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Expression and regulation of transforming growth factor beta1 mRNA and protein in rat fetal testis in vitro.

Abstract：

:The expression and secretion of Transforming Growth Factor beta1 (TGFbeta1) by cultured testes of day 20.5 rat fetuses were investigated. The testes were found to express two TGFbeta1 mRNA transcripts of 2.5 and 1.8 kb. By using mink lung epithelial cell bioassay based on the measurement of the inhibition of tritiated thymidine incorporation in response to TGFbeta1 immunoreactive material, the fetal testes were shown to secrete TGFbeta1 protein in organ culture. This secretion was positively regulated by dibutyryl cyclic AMP or by LH and FSH together, but not by LH alone and very slightly by FSH alone, which suggests interactions between Leydig and Sertoli cells for the control of TGFbeta1 production. These regulations probably take place at a posttranscriptional step since no concomitant increase of TGFbeta1 mRNA levels was observed. Such a positive regulation of TGFbeta1 secretion by gonadotropins could be a characteristic of the rat fetal testis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Gautier C,Levacher C,Saez JM,Habert R

doi

10.1006/bbrc.1997.6914

subject

Has Abstract

pub_date

1997-07-09 00:00:00

pages

135-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(97)96914-X

journal_volume

236

pub_type

杂志文章

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