Peritoneal mesothelioma in recurrent familial peritonitis.

Abstract:

:A 39-year-old man had a 2-year history of fatigue, weight loss, drug-resistant ascites, and decreased intestinal motility. During adolescence he began to suffer frequent episodes of acute benign peritonitis that spontaneously subsided at age 35. The fact that his younger brother was taking colchicine for the same symptoms led us to diagnose familial Mediterranean fever (FMF). The medical workup revealed uniform thickening of the intestinal wall with no signs of amyloidosis. Exploratory laparotomy revealed diffuse peritoneal mesothelioma that proved to be unresponsive to chemotherapy. There was no history of asbestos exposure. It is probable that the chronic peritoneal inflammation was responsible for the development of this tumor, although in almost all cases of FMF this phenomenon causes only limited peritoneal fibrosis or, less commonly, encapsulating peritonitis. A computerized search of the literature indicates that this is the second report of peritoneal mesothelioma associated with FMF.

journal_name

J Clin Gastroenterol

authors

Gentiloni N,Febbraro S,Barone C,Lemmo G,Neri G,Zannoni G,Capelli A,Gasbarrini G

doi

10.1097/00004836-199706000-00023

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

276-9

issue

4

eissn

0192-0790

issn

1539-2031

journal_volume

24

pub_type

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