IgA and temperature dependent IgG complex formation in a patient with Waldenström's hypergammaglobulinaemic purpura.

abstract：:Human umbilical vein endothelial cells (HUVEC) were investigated for their ability to produce neopterin, a biochemical marker for an activated immune system. Interferon-gamma (IFN-gamma), IL-1 alpha, IL-2, IL-6, tumour necrosis factor-alpha, granulocyte/macrophage colony stimulating factor, phytohaemagglutinin and con...

journal_title：Clinical and experimental immunology

authors： Andert SE,Griesmacher A,Zuckermann A,Müller MM

更新日期：1992-06-01 00:00:00

abstract：:Peripheral blood mononuclear cells from 97 predominantly lepromatous leprosy patients and 11 control subjects were tested in a lymphoproliferative assay for response to Mycobacterium leprae (whole and sonicated), and sonicated M. vaccae, M. tuberculosis, and M. scrofulaceum, in the presence and absence of three types ...

journal_title：Clinical and experimental immunology

authors： Barnass S,Mace J,Steele J,Torres P,Gervasoni B,Ravioli R,Terencio J,Rook GA,Waters MF

更新日期：1986-04-01 00:00:00

abstract：:Modern era advancements in medical care, with improved treatment of infections, can result in delayed diagnosis of congenital immunodeficiencies. In this study we present a retrospective cohort of 16 patients diagnosed with Chronic Granulomatous Disease (CGD) at adulthood. Some of the patients had a milder clinical ph...

journal_title：Clinical and experimental immunology

authors： Barkai T,Somech R,Broides A,Gavrieli R,Wolach B,Marcus N,Hagin D,Stauber T

更新日期：2020-09-01 00:00:00

abstract：:Reduced microbial exposure in early life may contribute to the increase of atopic diseases in 'westernized' societies but the underlying mechanisms remain elusive. The objective of this study was to examine how exposure to bacterial lipopolysaccharide (LPS) during early antigen encounter might influence the maturation...

journal_title：Clinical and experimental immunology

authors： Haddeland U,Sletten GB,Brandtzaeg P,Nakstad B

更新日期：2005-02-01 00:00:00

abstract：:Autoimmune diseases are either tissue-specific like multiple sclerosis (MS) or multisystemic like systemic lupus erythematosus (SLE), although clinically both exhibit common features. To gain insight into the properties of the genes involved in each disease we have investigated the gene expression signature of periphe...

journal_title：Clinical and experimental immunology

authors： Mandel M,Gurevich M,Pauzner R,Kaminski N,Achiron A

更新日期：2004-10-01 00:00:00

abstract：:We have demonstrated that mannose-binding lectin (MBL) recognizes various slow-growing, pathogenic mycobacteria [Mycobacterium tuberculosis (MTB), M. bovis, M. kansasii, M. gordonae] as well as non-pathogenic M. smegmatis. Recognition resulted in activation of the lectin pathway (LP) of complement and an enhancement o...

journal_title：Clinical and experimental immunology

authors： Bartlomiejczyk MA,Swierzko AS,Brzostek A,Dziadek J,Cedzynski M

更新日期：2014-11-01 00:00:00

abstract：:The aim of this study was to identify the epitopes recognized by antibodies to the asialoglycoprotein receptor, a specific hepatocyte protein, from sera of patients with autoimmune hepatitis. An ELISA test was used to detect anti-asialoglycoprotein receptor antibodies in the sera of patients with autoimmune hepatitis....

journal_title：Clinical and experimental immunology

authors： Hajoui O,Martin S,Alvarez F

更新日期：1998-09-01 00:00:00

abstract：:Recently, naturally occurring antibodies to IFN-alpha were discovered in a few systemic lupus erythematosus (SLE) and cancer patients; however, in most patients monitored for anti-IFN antibodies before treatment, no antibodies were found. In an attempt to explain the 'IFN-blocking effect' that we observed in all serum...

journal_title：Clinical and experimental immunology

authors： Ross C,Hansen MB,Schyberg T,Berg K

更新日期：1990-10-01 00:00:00

abstract：:Human gut-associated immunoregulatory events were studied in a pokeweed mitogen (PWM)-stimulated culture system using lymphocytes obtained from the mesenteric lymph nodes (MLN) of female subjects undergoing gastroplasty for obesity. Compared with peripheral blood lymphocytes, lymphocytes obtained from MLN secreted IgG...

journal_title：Clinical and experimental immunology

authors： Pang G,Yeung S,Clancy RL,Cripps AW,Hennessy EJ,Santhanam AN

更新日期：1986-04-01 00:00:00

abstract：:Proliferation of mesangial cells is a hallmark of glomerular disease, and understanding the regulatory mechanisms is critically important. The purpose of this study was to examine the relationship between mesangial cell proliferation and phosphorylated signal transducer and activator of transcription (STAT) 3 and to d...

journal_title：Clinical and experimental immunology

authors： Hirai T,Masaki T,Kuratsune M,Yorioka N,Kohno N

更新日期：2006-05-01 00:00:00

abstract：:The number of thymic epithelial cells containing the serum thymic factor (FTS or thymulin), assessed by indirect immunofluorescence using an anti-FTS monoclonal antibody, was studied in the thymus of normal and autoimmune mice as a function of age. In normal mice the number of FTS+ cells was constant until the age of ...

journal_title：Clinical and experimental immunology

authors： Savino W,Dardenne M,Bach JF

更新日期：1983-04-01 00:00:00

abstract：:A retrospective chart review was conducted at a single centre, capturing data on 173 primary immunodeficiency disease (PIDD) patients, including 40 obese patients, using subcutaneous administration of immunoglobulin (Ig) (SCIG) (16 or 20%) delivered by infusion pump or subcutaneous (s.c.) rapid push. Patients previous...

journal_title：Clinical and experimental immunology

authors： Shapiro R

更新日期：2013-08-01 00:00:00

abstract：:We have previously used the antibody-mediated binding of bacteria to identify Ig-bearing cells and the natural binding of bacteria to identify several lymphocyte subpopulations. By using bacteria this identification can be carried out in conventional blood smears since bacteria are small and easily distinguished from ...

journal_title：Clinical and experimental immunology

authors： Bratescu A,Mayer E,Teodorescu M

更新日期：1980-09-01 00:00:00

abstract：:Increased stimulation of Th2 cytokines may contribute to the development of persistent ocular chlamydial infection, resulting in the blinding pathological changes of trachoma. Proliferation and cytokine production profiles of PBMC in response to stimulation with antigens of Chlamydia trachomatis were compared in 30 pa...

journal_title：Clinical and experimental immunology

authors： Holland MJ,Bailey RL,Conway DJ,Culley F,Miranpuri G,Byrne GI,Whittle HC,Mabey DC

更新日期：1996-09-01 00:00:00

abstract：:We investigated changes in circulating T helper type 17 (Th17) cells following anti-tumour necrosis factor (TNF) in rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients. Peripheral blood mononuclear cells (PBMC) were isolated from 25 RA, 15 AS and eight PsA patients at baseline...

journal_title：Clinical and experimental immunology

authors： Hull DN,Williams RO,Pathan E,Alzabin S,Abraham S,Taylor PC

更新日期：2015-09-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is characterized by an abnormal regulatory T cell (T(reg)) response and increases in T helper type 1 (Th1) and Th17 cell responses. It is unclear if dysregulation of microRNAs (miRNA) within T(reg) cells contributes to the abnormal inflammatory response in COPD. In this stu...

journal_title：Clinical and experimental immunology

authors： Chatila WM,Criner GJ,Hancock WW,Akimova T,Moldover B,Chang JK,Cornwell W,Santerre M,Rogers TJ

更新日期：2014-07-01 00:00:00

abstract：:We set out to examine the effect of gold treatment on the Th2-dependent antibodies IgG4 and IgE in relation to other IgG subclasses in patients with rheumatoid arthritis (RA). Eighty-five gold-treated RA patients and 82 RA controls were studied. Serum IgG subclass concentrations were measured by ELISA, IgE was measure...

journal_title：Clinical and experimental immunology

authors： Kiely PD,Helbert MR,Miles J,Oliveira DB

更新日期：2000-05-01 00:00:00

abstract：:Ten out of 14 rhesus monkeys developed arthritis after a single immunization with bovine type II collagen (B-CII). In contrast to primary resistant monkeys, arthritic animals showed a B-CII specific T cell proliferation during the induction phase of the disease. All surviving animals showed a full remission of the dis...

journal_title：Clinical and experimental immunology

authors： Bakker NP,van Erck MG,'t Hart LA,Jonker M

更新日期：1991-11-01 00:00:00

abstract：:Cell-mediated cytotoxicity (CTX) of meningioma patients was assessed postoperatively by a [3H]proline microcytotoxicity test. Autologous and allogeneic tumour cells were used for prelabelling with isotope and peripheral blood lymphocytes added in a ratio of 200:1. After 60 hg the plates were washed and residual CMP co...

journal_title：Clinical and experimental immunology

authors： Pees HW,Seidel B

更新日期：1976-05-01 00:00:00

abstract：:Previous studies of an experimental human immunoglobulin preparation for intravenous use, containing normal pooled IgM (IVIgM), have shown its beneficial therapeutic effect in experimental autoimmune diseases. The mechanisms of its immunomodulatory activity remain however, poorly understood. In the experiments reporte...

journal_title：Clinical and experimental immunology

authors： Vassilev T,Mihaylova N,Voynova E,Nikolova M,Kazatchkine M,Kaveri S

更新日期：2006-07-01 00:00:00

abstract：:Inducible co-stimulator-positive (ICOS) and programmed cell death 1-positive (PD-1) are important markers for follicular helper T cells (Tfh); however, their roles and clinical values in ulcerative colitis (UC) remain unknown. In this study, we recruited 68 UC patients and 34 healthy controls. Circulating ICOS+ , PD-1...

journal_title：Clinical and experimental immunology

authors： Long Y,Zhao X,Liu C,Xia C,Liu C

更新日期：2020-10-01 00:00:00

abstract：:The proliferative response of preparations of whole PBMC populations from 20 healthy individuals and 28 multiple sclerosis (MS) patients to purified protein derivative (PPD) and myelin basic protein (MBP) was monitored in a kinetic assay over a period of up to 10 days. PPD produced a classical secondary response in bo...

journal_title：Clinical and experimental immunology

authors： Ponsford M,Mazza G,Coad J,Campbell MJ,Zajicek J,Wraith DC

更新日期：2001-05-01 00:00:00

abstract：:Macrophages play a central role in inflammation and host defence against microorganisms, but they also participate actively in the resolution of inflammation after alternative activation. However, it is not known whether the resolution of inflammation requires alternative activation of new resting monocytes/macrophage...

journal_title：Clinical and experimental immunology

authors： Porcheray F,Viaud S,Rimaniol AC,Léone C,Samah B,Dereuddre-Bosquet N,Dormont D,Gras G

更新日期：2005-12-01 00:00:00

abstract：:This longitudinal study investigates the change of erythrocyte complement receptor (E-CR1) expression in patients with severe acute respiratory syndrome (SARS). Circulating E-CR1 expression was semiquantified by flow cytometric analyses in 54 SARS patients and in 212 healthy individuals as a control. Since E-CR1 expre...

journal_title：Clinical and experimental immunology

authors： Wang FS,Chu FL,Jin L,Li YG,Zhang Z,Xu D,Shi M,Wu H,Moulds JM

更新日期：2005-01-01 00:00:00

abstract：:Anaemia of chronic disease (ACD) is frequently found in rheumatoid arthritis (RA). In the pathogenesis of ACD both cytokines, such as tumour necrosis factor-alpha (TNF-alpha), IL-1 and IL-6 as well as a relative deficiency of erythropoietin (EPO), are thought to play a key role. In the present study the role of IL-6 i...

journal_title：Clinical and experimental immunology

authors： Jongen-Lavrencic M,Peeters HR,Rozemuller H,Rombouts WJ,Martens AC,Vreugdenhil G,Pillay M,Cox PH,Bijser M,Brutel G,Breedveld FC,Swaak AJ

更新日期：1996-02-01 00:00:00

abstract：:Bovine type II collagen administered to non-pregnant female DBA/1 mice caused arthritis in 55% of animals with a mean onset time of 70 days following immunization. Of collagen-treated females subsequently becoming syngeneically pregnant before the onset of arthritis, all developed the disease within 10 days of parturi...

journal_title：Clinical and experimental immunology

authors： Waites GT,Whyte A

更新日期：1987-03-01 00:00:00

abstract：:Silicosis is a chronic progressive granulomatous and fibrotic lung disease caused by inhaled silica. Although the causative agent is known, the pathogenesis, especially the immunologic response, is not well understood. We examined two important components of cell-mediated immune responses in the lungs of rats with sil...

journal_title：Clinical and experimental immunology

authors： Struhar DJ,Harbeck RJ,Gegen N,Kawada H,Mason RJ

更新日期：1989-08-01 00:00:00

abstract：:Current therapies for inflammatory bowel diseases (IBD) are aimed at controlling the exacerbated response in the gut, but no treatment is fully effective for many refractory patients. Mesenchymal stromal cells (MSC) are multi-potent cells with regulatory immunosuppressive activity that may control inflammatory disease...

journal_title：Clinical and experimental immunology

authors： Alves VBF,de Sousa BC,Fonseca MTC,Ogata H,Caliári-Oliveira C,Yaochite JNU,Rodrigues Júnior V,Chica JEL,da Silva JS,Malmegrim KCR,Pernomian L,Cardoso CR

更新日期：2019-05-01 00:00:00

abstract：:Human mononuclear leucocytes (MNL) or the adherent fraction (monocytes) produced tumour necrosis factor-alpha (TNF-alpha) (by ELISA) in culture when stimulated with killed Staphylococcus aureus. The bisbenzylisoquinoline alkaloid, tetrandrine inhibited the capacity of MNL and monocytes to produce TNF-alpha at a concen...

journal_title：Clinical and experimental immunology

authors： Ferrante A,Seow WK,Rowan-Kelly B,Thong YH

更新日期：1990-05-01 00:00:00

abstract：:Calculated globulin (total protein - albumin) is usually tested as part of a liver function test profile in both primary and secondary care and determines the serum globulin concentration, of which immunoglobulins are a major component. The main use hitherto of calculated globulin is to detect paraproteins when the le...

journal_title：Clinical and experimental immunology

authors： Jolles S,Borrell R,Zouwail S,Heaps A,Sharp H,Moody M,Selwood C,Williams P,Phillips C,Hood K,Holding S,El Shanawany T

更新日期：2014-09-01 00:00:00