Abstract：
:Our previous in vivo studies on angiostrongyliasis showed that PF1022A had stronger killing effects against female adults than against males. No killing effects were observed against young adult worms in the central nervous system. To characterize the former in vivo action of PF1022A, in vitro effects of PF1022A on the motility of Angiostrongylus cantonensis were studied directly. Few differences in the efficacy were observed between male and female worms, but dose- and time-dependent inhibition was observed in adults treated with PF1022A at 10(-7)-10(-11) g/ml. PF1022A was slightly less effect we against young-adult worms than against adult worms. Minor effects of PF1022A were observed on the third-stage larvae. These results suggest that selectivity against adult females in vivo could be attributable to non-neuropharmacological mechanisms and that PF1022A does not pass through the blood-brain barrier in host animals.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Kachi S,Terada M,Hashimoto Hdoi
10.1007/s004360050301subject
Has Abstractpub_date
1997-01-01 00:00:00pages
578-82issue
6eissn
0932-0113issn
1432-1955journal_volume
83pub_type
杂志文章abstract：:The malaria parasite, Plasmodium falciparum, invades the human erythrocyte through a complex interaction with erythrocyte receptors characterized by patterns of resistance to various enzymes. As invasion rates are influenced by blood group polymorphisms, we reasoned that the extremely rare rhesus null (Rh(null)) eryth...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-007-0756-8
更新日期：2008-01-01 00:00:00
abstract：:The free-living amoebae, Acanthamoeba, can act as opportunistic parasites on a wide range of vertebrates and are becoming a serious threat to human health due to the resistance of their cysts to harsh environmental conditions, disinfectants, some water treatment practices, and their ubiquitous distribution. Subgenus c...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-014-3945-2
更新日期：2014-08-01 00:00:00
abstract：:Haemoproteus spp. are cosmopolitan vector-born haemosporidian parasites, some species of which cause diseases in non-adapted birds. Recent polymerase chain reaction (PCR)-based studies have detected mitochondrial cytochrome b gene lineages of these Haemoproteus parasites in blood-sucking mosquitoes and speculated abou...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-013-3375-6
更新日期：2013-06-01 00:00:00
abstract：:Malaria is caused by unicellular parasites of the genus Plasmodium, which reside in erythrocytes during the clinically relevant stage of infection. To separate parasite from host cell material, haemolytic agents such as saponin are widely used. Previous electron microscopy studies on saponin-treated parasites reported...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-020-06932-9
更新日期：2020-12-01 00:00:00
abstract：:In freshwater ecosystems, snails can significantly influence the competition between primary producers through grazing of periphyton. This activity can potentially be modified by trematodes, a large group of parasites which mostly use molluscs as the first intermediate host. Available studies, however, show contradict...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-018-6052-y
更新日期：2018-11-01 00:00:00
abstract：:Neospora caninum is an intracellular protozoan that infects domestic and wild canids as well as many warm-blooded animals as shown by the isolation of viable parasites. The effectiveness of diagnostic tests for detecting specific antibodies against N. caninum is hampered by potential cross-reaction with other Coccidia...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-013-3309-3
更新日期：2013-05-01 00:00:00
abstract：:Rodents are intermediate hosts for many species of Sarcocystis. Little is known of Sarcocystis cymruensis that uses the Brown rat (Rattus norvegicus) as intermediate hosts and the domestic cat (Felis catus) as experimental definitive host. Here, we identified and described Sarcocystis cymruensis in naturally infected ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-018-5799-5
更新日期：2018-04-01 00:00:00
abstract：:Systematic, continuous mosquito surveillance is considered the most reliable tool to predict the spread and establishment of alien mosquito species such as the Asian tiger mosquito (Aedes albopictus), Japanese bush mosquito (Aedes japonicus), and the transmission risk of mosquito-borne arboviruses to humans. Only sing...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-019-06287-w
更新日期：2019-05-01 00:00:00
abstract：:Experimental concurrent infection with two or more parasite species in mammalian host models may result in heterologous antagonistic and synergistic interactions ranging in magnitude from reduced/enhanced growth and fecundity to blockage/enhancement of establishment/expulsion. With some exceptions only, there is a rea...
journal_title：Parasitology research
pub_type： 杂志文章,评审
doi：10.1007/BF00538196
更新日期：1987-01-01 00:00:00
abstract：:Wild birds are common hosts of ticks and can transport them for long distances, contributing to the spreading of tick-borne pathogens. The information about ticks on birds and tick-borne pathogens in Greece is limited. The present study aimed to evaluate the prevalence and species of ticks infesting wild resident bird...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-016-4943-3
更新日期：2016-05-01 00:00:00
abstract：:Increased gametocytemia in infections with resistant strains of Plasmodium species and their enhanced transmissibility are a matter of concern in planning and evaluating the impact of malaria control strategies. Various studies have determined weekly gametocyte carriage in response to antimalarial drugs in clinical tr...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-014-3789-9
更新日期：2014-04-01 00:00:00
abstract：:Dimethyl sulfoxide (DMSO), commonly used for cryoprotection or for the solvation of cytoskeleton-modifying drugs, causes changes in the topology of the plasma membrane of the tegumental brush border in the tapeworm Hymenolepis diminuta; however, relatively long exposures of high concentrations are required. In tapewor...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00936184
更新日期：1992-01-01 00:00:00
abstract：:In Egypt, reclaiming portions of the desert using water from the Nile has resulted in large-scale invasion of Biomphalaria alexandrina in these regions. Studies exploring the local adaptation of Schistosoma mansoni to its snail host have been carried out to predict the extension of schistosomiasis to newly reclaimed a...
journal_title：Parasitology research
pub_type： 杂志文章,meta分析
doi：10.1007/s00436-014-3756-5
更新日期：2014-03-01 00:00:00
abstract：:In frozen sections of the acanthocephalan Pomphorhynchus laevis, which is a frequent intestinal parasite of cyprinid and salmonid fishes, leucine aminopeptidase (APase) was localized histochemically in outer parts of the presomal bulbus as well as in all layers and most nuclei of the metasomal body wall. Enzyme activi...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00932697
更新日期：1994-01-01 00:00:00
abstract：:The chemotherapy of visceral leishmaniasis (VL) has several limitations including resistance and toxicity of the existing drugs. Downregulation of immune system further aggravates the problems. To combat this situation, leishmanicidal efficacy of already marketed standard antifungal drug, fluconazole under the approac...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-010-2230-2
更新日期：2011-04-01 00:00:00
abstract：:We examined the in vitro effect of increasing gliotoxin concentrations on the infectivity of Toxoplasma gondii for NIH-3T3 murine fibroblasts and on Toxoplasma chymotrypsin-like activity, which is specific to the proteasome. Parasite penetration of host cells was not modified by a high gliotoxin concentration (1 micro...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-002-0644-1
更新日期：2002-08-01 00:00:00
abstract：:In order to identify brain cell types that serve as host cells of Toxoplasma gondii encystation primary cultures from murine brain were infected and stained for neural and parasite stage-specific markers. In mixed culture inoculated with T. gondii tachyzoites, MAP2+ neurons, GFAP+ astrocytes, F4/80+ microglia, and O1+...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050311
更新日期：1997-01-01 00:00:00
abstract：:Under natural conditions, eukaryote cells may contain bacteria. Arthropods such as ticks, insects or mites are a group particularly favoured by the obligate intracellular bacteria. While arthropods are vectors for some of them, other bacteria inhabit invertebrate host cells having entered mutualistic interactions. Suc...
journal_title：Parasitology research
pub_type： 杂志文章,评审
doi：10.1007/s00436-006-0412-8
更新日期：2007-04-01 00:00:00
abstract：:We examine the taxonomic composition and endemism of adult helminth parasites of freshwater fishes of Mexico, with regard to the main hydrological basins of the country. A presence-absence matrix, including every species of adult helminth parasites of freshwater fishes from 23 Mexican hydrological basins was compiled ...
journal_title：Parasitology research
pub_type： 杂志文章,评审
doi：10.1007/s00436-012-3175-4
更新日期：2013-01-01 00:00:00
abstract：:A pellet freezing method, one type of rapid freezing protocol, was established for Trichomonas vaginalis. As cryoprotectants, 5-20% dimethylsulfoxide (DMSO), ethylene glycol, propylene glycol, and glycerol were used. Of these, DMSO showed a high protective effect, with a maximum effect at a concentration of 20%. No ef...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-007-0559-y
更新日期：2007-09-01 00:00:00
abstract：:A monoclonal antibody raised against membrane proteins of Toxoplasma gondii with molecular weights of 35 and 21 kDa also reacts strongly and "specifically" with surface antigens of Pneumocystis carinii with molecular weights of 394.2 and 69 kDa when used in a direct immunofluorescence antibody test, on the one hand, a...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00930914
更新日期：1991-01-01 00:00:00
abstract：:In this paper, we cloned a novel full-length cDNA that encodes a Trichinella spiralis cathepsin B-like protease gene (TsCPB) using 3'-RACE PCR. The recombinant mature TsCPB protein (rTsCPB) was then expressed in an Escherichia coli expression system and purified with Ni-affinity chromatography. Real-time quantitative ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-013-3497-x
更新日期：2013-09-01 00:00:00
abstract：:This study presents the ultrastructural characteristics of sporogenesis in the genus Myxobolus which infects four economically important Egyptian fishes: Oreochromis niloticus niloticus, Barbus bynni, Labeo niloticus and Hydrocynus forskalii, specimens of which were collected at Giza city. Although the cysts were obse...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-004-1250-1
更新日期：2005-02-01 00:00:00
abstract：:A LightCycler real-time polymerase chain reaction (PCR) assay was developed to detect Wuchereria bancrofti DNA in blood-fed mosquitoes. The assay is based on fluorescence melting curve analysis of the PCR product generated from a family of repeated DNA elements: the 182 bp SspI repeat, specific to the genus Wuchereria...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-004-1221-6
更新日期：2004-11-01 00:00:00
abstract：:The Leishmania amazonensis telomerase gene was cloned by a polymerase chain reaction-based strategy using primers designed from a Leishmania major sequence that shared similarities with conserved telomerase motifs. The genes from three other species were cloned for comparative purposes. A ClustalW multiple-sequence al...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-005-0036-4
更新日期：2006-04-01 00:00:00
abstract：:Pathogen-free rainbow trout (Oncorhynchus mykiss) aged 735 degree days were experimentally exposed to a low dose of infectious Myxobolus cerebralis (20 triactinomyxons fish(-1)). Three time periods were chosen for sampling that included 10 days (d), 67 d, and 5 months (mo) post exposure. Five diagnostic assays were us...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-006-0166-3
更新日期：2006-09-01 00:00:00
abstract：:Prior studies have shown that filarial nematodes can effectively metabolize hydrogen peroxide in excess of that generated by activated host cells. However, the mechanisms of H2O2 removal by the filarial parasites are unclear. Herein we report the results of studies carried out on the biochemical activity and on immuno...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050032
更新日期：2000-03-01 00:00:00
abstract：:The nematode Teladorsagia circumcincta is a polymorphic species, morphs T. c. trifurcata and T. c. circumcincta being the most frequent. Among other traits, T. c. trifurcata has lower infectivity than T. c. circumcincta. Anthelmintic treatments that regularly remove populations should favour the more infective T. c. c...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360100387
更新日期：2001-09-01 00:00:00
abstract：:This study evaluated, for the first time, the genetic diversity of Toxoplasma gondii isolates from free-range chickens from the state of Paraíba, Northeast Brazil. Tissue samples from 33 chickens from properties in five municipalities of Paraíba (Esperança, Olho d'Água, Malta, Monteiro, and Patos) were bioassayed in m...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-017-5531-x
更新日期：2017-08-01 00:00:00
abstract：:Infectious agents, including parasites, often have oncogenic potential. However, there has been no study on the association between Strongyloides stercoralis infection and cancer risk. Therefore, we investigated the relationship between S. stercoralis infection and the occurrence of hepato-pancreato-biliary cancer. Th...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-007-0648-y
更新日期：2007-10-01 00:00:00
