The choice of treatment after incomplete adenomectomy in acromegaly: proton--versus high voltage radiation.


:The authors report the results of a study designed to compare the effectiveness of two different types of radiation in patients with acromegaly where surgical therapy had failed to normalize growth hormone (GH). Longterm follow-up after conventional high voltage radiation in 17 patients and proton therapy in 13 patients confirmed a similar reduction of GH levels in both groups. After 4.5 years a decrease of about 80% was achieved. After "conventional radiation" GH was normal in 8 (47%) and near normal in 6 (35%) while proton therapy resulted in normalization in 5 and improvement in 5 (38%). The slightly better results of "conventional radiation" must be attributed to lower pretreatment levels of GH. Side effects as additional pituitary deficits and oculomotor palsies were more often seen after proton treatment. Since the results of both radiation methods are similar and proton therapy has a tendency to more serious side effects we recommend "conventional radiation" as secondary treatment of acromegaly.


Acta Neurochir (Wien)


Acta neurochirurgica


Lüdecke DK,Lutz BS,Niedworok G




Has Abstract


1989-01-01 00:00:00












  • Intracranial glioependymal (neuroglial) cysts: a systematic review.

    abstract:BACKGROUND:Glioependymal cysts (GECs) are benign intracranial cysts that have been rarely reported in the literature. The exact pathogenesis of these developmental anomalies is controversial. Moreover, the terminology used to name GECs and other intracranial cysts is confusing because they are undistinguishably reporte...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Robles LA,Paez JM,Ayala D,Boleaga-Duran B

    更新日期:2018-07-01 00:00:00

  • Morphological and haemodynamic aspects of cerebral aneurysms.

    abstract::4 patients with aneurysms of different size and location were examined by cerebral angiography, computed tomography, angio-computed tomography, magnetic resonance imaging and angiography, in order to demonstrate haemodynamic and morphological aspects of cerebral aneurysms. Turbulent flow within aneurysms could be show...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Nüssel F,Wegmüller H,Huber P

    更新日期:1993-01-01 00:00:00

  • Virtual MRI endoscopy: detection of anomalies of the ventricular anatomy and its possible role as a presurgical planning tool for endoscopic third ventriculostomy.

    abstract:BACKGROUND:Many anatomical anomalies have the potential to impair the efficacy of endoscopic third ventriculostomy (ETV) and increase the surgical morbidity. By virtual magnetic resonance imaging (MRI) endoscopy, the real endoscopic view into the ventricular system can be simulated. It was the objective of the present ...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Rohde V,Krombach GA,Struffert T,Gilsbach JM

    更新日期:2001-11-01 00:00:00

  • Treatment of cavernous malformations in supratentorial eloquent areas: experience after 10 years of patient-tailored surgical protocol.

    abstract:BACKGROUND:Eloquent area surgery has become safer with the development of intraoperative neurophysiological monitoring and brain mapping techniques. However, the usefulness of intraoperative electric brain stimulation techniques applied to the management and surgical treatment of cavernous malformations in supratentori...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Sanmillan JL,Lopez-Ojeda P,Fernández-Conejero I,Fernández-Coello A,Plans G,Ali-Ciurana Y,Gabarrós A

    更新日期:2018-10-01 00:00:00

  • Assessment and prognosis of coma after head injury.

    abstract::The Glasgow Coma Scale, based upon eye opening, verbal and motor responses has proved a practical and consistent means of monitoring the state of head injured patients. Observations made in the early stages after injury define the depth and duration of coma and, when combined with clinical features such as a patient's...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Teasdale G,Jennett B

    更新日期:1976-01-01 00:00:00

  • Pituitary apoplexy: an overview of 186 cases published during the last century.

    abstract:BACKGROUND:Pituitary apoplexy is a rare and life-threatening complication occurring in 0.6-10.5% of all cases of pituitary adenomas. Although the association between pituitary apoplexy and visual dysfunction has been recognized for a long time, the optimal management of this problem still remains controversial. The pur...

    journal_title:Acta neurochirurgica

    pub_type: 历史文章,杂志文章,评审


    authors: Turgut M,Ozsunar Y,Başak S,Güney E,Kir E,Meteoğlu I

    更新日期:2010-05-01 00:00:00

  • Clinical evaluation of a real-time inverse planning for Gamma Knife radiosurgery by convex optimization: a prospective comparative trial in a series of vestibular schwannoma patients.

    abstract:BACKGROUND:Gamma Knife radiosurgery (GKRS) inverse dose planning is currently far from competing effectively with the quality of dose planning developed by experienced experts. A new inverse planning (IP) method based on « efficient convex optimization algorithms » is proposed, providing high-quality dose plans in real...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Régis J,Hamdi H,Loundou A,Merly L,Castillo L,Balossier A,Spatola G

    更新日期:2021-01-05 00:00:00

  • Incidence of local in-brain progression after supramarginal resection of cerebral metastases.

    abstract:BACKGROUND:Microsurgical circumferential stripping of intracerebral metastases is often insufficient in achieving local tumor control. Supramarginal resection may improve local tumor control. METHODS:A retrospective analysis was performed for patients who underwent supramarginal resection of a cerebral metastasis by a...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Kamp MA,Rapp M,Slotty PJ,Turowski B,Sadat H,Smuga M,Dibué-Adjei M,Steiger HJ,Szelényi A,Sabel M

    更新日期:2015-06-01 00:00:00

  • Abnormal muscle response monitoring during microvascular decompression for hemifacial spasm.

    abstract:BACKGROUND:Several studies have investigated the relation between intraoperative abnormal muscle response (AMR) findings and postoperative results in patients undergoing microvascular decompression (MVD) for hemifacial spasm (HFS). However, there is some debate over the reliability of AMR as an indicator of postoperati...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Yamashita S,Kawaguchi T,Fukuda M,Watanabe M,Tanaka R,Kameyama S

    更新日期:2005-09-01 00:00:00

  • Lumbar microendoscopic discectomy: surgical technique and nuances.

    abstract:BACKGROUND:Lumbar microendoscopic discectomy (MED) is a minimally invasive transmuscular approach that combines standard lumbar microsurgical techniques with endoscopy. MED advantages include reduced tissue trauma, direct visualization of the nerve root and disc disease, and allowing bony decompression in cases with sp...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Azab WA,Nasim K,Najibullah M

    更新日期:2016-04-01 00:00:00

  • Proliferating cell nuclear antigen (PCNA) immunostaining as an alternative to bromodeoxyuridine (BrdU) immunostaining for brain tumours in paraffin embedded sections.

    abstract::Immunohistochemical staining for proliferating cell nuclear antigen (PCNA) and BrdU using anti-PCNA and anti-BrdU monoclonal antibodies, respectively, was performed in 16 human brain tumours, including 3 glioblastomas multiforme, 2 anaplastic astrocytomas, 1 cerebellar astrocytoma, 2 recurrent meningiomas, 4 non-recur...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Sasaki A,Naganuma H,Kimura R,Isoe S,Nakano S,Nukui H,Suzuki K,Kawaoi A

    更新日期:1992-01-01 00:00:00

  • Acquired hydrocephalus. II. Diagnostic and prognostic value of quantitative isotope ventriculography (QIV), lumbar isotope cisternography (LIC), pneumoencephalography, and continuous intraventricular pressure recording (CIP).

    abstract::The diagnostic and prognostic values of quantitative isotope ventriculography (QIV), lumbar isotope cisternography (LIC), pneumoencephalography (PEG), and continuous intraventricular pressure recording (CIP) were assessed on the basis of the clinical course in 160 patients suspected of having acquired hydrocephalus. T...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Jensen F,Jensen FT

    更新日期:1979-01-01 00:00:00

  • Computer tomography (CT) orientated rotary stereotactic system. A technical note.

    abstract::The system consists of an inverted U-shaped frame with right angled corners, so mounted that it can be adjusted vertically, antero-posteriorly and made to rotate on an axis ("the axis of the frame") formed by its free ends. The frame carries an arc probe carrier whose probe holder slides on an arc which is centered on...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Patil AA

    更新日期:1983-01-01 00:00:00

  • Prevention of cerebral vasospasm with OKY-046 an imidazole derivative and a thromboxane synthetase inhibitor. A preliminary co-operative clinical study.

    abstract::The prevention of cerebral vasospasm with OKY-046, an imidazole derivative and a thromboxane synthetase inhibitor, was studied co-operatively at ten neurosurgical services. Intravenous administrations of 2, 5 or 10 mu/kg/minute of OKY-046 were given continuously from the earliest possible day to the 14th SAH-day to 82...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Suzuki S,Iwabuchi T,Tanaka T,Kanayama S,Ottomo M,Hatanaka M,Aihara H

    更新日期:1985-01-01 00:00:00

  • Giant cell tumor of the lumbar spine with intraperitoneal growth: case report and review of literature.

    abstract::Giant cell tumors of the spine are uncommon. Usually they are benign and solitary, but locally very aggressive. Most of them occur at the sacral spine. There are only 26 reported cases in the literature involving this type of tumor in the lumbar spine, in particular exhibiting an intraperitoneal growth. We present the...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章,评审


    authors: Munoz-Bendix C,Cornelius JF,Bostelmann R,Gierga K,Steiger HJ

    更新日期:2013-07-01 00:00:00

  • Foramen ovale cannulation guided by intraoperative computed tomography with magnetic resonance image fusion plays a role in improving the long-term outcome of percutaneous radiofrequency trigeminal rhizotomy.

    abstract:BACKGROUND:Percutaneous radiofrequency trigeminal rhizotomy (RF-TR) is a well-established treatment for patients suffering from trigeminal neuralgia (TN) as a primary modality or for those refractory to medical treatment. However, few existing studies have identified intraoperative parameter or navigation technique tha...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Tsai PJ,Lee MH,Chen KT,Huang WC,Yang JT,Lin MH

    更新日期:2019-07-01 00:00:00

  • The cranial nerve vascular compression syndrome: II. A review of pathophysiology.

    abstract::The various hypotheses regarding the pathophysiologies of trigeminal neuralgia and hemifacial spasm are reviewed, and the results of recent physiological studies on the pathogenesis of hemifacial spasm are discussed. Evidence is presented that strongly supports the hypothesis that the symptoms and signs of hemifacial ...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章,评审


    authors: Møller AR

    更新日期:1991-01-01 00:00:00

  • Carpal tunnel syndrome and acromegaly.

    abstract::50 patients with acromegaly and carpal tunnel syndrome have been examined electrophysiologically before and after transnasal operation of the pituitary adenoma. 32 of the 50 patients (64%) had symptoms of carpal tunnel syndrome. 13 of them had neurological deficits. 28 of the examined patients had pathological neurogr...

    journal_title:Acta neurochirurgica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Baum H,Lüdecke DK,Herrmann HD

    更新日期:1986-01-01 00:00:00

  • Surgical resection of tumors located in subcortex of language area.

    abstract:OBJECT:Although functional mapping facilitates the planning of surgery in and around eloquent areas, the resection of tumors adjacent to language areas remains challenging. In this report, we took notice that the language areas (Broca's and Wernicke's) present at the perisylvian fissure. We posit that if there is non-e...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Sakurada K,Sato S,Sonoda Y,Kokubo Y,Saito S,Kayama T

    更新日期:2007-02-01 00:00:00

  • Long-term evaluation of EC-IC bypass patency.

    abstract::The EC-IC Bypass Study Group could not detect any benefit from surgery compared to medical management in the prevention of stroke in 1985 [15]. During the past years surgical revascularization was re-evaluated and considered as an appropriate treatment for a small subgroup of patients with recurrent focal cerebral isc...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Schick U,Zimmermann M,Stolke D

    更新日期:1996-01-01 00:00:00

  • Computed tomography and magnetic resonance imaging of mild head injury--is it appropriate to classify patients with Glasgow Coma Scale score of 13 to 15 as "mild injury"?

    abstract:OBJECTIVE:The purpose of this study is to examine the relation between Glasgow Coma Scale (GCS) score and findings on computed tomography (CT) and magnetic resonance (MR) imaging of patients with mild head injury presenting GCS scores between 13 and 15. METHODS:Data were collected from all consecutive patients with mi...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Uchino Y,Okimura Y,Tanaka M,Saeki N,Yamaura A

    更新日期:2001-10-01 00:00:00

  • Comparison of surgical exposure and maneuverability associated with microscopy and endoscopy in the retrolabyrinthine and transcrusal approaches to the retrochiasmatic region: a cadaveric study.

    abstract:BACKGROUND:The retrolabyrinthine and transcrusal approaches (RLA and TCA, respectively) are the two most often used posterior transpetrosal approaches that are used to treat lesions in the retrochiasmatic region. Endoscopes are increasingly used in neurosurgical practice. To determine whether a difference exists betwee...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Yang J,Zhang F,Xu A,Li H,Ding Z

    更新日期:2016-04-01 00:00:00

  • Thoracolumbar extradural arachnoid cysts: a study of 14 consecutive cases.

    abstract:BACKGROUND:To investigate characteristic clinical and radiological features of extradural arachnoid cysts (EDACs) in the thoracolumbar region, a retrospective review of medical records and imaging studies was performed. EDACs are well known but relatively rare lesions in the thoracolumbar spinal canal. The most common ...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Oh JK,Lee DY,Kim TY,Yi S,Ha Y,Kim KN,Shin H,Kim DS,Yoon DH

    更新日期:2012-02-01 00:00:00

  • New treatment protocol by intra-operative radiation therapy for metastatic brain tumours.

    abstract::In patients with brain metastasis from lung cancer, we have been able to control local recurrence in approximately 80% of cases. But many of them tend to show brain atrophy with mental deterioration developing a few months after whole brain radiation. To prevent brain atrophy, we have attempted treating patients, whos...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Nakamura O,Matsutani M,Shitara N,Okamoto K,Kaneko M,Nakamura H,Asai A,Ueki K,Shimizu T,Tanaka Y

    更新日期:1994-01-01 00:00:00

  • Subaxial cervical juxtafacet cysts: single institution surgical experience and literature review.

    abstract:OBJECTIVES:Juxtafacet cysts (JFCs) of the subaxial cervical spine are rare causes of neurological deficits. Their imaging characteristics, relationship to segmental instability, and potential for inducing acute symptomatic deterioration have only been described in a few case reports and small case series. The objective...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章,评审


    authors: Uschold T,Panchmatia J,Fusco DJ,Abla AA,Porter RW,Theodore N

    更新日期:2013-02-01 00:00:00

  • Investigation of epileptic structure properties by transfer function.

    abstract::The paper deals with the possibility of applying linear control theory and the theory of statistical dynamics to the complex and quantitative analysis of electroencephalographic records. The aim is to specify signals in the brain environment, in particular sources, speed and direction of signals, and the determination...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Neuschl S,Hluchy L,Nádvornik P,Sramka M

    更新日期:1976-01-01 00:00:00

  • An analysis of retractions in neurosurgery and allied clinical and basic science specialties.

    abstract:BACKGROUND:As the volume of scientific publications increases, the rate of retraction of published papers is also likely to increase. In the present study, we report the characteristics of retracted papers from clinical neurosurgery and allied clinical and basic science specialties. METHODS:Retracted papers were ident...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Madhugiri VS,Nagella AB,Uppar AM

    更新日期:2021-01-01 00:00:00

  • A contribution to the rapid diagnosis of subdural empyema.

    abstract::The authors report their experience with CT scanning ina series of 4 cases of subdural empyema, over a period of 10 months; all the patients were male, aged 16 to 25 years. A review of the literature shows that this disease, in spite of the large variety and efficacy of the available antibiotics, is marked by a signif...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Hadj-Djilani M,Calliauw L

    更新日期:1982-01-01 00:00:00

  • How I do it: operative nuances of multiple burr hole surgery for moyamoya disease and syndrome.

    abstract:BACKGROUND:Burr hole surgery for moyamoya disease and moyamoya syndrome is known to be an effective, versatile, and relatively simple revascularization technique. We will focus on the technical operative aspects of multiple burr hole surgery as we perform it in our center. METHODS:Periosteal flaps are prepared and pla...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Lavrysen E,Menovsky T

    更新日期:2019-01-01 00:00:00

  • The effect of mild hypothermia, mannitol and insulin-induced hypoglycaemia on ischaemic infarct volume in the early period after permanent middle cerebral artery occlusion in the rat.

    abstract::We investigated the effect of mild hypothermia (32-34 degrees C), mannitol and insulin - induced hypoglycaemia on the ischaemic infarct volume on permanent middle cerebral artery occlusion with bilateral carotid artery ligation in rats. Temporalis muscle temperature as an indicator of brain temperature was monitored t...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Kazan S,Karasoy M,Baloğlu H,Tuncer R

    更新日期:1999-01-01 00:00:00