Clinical outcome of ulcerative proctitis in children.

Abstract:

BACKGROUND:Although the course of ulcerative proctitis in adults has been well described, little data are available concerning its clinical behavior in children and adolescents. This study sought to characterize the presentation, response to therapy, and long-term course of ulcerative proctitis in the pediatric population. METHODS:A retrospective chart review was conducted at five pediatric gastroenterology centers. RESULTS:A total of 38 subjects (mean age 11.6 years) were identified with ulcerative proctitis (mean follow-up 4.3 years). Symptoms were mild at diagnosis in 74% and moderate or severe in 26%. Thirty-two percent had a complaint of constipation at presentation. Cessation of symptoms was noted in 68% within 3 months of therapy, an additional 24% within 6 months, and 8% were still symptomatic despite 6 months of therapy. During any subsequent yearly follow-up interval, -55% of patients were asymptomatic, 40% had a chronic intermittent course, and < 5% were continuously symptomatic despite therapy. Eight subjects were treated with oral corticosteroids, one with 6-mercaptopurine, and one with cyclosporine. Extension of inflammation proximal to the rectosigmoid occurred in 11 of 38 subjects (29%), 0.5-11.3 years postdiagnosis. Seven of the 13 subjects (54%) followed for > or = 5 years had proximal extension of disease, and two had undergone colectomy. CONCLUSIONS:Despite a mild presentation in most subjects, ulcerative proctitis seems to have a high risk of proximal extension of disease. The overall response to therapy seems to be similar to that reported for ulcerative colitis in children. Follow-up endoscopic evaluation of patients with ulcerative proctitis seems warranted, especially in the setting of recurrent or recalcitrant symptoms.

authors

Hyams J,Davis P,Lerer T,Colletti RB,Bousvaros A,Leichtner A,Benkov K,Justinich C,Markowitz J

doi

10.1097/00005176-199708000-00004

subject

Has Abstract

pub_date

1997-08-01 00:00:00

pages

149-52

issue

2

eissn

0277-2116

issn

1536-4801

journal_volume

25

pub_type

杂志文章,多中心研究
  • Evaluation of oral rehydration solution by whole-gut perfusion in rats: effect of osmolarity, sodium concentration and resistant starch.

    abstract:BACKGROUND:Reduced osmolarity oral rehydration solution (ORS) improved small bowel absorption of fluid and electrolytes in segmental perfusion in experimental animals; this was borne out in clinical practice. Adding amylase-resistant starch (RS) to ORS is expected to increase colonic fluid absorption. This study used c...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/01.mpg.0000239998.43141.b2

    authors: Subramanya S,Ramakrishna BS,Binder HJ,Farthing MJ,Young GP

    更新日期:2006-11-01 00:00:00

  • Transient hypergastrinemia of 2 years' duration in a young pediatric patient.

    abstract::A 24-month-old female child experienced watery diarrhea, growth failure, and abdominal pain from age 3 months. Hypergastrinemia, hypochlorhydria, and fundic gastritis were documented. A secretin stimulation test was normal but protein meal stimulation revealed an abnormal serum gastrin response. Antral biopsies reveal...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198403000-00025

    authors: Euler AR,Lechago J,Byrne W,France GL

    更新日期:1984-03-01 00:00:00

  • Comparison of the cholesteryl ester composition of human milk from preterm and term mothers.

    abstract::Milk was obtained on postpartum days 2-3 (colostrum) and days 7, 21, 42, and 84 from mothers of 18 very premature (VPT, 26-30 weeks gestational age), 28 premature (PT, 31-36 weeks), and 6 term (T, 37-40 weeks) infants. Lipids were extracted in chloroform-methanol and analyzed by thin-layer (TLC) and gas liquid chromat...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198609000-00020

    authors: Bitman J,Wood DL,Mehta NR,Hamosh P,Hamosh M

    更新日期:1986-09-01 00:00:00

  • Diet and Exercise in Pediatric Liver Transplant Recipients: Behaviors and Association With Metabolic Syndrome.

    abstract:OBJECTIVE:The aim of the study is to analyze the impact of physical activity and eating behaviors on precursors of cardiovascular disease-including overweight/obesity, hypertension, low high-density lipoprotein, and impaired glucose tolerance-in pediatric liver transplant (LT) recipients and matched controls. METHOD:C...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002150

    authors: Chambers JH,Zerofsky M,Lustig RH,Rosenthal P,Perito ER

    更新日期:2019-01-01 00:00:00

  • Resting energy expenditure in infants with cystic fibrosis.

    abstract::To evaluate the contribution of energy expenditure to the energy imbalance seen in cystic fibrosis patients, resting energy expenditure was measured using open-circuit indirect calorimetry in eight infants with cystic fibrosis, aged 2-7 months (mean, 4), without overt lung disease and in 10 healthy age-matched control...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199402000-00015

    authors: Girardet JP,Tounian P,Sardet A,Veinberg F,Grimfeld A,Tournier G,Fontaine JL

    更新日期:1994-02-01 00:00:00

  • Bacterial [correction of baterial] translocation in humans.

    abstract::Bacterial translocation is a phenomenon in which live bacteria cross the intestinal barrier. The definition may be broadened to include transmural passage of bacterial cell wall components such as lipopolysaccharide and peptidoglycan polysaccharide. After translocation, bacteria or their products reach the mesenteric ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/00005176-200107000-00001

    authors: Lichtman SM

    更新日期:2001-07-01 00:00:00

  • Dysbiosis in Snoring Children: An Interlink to Comorbidities?

    abstract:BACKGROUND AND OBJECTIVES:Early microbial colonization has a key impact on infant health through nutritional, immunological, and metabolic programming. The origin of child snoring is multifactorial and complex, and may thereby also generate long-term health problems. The link between child snoring and gut microbes rema...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002161

    authors: Collado MC,Katila MK,Vuorela NM,Saarenpää-Heikkilä O,Salminen S,Isolauri E

    更新日期:2019-02-01 00:00:00

  • "Let there be bile"--understanding hepatic injury in cholestasis.

    abstract::Cholestatic liver disorders account for a large proportion of chronic liver ailments in adults, children and infants, and are among the leading indications for liver transplantation in all age groups. Recent studies have begun to characterize the cellular and molecular mechanisms of hepatocyte injury caused by the ret...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/01.mpg.0000226384.71859.16

    authors: Sokol RJ,Devereaux M,Dahl R,Gumpricht E

    更新日期:2006-07-01 00:00:00

  • Endotoxemia in protein-energy malnutrition.

    abstract::The plasma endotoxin levels of 16 severely malnourished Thai children were determined by the Limulus amebocyte lysate assay. Endotoxemia was present in seven children (44%) on admission to the hospital and was associated with the coexistence of vitamin A deficiency. Protein-energy malnutrition is associated with the p...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198803000-00012

    authors: Klein K,Fuchs GJ,Kulapongs P,Mertz G,Suskind RM,Olson RE

    更新日期:1988-03-01 00:00:00

  • Characterisation of the local inflammatory response in appendicitis.

    abstract::In this study we have characterised the local inflammatory response in acute suppurative appendicitis (S), focal appendicitis (F), and normal appendices (C). Enumeration of lymphocyte subpopulations, cells expressing IL-2 receptor, natural killer (NK) cells, monocytes and plasma cell isotypes and subclasses infiltrati...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199301000-00008

    authors: Tsuji M,Puri P,Reen DJ

    更新日期:1993-01-01 00:00:00

  • Clinical and Genetic Study of Children With Peutz-Jeghers Syndrome Identifies a High Frequency of STK11 De Novo Mutation.

    abstract:OBJECTIVES:The present study aims to identify the genotype-phenotype correlation in children with Peutz-Jeghers Syndrome (PJS) through the analysis of STK11 gene mutations in the context of clinical and pathological characteristics. METHOD:In this observational cohort study, the clinical characteristics of 18 families...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002166

    authors: Zhao HM,Yang YJ,Duan JQ,Ouyang HJ,Liu L,Yi LC,Xiao ZH,Zheng Y,Peng L,Attard TM,Li DY,You JY

    更新日期:2019-02-01 00:00:00

  • Tolerability, safety, and efficacy of PEG 3350 as a 1-day bowel preparation in children.

    abstract:OBJECTIVE:The aim of the study was to evaluate the tolerability, safety, and efficacy of polyethylene glycol (PEG) 3350 without electrolytes as a 1-day bowel preparation for colonoscopy in children. METHODS:A prospective study of 45 children undergoing colonoscopy prescribed PEG 3350 without electrolytes mixed with a ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3182758c69

    authors: Walia R,Steffen R,Feinberg L,Worley S,Mahajan L

    更新日期:2013-02-01 00:00:00

  • Hepatic abscess as a complication of Crohn's disease.

    abstract::A 17-year-old male with Crohn's disease presented with persistent fever and right upper quadrant tenderness. Ultrasonography and abdominal computerized axial tomography (CAT scan) showed two large loculated abscess cavities in the right lobe of the liver. Surgical drainage and antibiotic therapy led to resolution of b...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198302010-00021

    authors: Weinberg RJ,Klish WJ,Brown MR,Smalley JR,Emmens RW

    更新日期:1983-01-01 00:00:00

  • Reactive nitrogen species modulate the effects of rhein, an active component of senna laxatives, on human epithelium in vitro.

    abstract:BACKGROUND:Senna laxatives are used worldwide. However, their misuse can lead to chronic mucosal inflammation with the accumulation of pigment-laden leukocytes and may cause colon cells to undergo apoptosis. This study explores the mechanisms by which rhein, an active component of senna, acts on a human intestinal cell...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-200205000-00011

    authors: Raimondi F,Santoro P,Maiuri L,Londei M,Annunziata S,Ciccimarra F,Rubino A

    更新日期:2002-05-01 00:00:00

  • Assessment of the Family History of Patients With Ulcerative Colitis at a Single Center in Japan.

    abstract:OBJECTIVES:The prevalence of ulcerative colitis (UC) differs by country, which is likely due to differences in genetic factors among ethnicities. Moreover, the prevalence of pediatric UC with a family history (FH) is 4.1% in Japanese patients; its clinical course begins at an early age and is more severe. Recently, a g...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001275

    authors: Fujii T,Sato M,Hosoi K,Ohbayashi N,Ikuse T,Jimbo K,Aoyagi Y,Kudo T,Ohtsuka Y,Shimizu T

    更新日期:2016-11-01 00:00:00

  • Effects of oral administration of bifidobacterium breve on fecal lactic acid and short-chain fatty acids in low birth weight infants.

    abstract:OBJECTIVES:Short-chain fatty acids (SCFAs) are known to provide energy to colonocytes, whereas overproduction of SCFAs can cause mucosal injury in premature infants. Our objective was to investigate the effects of the oral administration of Bifidobacterium breve M-16V (B breve) on fecal lactic acid and SCFAs in low bir...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/01.mpg.0000252184.89922.5f

    authors: Wang C,Shoji H,Sato H,Nagata S,Ohtsuka Y,Shimizu T,Yamashiro Y

    更新日期:2007-02-01 00:00:00

  • Polymorphonuclear leukocytes and human colostrum: effects of in vivo and in vitro exposure.

    abstract::Polymorphonuclear leukocytes (PMN) from human colostrum were compared with blood and oral exudate PMN from the same donors for their locomotive, respiratory burst, phagocytic, and shape change (polarization) capabilities. Blood PMN were functionally superior to PMN from other sites. Colostrum PMN were similar to oral ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199311000-00016

    authors: Buescher ES,McIlheran SM

    更新日期:1993-11-01 00:00:00

  • Impact of early dietary intake and blood lipid composition of long-chain polyunsaturated fatty acids on later visual development.

    abstract:BACKGROUND:In contrast to human milk, current infant formulas in the United States do not contain omega3 and omega6 long-chain polyunsaturated fatty acids. This may lead to suboptimal blood lipid fatty acid profiles and to a measurable diminution of visual function in developing term infants. The need for docosahexaeno...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005176-200011000-00016

    authors: Hoffman DR,Birch EE,Birch DG,Uauy R,Castañeda YS,Lapus MG,Wheaton DH

    更新日期:2000-11-01 00:00:00

  • Reporting outcome measures in trials of infant colic.

    abstract:OBJECTIVES:Infant colic (IC), with an estimated prevalence of 5% to 25%, has a high impact on health care costs. Furthermore, reported negative sequelae are disturbed parent-infant interaction, increased susceptibility to abdominal pain, and even child abuse. Its etiology remains unknown, leading to a wide variety in i...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/MPG.0000000000000412

    authors: Steutel NF,Benninga MA,Langendam MW,de Kruijff I,Tabbers MM

    更新日期:2014-09-01 00:00:00

  • Increasing incidence of paediatric inflammatory bowel disease in northern Stockholm County, 2002-2007.

    abstract:OBJECTIVES:A sharp increase in paediatric (younger than 16 years) inflammatory bowel disease (IBD) incidence was observed in northern Stockholm County, Sweden, in 1990-2001. The increasing incidence was primarily explained by a rising incidence of Crohn disease (CD). Here, we present an update on the trends in incidenc...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e31828f21b4

    authors: Malmborg P,Grahnquist L,Lindholm J,Montgomery S,Hildebrand H

    更新日期:2013-07-01 00:00:00

  • Comparison of Recommendations for Treatment of Chronic Hepatitis C Virus Infection in Children and Adolescents: A Position Paper of the Federation of International Societies of Pediatric Gastroenterology, Hepatology, and Nutrition.

    abstract:OBJECTIVE:This position paper written by the Hepatitis Expert Team of the Federation of International Societies of Pediatric Gastroenterology, Hepatology, and Nutrition aimed to systematically evaluate clinical practice guidelines (CPGs), medical consensus, and position papers on the use of direct-acting antivirals (DA...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002710

    authors: Indolfi G,Fischler B,Gonzalez-Peralta RP,Ciocca M,Porta G,Neelam M,El-Guindi M,Kelly D,Ni YH,Sibal A,Leung DH,Chang MH,Hepatitis Expert Team of the Federation of International Societies of Pediatric Gastroenterology, Hepatology,

    更新日期:2020-05-01 00:00:00

  • Genetic polymorphisms of CD14, toll-like receptor 4, and caspase-recruitment domain 15 are not associated with necrotizing enterocolitis in very low birth weight infants.

    abstract:OBJECTIVES:Inadequate response of the innate immune system to bacterial antigens present in the intestinal flora may play a role in the development of necrotizing enterocolitis (NEC). Pattern recognition receptors such as CD14, toll-like receptor (TLR) 4, and caspase-recruitment domain (CARD) 15 bind bacterial lipopoly...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/01.mpg.0000192246.47959.b2

    authors: Szebeni B,Szekeres R,Rusai K,Vannay A,Veres G,Treszl A,Arató A,Tulassay T,Vásárhelyi B

    更新日期:2006-01-01 00:00:00

  • Serum 25-hydroxyvitamin D levels in preschool-age children in northern Sweden are inadequate after summer and diminish further during winter.

    abstract:BACKGROUND AND OBJECTIVE:Despite studies indicating that vitamin D intake among Swedish children does not meet the recommendation, little is known of their vitamin D status. The aim of the present study was to examine vitamin D status in preschool-age children in relation to vitamin D intake, season, body mass index, a...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3182838e5b

    authors: Öhlund I,Silfverdal SA,Hernell O,Lind T

    更新日期:2013-05-01 00:00:00

  • Expression of intestinal and lung alkaline sphingomyelinase and neutral ceramidase in cystic fibrosis f508del transgenic mice.

    abstract:OBJECTIVES:The intestinal brush border enzymes alkaline sphingomyelinase (alk-SMase) and neutral ceramidase (CDase) digest milk sphingomyelin in suckling neonates. In addition, alk-SMase, CDase, and acid sphingomyelinase (acid-SMase) have been implicated in sphingolipid signaling, which exhibits abnormalities in cystic...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3181826daf

    authors: Ohlsson L,Hjelte L,Hühn M,Scholte BJ,Wilke M,Flodström-Tullberg M,Nilsson A

    更新日期:2008-11-01 00:00:00

  • Faecal calprotectin in term and preterm neonates.

    abstract:OBJECTIVES:The aim of this review was to examine the characteristics of the faecal calprotectin assay in neonates and the evidence for its use as a noninvasive marker of intestinal illnesses during the neonatal period. METHODS:Bibliographic searches were performed in the MEDLINE electronic database up to February 2010...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/MPG.0b013e3181e2ad72

    authors: Kapel N,Campeotto F,Kalach N,Baldassare M,Butel MJ,Dupont C

    更新日期:2010-11-01 00:00:00

  • Systematic Evaluation of Diagnostic Delay in Pediatric Inflammatory Bowel Disease.

    abstract::We evaluated the diagnostic delay (time from first symptoms to diagnosis) in 100 pediatric patients with Crohn disease (CD) and 75 patients with ulcerative colitis (UC). Median (interquartile range) diagnostic delay in patients with CD was 4 (2-8) (range 0-82) months compared with 2 (1-7) (range 0-52) months in patien...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001238

    authors: Schoepfer AM,Vavricka S,Safroneeva E,Fournier N,Manser C,Frei P,Deltenre P,Rogler G,Straumann A,Ezri J,Nydegger A,Braegger C

    更新日期:2017-02-01 00:00:00

  • Impact of Breast Milk, Respiratory Insufficiency, and Gastroesophageal Reflux Disease on Enteral Feeding in Infants With Omphalocele.

    abstract:OBJECTIVES:The aim of this study was to document the process of achieving full enteral feeding in infants with omphalocele and to identify factors that affect feeding success. METHODS:After institutional review board approval (study no. 5100169), 123 infants with omphalocele, born between 1993 and 2011 were reviewed. ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001463

    authors: Haug S,St Peter S,Ramlogan S,Goff D,Thorpe D,Hopper A,Baerg J

    更新日期:2019-06-01 00:00:00

  • Donor Human Milk and Fortifier Use in United States Level 2, 3, and 4 Neonatal Care Hospitals.

    abstract:OBJECTIVE:In 2011, the United States Surgeon General issued a call to action to "identify and address obstacles to greater availability of safe banked donor milk for fragile infants." The purpose of the present study is to analyze patterns in donor human milk (DHM) and fortifier use in level 2, 3, and 4 neonatal facili...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001790

    authors: Perrin MT

    更新日期:2018-04-01 00:00:00

  • Exocrine pancreatic function in children with progressive familial intrahepatic cholestasis type 2.

    abstract::In progressive familial intrahepatic cholestasis type 2 (PFIC-2), severe steatorrhea is often documented. However, pancreatic exocrine secretion has not yet been studied. In 14 children with PFIC-2, pancreatic function was assessed using standard fecal tests. Normal fecal lipase concentrations excluded isolated lipase...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/01.mpg.0000218154.26792.6a

    authors: Walkowiak J,Jankowska I,Pawlowska J,Strautnieks S,Bull L,Thompson R,Herzig KH,Socha J

    更新日期:2006-04-01 00:00:00

  • Gastrointestinal Symptoms Predictors of Health-Related Quality of Life in Patients With Inflammatory Bowel Disease.

    abstract:OBJECTIVES:The aim of the study was to investigate the multidimensional gastrointestinal symptoms predictors of generic health-related quality of life (HRQOL) in pediatric patients with inflammatory bowel disease from the perspectives of pediatric patients and parents. METHODS:The Pediatric Quality of Life Inventory G...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MPG.0000000000001428

    authors: Varni JW,Shulman RJ,Self MM,Saeed SA,Patel AS,Nurko S,Neigut DA,Saps M,Franciosi JP,Denham JM,Zacur GM,Dark CV,Bendo CB,Pohl JF,Pediatric Quality of Life Inventory Gastrointestinal Symptoms Module Testing Study Consortium.

    更新日期:2016-12-01 00:00:00