Abstract:
:Lipid-based dose forms, which encompass a wide variety of compositional and functional characteristics, can be advantageously utilized for the formulation of lipophilic drugs. There has been a traditional reluctance to develop lipid-based dose forms due to potential problems of chemical and physical instability, and a paucity of knowledge regarding formulation design algorithms and technology transfer issues. However, there is a current resurgence of interest in lipid-based dose forms due to potential commercial and pharmaceutical benefits, and the industry trend towards the discovery/development of increasingly hydrophobic (and potent) new chemical entities. This mini-review describes some emerging formulation and biopharmaceutic strategies that hold promise for better understanding how to design and evaluate lipid-based dose forms.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Charman WNdoi
10.1002/1520-6017(200008)89:8<967::aid-jps1>3.0.cosubject
Has Abstractpub_date
2000-08-01 00:00:00pages
967-78issue
8eissn
0022-3549issn
1520-6017pii
S0022-3549(16)30643-8journal_volume
89pub_type
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