Startle modulation in children at risk for anxiety disorders and/or alcoholism.

Abstract:

OBJECTIVE:To examine the startle reflex as a possible vulnerability marker among offspring of parents with anxiety disorders and/or alcoholism. METHOD:The subjects were 66 male and female offspring (aged 10 to 17 years) of proband who participated in a family study of comorbidity of alcoholism and anxiety disorders. Testing consisted of examining the startle reflex and its modulation by prepulse stimuli (prepulse facilitation and prepulse inhibition). RESULTS:Different components of the startle discriminated among children of parents with anxiety disorders, children of alcoholics, and children of normal controls. Specifically startle magnitude was elevated in children with a parental history of an anxiety disorder, whereas startle habituation and prepulse inhibition were impaired in children with a parental history of alcoholism. CONCLUSION:These findings suggest that individual differences in the startle reflex may serve as a vulnerability marker for the development of anxiety disorders and alcohol problems.

authors

Grillon C,Dierker L,Merikangas KR

doi

10.1097/00004583-199707000-00014

subject

Has Abstract

pub_date

1997-07-01 00:00:00

pages

925-32

issue

7

eissn

0890-8567

issn

1527-5418

pii

S0890-8567(09)62548-X

journal_volume

36

pub_type

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