Suggestive linkage of the child behavior checklist juvenile bipolar disorder phenotype to 1p21, 6p21, and 8q21.

Abstract:

OBJECTIVE:Several studies have documented a profile of elevated scores on the Attention Problems, Aggressive Behavior and Anxious/Depressed scales of the Child Behavior Checklist (CBCL) in youth with bipolar disorder. The sum of these scales, referred to as the CBCL Juvenile Bipolar Disorder (JBD) phenotype, has modest diagnostic utility, and high scores are associated with severity of psychopathology and poor outcome. Recently, a genomewide linkage scan of this measure in ADHD sibling pairs revealed a region of suggestive linkage on chromosome 2q21. The current study aimed to further identify quantitative trait loci that influence the CBCL-JBD phenotype by using a dense and thus, arguably, more powerful set of single-nucleotide polymorphism markers in a different ADHD sibling pair sample. METHOD:Subjects were 765 individuals from 154 families with CBCL data enrolled in a linkage study of ADHD. Linkage analyses were completed using a multipoint maximum likelihood variance components approach implemented using the statistical program SOLAR. RESULTS:Heritability of the CBCL-JBD phenotype was estimated at .71. Although no regions of the genome surpassed empirically derived criteria for significant linkage (p = .000038), peaks on 1p21.1 (p = .00037; LOD = 2.76), 6p21.3 (p = .00054; LOD =2.60), and 8q21.13 (p = .00081; LOD = 2.44) surpassed the threshold for suggestive linkage (p = .002). These regions have been highlighted in genomewide scans of bipolar disorder in adults, schizophrenia, autism, and ADHD. CONCLUSIONS:Findings raise the possibility that genes in these regions influence variation on the CBCL-JBD scale and the emotional and behavioral dysregulation associated with severe psychopathology.

authors

Doyle AE,Biederman J,Ferreira MA,Wong P,Smoller JW,Faraone SV

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

378-87

issue

4

eissn

0890-8567

issn

1527-5418

pii

S0890-8567(10)00084-5

journal_volume

49

pub_type

杂志文章
  • Evaluation of a preventive intervention for maltreated infants and toddlers in foster care.

    abstract:OBJECTIVE:To determine the effectiveness of an intervention designed to improve outcomes for infants and toddlers in foster care. METHOD:Records were reviewed for all children who were adjudicated as in need of care in a specific parish in Louisiana between 1991 and 1998. This period included 4 years before and 4 year...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004583-200102000-00016

    authors: Zeanah CH,Larrieu JA,Heller SS,Valliere J,Hinshaw-Fuselier S,Aoki Y,Drilling M

    更新日期:2001-02-01 00:00:00

  • Dimensions of oppositionality in a Brazilian community sample: testing the DSM-5 proposal and etiological links.

    abstract:OBJECTIVE:Investigating dimensions of oppositional symptoms may help to explain heterogeneity of etiology and outcomes for mental disorders across development and provide further empirical justification for the DSM-5-proposed modifications of oppositional defiant disorder (ODD). However, dimensions of oppositionality h...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2013.01.004

    authors: Krieger FV,Polanczyk VG,Goodman R,Rohde LA,Graeff-Martins AS,Salum G,Gadelha A,Pan P,Stahl D,Stringaris A

    更新日期:2013-04-01 00:00:00

  • Maternal depression and warmth during childhood predict age 20 neural response to reward.

    abstract:OBJECTIVE:Early parenting experiences likely shape children's brain development, with consequences potentially extending into adulthood. Parents' affective disorders and expressions of positive affect could exert an influence on affect-related circuitry. The current study evaluated how maternal depression and maternal ...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2013.10.003

    authors: Morgan JK,Shaw DS,Forbes EE

    更新日期:2014-01-01 00:00:00

  • Lack of Gender-Related Differences in Childhood-Onset Schizophrenia.

    abstract:OBJECTIVE:Gender differences, including younger age of onset and greater premorbid deficits in men, have been reported in adult-onset schizophrenia. This study comprehensively evaluated gender differences in childhood-onset schizophrenia (COS), a rare variant of the disorder. METHOD:Demographic, premorbid, clinical, f...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2016.05.022

    authors: Ordóñez AE,Loeb FF,Zhou X,Shora L,Berman RA,Broadnax DD,Gochman P,Liu S,Rapoport JL

    更新日期:2016-09-01 00:00:00

  • Do Parental Psychiatric Symptoms Predict Outcome in Children With Psychiatric Disorders? A Naturalistic Clinical Study.

    abstract:OBJECTIVE:Parental psychiatric symptoms can negatively affect the outcome of children's psychopathology. Studies thus far have mainly shown a negative effect of maternal depression. This study examined the associations between a broad range of psychiatric symptoms in mothers and fathers and the child's outcome. METHOD...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2018.05.017

    authors: Wesseldijk LW,Dieleman GC,van Steensel FJA,Bleijenberg EJ,Bartels M,Bögels SM,Middeldorp CM

    更新日期:2018-09-01 00:00:00

  • Comparison of diagnostic criteria for attention-deficit hyperactivity disorder in a county-wide sample.

    abstract:OBJECTIVE:To examine teacher-reported prevalence rates for attention-deficit hyperactivity disorder (ADHD) based on DSM-III-R and DSM-IV in the same population. METHOD:Teachers completed questionnaires in which they rated all their students on all DSM-III-R and DSM-IV symptoms for disruptive behavior disorders except ...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199603000-00013

    authors: Wolraich ML,Hannah JN,Pinnock TY,Baumgaertel A,Brown J

    更新日期:1996-03-01 00:00:00

  • Preventive intervention for maltreated preschool children: impact on children's behavior, neuroendocrine activity, and foster parent functioning.

    abstract:OBJECTIVE:This article describes the results of a pilot study that evaluated the effectiveness of the Early Intervention Foster Care (EIFC) program in the period immediately following a child's placement in a new foster home. METHOD:Data were collected from an EIFC group, a regular foster care group, and a community c...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-200011000-00009

    authors: Fisher PA,Gunnar MR,Chamberlain P,Reid JB

    更新日期:2000-11-01 00:00:00

  • Dr. Loades and Prof. Reynolds Reply.

    abstract::It is heartening to see that our rapid systematic review1 is stimulating others to highlight the needs of particular subsets of vulnerable children and adolescents. We found evidence that loneliness in children and adolescents is associated with increased depression and anxiety symptoms both cross-sectionally and long...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 评论,信件

    doi:10.1016/j.jaac.2020.08.437

    authors: Loades ME,Reynolds S

    更新日期:2021-01-01 00:00:00

  • Methylphenidate and behavior modification in children with ADHD and comorbid ODD or CD: main and incremental effects across settings.

    abstract:OBJECTIVE:Although the combination of methylphenidate (MPH) and behavior modification (BMOD) has been advocated to enhance clinical outcome for children with attention-deficit hyperactivity disorder (ADHD) and comorbid disruptive disorders, few group studies have been conducted. This study evaluates the separate and in...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004583-199905000-00020

    authors: Kolko DJ,Bukstein OG,Barron J

    更新日期:1999-05-01 00:00:00

  • Adolescents with ADHD: patterns of behavioral adjustment, academic functioning, and treatment utilization.

    abstract::Adolescents with attention deficit hyperactivity disorder (ADHD) were compared with a control group on a comprehensive assessment battery. More ADHD teenagers had oppositional defiant disorder (68%) and conduct disorder (39%) and were rated as more impaired in social competence, behavioral and emotional adjustment, an...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0890-8567(10)80010-3

    authors: Barkley RA,Anastopoulos AD,Guevremont DC,Fletcher KE

    更新日期:1991-09-01 00:00:00

  • Mapping Early Symptom Trajectories in Autism Spectrum Disorder: Lessons and Challenges for Clinical Practice and Science.

    abstract::Variability in the trajectory of clinical symptoms in the early emerging presentation of young children with autism spectrum disorder (ASD) exists within an individual child over time and between different children at any point in time and across time. Georgiades et al.1 recently coined the term "chronogeneity" to ind...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 评论,社论

    doi:10.1016/j.jaac.2018.06.021

    authors: Charman T

    更新日期:2018-11-01 00:00:00

  • The use of signal detection theory to assess DSM-III-R criteria for autistic disorder.

    abstract::Sixty cases from the DSM-III-R field trials for autistic disorder (AD) were studied to derive an optimally sensitive and specific combination of scoring criteria based on the 16 DSM-III-R criteria for AD. Signal detection theory, a statistical method new to psychiatric research, was applied. Two of the sixteen criteri...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-198907000-00013

    authors: Siegel B,Vukicevic J,Elliott GR,Kraemer HC

    更新日期:1989-07-01 00:00:00

  • Further evidence of the reliability and validity of DSM-IV ODD and CD in preschool children.

    abstract:OBJECTIVE:To test the reliability and validity of DSM-IV oppositional defiant and conduct disorders (ODD and CD) and symptoms using the Kiddie Disruptive Behavior Disorders Schedule and generate data on the manifestation of symptoms of ODD and CD in 3- to 5-year-old children. METHOD:One hundred twenty-three consecutiv...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/CHI.0b013e31803062d3

    authors: Keenan K,Wakschlag LS,Danis B,Hill C,Humphries M,Duax J,Donald R

    更新日期:2007-04-01 00:00:00

  • Does actigraphy differentiate ADHD subtypes in a clinical research setting?

    abstract:OBJECTIVE:To compare subtypes of attention-deficit/hyperactivity disorder (ADHD) (predominantly inattentive and combined types) and a comparison group on an objective measure of activity level (actigraphy). METHOD:Actigraphs were worn by 64 children (49 boys, 15 girls) during a full-day clinical diagnostic assessment;...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-200006000-00014

    authors: Dane AV,Schachar RJ,Tannock R

    更新日期:2000-06-01 00:00:00

  • The correlates of planning in adolescent suicide attempts.

    abstract::Adolescent suicide attempts are often impulsive. It has been suggested that individuals who make nonimpulsive (premeditated) attempts have greater suicidal intent and are more hopeless than the impulsive attempters. Eighty-six adolescent suicide attempters were categorized according to the degree of premeditation of t...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199101000-00014

    authors: Brown LK,Overholser J,Spirito A,Fritz GK

    更新日期:1991-01-01 00:00:00

  • Psychopathology among substance abusing juvenile offenders.

    abstract::The prevalence of substance abuse and coexisting DSM-III psychiatric disorders was evaluated in 111 juvenile offenders. As expected, a high rate of conduct disorder (91%) was present in both substance abusing and nonsubstance abusing juvenile offenders. However, significantly higher rates of attention deficit disorder...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199107000-00007

    authors: Milin R,Halikas JA,Meller JE,Morse C

    更新日期:1991-07-01 00:00:00

  • The Research Domain Criteria (RDoC) Project and Studies of Risk and Resilience in Maltreated Children.

    abstract:OBJECTIVE:The Research Domain Criteria (RDoC) project was initiated to develop, for research purposes, new ways of classifying mental disorders based on dimensions of observable behavior and neurobiological measures. This article reviews the rationale behind the RDoC program, its goals, and central tenets; discusses ap...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaac.2015.06.001

    authors: Kaufman J,Gelernter J,Hudziak JJ,Tyrka AR,Coplan JD

    更新日期:2015-08-01 00:00:00

  • Clozapine for the treatment of adolescents with schizophrenia.

    abstract::Despite recent reports that clozapine is useful for the treatment of chronic schizophrenics resistant to neuroleptics, no studies have been reported in adolescents with schizophrenia. Despite the risk of potentially fatal agranulocytosis, clozapine's use in adolescents may become important because of its lack of extra...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199201000-00024

    authors: Birmaher B,Baker R,Kapur S,Quintana H,Ganguli R

    更新日期:1992-01-01 00:00:00

  • Editorial: Tracing the Neural Origins of Psychopathology in Epidemiological Cohorts.

    abstract::The period spanning late childhood and early adulthood is of critical importance to mental health. This is a time of extensive brain reorganization, driven by interactions between environmental exposures, changes in the social role of individuals, and biologically programmed processes, which sets the foundation for ad...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 评论,社论

    doi:10.1016/j.jaac.2019.03.010

    authors: Frangou S

    更新日期:2019-11-01 00:00:00

  • Startle modulation in children at risk for anxiety disorders and/or alcoholism.

    abstract:OBJECTIVE:To examine the startle reflex as a possible vulnerability marker among offspring of parents with anxiety disorders and/or alcoholism. METHOD:The subjects were 66 male and female offspring (aged 10 to 17 years) of proband who participated in a family study of comorbidity of alcoholism and anxiety disorders. T...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199707000-00014

    authors: Grillon C,Dierker L,Merikangas KR

    更新日期:1997-07-01 00:00:00

  • Behavioral and neural consequences of prenatal exposure to nicotine.

    abstract:OBJECTIVE:To review evidence for the neurodevelopmental effects of in utero exposure to nicotine. Concerns about long-term cognitive and behavioral effects of prenatal exposure to nicotine arise from reports of increased rates of disruptive behavioral disorders in children whose mothers smoked during pregnancy. The rel...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,评审

    doi:10.1097/00004583-200106000-00007

    authors: Ernst M,Moolchan ET,Robinson ML

    更新日期:2001-06-01 00:00:00

  • Child and adolescent psychopharmacology in the new millennium: a workshop for academia, industry, and government.

    abstract:OBJECTIVE:To give academic researchers, government officials, and industry scientists an opportunity to assess the state of pediatric psychopharmacology and identify challenges facing professionals in the field. METHOD:Increased federal spending and the introduction of pediatric exclusivity led to large increases in p...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/01.chi.0000194568.70912.ee

    authors: Deveaugh-Geiss J,March J,Shapiro M,Andreason PJ,Emslie G,Ford LM,Greenhill L,Murphy D,Prentice E,Roberts R,Silva S,Swanson JM,VAN Zwieten-Boot B,Vitiello B,Wagner KD,Mangum B

    更新日期:2006-03-01 00:00:00

  • Attachment-based family therapy for depressed adolescents: a treatment development study.

    abstract:OBJECTIVE:To design a treatment manual and adherence measure for attachment-based family therapy (ABFT) for adolescent depression and to collect pilot data on the treatment's efficacy. METHOD:Over a period of 2 years, 32 adolescents meeting criteria for major depressive disorder (MDD) were randomly assigned to 12 week...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004583-200210000-00008

    authors: Diamond GS,Reis BF,Diamond GM,Siqueland L,Isaacs L

    更新日期:2002-10-01 00:00:00

  • Anxiety and intrafamilial stress in children with hemophilia after the HIV crisis.

    abstract:OBJECTIVE:The 12-month prevalence of DSM-III-R anxiety disorders and intrafamilial stress ratings were determined in 23 children with hemophilia, 37 children with asthma, and 31 healthy children. METHOD:Diagnoses were made using the parent and child versions of the Kiddie Schedule for Affective Disorders and Schizophr...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199305000-00011

    authors: Bussing R,Burket RC

    更新日期:1993-05-01 00:00:00

  • Factors protecting children living in disharmonious homes: maternal reports.

    abstract::This study investigated factors which were protective to children living in disharmonious homes. The sample was drawn from a representative sample of children aged 9 to 12 who took part in a previous general population study. Semi-structured interviews with both parents were used to assess the quality of the parental ...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199001000-00011

    authors: Jenkins JM,Smith MA

    更新日期:1990-01-01 00:00:00

  • Neuroanatomical correlates of temperament in early adolescents.

    abstract:OBJECTIVE:Temperament refers to enduring behavioral characteristics that underpin individual differences in human behavior, including risk for psychopathology. Research attempting to investigate the neurobiological basis of temperament represents an important step toward elucidating the biological mechanisms underlying...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/CHI.0b013e31816bffca

    authors: Whittle S,Yücel M,Fornito A,Barrett A,Wood SJ,Lubman DI,Simmons J,Pantelis C,Allen NB

    更新日期:2008-06-01 00:00:00

  • Relative cost-effectiveness of treatments for adolescent depression: 36-week results from the TADS randomized trial.

    abstract:OBJECTIVE:The cost-effectiveness of three active interventions for major depression in adolescents was compared after 36 weeks of treatment in the Treatment of Adolescents with Depression Study. METHOD:Outpatients aged 12 to 18 years with a primary diagnosis of major depression participated in a randomized controlled ...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/CHI.0b013e3181a2b319

    authors: Domino ME,Foster EM,Vitiello B,Kratochvil CJ,Burns BJ,Silva SG,Reinecke MA,March JS

    更新日期:2009-07-01 00:00:00

  • Feasibility of dialectical behavior therapy for suicidal adolescent inpatients.

    abstract:OBJECTIVE:To evaluate the feasibility of dialectical behavior therapy (DBT) implementation in a general child and adolescent psychiatric inpatient unit and to provide preliminary effectiveness data on DBT versus treatment as usual (TAU). METHOD:Sixty-two adolescents with suicide attempts or suicidal ideation were admi...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004583-200403000-00008

    authors: Katz LY,Cox BJ,Gunasekara S,Miller AL

    更新日期:2004-03-01 00:00:00

  • Defining treatment response and remission in obsessive-compulsive disorder: a signal detection analysis of the Children's Yale-Brown Obsessive Compulsive Scale.

    abstract:OBJECTIVE:To examine the optimal Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) percent reduction cutoffs for predicting treatment response and clinical remission among children and adolescents with obsessive-compulsive disorder (OCD). METHOD:Youth with OCD (N = 109; range 7 to 19 years) received 14 sessio...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2010.04.005

    authors: Storch EA,Lewin AB,De Nadai AS,Murphy TK

    更新日期:2010-07-01 00:00:00

  • Risk factors for presenting problems in child psychiatric emergencies.

    abstract:OBJECTIVE:To determine demographic and school-related risk factors for psychiatric emergencies presented by children in a hospital emergency room serving the majority of an urban community. METHOD:1,436 consecutive psychiatric emergency room visits for children younger than 16 years of age seen over a 10-year period w...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199609000-00014

    authors: Peterson BS,Zhang H,Santa Lucia R,King RA,Lewis M

    更新日期:1996-09-01 00:00:00