKGROUND:Chronic subdural haematoma (cSDH) is a common disease in neurosurgical practise, especially in elderly patients. This is of growing importance as the number of elderly people in the population is increasing steadily. There are scarce data focussing especially on elderly patients with cSDH. This study intende...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-012-1434-x
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:Aneurysms associated with brain arteriovenous malformations (bAVMs) influence the natural history of these lesions and pose important therapeutic challenges. However, the epidemiology, natural history, and appropriate management of the aneurysms associated with bAVMs are not completely understood due to the ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,meta分析
doi：10.1007/s00701-016-2957-3
更新日期：2016-11-01 00:00:00
abstract：:To evaluate the operative mortality and morbidity of definitive intracranial microsurgical aneurysm obliteration as a function of timing of early operative intervention and as a function of clinical condition at the acute state, we retrospectively review 164 consecutive patients who underwent surgery within 72 hours f...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01728872
更新日期：1982-01-01 00:00:00
abstract：:The long-term outcome in 26 patients following operation of intracranial saccular aneurysms before the age of twenty is presented. The duration of follow-up ranged from 4 to 33 years (mean 14 years). The oldest patient is now 51 years old. 19 patients (73%) made a complete or good recovery with resumption of normal li...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01476214
更新日期：1985-01-01 00:00:00
abstract：:A case of cauda equina paraganglioma is described; subsequent intracranial and intraspinal metastases occurred after partial resection and adjunctive radiotherapy. Cerebrospinal fluid dissemination is a rare complication of spinal paragangliomas. Factors predictive of this unusual biological behaviour are discussed. ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01420312
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:Dystonia has been treated well using deep brain stimulation at the globus pallidus internus (GPi DBS). Dystonia can be categorized as two basic types of movement, phasic-type and tonic-type. Cervical dystonia is the most common type of focal dystonia, and sequential differences in clinical outcomes between p...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-015-2646-7
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Specific microanatomical characteristics of the trigeminal nerve root (TNR) blood supply and close neurovascular relationships with surrounding vessels as well as their possible clinical significance were the main reasons for this study. METHOD:The vasculature of 25 adult and four fetal TNRs were microdisse...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-010-0913-1
更新日期：2011-05-01 00:00:00
abstract：OBJECTIVE:To introduce reliable and minimally invasive virtual surgical planning for superficial temporal artery to middle cerebral artery (STA-MCA) bypass surgery using three-dimensional (3-D) rotational reconstruction digital subtraction angiography (DSA). METHODS:Twenty-eight consecutive patients (11 women and 17 m...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-010-0681-y
更新日期：2010-09-01 00:00:00
abstract：:An experimental technique for producing delayed cerebral vasospasm in a rabbit model is described. The basilar artery is punctured via the transclival route and angiographic verification is illustrated. ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01406370
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:The mechanisms underlying post-extracranial to intracranial (EC-IC) bypass neurocognitive changes are poorly understood. METHODS:Data from 55 patients who underwent a unilateral EC-IC bypass for atherosclerotic internal carotid artery (ICA)/middle cerebral artery (MCA) steno-occlusive disease were retrospec...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-015-2620-4
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:The exact aetiology, growth and rupture of intracranial aneurysms is unclear. In this study we investigated a possible association between intracranial aneurysm rupture and polymorphism of the endothelial nitric oxide synthase gene G894T. METHODS:Endothelial nitric oxide synthase gene polymorphism of 53 pat...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-007-1467-8
更新日期：2008-01-01 00:00:00
abstract：:The characteristic findings of metrizamide CT cisternography in two cases of epidermoid are reported. The main finding was a "cauliflower-like" appearance and was thought to be caused by the irregular interstices of epidermoids. Metrizamide CT cisternography may be helpful in making a diagnosis of an epidermoid. ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01400854
更新日期：1984-01-01 00:00:00
abstract：:An investigation was carried out in 28 patients in order to evaluate the relationship between angiographically documented vasospasm, amount of subarachnoid blood found at surgery around ruptured intracranial aneurysms, and delayed ischaemic deficits. Angiography was performed at time intervals ranging between 5 and 17...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01401750
更新日期：1982-01-01 00:00:00
abstract：:A saccular cerebral aneurysm was incidentally found at the bifurcation of a fenestrated anterior cerebral artery of 35-week-old Sprague-Dawley rat. The animal had been fed a normal laboratory diet. The internal lamina extended for a short distance into the neck of the aneurysm and then suddenly disappeared. The medial...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01405700
更新日期：1991-01-01 00:00:00
abstract：:We present the case of a 51-year-old female who had a four-year history of Parkinson's disease with severe "on-off' and disabling progression of symptoms on chronic levodopa therapy. After obtaining FDA approval, we implanted a Medtronic deep brain stimulation lead stereotactically into the right anterior pallidum con...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF02188792
更新日期：1995-01-01 00:00:00
