Abstract:
OBJECTIVE:To provide an overview of the genetic epidemiology of substance use and misuse in adolescents. METHOD:A selective review of genetically informative research strategies, their limitations, and key findings examining issues related to the heritability of substance use and substance use disorders in children and adolescents is presented. RESULTS:Adoption, twin, and extended-family designs have established there is a strong heritable component to liability to nicotine, alcohol, and illicit drug dependence in adults. However, shared environmental influences are relatively stronger in youth samples and at earlier stages of substance involvement (e.g., use). There is considerable overlap in the genetic influences associated with the abuse/dependence across drug classes, and shared genetic influences contribute to the commonly observed associations between substance-use disorders and externalizing and, to a lesser extent, internalizing psychopathology. Rapid technologic advances have made the identification of specific gene variants that influence risks for substance-use disorders feasible, and linkage and association (including genomewide association studies) have identified promising candidate genes implicated in the development of substance-use disorders. CONCLUSIONS:Studies using genetically informative research designs, including those that examine aggregate genetic factors and those examining specific gene variants, individually and in interaction with environmental influences, offer promising avenues not only for delineating genetic effects on substance-use disorders but also for understanding the unfolding of risk across development and the interaction between environmental and genetic factors in the etiology of these disorders.
journal_name
J Am Acad Child Adolesc Psychiatryauthors
Lynskey MT,Agrawal A,Heath ACdoi
10.1016/j.jaac.2010.09.004subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1202-14issue
12eissn
0890-8567issn
1527-5418pii
S0890-8567(10)00675-1journal_volume
49pub_type
杂志文章,评审abstract:OBJECTIVE:To conduct a placebo-controlled study of the effectiveness of a universal school-based depression prevention program. METHOD:Three hundred ninety-two students age 13 to 15 from two schools were randomized to intervention (RAP-Kiwi) and placebo programs run by teachers. RAP-Kiwi was an 11-session manual-based...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004583-200405000-00007
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:To assess the predictors of treatment outcome across treatments, as well as those associated with differential treatment response. METHOD:One hundred seven adolescent outpatients, aged 13 to 18 years, with DSM-III-R major depression were randomly assigned to one of three manual-based, brief (12 to 16 session...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004583-199809000-00010
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:This study was designed to examine the role of DNA variants of the dopamine D4 receptor gene (DRD4) in smoking experimentation in adolescents and to determine the extent to which novelty seeking (NS) could account for a possible effect of DRD4 on tobacco use. METHOD:Participants were from a longitudinal stud...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/01.chi.0000155980.01792.7f
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:Diet quality is related to the risk for depression and anxiety in adults and adolescents; however, the possible impact of maternal and early postnatal nutritional exposures on children's subsequent mental health is unexplored. METHOD:The large prospective Norwegian Mother and Child Cohort Study recruited pre...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1016/j.jaac.2013.07.002
更新日期:2013-10-01 00:00:00
abstract::This practice parameter describes the epidemiology, clinical picture, differential diagnosis, course, risk factors, and pharmacological and psychotherapy treatments of children and adolescents with major depressive or dysthymic disorders. Side effects of the antidepressants, particularly the risk of suicidal ideation ...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/chi.0b013e318145ae1c
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:Family interventions have been found to be effective in pediatric bipolar disorder (BD). This study examined the moderating effects of parental expressed emotion (EE) on the 2-year symptomatic outcomes of adolescent BD patients assigned to family-focused therapy for adolescents (FFT-A) or a brief psychoeducat...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/CHI.0b013e3181a0ab9d
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:The 12-month prevalence of DSM-III-R anxiety disorders and intrafamilial stress ratings were determined in 23 children with hemophilia, 37 children with asthma, and 31 healthy children. METHOD:Diagnoses were made using the parent and child versions of the Kiddie Schedule for Affective Disorders and Schizophr...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199305000-00011
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVE:Social skills group training (SSGT) for children and adolescents with autism spectrum disorder (ASD) is widely applied, but effectiveness in real-world practice has not yet been properly evaluated. This study sought to bridge this gap. METHOD:This 12-week pragmatic randomized controlled trial of SSGT compare...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jaac.2017.05.001
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:To examine concordance between parent and teacher reports of DSM-IV attention-deficit/hyperactivity disorder (ADHD) and its symptoms. METHOD:Parents and teachers of 74 clinically referred children were interviewed using the ADHD module of the Diagnostic Interview Schedule for Children. Parent-teacher agreeme...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-200003000-00012
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:To examine the feasibility and efficacy of a manual-based cognitive-behavioral therapy (CBT) in reducing depressive symptomatology in adolescents with inflammatory bowel disease (IBD). Primary and Secondary Control Enhancement Therapy-Physical Illness (PASCET-PI) modified for youths with IBD was compared to t...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1097/chi.0b013e3180f6341f
更新日期:2007-10-01 00:00:00
abstract::How should treatment be initiated for children with obsessive-compulsive disorder (OCD)? This editorial comments on an article by Melin and colleagues,1 published in this issue, from the NordLOTS study, which reports excellent outcomes from cognitive behavior therapy (CBT) for children with OCD. Children continued to ...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 评论,社论
doi:10.1016/j.jaac.2019.03.015
更新日期:2020-02-01 00:00:00
abstract::The authors report an open clinical trial of clomipramine for chronic stereotypic and self-injurious behaviors in 11 consecutive patients with concomitant developmental disorders. Ten patients (91%) had marked decreases in rates of target behaviors. No seizures occurred despite the inclusion of six patients with previ...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 临床试验,杂志文章
doi:10.1097/00004583-199211000-00027
更新日期:1992-11-01 00:00:00
abstract::Behavioral comorbidity is the rule rather than the exception in autism spectrum disorder (ASD), and the co-occurrence of autistic traits with subclinical manifestations of other psychiatric syndromes (eg, anxiety, developmental coordination disorder) extends to the general population, where there is strong evidence fo...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 社论
doi:10.1016/j.jaac.2019.07.008
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:Several studies have documented a profile of elevated scores on the Attention Problems, Aggressive Behavior and Anxious/Depressed scales of the Child Behavior Checklist (CBCL) in youth with bipolar disorder. The sum of these scales, referred to as the CBCL Juvenile Bipolar Disorder (JBD) phenotype, has modest...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:
更新日期:2010-04-01 00:00:00
abstract::A great deal has been learned in the aftermath of the Columbine High School massacre, and the science of prevention of mass casualties has matured over the past two decades. This article provides commentary on a new synthesis of the knowledge base, and incorporates very recent work from disparate disciplines that have...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 评论,社论
doi:10.1016/j.jaac.2019.11.003
更新日期:2020-01-01 00:00:00
abstract::To assess children's mental health service needs and utilization patterns for a state planning effort, a cross-sectional survey that sampled 822 children aged 6 to 11 of a metropolitan center was conducted. When reports of parents and teachers were combined, 38.5% of children were screened to be at risk of psychiatric...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199209000-00025
更新日期:1992-09-01 00:00:00
abstract:OBJECTIVE:The goals of this study were (1) to determine the prevalence of child maltreatment in hospitalized children and adolescents with developmental disabilities and concomitant psychiatric disorders, and (2) to identify the contribution of specific mother and child characteristics to the use of more severe discipl...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199405000-00015
更新日期:1994-05-01 00:00:00
abstract::A twin study examines the relationship of affect attunement to four factors of development: zygosity, temperament, attachment, and twin preference. Affect attunement occurs when an infant expresses affect and a mother responds cross-modally, matching duration, intensity, and rhythm. A sample of 16, same sex, healthy t...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-198903000-00017
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVE:To determine whether adolescents with major depressive disorder have disturbances in their cellular immunity and to study whether the immunological changes detected are specific to depression or are general responses to stress. METHOD:Twenty subjects with major depressive disorder, 17 nondepressed subjects w...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199406000-00008
更新日期:1994-06-01 00:00:00
abstract:OBJECTIVE:Most research on irritability and child psychopathology has focused on depressive disorders, bipolar disorder, and/or oppositional defiant disorder (ODD). Less is known about relationships between child anxiety and irritability and moderators of such associations. METHOD:Structural equation modeling (SEM) wa...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1016/j.jaac.2015.10.007
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To develop a reliable and valid child and parent self-report instrument to screen children with anxiety disorders. METHOD:An 85-item questionnaire was administered to 341 outpatient children and adolescents and 300 parents. Utilizing item analyses and factor analyses, the original scale was reduced to 38 ite...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199704000-00018
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVE:This project was designed to provide prospective data on the clinical presentation and longitudinal course of depression in children and adolescents. METHOD:Children and their parent(s) completed a structured diagnostic interview (Schedule for Affective Disorders and Schizophrenia for School Age Children) at...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199307000-00003
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVE:To compare, in adolescents and adults with anorexia nervosa and bulimia nervosa, eating disorder symptomatology and comorbid affective and anxiety states. METHOD:Two hundred fifty consecutive, female inpatients on an eating disorders unit were studied. They were given the Beck Depression Inventory; the Depre...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199503000-00024
更新日期:1995-03-01 00:00:00
abstract::Sixty cases from the DSM-III-R field trials for autistic disorder (AD) were studied to derive an optimally sensitive and specific combination of scoring criteria based on the 16 DSM-III-R criteria for AD. Signal detection theory, a statistical method new to psychiatric research, was applied. Two of the sixteen criteri...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-198907000-00013
更新日期:1989-07-01 00:00:00
abstract:OBJECTIVE:Depression represents a major public health concern, and prevalence increases significantly during adolescence. The high school transition may exacerbate the risk of depression for youth with pre-existing vulnerability. The High School Transition Program (HSTP) is a brief, skills-based intervention that has d...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1016/j.jaac.2019.05.031
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:It is unclear whether the structure of obsessive-compulsive disorder (OCD) symptoms seen in adults is preserved in pediatric samples. METHOD:A total of 238 children and adolescents referred to a specialty pediatric OCD clinic were administered the Children's Yale-Brown Obsessive Compulsive Scale Symptom Chec...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/CHI.0b013e31816b73c0
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:Co-occurrence of psychiatric disorders was investigated among 52 adolescent substance abusers and 23 non-substance-abusing adolescents with conduct and/or oppositional defiant disorders, admitted to the same inpatient facility. METHOD:During independent face-to-face interviews with parent(s) or caretaker(s) ...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199405000-00005
更新日期:1994-05-01 00:00:00
abstract::Variability in the trajectory of clinical symptoms in the early emerging presentation of young children with autism spectrum disorder (ASD) exists within an individual child over time and between different children at any point in time and across time. Georgiades et al.1 recently coined the term "chronogeneity" to ind...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 评论,社论
doi:10.1016/j.jaac.2018.06.021
更新日期:2018-11-01 00:00:00
abstract::This report provides preliminary evidence for the efficacy of clomipramine in the treatment of young adults with autistic disorder. Four of five outpatients with autistic disorder showed significant improvement in social relatedness, obsessive compulsive symptoms, and aggressive and impulsive behavior with clomipramin...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199207000-00025
更新日期:1992-07-01 00:00:00
abstract::Anxiety disorders are among the most common psychiatric illnesses in childhood and adolescence.1 The mainstays of treatment for childhood anxiety disorders are cognitive-behavioral therapy (CBT) and medications.2 Both of these treatments focus primarily on the child. However, parents and families often play a major ro...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 评论,社论
doi:10.1016/j.jaac.2019.04.025
更新日期:2020-03-01 00:00:00