Factors affecting the extension of peritumoural brain oedema. A CT-study.

Abstract:

:In human brain tumours the extension of peritumoural brain oedema may vary considerably. 37 brain tumours of various pathology and 2 abscesses were examined to identify the factors and mechanisms responsible for the oedema spreading. Peritumoural oedema profiles were determined towards the white matter and ventricle by measuring the CT-numbers of consecutive tissue blocks of 3.0-3.6 mm from the tumour to the normal white matter or the ventricle. It was found that neither the size of the tumour nor the histology has a close relationship to the amount of peritumoural oedema. The distance of oedema spreading rather is determined by the amount of fluid accumulation in the white matter immediately bordering the tumour. This relationship corresponds to a semilogarithmic function and represents the relation between the tumour-adjacent accumulation of extracellular fluid volume and the distance of extracellular fluid movement. The analysis of this relation leads to the suggestion that pressure gradients and bulk flow are involved in the development of human peritumoural oedema.

journal_name

Acta Neurochir (Wien)

journal_title

Acta neurochirurgica

authors

Reulen HJ,Graber S,Huber P,Ito U

doi

10.1007/BF01793077

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

19-24

issue

1-2

eissn

0001-6268

issn

0942-0940

journal_volume

95

pub_type

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