Demonstration of two disease specific antigens in circulating immune complexes.

abstract：:Clustering activity for neutrophil granulocytes was generated in pooled normal human serum (NHS) by incubation of the serum with preformed IgG aggregates, but not in heat-treated NHS (56 degrees C, 30 min), indicating that the function was complement-dependent. Judging from results of experiments with complement-defic...

journal_title：Clinical and experimental immunology

authors： Sturfelt G,Jonsson H,Hellmer G,Sjöholm AG

更新日期：1993-08-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial fibroblast hyperplasia and bone erosion. Fibroblast-like synoviocytes (FLS) play a pivotal role in RA pathogenesis through aggressive migration and matrix invasion, and certain proinflammatory cytokines may affect synoviocyte invasio...

journal_title：Clinical and experimental immunology

authors： Xing R,Jin Y,Sun L,Yang L,Li C,Li Z,Liu X,Zhao J

更新日期：2016-05-01 00:00:00

abstract：:Expression of the inducible form of nitric oxide synthase (iNOS) has been found to be up-regulated in cytokine-stimulated mesangial cells (MC) and in experimental glomerulonephritis. Since direct toxicity of nitric oxide (NO) has been implicated in damage of bacteria, neoplastic and intact pancreatic cells, we investi...

journal_title：Clinical and experimental immunology

authors： Hruby Z,Beck KF

更新日期：1997-01-01 00:00:00

abstract：:A microplate radioimmunoassay for IgG, IgA and IgM antiglobulins reactive with rabbit IgG was performed on sera from 69 patients with various connective tissue diseases. IgM antiglobulins were detected in rheumatoid arthritis, systemic sicca syndrome and some patients with systemic vasculitis. IgA antiglobulins were f...

journal_title：Clinical and experimental immunology

authors： Elkon KB,Caeiro F,Gharavi AE,Patel BM,Ferjencik PP,Hughes GR

更新日期：1981-12-01 00:00:00

abstract：:In vitro IgG synthesis by peripheral blood mononuclear cells (PBM) from patients with chronic liver disease (CLD) was studied. In addition, the effect of pokeweed mitogen (PWM), polyadenylic-polyuridylic acid complexes (poly A:U) and thymosin fraction 5 on IgG synthesis was determined. Unstimulated cultures of PBM fro...

journal_title：Clinical and experimental immunology

authors： Mutchnick MG,Lederman HM,Missirian A,Johnson AG

更新日期：1981-02-01 00:00:00

abstract：:The T cell response to different Leishmania donovani antigens was investigated using peripheral blood mononuclear cells (PBMC) from Kenyans cured of visceral leishmaniasis and non-exposed Danes. Crude promastigote and amastigote antigens both induced proliferation and interferon-gamma (IFN-gamma) production in PBMC fr...

journal_title：Clinical and experimental immunology

authors： Kurtzhals JA,Hey AS,Jardim A,Kemp M,Schaefer KU,Odera EO,Christensen CB,Githure JI,Olafson RW,Theander TG

更新日期：1994-06-01 00:00:00

abstract：:During the past decade several notable viruses have suddenly emerged from obscurity or anonymity to become serious global health threats, provoking concern regarding their sustained epidemic transmission in immunologically naive human populations. With each new threat comes the call for rapid vaccine development. Inde...

journal_title：Clinical and experimental immunology

authors： Afrough B,Dowall S,Hewson R

更新日期：2019-05-01 00:00:00

abstract：:Haematopoietic stem cell transplantation (HSCT) is an immunological treatment that has been used for more than 40 years to cure a variety of diseases. The procedure is associated with serious side effects, due to the severe impairment of the immune system induced by the treatment. After a conditioning regimen with hig...

journal_title：Clinical and experimental immunology

authors： Bemark M,Holmqvist J,Abrahamsson J,Mellgren K

更新日期：2012-01-01 00:00:00

abstract：:A solid-phase platelet membrane enzyme linked immunosorbent assay (ELISA) was developed for the detection of circulating platelet binding IgG in serum. 18 out of 28 (64%) sera from patients with chronic idiopathic thrombocytopenic purpura (ITP) and 10 out of 21 (48%) sera from patients with acute ITP contained more pl...

journal_title：Clinical and experimental immunology

authors： Winiarski J,Ekelund E

更新日期：1986-02-01 00:00:00

abstract：:We describe a patient with hypergammaglobulinaemic purpura and show that the serum contains IgG and IgA immune complexes sedimenting between IgM and IgG on ultracentrifugation. The complexes containing IgG were markedly temperature dependent. A drop in temperature from 37 degrees C to 28 degrees C gave a seventeen-fol...

journal_title：Clinical and experimental immunology

authors： Roberts-Thomson PJ,Kemp AS

更新日期：1980-01-01 00:00:00

abstract：:Thyroid autoantigens require internalization and processing by antigen-presenting cells to induce immune responses. Besides pinocytosis, antigen uptake can be receptor-mediated. The mannose receptor (ManR) has a cysteine rich domain (CR) and eight carbohydrate recognition domains (CRD) that bind glycosylated proteins....

journal_title：Clinical and experimental immunology

authors： Chazenbalk GD,Pichurin PN,Guo J,Rapoport B,McLachlan SM

更新日期：2005-02-01 00:00:00

abstract：:The cytotoxic responses of peripheral blood lymphocytes from cottontop tamarins to in vitro restimulation with autologous lymphoblastoid cell lines (LCL) were assayed. Lymphocytes from immune tamarins that had recovered from EBV challenge developed potent cytotoxicity for natural killer (NK) cell targets and for autol...

journal_title：Clinical and experimental immunology

authors： Wilson AD,Shooshstari M,Finerty S,Watkins P,Morgan AJ

更新日期：1996-02-01 00:00:00

abstract：:IgG2 deficiency has been recently associated with the appearance of vasculitis. None of the 42 patients with IgG2 deficiency whom we studied has a history of vasculitis. We have also studied 56 patients with vasculitis, and found four of them with IgG2 levels below the normal range for their age. As a group, the vascu...

journal_title：Clinical and experimental immunology

authors： Jiménez A,López-Trascasa M,Fontán G

更新日期：1989-11-01 00:00:00

abstract：:An original representative of histamine-containing peptidomimetics L-glutamyl-histamine (L-Glu-Hist) was synthesized and characterized as a cytokine mimic leading to cellular responses of improved specificity. The energy-minimized 3-D conformations of L-Glu-Hist derived from its chemical structure resulted in stabiliz...

journal_title：Clinical and experimental immunology

authors： Babizhayev MA,Semiletov YA,Lul'kin YA,Sakina NL,Savel'yeva EL,Alimbarova LM,Barinskii IP

更新日期：2005-03-01 00:00:00

abstract：:We report on the experience of establishing a national network for a quality control programme in evaluating CD4 cell counts in most Italian centres involved in the care of patients with HIV disease. The 68 centres were divided according to their geographical location into eight groups, and twice a year (tests A and B...

journal_title：Clinical and experimental immunology

authors： Pandolfi F,Alario C,Girardi E,Rava L,Ippolito G,Kunkl A,Aiuti F

更新日期：1998-03-01 00:00:00

abstract：:We have reported recently that mouse liver NK cells and NK1 x 1+ T cells were activated by bacterial superantigens via the IL-12 production from Kupffer cells. In the present study, we examined the effect of staphyloccoccal enterotoxin A (SEA) on human T cells with NK cell markers, CD56 or CD57 (NK-type T cells). Afte...

journal_title：Clinical and experimental immunology

authors： Ami K,Ohkawa T,Koike Y,Sato K,Habu Y,Iwai T,Seki S,Hiraide H

更新日期：2002-06-01 00:00:00

abstract：:A solid-phase radioimmunoassay was developed to detect antibodies to liver membrane antigens in sera of patients with HBsAg-negative and -positive liver diseases and primary non-hepatic autoimmune diseases. Ten of fourteen patients with HBsAg-negative CAH had autoantibodies detected by RIA; negative results were obtai...

journal_title：Clinical and experimental immunology

authors： Manns M,Meyer zum Büschenfelde KH,Hütteroth TH,Hess G

更新日期：1980-11-01 00:00:00

abstract：:Five out of 51 sera (10%) from patients with progressive systemic sclerosis reacted by immunoblotting with tissue concanavalin A binding glycoproteins of 50 kD and 45 kD Mr, whereas only one out of 133 control sera gave the same reaction (P less than 0.001). The antigens were localized to the microsomal fractions of t...

journal_title：Clinical and experimental immunology

authors： Alderuccio F,Witherden D,Toh BH,Barnett A

更新日期：1989-10-01 00:00:00

abstract：:Peripheral leucocytes and platelets from twenty healthy volunteers were incubated in vitro with radiographic contrast media (diatrizoate-Hypaque, iothalamate-Conray and iodipamide-Cholografin) under varying conditions. All radiographic contrast media (RCM) were able to induce histamine release from peripheral leucocyt...

journal_title：Clinical and experimental immunology

authors： Ring J,Arroyave CM,Frizler MJ,Tan EM

更新日期：1978-04-01 00:00:00

abstract：:Parechymal cells (PC) were prepared by digestion of perfused, lavaged rat lung in a mixture of collagenase and DNase, and harvested on a discontinuous percoll gradient. The process yielded on average 1.0 X 10(8) viable cells/gram tissue. PC were pulsed with soluble antigen, and tested for their capacity to trigger ant...

journal_title：Clinical and experimental immunology

authors： Holt PG,Degebrodt A,O'Leary C,Krska K,Plozza T

更新日期：1985-12-01 00:00:00

abstract：:Delayed hypersensitivity skin reactions to tuberculin when injected alone or in mixture with antigens of M. leprae were examined in leprosy patients and in healthy controls. The tuberculin reaction was significantly inhibited in more than one half of both LL and BT patients by the soluble extract of M. leprae (leprosi...

journal_title：Clinical and experimental immunology

authors： Sengupta U,Sinha S,Ramu G,Lamb J,Ivanyi J

更新日期：1987-04-01 00:00:00

abstract：:The immune system and the kidneys are closely linked. In health the kidneys contribute to immune homeostasis, while components of the immune system mediate many acute forms of renal disease and play a central role in progression of chronic kidney disease. A dysregulated immune system can have either direct or indirect...

journal_title：Clinical and experimental immunology

authors： Tecklenborg J,Clayton D,Siebert S,Coley SM

更新日期：2018-05-01 00:00:00

abstract：:Hyperlipidaemia accompanies chronic renal disease either as a consequence of the renal dysfunction or as part of generalized metabolic derangements. Under both situations, the lipid profile is characterized by accumulation of triglyceride-rich lipoproteins (TGRLs). This lipid profile is recognized as a risk factor for...

journal_title：Clinical and experimental immunology

authors： Saja MF,Cook HT,Ruseva MM,Szajna M,Pickering MC,Woollard KJ,Botto M

更新日期：2018-06-01 00:00:00

abstract：:Both MRL-lpr/lpr (lpr) and BXSB mice fall victim to autoimmune disease as a function of age. To combine their properties, brother-sister mating of (female lpr x male BXSB)F1 mice was done. Mice for mating were selected according to indicators of early onset of glomerulonephritis and subsequent early death (i.e., EOD)....

journal_title：Clinical and experimental immunology

authors： Honda S,Nemoto K,Mae T,Kinjoh K,Kyogoku M,Kawamura H,Miyazawa S,Weerashinghe A,Watanabe H,Narita J,Koya T,Arakawa M,Abo T

更新日期：1999-04-01 00:00:00

abstract：:The administration of the polyclonal activator HgCl2 (1 mg/kg i.p.) to Brown Norway (BN) rats on days 0, 2, 4 and 7 resulted in the cyclical production of anti-glomerular basement membrane (GBM) antibodies, the first peak of which occurred at day 14 with a smaller peak at day 26. Glomerular anti-GBM antibody levels we...

journal_title：Clinical and experimental immunology

authors： Savige JA,Lockwood CM

更新日期：1987-12-01 00:00:00

abstract：:Mutations in the signal transducer and activator of transcription 3 (STAT3) were reported to cause hyperimmunoglobulin E syndrome (HIES). The present study investigates T helper type 17 (Th17) responses triggered by the relevant stimuli Staphylococcus aureus and Candidia albicans in five 'classical' HIES patients, and...

journal_title：Clinical and experimental immunology

authors： van de Veerdonk FL,Marijnissen RJ,Joosten LA,Kullberg BJ,Drenth JP,Netea MG,van der Meer JW

更新日期：2010-01-01 00:00:00

abstract：:Enormous progress has been made during the last 25 years in our understanding of the aetiopathogenesis of the anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV). This has led to improvements in early diagnosis, treatment and secondary prevention of these diseases. Nevertheless, there are sti...

journal_title：Clinical and experimental immunology

authors： Kallenberg CG

更新日期：2011-05-01 00:00:00

abstract：:CBA/KlJms-lprcg/lprcg mice with a novel mutation producing systemic lymphoproliferation were investigated for their serological and histological characteristics. The mutant mice showed elevated levels of serum immunoglobulin, C1q-binding immune complexes and antibodies to nuclear antigens such as dsDNA and ssDNA and p...

journal_title：Clinical and experimental immunology

authors： Kimura M,Mohri H,Shimada K,Wakabayashi T,Kanai Y,Matsuzawa A

更新日期：1990-01-01 00:00:00

abstract：:A phenotypic and functional analysis of the circulating natural killer (NK) cell population was carried out in a series of patients with hairy cell leukaemia (HCL). The overall mean NK activity of both the mononuclear and T cell fractions was reduced compared to that of normal controls (466 lytic units (lu) v 573 lu a...

journal_title：Clinical and experimental immunology

authors： Foa R,Lauria F,Lusso P,Raspadori D,Fierro MT,Tazzari PL,Caudana L,Matera L

更新日期：1986-05-01 00:00:00

abstract：:Human lymphokine-activated killer (LAK) cells developed by an incubation of peripheral mononuclear cells with IL-2 express the membrane-associated lymphotoxin (LT)-related molecule (mLT). By a further cultivation of mLT expressing (mLT-positive) LAK cells for 24 h without IL-2, mLT disappears (mLT-negative LAK cells)....

journal_title：Clinical and experimental immunology

authors： Horiuchi A,Abe Y,Miyake M,Kimura K,Hitsumoto Y,Takeuchi N,Kimura S

更新日期：1994-04-01 00:00:00