Abstract:
BACKGROUND:Accumulating results have disclosed that early brain injury (EBI) may play a major role in the determination of the outcome of aneurysmal subarachnoid hemorrhage (SAH) patients. This study is of interest to examine the efficacy of pitavastatin, a 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase) inhibitor, on SAH-induced apoptosis. METHODS:A rodent double SAH model was employed. Pitavastatin was administered orally. CSF IL-1β, IL-6, IL-8 and TNF-α were measured (rt-PCR). Basilar arteries were harvested for C-Jun N-terminal kinase p46/p55 (cJNK (p46/p55)), matrix metallopeptidase-9 (MMP-9) (Western blot), caspase and Bcl-2 (rt-PCR) evaluation. RESULTS:Pitavastatin reduced the bioexpression of cJNK p55 compared with the SAH groups. Cleaved caspase-9a was significantly reduced in the pitavastatin-preconditioned group compared with the SAH group (p > 0.05). IL-1β and TNF-α levels were reduced in the pitavastatin-preconditioned group. Pretreatment with pitavastatin significantly reduced activated MMP-9, capsase-9a and B-cell lymphoma 2(Bcl) mRNA. CONCLUSION:Preconditioning with pitavastatin exerts its neuroprotective effect through the dual action of inhibiting cJNK(p46/p55) activation and reducing cleaved caspase-9a expression. Besides, the bioinhibition of MMP-9 may partially contribute to the neuroprotective effect. This study lends credence to the theory that statins, especially in the preconditioning status, may attenuate SAH-induced neuron apoptosis.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Chang CZ,Wu SC,Kwan AL,Lin CLdoi
10.1007/s00701-015-2399-3subject
Has Abstractpub_date
2015-06-01 00:00:00pages
1031-41; discussion 1041issue
6eissn
0001-6268issn
0942-0940journal_volume
157pub_type
杂志文章abstract::In theory, lymphokine-activated killer (LAK) cells offer a potential method to treat cerebral gliomas, especially low-grade gliomas. LAK cells would be administered by repeated injections straight into the cavity of a subtotally removed tumour. However, brain-tumour cyst fluid has been shown to be immunosuppressive in...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01400532
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Spinal epidural arachnoid cysts (EAC) are rare and may present with myelopathy, which can be completely curable with surgery. The majority of investigators believe that the repairment of dural defect is important to treat EAC. However, the necessity of excising EACs remains controversial. The purpose of this...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-012-1356-7
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Aneurysms associated with brain arteriovenous malformations (bAVMs) influence the natural history of these lesions and pose important therapeutic challenges. However, the epidemiology, natural history, and appropriate management of the aneurysms associated with bAVMs are not completely understood due to the ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,meta分析
doi:10.1007/s00701-016-2957-3
更新日期:2016-11-01 00:00:00
abstract::Event related potential recording and psychometric evaluation of cognitive impairment were carried out on 21 patients with brain tumours, 21 patients with severe head injuries and 24 controls. The tumour and trauma patients who met the psychometric inclusion criteria for dementia, but not the non-demented patients, ha...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01812285
更新日期:1986-01-01 00:00:00
abstract::In the present note, the cause of root compression in cases with degenerative lumbar spondylolisthesis is discussed in order to clarify the best method of surgery and to avoid iatrogenic damage of the cauda equina if a transpedicular fusion is going to be performed. The root compression is due to osteophytes growing o...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF02187192
更新日期:1995-01-01 00:00:00
abstract::One hundred patients with a verified subarachnoid haemorrhage were studied in a double blind, placebo-controlled trial at a single centre to determine the value and relative risks of tranexamic acid (TXA) in the management of ruptured intracranial aneurysms. The incidence of recurrent haemorrhage between active and pl...
journal_title:Acta neurochirurgica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01402177
更新日期:1990-01-01 00:00:00
abstract::The article presents an autosomal dominant Currarino syndrome with incomplete penetrance in three out of four members of the same family. The mother had only a bony sacral defect and no other signs. In the older daughter, the syndrome was completely developed with presacral cystic teratoma, a sacral defect and abdomin...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0220-x
更新日期:2009-09-01 00:00:00
abstract::The diagnostic and prognostic values of quantitative isotope ventriculography (QIV), lumbar isotope cisternography (LIC), pneumoencephalography (PEG), and continuous intraventricular pressure recording (CIP) were assessed on the basis of the clinical course in 160 patients suspected of having acquired hydrocephalus. T...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01430586
更新日期:1979-01-01 00:00:00
abstract::The indications and results of transsphenoidal surgery for pituitary adenomas are analysed. The advantages and disadvantages of Bromocriptine and radiotherapy are considered. Transsphenoidal surgery does not damage pre-existing pituitary function. It produces excellent results in micro and mesoadenomas, curing about 7...
journal_title:Acta neurochirurgica
pub_type: 传,历史文章,杂志文章
doi:10.1007/BF01435863
更新日期:1988-01-01 00:00:00
abstract::A lateral route between the SCM and the lateral border of the internal jugular vein is defined from an anatomical study for exposure of the VA. It offers the simplest route for controlling any part or the whole length of the VA, including its intracranial portion. Surgical indications are discussed on the basis of our...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01406753
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:As there are many collateral pathways between venous systems, intraoperative venous injury rarely induces venous infarction. In some patients, however, venous injury during microsurgical manipulation may cause acute and/or delayed serious complications. Although intraoperative evaluation using indocyanine gr...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-020-04617-x
更新日期:2020-10-21 00:00:00
abstract::Despite a body of evidence showing that various neurotrophic factors support the survival of nerve cells and stimulate axonal outgrowth, doubt remains about their optimal site of application as well as the more compelling question of what clinical benefit, if any, they would confer. Ciliary neurotrophic factor (CNTF) ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-005-0631-2
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The evolution of pituitary surgery has made it a safe and effective form of treatment; however, risks of inadequate tumor resection, cerebrospinal fluid (CSF) leak, pituitary dysfunction, and vascular injury still exist. The use of intraoperative ultrasonography (IOUS) in pituitary surgery has been well desc...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-020-04674-2
更新日期:2021-01-05 00:00:00
abstract::Recent animal research has provided evidence that brain ischaemia is associated with a shift of energy related metabolites (lactate, adenosine, inosine, and hypoxanthine) and several transmitters from the intracellular to the extracellular fluid (ECF). These chemical changes of the ECF reflect the energy crisis of the...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405420
更新日期:1990-01-01 00:00:00
abstract::The EC-IC Bypass Study Group could not detect any benefit from surgery compared to medical management in the prevention of stroke in 1985 [15]. During the past years surgical revascularization was re-evaluated and considered as an appropriate treatment for a small subgroup of patients with recurrent focal cerebral isc...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01411282
更新日期:1996-01-01 00:00:00
abstract::Early diagnosis of thoracic disc herniations has become more common with the advent of spinal magnetic resonance imaging (MRI). This early diagnosis combined with choosing the optimal surgical approach, to ensure adequate decompression without excessive cord and root manipulation, will achieve the optimum results. It ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01402509
更新日期:1991-01-01 00:00:00
abstract::Arachnoid cysts are frequent anomalies of the CNS. They are benign lesions within the arachnoid membrane and have been reported to occur in virtually all locations where arachnoid is present. An intraventricular location, however, is rare and occurrence within the fourth ventricle is particularly uncommon. The first r...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-009-0309-2
更新日期:2010-01-01 00:00:00
abstract::The authors report a series of 37 cases of unruptured aneurysms, admitted and operated upon over a 5 year period (1985-1990), which represents an incidence of 18% of the total number of aneurysm patients operated upon during this period. These unruptured aneurysms were discovered in 4 types of circumstances: 1) Associ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01541779
更新日期:1992-01-01 00:00:00
abstract::Treatment of vertebral epidural metastases has been in the past and still remains the object of special attention in an attempt to improve the quality of life of these patients. To assess the effects of and indications for surgery, the clinical histories of 53 patients with this malignant disease who had undergone dec...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01407520
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:The practice of endoscopic endonasal surgery is still limited in children because of the relative rarity of sellar lesions in the paediatric population. However, such an approach is increasingly reported in the literature as an alternative option to standard sublabial microsurgery, and its surgical results a...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-010-0929-6
更新日期:2011-04-01 00:00:00
abstract::The superficial middle cerebral veins (SMCVs) are large veins to drain the brain and therefore anatomical knowledge of them is important for neurosurgeons and neuroradiologists. In a patient with a ruptured blister aneurysm, we incidentally found during angiography an aberrant drainage of the SMCVs, which penetrated t...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-019-03838-z
更新日期:2019-04-01 00:00:00
abstract::4 patients with aneurysms of different size and location were examined by cerebral angiography, computed tomography, angio-computed tomography, magnetic resonance imaging and angiography, in order to demonstrate haemodynamic and morphological aspects of cerebral aneurysms. Turbulent flow within aneurysms could be show...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF02001461
更新日期:1993-01-01 00:00:00
abstract::Cavernous malformations (CM) occur very rarely in the ventricular system. We report a patient with a rare location in the third ventricle who had intermittent headaches as the initial symptom. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-004-0393-2
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Tarlov cysts (TCs) are expanded nerve root sheaths that occur near the dorsal root ganglion and result from increased intraspinal hydrostatic pressure. TCs most frequently affect the lumbosacral plexus and therefore may cause specific symptoms such as perineal pain and neurogenic bladder, bowel, and sphincte...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-018-3494-z
更新日期:2018-04-01 00:00:00
abstract::We report the case of a large osteoblastoma arising in the frontal bone of a 20-year-old female. The lesion was first noted after a fall, and grew steadily in size following further head injury during pregnancy. Initial plain radiography demonstrated an area of radiolucency, with subsequent cross-sectional imaging rev...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-016-3024-9
更新日期:2017-02-01 00:00:00
abstract::Regional cerebral blood flow (rCBF) was measured in three patients after relief of elevated intracranial pressure and restoration of normal cerebral perfusion pressure. Two patients, studied within 4 hours after closed head injury were found to have marked impairment of cortical blood flow and elevation of cerebrovasc...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01406289
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:To determine its roles in the diagnosis and the systemic evaluation of metastatic brain tumours, whole-body positron emission tomography (PET) using [18F]FDG was performed in 20 consecutive patients. METHODS:All patients were thought to be suffering or needing to be differentiated from metastatic brain tumo...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010050161
更新日期:1998-01-01 00:00:00
abstract::The characteristic findings of metrizamide CT cisternography in two cases of epidermoid are reported. The main finding was a "cauliflower-like" appearance and was thought to be caused by the irregular interstices of epidermoids. Metrizamide CT cisternography may be helpful in making a diagnosis of an epidermoid. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01400854
更新日期:1984-01-01 00:00:00
abstract::Intra-operative neurophysiological techniques allow reliable identification of the sensorimotor region and make their anatomical and functional preservation feasible. Monopolar cortical stimulation has recently been described as a new mapping technique. In the present study this method was compared to the "traditional...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010050433
更新日期:1999-01-01 00:00:00
abstract::The prevention of cerebral vasospasm with OKY-046, an imidazole derivative and a thromboxane synthetase inhibitor, was studied co-operatively at ten neurosurgical services. Intravenous administrations of 2, 5 or 10 mu/kg/minute of OKY-046 were given continuously from the earliest possible day to the 14th SAH-day to 82...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01476216
更新日期:1985-01-01 00:00:00