Abstract：
OBJECTIVE:To determine if changes in serum homocysteine values during folic acid supplementation can identify objectively healthy subjects with subclinical folate deficiency. DESIGN:Blood drawn and processed in a regimented fashion from fasting subjects. Serum homocysteine values determined by gas chromatography-mass spectrometry twice before and on days 5 and 8 of daily folic acid supplementation. SETTING:Outpatient University Hospital Clinical Research Center, Denver, Colorado. SUBJECTS:Subjectively healthy adults with normal hematologic and biochemical screening tests. INTERVENTION:Folic acid 1 mg daily for eight consecutive days. RESULTS:Homocysteine values of the group fell significantly during folic acid supplementation. Values pre supplementation were 7.8 +/- 1.8 and 7.4 +/- 2.4 mumol/L while values on days 5 and 8 of supplementation were 6.5 +/- 2.2 and 6.3 +/- 2.2 mumol/L. However, the homocysteine values of any given individual varied up to 60% (rises up to 7 mumol/L and falls of 5 mumol/L) during folic acid supplementation despite the controlled circumstances of blood handling, and an assay coefficient of variation of 8%. CONCLUSIONS:Although group values of serum homocysteine fall during folic acid supplementation, intraindividual variation is so great that subjects with subclinical folate deficiency can not be identified using this study design. Furthermore, these data suggest than an individuals homocysteine values vary enough that single values must be interpreted with caution.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Santhosh-Kumar CR,Deutsch JC,Ryder JW,Kolhouse JFdoi
10.1038/sj.ejcn.1600385subject
Has Abstractpub_date
1997-03-01 00:00:00pages
188-92issue
3eissn
0954-3007issn
1476-5640journal_volume
51pub_type
临床试验,杂志文章abstract：BACKGROUND/OBJECTIVES:Obese infants are more susceptible to develop adulthood obesity and its related comorbidities. Previous studies have shown the presence of hormones and growth factors in maternal breast milk that may influence infant adiposity. The aim of this study was to investigate differences in concentrations...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2014.205
更新日期：2015-05-01 00:00:00
abstract：:High serum antioxidant vitamins are increasingly being associated with reduced risk of coronary heart disease (CHD). Previous studies have not addressed the relationship between dietary antioxidant vitamins and risk of CHD although diet is a key factor which modifies blood antioxidant vitamin levels. In prospective st...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1992-02-01 00:00:00
abstract：:Women (n = 45; 18-48 years) with serum ferritin less than or equal to 20 micrograms/l and haemoglobin greater than 120 g/l participated in an iron supplement bioavailability study. They were randomized to one of three groups and given one of three different low-dose supplements (18-20 mg iron/d) for 6 months. One of t...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-01-01 00:00:00
abstract：OBJECTIVE:To assess the suitability of the body mass index (BMI) as an indicator of standard of living in developing countries. DESIGN, SETTING AND SUBJECTS:The analysis is based on data collected in the first two rounds of the Ghana Living Standards Survey, held in 1987/88 (GLSS-I) and 1988/89 (GLSS-II). The dataset ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600528
更新日期：1998-02-01 00:00:00
abstract：OBJECTIVES:To examine the effects of physical activity (PA) in adults with or without prehypertension at baseline on systolic blood pressure (SBP), diastolic blood pressure (DBP), and hypertension risk by gender. METHODS:A total of 5986 men and 6525 women (≥18 years old) without hypertension-related disease at baselin...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-020-0653-0
更新日期：2020-05-13 00:00:00
abstract：OBJECTIVE:Improving dietary status is an important development objective, but monitoring of progress in this area can be too costly for many low-income countries. This paper demonstrates a simple, inexpensive technique for monitoring household diets in Mozambique. DESIGN:Secondary analysis of data from an intensive fi...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601671
更新日期：2003-10-01 00:00:00
abstract：OBJECTIVE:To investigate whether iron supplementation can improve thyroid hormone function in iron-deficient adolescent girls. DESIGN:A double-blind randomized intervention study. SETTING:The study was performed from 2002 through 2003 in the Islamic Republic of Iran. SUBJECTS:103 iron-deficient non-anaemic girls who...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602349
更新日期：2006-04-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to examine the variation of enterolactone from fasting and non-fasting blood of middle-aged healthy women eating a normal diet to determine the usefulness of a single sample in epidemiological studies. SUBJECTS AND METHODS:Twenty-six women born between 1940 and 1950 were recruited ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602811
更新日期：2008-08-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-018-0290-z
更新日期：2019-07-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 已发布勘误
doi：10.1038/ejcn.2017.96
更新日期：2017-07-01 00:00:00
abstract：OBJECTIVE:To compare the validity of skinfold anthropometry (SFA) and bioelectrical impedance (BIA) for the measurement of body composition in patients with chronic renal failure (CRF). DESIGN:We compared measurement of % total body fat (%TBF) and fat-free mass (FFM) by BIA and SFA, with dual energy X-ray absorptiomet...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:The aim of this study was to evaluate the association of serum 25-hydroxyvitamin D (25(OH)D) with disability and frequency of relapses in relapsing-remitting multiple sclerosis (MS) patients. SUBJECTS/METHODS:The study included 184 patients with relapsing-remitting MS who were receiving immune-mo...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2016.51
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVES:To examine seasonality of 25-hydroxyvitamin D (25OH-D) levels in British preschool children and the effect of vitamin D supplementation on this. DESIGN:The National Diet and Nutrition Survey of children aged 1.5 4.5 y in Britain during 1992-3 measured dietary intakes and blood status indices, including thos...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600697
更新日期：1999-03-01 00:00:00
abstract：OBJECTIVE:To measure body water distribution and to evaluate the accuracy of eight-polar bioelectrical impedance analysis (BIA) for the assessment of total body water (TBW) and extracellular water (ECW) in severe obesity. DESIGN:Cross-sectional study. SETTING:Obesity clinic. SUBJECTS:In all, 75 women aged 18-66 y, 2...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602049
更新日期：2005-02-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:To determine which component of the metabolic syndrome (MetS) is the best predictor of its development. SUBJECTS/METHODS:In this cohort study, 2279 subjects aged 20-87 years without MetS selected from among the participants of the cross-sectional phase of the Tehran Lipid and Glucose Study (TLGS)...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2010.111
更新日期：2010-10-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/ejcn.2012.80
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Malnutrition is a common and underrecognized clinical problem among aged institutionalized patients. The aim of this study was to investigate how well nurses recognize malnutrition in elderly patients in long-term care hospitals in Helsinki. SUBJECTS AND METHODS:In this descriptive, cross-sect...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602916
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:The majority of hospital outpatients with undernutrition is unrecognized, and therefore untreated. There is a need for an easy and valid screening tool to detect undernutrition in this setting. The aim of this study was to determine the diagnostic accuracy of the MUST (Malnutrition Universal Scree...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,多中心研究
doi：10.1038/ejcn.2013.85
更新日期：2013-07-01 00:00:00
abstract：:The prevalence and aetiology of lowland endemic goitre was studied in Bawlle Village, Htan-ta-bin Township, Rangoon Division. The total goitre rate was found to be 40.9 per cent. Low urinary iodine excretion and high 24-h uptake of 131I by the thyroids of the subjects indicated iodine deficiency which was further conf...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1989-10-01 00:00:00
abstract：BACKGROUND:The ability to communicate food benefits is essential for the successful development of functional foods and their role in improving public health. However, the functional efficacy of foods often cannot be represented by food composition. The concept of virtual food components (VFCs)-food data that express h...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601769
更新日期：2004-02-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：
更新日期：1994-02-01 00:00:00
abstract：:Skeletal growth and changes in body composition during growth present important variations; body mass index and lean body mass related to age show important gender differences. The process of ossification is developed in two different ways, endochondral and intramembraneous. The former is characterised by the formatio...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/sj.ejcn.1600976
更新日期：2000-03-01 00:00:00
abstract：OBJECTIVE:To estimate the intake of ruminant trans fatty acids (TFA) in the Danish population aged 1-80 years. DESIGN:Descriptive study. SUBJECTS:A sex- and age-stratified random sample drawn from the Danish Civil Registration System. A total of 3098 participants (51% female) aged 1-80 years were included. The partic...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602316
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVE:To study the relation between sleep habits, nutritional status, growth and maturation in a group of African adolescent girls. The main hypothesis to be tested was that sleep length could be an effective way to spare energy, and thus malnourished girls sleep longer than normal girls. DESIGN:Three repeated yea...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601781
更新日期：2004-02-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602262
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:A high prevalence of Type 2 diabetes exists in Saudi Arabia. Epidemiological evidence suggests that low glycaemic index (GI) diets reduce diabetes risk. Yet, little is known about the GI of traditional Saudi Arabian staples such as Hassawi rice (HR). HR was evaluated in terms of its GI and insulin...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/ejcn.2011.4
更新日期：2011-05-01 00:00:00
abstract：OBJECTIVE:To assess how food shortage has been reflected in changes in nutritional status and dietary intake of resident and refugee populations in wartime Sarajevo. DESIGN:Longitudinal observations were carried out on residents (who stayed in their homes) and refugees (living in collective centres). Three out of four...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1995-10-01 00:00:00
abstract：:A low-cost locally based nutrition education programme was designed around the employment of a part-time dietitian with the aim of improving the nutritional intakes of Grampian Health Board staff. Its effectiveness was evaluated by assessment of habitual dietary intakes of staff, using a previously validated questionn...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1988-02-01 00:00:00
abstract：OBJECTIVE:To explore the relation between a wide range of alcohol consumptions and levels of the components of insulin-like growth factor system (IGFs) and adiponectin in humans. DESIGN:A cross-sectional study using controls from a case-control study on ovarian and endometrial cancer. SETTINGS:The study included wome...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602519
更新日期：2007-02-01 00:00:00
abstract：OBJECTIVE:To examine the effect of low-dose fish oil supplementation on specific growth factors, purported to play a central role in lesion formation, and also on the total growth factor activity of serum, as assessed by the induction of DNA synthesis in cultured human arterial smooth muscle cells. DESIGN:Randomized p...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601076
更新日期：2000-09-01 00:00:00
