Haem derivatives in subdural haematomas.

Abstract:

:The oxyhaemoglobin, methaemoglobin and bilirubin concentrations were determined in subdural haematomas and cerebrospinal fluid from 18 patients. The total haem derivative concentration ranged from 55 mumol/l to 13.9 mmol/l in the haematomas and from 0.1 mumol/l to 8.2 mumol/l in the cerebrospinal fluid. Bilirubin was the dominating fraction in haematomas with haem derivative concentrations lower than 1 mmol/l. For haematomas exceeding this value, the bilirubin transforming capacity seemed to have reached a maximum. More of the oxyhaemoglobin was oxidized to methaemoglobin in these cases, a reaction known to release superoxide radicals. The possible pathophysiological significance hereof, e.g. in cerebral vasospasm, is discussed.

journal_name

Acta Neurochir (Wien)

journal_title

Acta neurochirurgica

authors

Wahlgren NG,Lindquist C

doi

10.1007/BF01790770

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

109-13

issue

3-4

eissn

0001-6268

issn

0942-0940

journal_volume

95

pub_type

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