The hyperaemic response to a transient reduction in cerebral perfusion pressure. A modelling study.

Abstract:

:A mathematical model of cerebral blood flow and the cerebrospinal fluid circulation is described which permits the study of phenomena caused by dynamic changes in cerebrovascular autoregulatory or cerebrospinal fluid compensatory reserves. A transient decrease in cerebral perfusion pressure was produced by carotid artery compression. Comparison of the computer simulations with clinical and experimental data, reported elsewhere, suggests that the transient hyperaemic response (THR) is proportional to the strength of the autoregulatory response. The relationships between the magnitude and time course of the THR, and the period and level of reduction in CPP were studied. This model suggests that simple clinical tests based on the examination of THR using transcranial Doppler velocity measurements are of potential value for the non-invasive assessment of the autoregulatory reserve.

journal_name

Acta Neurochir (Wien)

journal_title

Acta neurochirurgica

authors

Czosnyka M,Pickard J,Whitehouse H,Piechnik S

doi

10.1007/BF01406364

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

90-7

issue

3-4

eissn

0001-6268

issn

0942-0940

journal_volume

115

pub_type

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