Pharmacological action of FPL 55712 on canine cerebral arterial segments.

Abstract:

:The pharmacological action of a leukotriene antagonist FPL 55712 was studied on canine cerebral arterial segments. FPL 55712 at concentrations of 10(-6)M and 10)-5)M showed dose-dependent inhibition of the constrictor responses of the artery to prostaglandin F2 alpha. The constrictor responses of the artery to either serotonin or haemoglobin were suppressed by 10(-5)M FPL 55712, while 10(-6)M FPL 55712 failed to alter the responses. The KCL-induced constriction was not affected by treatment with either 10(-6)M or 10(-5)M FPL 55712. The present results suggest that FPL 55712 has vasodilator properties other than those related to the inhibition of leukotrienes.

journal_name

Acta Neurochir (Wien)

journal_title

Acta neurochirurgica

authors

Sasaki T,Kassell NF,Turner DM,Comair YG,Yamashita M,Fujiwara S

doi

10.1007/BF01413283

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

81-3

issue

1-2

eissn

0001-6268

issn

0942-0940

journal_volume

74

pub_type

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