Neopterin release from human endothelial cells is triggered by interferon-gamma.

abstract：:The effect of administration of 0-2 mg of epinephrine (Parke-Davis) on circulatory lymphocytes was investigated in fifteen normal subjects. Blood samples were taken prior to, 10 and 20 min after, subcutaneous injections. Thymus-derived (T) cells were assayed by sheep red blood cell rosettes, bone marrow-derived (B) ce...

journal_title：Clinical and experimental immunology

authors： Yu DT,Clements PJ

更新日期：1976-09-01 00:00:00

abstract：:Autoreactivity to heat shock protein 60 (Hsp60) has been implicated in the pathogenesis and regulation of chronic inflammation, especially in autoimmune diseases. In transplantation, there is a lack of information regarding the cytokine profile and specificity of cells that recognize self-Hsp60 as well as the kinetics...

journal_title：Clinical and experimental immunology

authors： Caldas C,Luna E,Spadafora-Ferreira M,Porto G,Iwai LK,Oshiro SE,Monteiro SM,Fonseca JA,Lemos F,Hammer J,Ho PL,Kalil J,Coelho V

更新日期：2006-10-01 00:00:00

abstract：:Bacillus Calmette-Guérin (BCG) remains the only available and most widely administered vaccine against Mycobacterium tuberculosis (Mtb), yet it fails to protect vaccinated individuals either from primary infection or reactivation of latent tuberculosis (TB). Despite BCG's variable efficacy against TB, the fact remains...

journal_title：Clinical and experimental immunology

authors： Siddiqui KF,Amir M,Khan N,Rama Krishna G,Sheikh JA,Rajagopal K,Agrewala JN

更新日期：2015-08-01 00:00:00

abstract：:Cells from the peripheral blood of patients with B cell chronic lymphocytic leukaemia (B-CLL) and acute lymphoblastic leukaemia (ALL) were examined for the expression of MHC class II antigens, using a number of monoclonal antibodies (MoAb) including L243 (anti-DR) and TU22 (anti-DQ). There was wide variation in expres...

journal_title：Clinical and experimental immunology

authors： Guy K,Docherty LJ,Dewar AE

更新日期：1986-02-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) is known for its capacity to induce CD11c(+) myeloid dendritic cells to promote T helper type 2 (Th2)-skewed inflammatory responses. Although increased expression of TSLP was reported in the lesional skin of limited numbers of patients with atopic dermatitis (AD), the relationships...

journal_title：Clinical and experimental immunology

authors： Sano Y,Masuda K,Tamagawa-Mineoka R,Matsunaka H,Murakami Y,Yamashita R,Morita E,Katoh N

更新日期：2013-03-01 00:00:00

abstract：:Psoriasis is an immune-mediated inflammatory skin disease that mainly affects the skin barrier. Treatment for psoriasis mainly includes conventional immunosuppressive drugs. However, long-term treatment with global immunosuppressive agents may cause a variety of side effects, including nephrotoxicity and infections. K...

journal_title：Clinical and experimental immunology

authors： Liu C,Liu H,Lu C,Deng J,Yan Y,Chen H,Wang Y,Liang CL,Wei J,Han L,Dai Z

更新日期：2019-12-01 00:00:00

abstract：:Leucocyte adhesion deficiency type 1 (LAD-1) is characterized by the incapacity of leucocytes to carry out their adhesion functions via their CD11/CD18 antigens, which are also referred to as the leucocyte integrins. The patients generally suffer from poor wound healing and recurrent bacterial and fungal infections. I...

journal_title：Clinical and experimental immunology

authors： Mathew EC,Shaw JM,Bonilla FA,Law SK,Wright DA

更新日期：2000-07-01 00:00:00

abstract：:A preparation of the putative antibody in HN (Heymann's nephritis) lacking preformed immune complexes, obtained from the acid eluates of kidneys with HN, purified through ion exchange and gel-filtration chromatography, characterized by immunoelectrophoresis, sucrose density-gradient ultracentrifugation, 125I-Clq assay...

journal_title：Clinical and experimental immunology

authors： Makker SP,Kirson IJ,Moorthy B

更新日期：1982-02-01 00:00:00

abstract：:Proliferative responses by human peripheral blood mononuclear cells and rat spleen cells were measured to Pneumocystis carinii in a blastogenic assay using organisms obtained from rat lungs and propagated in tissue culture as the antigen. Responses occurred only in subjects with known prior exposure to P. carinii and ...

journal_title：Clinical and experimental immunology

authors： Hagler DN,Deepe GS,Pogue CL,Walzer PD

更新日期：1988-10-01 00:00:00

abstract：:Neurotrophins nerve growth factor (NGF), brain-derived growth factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) and their high-affinity tyrosine protein kinase receptor (Trk) family, TrkA, TrkB, TrkC, and low-affinity p75(NTR) receptor, are key molecules implicated in the development of the central nervou...

journal_title：Clinical and experimental immunology

authors： Samah B,Porcheray F,Gras G

更新日期：2008-03-01 00:00:00

abstract：:Transmembrane activator and calcium modulator and cyclophilin ligand interactor-immunoglobulin (TACI-Ig) is a human fusion protein that binds and neutralizes both B lymphocyte stimulator (BLyS), a cytokine shown to be a key regulator of B cell maturation, proliferation and survival, and a proliferation-inducing ligand...

journal_title：Clinical and experimental immunology

authors： Wang D,Chang Y,Wu Y,Zhang L,Yan S,Xie G,Qin Q,Jin J,Wang W,Fang J,Wei W

更新日期：2011-02-01 00:00:00

abstract：:Vulnerability to Streptococcus pneumoniae is most pronounced in children. The microbial virulence factors and the features of the host immune response contributing to this phenomenon are not completely understood. In the current study, the humoral immune response to separated Strep. pneumoniae surface proteins and the...

journal_title：Clinical and experimental immunology

authors： Lifshitz S,Dagan R,Shani-Sekler M,Grossman N,Fleminger G,Friger M,Nebenzahl YM

更新日期：2002-02-01 00:00:00

abstract：:In the present study we describe the in vitro transcription-translation of human melanocyte-specific protein Pmel17 cDNA and subsequent use of the resulting 35S-labelled Pmel17 in an RIA to analyse vitiligo sera for the presence of Pmel17 antibodies. Of 53 vitiligo sera examined in the assay, three (5.9%) were found t...

journal_title：Clinical and experimental immunology

authors： Kemp EH,Gawkrodger DJ,Watson PF,Weetman AP

更新日期：1998-12-01 00:00:00

abstract：:In this study the antigen-presenting capacity of human peritoneal cells and the influence of continuous ambulant peritoneal dialysis (CAPD) were studied. On average 6% of the peritoneal cells were dendritic cells (DC), with no difference between CAPD and control peritoneal cells. DC were enriched by selecting for non-...

journal_title：Clinical and experimental immunology

authors： Betjes MG,Tuk CW,Struijk DG,Krediet RT,Arisz L,Beelen RH

更新日期：1993-11-01 00:00:00

abstract：:A method is described for culturing intact human thyroid follicles, based on the study of 40 thyroidectomy specimens from normal (n = 18) and diseased glands (n = 22). Reversal of the normal polarity of thyrocytes, whereby the microvilli move from the colloid edge to the vascular pole of the cells, occurs gradually wh...

journal_title：Clinical and experimental immunology

authors： Hanafusa T,Pujol-Borrell R,Chiovato L,Doniach D,Bottazzo GF

更新日期：1984-09-01 00:00:00

abstract：:2-Chlorodeoxyadenosine (cladribine, CdA) is an immunosuppressive drug that is licensed to treat hairy cell leukaemia, and has been shown recently to have beneficial effects in patients with multiple sclerosis (MS). The therapeutic effects of CdA have been suggested to be mediated partly through its potent toxicity tow...

journal_title：Clinical and experimental immunology

authors： Singh V,Prajeeth CK,Gudi V,Bénardais K,Voss EV,Stangel M

更新日期：2013-08-01 00:00:00

abstract：:Elevation of intracellular cAMP levels has been shown previously to inhibit cytokine secretion by various cell types in vitro. Since salmeterol is a beta 2-agonist which activates adenylate cyclase, its ability to inhibit cytokine production was evaluated. Though salmeterol, and the related drug albuterol, did not inh...

journal_title：Clinical and experimental immunology

authors： Sekut L,Champion BR,Page K,Menius JA Jr,Connolly KM

更新日期：1995-03-01 00:00:00

abstract：:A more complete understanding of immune-mediated damage to the coronary arteries in children with Kawasaki disease (KD) is required for improvements in patient treatment and outcomes. We recently reported the transcriptional profile of KD coronary arteritis, and in this study sought to determine protein expression of ...

journal_title：Clinical and experimental immunology

authors： Cameron SA,White SM,Arrollo D,Shulman ST,Rowley AH

更新日期：2017-11-01 00:00:00

abstract：:Studies of human mucosal lymphoid follicles are rare and have been limited to children's Peyer's patches, which are visible at endoscopy. We investigated lymphoid follicles in ileum biopsies of 87 patients and surgical colon specimens from 66 cancer patients, and examined phenotype and function of isolated follicular ...

journal_title：Clinical and experimental immunology

authors： Junker Y,Bode H,Wahnschaffe U,Kroesen A,Loddenkemper C,Duchmann R,Zeitz M,Ullrich R

更新日期：2009-05-01 00:00:00

abstract：:Fourteen cadaver kidney donors were pretreated with a rapid infusion of 5 g of cyclophosphamide and 5 g of methylprednisolone in an attempt to reduce graft immunogenicity by altering immunogenic "passenger" leucocytes. The effects of this drug infusion on peripheral lymphocytes were monitored by measuring the ability ...

journal_title：Clinical and experimental immunology

authors： Jeffery JR,Guttmann RD,Charpentier B

更新日期：1976-09-01 00:00:00

abstract：:Blood monocytes of patients with thyroid autoimmune disease (TAID) display defects in rearranging their cortical actomyosin cytoskeleton ('polarize') in response to chemoattractants. Such rearrangements also take place after the adherence of monocytes to the extracellular matrix (ECM). It is therefore not surprising t...

journal_title：Clinical and experimental immunology

authors： Canning MO,Grotenhuis K,De Haan-Meulman M,De Wit HJ,Berghout A,Drexhage HA

更新日期：2001-07-01 00:00:00

abstract：:Oral immunization with 25 mg/day of ovalbumin resulted in a number of changes in non-specific immune responsiveness, including increases in antibody produced to T-dependent but not T-independent antigens and the abrogation of tolerance induced by both oral and intravenous routes. The effect was transient, sex- and str...

journal_title：Clinical and experimental immunology

authors： Stokes CR,Newby TJ,Bourne FJ

更新日期：1983-05-01 00:00:00

abstract：:The role of HLA-A*6802-restricted CD8+ T cells in chlamydial disease was investigated in human ocular infections. Peptides with predicted binding motifs for HLA-A*6802 were synthesized using sequences based on chlamydial antigens, major outer membrane protein (MOMP), macrophage infectivity potentiator (MIP) and heat s...

journal_title：Clinical and experimental immunology

authors： Mahdi OS,Whittle HC,Joof H,Mabey DC,Bailey RL

更新日期：2001-01-01 00:00:00

abstract：:Patients with common variable immunodeficiency (CVID) have reduced numbers and frequencies of dendritic cells (DCs) in blood, and there is also evidence for defective activation through Toll-like receptors (TLRs). Collectively, these observations may point to a primary defect in the generation of functional DCs. Here,...

journal_title：Clinical and experimental immunology

authors： Taraldsrud E,Fevang B,Aukrust P,Beiske KH,Fløisand Y,Frøland S,Rollag H,Olweus J

更新日期：2014-03-01 00:00:00

abstract：:We set out to examine the effect of gold treatment on the Th2-dependent antibodies IgG4 and IgE in relation to other IgG subclasses in patients with rheumatoid arthritis (RA). Eighty-five gold-treated RA patients and 82 RA controls were studied. Serum IgG subclass concentrations were measured by ELISA, IgE was measure...

journal_title：Clinical and experimental immunology

authors： Kiely PD,Helbert MR,Miles J,Oliveira DB

更新日期：2000-05-01 00:00:00

abstract：:A complete functional deficiency of C1q is described in a patient suffering from SLE. From reduced plasma C1 activity of the parents a hereditary trait was assumed. The defective C1q molecule was haemolytically inactive, did not bind to immune complexes, and was not recognized by the monocyte C1q receptor. C1 activity...

journal_title：Clinical and experimental immunology

authors： Kirschfink M,Petry F,Khirwadkar K,Wigand R,Kaltwasser JP,Loos M

更新日期：1993-11-01 00:00:00

abstract：:Opisthorchis viverrini infection is associated with human hepatobiliary disease and cholangiocarcinoma, but the role of the immune response in the pathogenesis of infection is unclear. Here ultrasonography was used to examine the biliary tracts of residents from an endemic community. Delayed-type hypersensitivity resp...

journal_title：Clinical and experimental immunology

authors： Haswell-Elkins MR,Sithithaworn P,Mairiang E,Elkins DB,Wongratanacheewin S,Kaewkes S,Mairiang P

更新日期：1991-05-01 00:00:00

abstract：:Extracorporeal photopheresis (ECP) has been used as a prophylactic and therapeutic option to avoid and treat rejection after heart transplantation (HTx). Tolerance-inducing effects of ECP such as up-regulation of regulatory T cells (T(regs)) are known, but specific effects of ECP on regulatory T cell (T(reg)) subsets ...

journal_title：Clinical and experimental immunology

authors： Dieterlen MT,Bittner HB,Pierzchalski A,Dhein S,Mohr FW,Barten MJ

更新日期：2014-04-01 00:00:00

abstract：:The capacity of peripheral blood mononuclear (PBM) cells from patients with leprosy to generate immunoglobulin-secreting cells in response to pokeweed mitogen (PWM) was evaluated by a reverse haemolytic plaque forming cell (PFC) assay. The PFC responses of PBM cells from patients with lepromatous (Lpr) leprosy were si...

journal_title：Clinical and experimental immunology

authors： Bullock WE,Watson S,Nelson KE,Schauf V,Makonkawkeyoon S,Jacobson RR

更新日期：1982-07-01 00:00:00

abstract：:Analysis of the VH gene repertoire of the J558 family was done in lipopolysaccharide (LPS)-stimulated resting cells and in vivo activated cells derived from C57Bl/6-lpr mice (IghCb). Using a restriction fragment length polymorphism (RFLP) based on digestion with the restriction enzyme Pstl, the expression of the subfa...

journal_title：Clinical and experimental immunology

authors： Alarcón-Riquelme ME,Fernández C

更新日期：1995-02-01 00:00:00